EA199801044A1 - Модуляторы регенерации тканей - Google Patents
Модуляторы регенерации тканейInfo
- Publication number
- EA199801044A1 EA199801044A1 EA199801044A EA199801044A EA199801044A1 EA 199801044 A1 EA199801044 A1 EA 199801044A1 EA 199801044 A EA199801044 A EA 199801044A EA 199801044 A EA199801044 A EA 199801044A EA 199801044 A1 EA199801044 A1 EA 199801044A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- modulators
- tissue regeneration
- proteins
- stimulated
- damaged
- Prior art date
Links
- 230000017423 tissue regeneration Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001172 regenerating effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Abstract
Описаны белки, которые стимулируются в поврежденных или регенерирующих тканях, и ДНК, кодирующая эти белки, а также терапевтические композиции и способы лечения с использованием этих соединений.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1822896P | 1996-05-24 | 1996-05-24 | |
US2344296P | 1996-08-23 | 1996-08-23 | |
PCT/US1997/009303 WO1997044460A1 (en) | 1996-05-24 | 1997-05-23 | Modulators of tissue regeneration |
Publications (2)
Publication Number | Publication Date |
---|---|
EA199801044A1 true EA199801044A1 (ru) | 1999-04-29 |
EA004402B1 EA004402B1 (ru) | 2004-04-29 |
Family
ID=26690881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA199801044A EA004402B1 (ru) | 1996-05-24 | 1997-05-23 | Модуляторы регенерации тканей |
Country Status (27)
Country | Link |
---|---|
US (4) | US6664385B1 (ru) |
EP (2) | EP0907735B9 (ru) |
JP (3) | JP4602482B2 (ru) |
CN (1) | CN1147584C (ru) |
AT (1) | ATE318903T1 (ru) |
AU (1) | AU712289B2 (ru) |
BG (1) | BG64678B1 (ru) |
BR (1) | BR9709115A (ru) |
CA (1) | CA2257851C (ru) |
CZ (1) | CZ295936B6 (ru) |
DE (1) | DE69735364T3 (ru) |
DK (1) | DK0907735T5 (ru) |
EA (1) | EA004402B1 (ru) |
EE (1) | EE04817B1 (ru) |
ES (1) | ES2258793T5 (ru) |
HK (1) | HK1021746A1 (ru) |
HU (1) | HU226205B1 (ru) |
IL (1) | IL127162A (ru) |
IS (1) | IS2636B (ru) |
NO (2) | NO327597B1 (ru) |
NZ (1) | NZ336467A (ru) |
PL (1) | PL188826B1 (ru) |
PT (1) | PT907735E (ru) |
SI (1) | SI0907735T2 (ru) |
SK (1) | SK285461B6 (ru) |
TR (1) | TR199802421T2 (ru) |
WO (1) | WO1997044460A1 (ru) |
Families Citing this family (53)
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SK285461B6 (sk) * | 1996-05-24 | 2007-02-01 | Biogen Idec Ma Inc. | Izolovaný polypeptid KIM, modulátor tkanivovej regenerácie a nukleová kyselina, ktorá ho kóduje, spôsob prípravy polypeptidu a farmaceutická kompozícia obsahujúca polypeptid |
AU7592998A (en) * | 1997-05-23 | 1998-12-11 | Biogen, Inc. | Modulators of tissue regeneration |
SK287538B6 (sk) | 1998-03-20 | 2011-01-04 | Commonwealth Scientific And Industrial Research Organisation | Syntetický gén obsahujúci dispergovanú alebo cudzorodú deoxyribonukleovú molekulu, génový konštrukt obsahujúci tento syntetický gén a prípravok obsahujúci tento syntetický gén |
AUPP249298A0 (en) | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
US6423885B1 (en) | 1999-08-13 | 2002-07-23 | Commonwealth Scientific And Industrial Research Organization (Csiro) | Methods for obtaining modified phenotypes in plant cells |
EP1160321A1 (en) * | 2000-05-31 | 2001-12-05 | Sanofi-Synthelabo | Kidney Injury Novel Gene-1: Isolation and therapeutic applications |
AU6986201A (en) * | 2000-06-16 | 2002-01-02 | Biogen Inc | Renal regulatory elements and methods of use thereof |
US6812002B2 (en) * | 2000-08-30 | 2004-11-02 | Pfizer Inc. | Osteoactivin protein and nucleic acids encoding the same, compositions and methods of stimulating bone differentiation |
DE60224275T2 (de) * | 2001-06-01 | 2008-12-11 | Biogen Idec Ma Inc., Cambridge | Moleküle und verfahren zur inhibierung der freisetzung von kim-1 |
WO2003002722A2 (en) | 2001-06-29 | 2003-01-09 | The Board Of Trustees Of The Leland Stanford Junior University | T cell regulatory genes and methods of use thereof |
US8709412B2 (en) | 2001-06-29 | 2014-04-29 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation of TIM receptor activity in combination with cytoreductive therapy |
WO2003080856A2 (en) * | 2002-03-19 | 2003-10-02 | Curagen Corporation | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
ES2311122T3 (es) | 2002-12-30 | 2009-02-01 | Biogen Idec Ma Inc. | Antagonistas de kim-1 y uso para la modulacion del sistema inmune. |
AU2004224390A1 (en) * | 2003-03-19 | 2004-10-07 | Abgenix, Inc. | Antibodies against T cell immunoglobulin domain and mucin domain 1 (TIM-1) antigen and uses thereof |
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US20050272101A1 (en) * | 2004-06-07 | 2005-12-08 | Prasad Devarajan | Method for the early detection of renal injury |
