ATE121100T1 - Ein neues thrombomodulin ähnliches glykoprotein erhältlich aus harn. - Google Patents

Ein neues thrombomodulin ähnliches glykoprotein erhältlich aus harn.

Info

Publication number
ATE121100T1
ATE121100T1 AT89123963T AT89123963T ATE121100T1 AT E121100 T1 ATE121100 T1 AT E121100T1 AT 89123963 T AT89123963 T AT 89123963T AT 89123963 T AT89123963 T AT 89123963T AT E121100 T1 ATE121100 T1 AT E121100T1
Authority
AT
Austria
Prior art keywords
urine
thrombomodulin
available
new glycoprotein
glycoprotein similar
Prior art date
Application number
AT89123963T
Other languages
English (en)
Inventor
Yasuyuki Kunihiro
Ryo Tanaka
Michio Ichimura
Akio Uemura
Nobuo Ohzawa
Ei Mochida
Original Assignee
Mochida Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mochida Pharm Co Ltd filed Critical Mochida Pharm Co Ltd
Application granted granted Critical
Publication of ATE121100T1 publication Critical patent/ATE121100T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/834—Urine; urinary system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT89123963T 1988-12-27 1989-12-27 Ein neues thrombomodulin ähnliches glykoprotein erhältlich aus harn. ATE121100T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP33041388 1988-12-27
JP28524089 1989-11-01

Publications (1)

Publication Number Publication Date
ATE121100T1 true ATE121100T1 (de) 1995-04-15

Family

ID=26555801

Family Applications (2)

Application Number Title Priority Date Filing Date
AT94113062T ATE215967T1 (de) 1988-12-27 1989-12-27 Aus harn isolierte antikoagulierende verbindung
AT89123963T ATE121100T1 (de) 1988-12-27 1989-12-27 Ein neues thrombomodulin ähnliches glykoprotein erhältlich aus harn.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT94113062T ATE215967T1 (de) 1988-12-27 1989-12-27 Aus harn isolierte antikoagulierende verbindung

Country Status (8)

Country Link
US (2) US5202421A (de)
EP (2) EP0376251B1 (de)
AT (2) ATE215967T1 (de)
AU (2) AU626365B2 (de)
CA (1) CA2006658C (de)
DE (2) DE68929388T2 (de)
ES (1) ES2073425T3 (de)
GR (1) GR3015765T3 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202421A (en) * 1988-12-27 1993-04-13 Mochida Pharmaceutical Co., Ltd. Anticoagulant substance obtained from urine and process for the preparation thereof
WO1992000325A1 (en) * 1990-06-27 1992-01-09 Mochida Pharmaceutical Co., Ltd. Anticoagulant polypeptides
EP0689843B1 (de) * 1993-12-17 2003-09-10 Mochida Pharmaceutical Co., Ltd. Lösliches thrombomodulin enthaltende zubereitung
US5981716A (en) * 1995-06-07 1999-11-09 Gruppo Lepettit, S.P.A. Process for the purification of proteins
JP4067117B2 (ja) * 1995-06-09 2008-03-26 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 選択性スロンビン抑制剤としてのブラジキニン同族体
JP3745805B2 (ja) * 1995-10-24 2006-02-15 日本ケミカルリサーチ株式会社 トロンボモジュリンの精製方法
US6982249B1 (en) 1997-04-23 2006-01-03 The Regents Of The University Of Michigan Bradykinin analogs as selective inhibitors of cell activation
WO1999018994A1 (fr) * 1997-10-15 1999-04-22 Asahi Kasei Kogyo Kabushiki Kaisha Procede pour conserver la qualite d'une solution parenterale aqueuse de thrombomoduline pour l'entreposage ou la distribution
DE19749197A1 (de) * 1997-11-07 1999-05-12 Dade Behring Marburg Gmbh Verfahren zur Bestimmung des antikoagulatorischen Potentials einer Probe
DE19945351C2 (de) * 1999-09-22 2002-04-18 Lohmann Therapie Syst Lts Verfahren zum Auffinden und zur Isolierung pharmakologisch wirksamer Verbindungen aus Substanzgemischen
CN1352087A (zh) * 2000-11-02 2002-06-05 上海博德基因开发有限公司 一种新的多肽——人糖蛋白42和编码这种多肽的多核苷酸
CA2486113A1 (en) * 2002-05-17 2003-12-04 Wyeth Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins
JP2006096668A (ja) * 2002-11-08 2006-04-13 Ono Pharmaceut Co Ltd エラスターゼ阻害剤と血液凝固系および／または線溶系酵素阻害剤との組み合わせからなる医薬
US20070086958A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Formation of medically useful gels comprising microporous particles and methods of use
US20070087061A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Method and composition for creating and/or activating a platelet-rich gel by contact with a porous particulate material, for use in wound care, tissue adhesion, or as a matrix for delivery of therapeutic components
KR20090051777A (ko) * 2006-10-06 2009-05-22 아사히 가세이 파마 가부시키가이샤 파종성 혈관내 혈액 응고 증후군의 치료 및/또는 개선제
NZ579873A (en) 2007-03-23 2011-11-25 Asahi Kasei Pharma Corp Method for producing soluble thrombomodulin of high purity
JP2011178687A (ja) * 2010-02-26 2011-09-15 Kochi Univ 造血細胞移植に伴う疼痛の予防および／または治療剤
NZ602852A (en) 2010-04-30 2014-03-28 Asahi Kasei Pharma Corp Highly-purified soluble thrombomodulin and method for producing same
AU2012337838B2 (en) 2011-11-15 2016-04-21 Asahi Kasei Pharma Corporation Medicament for therapeutic treatment and/or improvement of sepsis

