ATE135702T1 - Aryl- oder heteroaryl-1-alkyl-pyrrol-2- carbonsäure-derivate, zur behandlung von durch interleukin-1 hervorgerufenen erkrankungen - Google Patents

Aryl- oder heteroaryl-1-alkyl-pyrrol-2- carbonsäure-derivate, zur behandlung von durch interleukin-1 hervorgerufenen erkrankungen

Info

Publication number
ATE135702T1
ATE135702T1 AT90101809T AT90101809T ATE135702T1 AT E135702 T1 ATE135702 T1 AT E135702T1 AT 90101809 T AT90101809 T AT 90101809T AT 90101809 T AT90101809 T AT 90101809T AT E135702 T1 ATE135702 T1 AT E135702T1
Authority
AT
Austria
Prior art keywords
pyrrol
interleukin
heteroaryl
aryl
alkyl
Prior art date
Application number
AT90101809T
Other languages
English (en)
Inventor
Roger A Parker
George Ku
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Application granted granted Critical
Publication of ATE135702T1 publication Critical patent/ATE135702T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
AT90101809T 1989-01-31 1990-01-30 Aryl- oder heteroaryl-1-alkyl-pyrrol-2- carbonsäure-derivate, zur behandlung von durch interleukin-1 hervorgerufenen erkrankungen ATE135702T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30414189A 1989-01-31 1989-01-31

Publications (1)

Publication Number Publication Date
ATE135702T1 true ATE135702T1 (de) 1996-04-15

Family

ID=23175237

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90101809T ATE135702T1 (de) 1989-01-31 1990-01-30 Aryl- oder heteroaryl-1-alkyl-pyrrol-2- carbonsäure-derivate, zur behandlung von durch interleukin-1 hervorgerufenen erkrankungen

Country Status (17)

Country Link
EP (1) EP0381141B1 (de)
JP (1) JP2841305B2 (de)
KR (1) KR0139288B1 (de)
CN (1) CN1022754C (de)
AR (1) AR245694A1 (de)
AT (1) ATE135702T1 (de)
AU (1) AU629290B2 (de)
CA (1) CA2008616C (de)
DE (1) DE69025967T2 (de)
ES (1) ES2087093T3 (de)
FI (1) FI900464A0 (de)
HU (1) HU209290B (de)
IL (1) IL93187A (de)
NO (1) NO174887C (de)
NZ (1) NZ232278A (de)
PT (1) PT93009A (de)
ZA (1) ZA90554B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
AU625688B2 (en) * 1989-01-31 1992-07-16 Merrell Dow Pharmaceuticals Inc. Method of using aryl- or heteroaryl-1-alkyl-pyrrole-2- carboxylic acid compounds in the treatment of interleukin-1 mediated conditions
EP2451779B1 (de) 2009-07-10 2014-09-03 The General Hospital Corporation Etomidat-analoge, die die adrenokortikale steroidsynthese nicht hemmen
CN102114430B (zh) * 2009-12-30 2013-06-05 上海睿智化学研究有限公司 催化剂、其制备方法及n-烷基吡咯衍生物的制备方法
CA2861071C (en) 2012-01-13 2017-09-12 The General Hospital Corporation Etomidate and metomidate derivatives and their use as anesthetics

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4112112A (en) * 1976-06-29 1978-09-05 Merck & Co., Inc. Pyrrolo[2,1-b] [3]benzazepines useful for producing a skeletal muscle relaxing or tranquilizing effect
JPS54128567A (en) * 1978-03-28 1979-10-05 Teijin Ltd 1-substituted-4-acyl-2-pyrrolecarboxylic acid derivative

Also Published As

Publication number Publication date
HUT53868A (en) 1990-12-28
DE69025967T2 (de) 1996-08-29
EP0381141B1 (de) 1996-03-20
IL93187A (en) 1994-12-29
KR900011725A (ko) 1990-08-02
NO900432L (no) 1990-08-01
JPH02247165A (ja) 1990-10-02
ES2087093T3 (es) 1996-07-16
AU4875990A (en) 1990-08-09
CA2008616C (en) 2000-07-18
HU900592D0 (en) 1990-04-28
CN1022754C (zh) 1993-11-17
NO174887C (no) 1994-07-27
NZ232278A (en) 1992-07-28
IL93187A0 (en) 1990-11-05
EP0381141A2 (de) 1990-08-08
EP0381141A3 (de) 1991-11-21
AR245694A1 (es) 1994-02-28
NO174887B (no) 1994-04-18
CA2008616A1 (en) 1990-07-31
ZA90554B (en) 1990-10-31
FI900464A0 (fi) 1990-01-30
CN1044653A (zh) 1990-08-15
DE69025967D1 (de) 1996-04-25
PT93009A (pt) 1990-07-31
AU629290B2 (en) 1992-10-01
NO900432D0 (no) 1990-01-30
JP2841305B2 (ja) 1998-12-24
HU209290B (en) 1994-04-28
KR0139288B1 (ko) 1998-05-15

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Legal Events

Date Code Title Description
EEFA Change of the company name
REN Ceased due to non-payment of the annual fee