RU2283666C9 (ru) * | 2004-05-14 | 2007-03-10 | Бизяев Алексей Вячеславович | Средство для активации восстановления структуры и функции поврежденных тканей и органов |
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DE602006016413D1 (de) | 2005-03-02 | 2010-10-07 | Biogen Idec Inc | Kim-1-antikörper zur behandlung von th2-vermittelten erkrankungen |
US20070037232A1 (en) * | 2005-03-31 | 2007-02-15 | Barasch Jonathan M | Detection of NGAL in chronic renal disease |
US20080090304A1 (en) * | 2006-10-13 | 2008-04-17 | Barasch Jonathan Matthew | Diagnosis and monitoring of chronic renal disease using ngal |
JP2009515897A (ja) | 2005-11-10 | 2009-04-16 | キュラジェン コーポレイション | T細胞の免疫グロブリンドメインおよびムチンドメイン1(tim−1)抗原に対する抗体を用いて卵巣癌および腎臓癌を処置する方法 |
EP2035835B1 (en) | 2006-05-30 | 2011-12-28 | Antibodyshop A/S | Methods for rapid assessment of severity of a trauma |
EP2602624A1 (en) * | 2006-08-07 | 2013-06-12 | Antibodyshop A/S | Diagnostic test to exclude significant renal injury |
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US20090297479A1 (en) * | 2008-03-28 | 2009-12-03 | Kiyoshi Ariizumi | Dc-hil conjugates for treatment of t-cell disorders |
NZ610356A (en) * | 2008-08-28 | 2015-03-27 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
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CN104399089B (zh) | 2008-10-21 | 2017-04-19 | 阿斯图特医药公司 | 用于诊断和预后肾损伤和肾衰竭的方法和组合物 |
NZ592488A (en) | 2008-11-10 | 2012-10-26 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
CN104034901A (zh) * | 2008-11-22 | 2014-09-10 | 阿斯图特医药公司 | 用于诊断和预后肾损伤和肾衰竭的方法和组合物 |
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JP2013519095A (ja) | 2010-02-05 | 2013-05-23 | アスチュート メディカル,インコーポレイテッド | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
KR20140051754A (ko) | 2010-02-26 | 2014-05-02 | 아스튜트 메디컬 인코포레이티드 | 신장 손상 및 신부전의 진단 및 예후를 위한 방법 및 조성물 |
JP2013529907A (ja) | 2010-05-24 | 2013-07-25 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | Ngalタンパク質変異体及びその使用 |
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-
1997
- 1997-05-23 SK SK1609-98A patent/SK285461B6/sk not_active IP Right Cessation
- 1997-05-23 DK DK97932145.2T patent/DK0907735T5/da active
- 1997-05-23 ES ES97932145T patent/ES2258793T5/es not_active Expired - Lifetime
- 1997-05-23 CZ CZ19983813A patent/CZ295936B6/cs not_active IP Right Cessation
- 1997-05-23 NZ NZ336467A patent/NZ336467A/xx not_active IP Right Cessation
- 1997-05-23 AT AT97932145T patent/ATE318903T1/de active
- 1997-05-23 EA EA199801044A patent/EA004402B1/ru not_active IP Right Cessation
- 1997-05-23 SI SI9730732T patent/SI0907735T2/sl unknown
- 1997-05-23 IL IL127162A patent/IL127162A/en not_active IP Right Cessation
- 1997-05-23 AU AU35676/97A patent/AU712289B2/en not_active Expired
- 1997-05-23 WO PCT/US1997/009303 patent/WO1997044460A1/en active IP Right Grant
- 1997-05-23 CA CA2257851A patent/CA2257851C/en not_active Expired - Lifetime
- 1997-05-23 HU HU9902770A patent/HU226205B1/hu unknown
- 1997-05-23 EP EP97932145A patent/EP0907735B9/en not_active Expired - Lifetime
- 1997-05-23 EP EP05111979A patent/EP1655367A1/en not_active Withdrawn
- 1997-05-23 PT PT97932145T patent/PT907735E/pt unknown
- 1997-05-23 EE EE9800409A patent/EE04817B1/xx unknown
- 1997-05-23 CN CNB971958289A patent/CN1147584C/zh not_active Expired - Lifetime
- 1997-05-23 DE DE69735364T patent/DE69735364T3/de not_active Expired - Lifetime
- 1997-05-23 TR TR1998/02421T patent/TR199802421T2/xx unknown
- 1997-05-23 BR BR9709115A patent/BR9709115A/pt not_active Application Discontinuation
- 1997-05-23 JP JP54298697A patent/JP4602482B2/ja not_active Expired - Lifetime
- 1997-05-23 PL PL97330313A patent/PL188826B1/pl unknown
-
1998
- 1998-11-20 IS IS4902A patent/IS2636B/is unknown
- 1998-11-20 NO NO985427A patent/NO327597B1/no not_active IP Right Cessation
- 1998-11-23 US US09/197,970 patent/US6664385B1/en not_active Expired - Lifetime
- 1998-11-30 BG BG102967A patent/BG64678B1/bg unknown
-
2000
- 2000-01-21 HK HK00100386A patent/HK1021746A1/xx not_active IP Right Cessation
-
2003
- 2003-09-04 US US10/655,506 patent/US20050089868A1/en not_active Abandoned
-
2006
- 2006-08-08 US US11/463,227 patent/US20060286031A1/en not_active Abandoned
- 2006-08-08 US US11/463,239 patent/US20070141590A1/en not_active Abandoned
-
2007
- 2007-09-11 JP JP2007236021A patent/JP4316640B2/ja not_active Expired - Lifetime
-
2008
- 2008-07-18 JP JP2008187615A patent/JP2009039111A/ja not_active Withdrawn
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2009
- 2009-03-03 NO NO20090945A patent/NO20090945L/no not_active Application Discontinuation
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