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4810232B1 (de) * 1970-09-04 1973-04-02
BE791783A (fr) * 1972-11-23 1973-05-23 Lilly Co Eli Polypeptides et procede pour les preparer
JPS60199819A (ja) * 1984-03-23 1985-10-09 Kowa Co トロンビン結合性物質およびその製法
JPH0753667B2 (ja) * 1985-08-09 1995-06-07 新技術開発事業団 骨髄移植療法補助剤
CA1265446A (en) * 1985-09-30 1990-02-06 Masahiro Maki Anticoagulating substance, process for preparing same and anticoagulant comprising same as an effective component
JPH0689014B2 (ja) * 1986-01-21 1994-11-09 興和株式会社 トロンビン結合性物質およびその製法
DE3750664T2 (de) * 1986-07-15 1995-06-22 Kowa Co Throminbindende Substanz und Verfahren zu ihrer Herstellung.
JPS6330423A (ja) * 1986-07-22 1988-02-09 Kowa Co トロンビン結合性物質およびその製法
JPH0764878B2 (ja) * 1986-10-14 1995-07-12 興和株式会社 抗血液凝固物質及びその製法
EP0816494A1 (de) * 1987-01-08 1998-01-07 Asahi Kasei Kogyo Kabushiki Kaisha DNS kodierend für ein Peptid das die Wirkung des Proteins C mit Thrombin beschleunigt und Verfahren zu dessen Herstellung
US4912207A (en) * 1987-05-06 1990-03-27 Washington University DNA clone of human thrombomodulin and portions thereof
JPH0219399A (ja) * 1988-07-05 1990-01-23 Oklahoma Medical Res Found トロンビン結合ポリピペプチド
JPH0720997B2 (ja) * 1988-08-29 1995-03-08 興和株式会社 新規なトロンビン結合性物質及びその製法
US5202421A (en) * 1988-12-27 1993-04-13 Mochida Pharmaceutical Co., Ltd. Anticoagulant substance obtained from urine and process for the preparation thereof

