ES2087093T3 - Derivados de acidos aril- o heteroaril-1-alquil-pirrol-2-carboxilicos utiles en el tratamiento de enfermedades mediadas por la interleuquina-1. - Google Patents

Derivados de acidos aril- o heteroaril-1-alquil-pirrol-2-carboxilicos utiles en el tratamiento de enfermedades mediadas por la interleuquina-1.

Info

Publication number
ES2087093T3
ES2087093T3 ES90101809T ES90101809T ES2087093T3 ES 2087093 T3 ES2087093 T3 ES 2087093T3 ES 90101809 T ES90101809 T ES 90101809T ES 90101809 T ES90101809 T ES 90101809T ES 2087093 T3 ES2087093 T3 ES 2087093T3
Authority
ES
Spain
Prior art keywords
heteroaril
pirrol
aril
interleukin
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90101809T
Other languages
English (en)
Inventor
Roger A Parker
George Ku
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2087093T3 publication Critical patent/ES2087093T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

ESTE INVENTO RELATA EL NUEVO COMPUESTO ARIL - O HETEROARIL - 1 - ALQUIL PIRROL - 2 - ACIDO CARBOXILICO, UTIL EN EL TRATAMIENTO DEL INTERLEUKIN - 1.
ES90101809T 1989-01-31 1990-01-30 Derivados de acidos aril- o heteroaril-1-alquil-pirrol-2-carboxilicos utiles en el tratamiento de enfermedades mediadas por la interleuquina-1. Expired - Lifetime ES2087093T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30414189A 1989-01-31 1989-01-31

Publications (1)

Publication Number Publication Date
ES2087093T3 true ES2087093T3 (es) 1996-07-16

Family

ID=23175237

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90101809T Expired - Lifetime ES2087093T3 (es) 1989-01-31 1990-01-30 Derivados de acidos aril- o heteroaril-1-alquil-pirrol-2-carboxilicos utiles en el tratamiento de enfermedades mediadas por la interleuquina-1.

Country Status (17)

Country Link
EP (1) EP0381141B1 (es)
JP (1) JP2841305B2 (es)
KR (1) KR0139288B1 (es)
CN (1) CN1022754C (es)
AR (1) AR245694A1 (es)
AT (1) ATE135702T1 (es)
AU (1) AU629290B2 (es)
CA (1) CA2008616C (es)
DE (1) DE69025967T2 (es)
ES (1) ES2087093T3 (es)
FI (1) FI900464A0 (es)
HU (1) HU209290B (es)
IL (1) IL93187A (es)
NO (1) NO174887C (es)
NZ (1) NZ232278A (es)
PT (1) PT93009A (es)
ZA (1) ZA90554B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
ZA90555B (en) * 1989-01-31 1990-10-31 Merrell Pharma Inc Method of using aryl-or heteroaryl-1-alkyl-pyrrole-2-carboxylic acid compounds in the treatment of interleukin-1 mediated conditions
CA2767112C (en) * 2009-07-10 2018-06-19 The General Hospital Corporation Etomidate analogues that do not inhibit adrenocortical steroid synthesis
CN102114430B (zh) * 2009-12-30 2013-06-05 上海睿智化学研究有限公司 催化剂、其制备方法及n-烷基吡咯衍生物的制备方法
RS56025B1 (sr) 2012-01-13 2017-09-29 Massachusetts Gen Hospital Anestetička jedinjenja i odgovarajući postupci primene

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4112112A (en) * 1976-06-29 1978-09-05 Merck & Co., Inc. Pyrrolo[2,1-b] [3]benzazepines useful for producing a skeletal muscle relaxing or tranquilizing effect
JPS54128567A (en) * 1978-03-28 1979-10-05 Teijin Ltd 1-substituted-4-acyl-2-pyrrolecarboxylic acid derivative

Also Published As

Publication number Publication date
AR245694A1 (es) 1994-02-28
CN1044653A (zh) 1990-08-15
JPH02247165A (ja) 1990-10-02
JP2841305B2 (ja) 1998-12-24
HU900592D0 (en) 1990-04-28
NO900432L (no) 1990-08-01
NO174887C (no) 1994-07-27
HUT53868A (en) 1990-12-28
AU629290B2 (en) 1992-10-01
AU4875990A (en) 1990-08-09
HU209290B (en) 1994-04-28
PT93009A (pt) 1990-07-31
DE69025967D1 (de) 1996-04-25
ATE135702T1 (de) 1996-04-15
KR0139288B1 (ko) 1998-05-15
IL93187A0 (en) 1990-11-05
FI900464A0 (fi) 1990-01-30
EP0381141B1 (en) 1996-03-20
NZ232278A (en) 1992-07-28
EP0381141A2 (en) 1990-08-08
EP0381141A3 (en) 1991-11-21
KR900011725A (ko) 1990-08-02
IL93187A (en) 1994-12-29
NO174887B (no) 1994-04-18
ZA90554B (en) 1990-10-31
DE69025967T2 (de) 1996-08-29
NO900432D0 (no) 1990-01-30
CA2008616C (en) 2000-07-18
CA2008616A1 (en) 1990-07-31
CN1022754C (zh) 1993-11-17

Similar Documents

Publication Publication Date Title
ES507394A0 (es) Mejoras en el objeto de la patente de invencion n.487.721 por procedimiento de preparacion de nuevos derivados del nortropano.
EE03969B1 (et) (Metüülsulfonüül)fenüül-2-(5H)-furanoonid, nende kasutamine ja farmatseutilised kompositsioonid
ATE277929T1 (de) Immunsuppressive wirkungen von pteridinderivaten
MEP10408A (en) Platinum derivative pharmaceutical formulations
BR0011130A (pt) Inibidores de metaloproteases
YU31801A (sh) Amidi antranilne kiseline i njihova upotreba kao leka
FI963070A (fi) Klooripyrimidiinivälituotteita
CY1106032T1 (el) Υποκατασταθεισες πυραζολες
EE05287B1 (et) Tsklopentanoindoolid, nende kasutamine ravimi valmistamiseks ning neid sisaldav farmatseutiline kompositsioon
YU82702A (sh) Ortosupstituisani amidi antranilne kiseline i njihova primena kao sredstva za lečenje
BR9708114A (pt) Análogos xantona para o tratamento de doenças infecciosas.
ES2061688T3 (es) Composiciones farmaceuticas que comprenden una calcitonina y un glicirricinato como mejorador de la absorcion.
PT888271E (pt) Derivados de benzamidina substituidos com derivados de aminoacidos e hidroxiacidos e sua utilizacao como anticoagulantes
ES2174921T3 (es) Inhibidores de la proteasa del vih.
YU63696A (sh) Novi fenilamidin-derivati, postupci za njihovo pripremanje i njihova primena kao lekova
MX9305093A (es) Nuevos derivadosindano-2 mercaptoacetilamina triciclicos 2-sustituidos, utiles como inhibidores de la encefalinasa.
AU641279B2 (en) Oligosaccharide derivatives
ES2087093T3 (es) Derivados de acidos aril- o heteroaril-1-alquil-pirrol-2-carboxilicos utiles en el tratamiento de enfermedades mediadas por la interleuquina-1.
FI844232A0 (fi) Purinderivat.
ES2182035T3 (es) Derivados del bisarilciclobuteno como inhibidores de ciclooxigenasa.
ES2051954T3 (es) 2-aminotiazoles substituidos.
FI922428A0 (fi) Nya 2-amino-5-cyan-1,4- dihydropyridiner, foerfarande foer deras framstaellning och deras anvaendning i laekemedel.
IT7826263A0 (it) Derivati del piranocromone e composizione terapeutica comprendente gli stessi, per il trattamento di malattie allergiche.
ES2074257T3 (es) Derivados de aminoacidos.
ES2144857T3 (es) Utilizacion de derivados benzonaftalenicos para la fabricacion de medicamentos destinados para el tratamiento de las enfermedades del sistema nervioso.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 0381141

Country of ref document: ES