Also Published As

Publication number Publication date
AU2742892A (en) 1993-01-07
CA2006658C (en) 2000-03-28
ATE215967T1 (de) 2002-04-15
ES2073425T3 (es) 1995-08-16
EP0376251B1 (de) 1995-04-12
EP0376251A3 (en) 1990-12-19
GR3015765T3 (en) 1995-07-31
US5300490A (en) 1994-04-05
DE68922202T2 (de) 1995-09-21
EP0632055A1 (de) 1995-01-04
DE68929388D1 (de) 2002-05-16
EP0632055B1 (de) 2002-04-10
CA2006658A1 (en) 1990-06-27
AU4727889A (en) 1990-08-16
EP0376251A2 (de) 1990-07-04
DE68922202D1 (de) 1995-05-18
AU626365B2 (en) 1992-07-30
AU653269B2 (en) 1994-09-22
DE68929388T2 (de) 2002-11-14
US5202421A (en) 1993-04-13

Similar Documents

Publication Publication Date Title
ATE121100T1 (de) Ein neues thrombomodulin ähnliches glykoprotein erhältlich aus harn.
DE3772429D1 (de) Pharmazeutisches praeparat zur behandlung von peridontalkrankheiten.
DE69230112D1 (de) Fortschrittliches arzneistoffabgabesystem und verfahren zur behandlung von psychiatrischen, neurologischen und anderen erkrankungen mit carbamazepin
DE3855921D1 (de) Verfahren und Desoxyribonukleinsäure zur Herstellung von Gewebefaktor-Protein
ATE66374T1 (de) Zubereitungen und verfahren zur behandlung von blutungsstoerungen.
DE3879873D1 (de) Physiologisch aktive substanzen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DK254887A (da) Salve til behandling af hudsygdomme
IT8322855A0 (it) Composizione farmaceutica per la cura delle arteriopatie periferiche.
DE3685853D1 (de) Mittel zur behandlung von knochenkrankheiten.
ATE84877T1 (de) Verfahren zur kristallmorphologischen blut- und harnanalyse, zur fruehdiagnose und zur herstellung von arzneimitteln.
FR2510889B1 (fr) Medicament contenant certains phosphates ribofurannosyl-3',5'-cycliques substitues en 6, 8 pour le traitement de maladies proliferatives de la peau
ATE174798T1 (de) Die herstellung von zusammensetzungen zur behandlung von krankheiten der zellproliferation
IT8721115A0 (it) Fitopreparato per la cura di affezioni cutanee.
ATE151774T1 (de) Cyclopentanperhydrophenanthren-17-beta-(3-furyl - 3-derivate und pharmazeutische präparate davon, zur behandlung von kardiovaskulär-erkrankungen
DE3787437D1 (de) Sialosylcholesterol, verfahren zu dessen herstellung und arzneimittel zur behandlung von krankheiten des nervensystems.
DE69200412D1 (de) 3-substituierte 1,2,3,4-oxatriazol-5-iminderivate, verfahren zur herstellung sowie diese enthaltende arzneimittel.
FR2614203B1 (fr) Composition pharmaceutique pour le traitement des maladies de la peau et son procede de preparation.
DK10188A (da) Middel til behandling af virussygdomme
DK113789D0 (da) Thiosulfinsyrederivater, deres anvendelse til behandling af betaendelsessygdomme samt laegemiddel indeholdende disse stoffer
ATE135702T1 (de) Aryl- oder heteroaryl-1-alkyl-pyrrol-2- carbonsäure-derivate, zur behandlung von durch interleukin-1 hervorgerufenen erkrankungen
ATE126437T1 (de) Verwendung von depogen zur behandlung von eingeschränktem blutkreislauf.
DK417889D0 (da) Anvendelse af 2-azabicyklo(2.2.2.)-carboxylsyrederivater til fremstilling af medicinske produkter til behandling af vaskulaere sygdomme
DE3688414D1 (de) Verwendung von chinolinderivaten zur herstellung von medikamenten zur behandlung von zerebralen gefaesskrankheiten und zerebraler senilitaet.
DE68914886D1 (de) Mittel zur Behandlung von Raynaud's Krankheit.
ATE136776T1 (de) Verwendung von heptastigmin zur behandlung der zerebralen ictus

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee