IS4902A - Stilliefni fyrir endurmyndun vefja - Google Patents

Stilliefni fyrir endurmyndun vefja

Info

Publication number
IS4902A
IS4902A IS4902A IS4902A IS4902A IS 4902 A IS4902 A IS 4902A IS 4902 A IS4902 A IS 4902A IS 4902 A IS4902 A IS 4902A IS 4902 A IS4902 A IS 4902A
Authority
IS
Iceland
Prior art keywords
adjuster
tissue regeneration
purified
new
nucleic acid
Prior art date
Application number
IS4902A
Other languages
English (en)
Other versions
IS2636B (is
Inventor
Sanicola-Nadel Michele
V. Bonventre Joseph
A. Hession Catherine
Ichimura Takaharu
Wei Henry
L. Cate Richard
Original Assignee
Biogen Idec Ma Inc.
The Genaral Hospital Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26690881&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IS4902(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biogen Idec Ma Inc., The Genaral Hospital Corporation filed Critical Biogen Idec Ma Inc.
Publication of IS4902A publication Critical patent/IS4902A/is
Publication of IS2636B publication Critical patent/IS2636B/is

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082Supracellular entities, e.g. tissue, organisms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Electrotherapy Devices (AREA)
IS4902A 1996-05-24 1998-11-20 Stilliefni fyrir endurmyndun vefja IS2636B (is)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1822896P 1996-05-24 1996-05-24
US2344296P 1996-08-23 1996-08-23
PCT/US1997/009303 WO1997044460A1 (en) 1996-05-24 1997-05-23 Modulators of tissue regeneration

Publications (2)

Publication Number Publication Date
IS4902A true IS4902A (is) 1998-11-20
IS2636B IS2636B (is) 2010-06-15

Family

ID=26690881

Family Applications (1)

Application Number Title Priority Date Filing Date
IS4902A IS2636B (is) 1996-05-24 1998-11-20 Stilliefni fyrir endurmyndun vefja

Country Status (26)

Country Link
US (4) US6664385B1 (is)
EP (2) EP1655367A1 (is)
JP (3) JP4602482B2 (is)
CN (1) CN1147584C (is)
AT (1) ATE318903T1 (is)
AU (1) AU712289B2 (is)
BG (1) BG64678B1 (is)
BR (1) BR9709115A (is)
CA (1) CA2257851C (is)
CZ (1) CZ295936B6 (is)
DE (1) DE69735364T3 (is)
DK (1) DK0907735T5 (is)
EA (1) EA004402B1 (is)
EE (1) EE04817B1 (is)
ES (1) ES2258793T5 (is)
HU (1) HU226205B1 (is)
IL (1) IL127162A (is)
IS (1) IS2636B (is)
NO (2) NO327597B1 (is)
NZ (1) NZ336467A (is)
PL (1) PL188826B1 (is)
PT (1) PT907735E (is)
SI (1) SI0907735T2 (is)
SK (1) SK285461B6 (is)
TR (1) TR199802421T2 (is)
WO (1) WO1997044460A1 (is)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2258793T5 (es) * 1996-05-24 2010-01-25 Biogen Idec Ma Inc. Moduladores de la regeneracion tisular.
AU7592998A (en) * 1997-05-23 1998-12-11 Biogen, Inc. Modulators of tissue regeneration
CA2323726C (en) 1998-03-20 2005-02-08 Benitec Australia Ltd. Control of gene expression
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
EP1160321A1 (en) * 2000-05-31 2001-12-05 Sanofi-Synthelabo Kidney Injury Novel Gene-1: Isolation and therapeutic applications
NZ523475A (en) * 2000-06-16 2004-09-24 Biogen Inc Renal regulatory elements and methods of use thereof
US6812002B2 (en) * 2000-08-30 2004-11-02 Pfizer Inc. Osteoactivin protein and nucleic acids encoding the same, compositions and methods of stimulating bone differentiation
ATE382060T1 (de) * 2001-06-01 2008-01-15 Biogen Idec Inc Moleküle und verfahren zur inhibierung der freisetzung von kim-1
US8709412B2 (en) 2001-06-29 2014-04-29 The Board Of Trustees Of The Leland Stanford Junior University Modulation of TIM receptor activity in combination with cytoreductive therapy
WO2003002722A2 (en) * 2001-06-29 2003-01-09 The Board Of Trustees Of The Leland Stanford Junior University T cell regulatory genes and methods of use thereof
US20050014687A1 (en) * 2002-03-19 2005-01-20 Anderson David W. Therapeutic polypeptides, nucleic acids encoding same, and methods of use
CN1835769B (zh) 2002-12-30 2011-06-29 比奥根艾迪克Ma公司 Kim-1拮抗剂及其在免疫系统调节中的应用
US8067544B2 (en) * 2003-03-19 2011-11-29 Curagen Corporation Antibodies against T cell immunoglobulin domain and mucin domain 1 (TIM-1) antigen and uses thereof
EP2083270B1 (en) * 2003-03-27 2019-06-12 Children's Hospital Medical Center A method and kit for detecting the early onset of renal tubular cell injury
US20050272101A1 (en) * 2004-06-07 2005-12-08 Prasad Devarajan Method for the early detection of renal injury
JP2007536260A (ja) 2004-05-06 2007-12-13 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク 虚血性および腎毒性障害の軽減および改善用ngal
RU2283666C9 (ru) * 2004-05-14 2007-03-10 Бизяев Алексей Вячеславович Средство для активации восстановления структуры и функции поврежденных тканей и органов
US20060003345A1 (en) * 2004-06-30 2006-01-05 Pfizer Inc RNA bioassay
EP3208616B1 (en) * 2004-12-20 2018-09-26 Antibodyshop A/S Determination of neutrophil gelatinase-associated lipocalin (ngal) as a diagnostic marker for renal disorders
EP2251037B1 (en) 2005-03-02 2015-01-14 Biogen Idec MA Inc. KIM-1 antibodies for treatment of TH1/TH2-mediated conditions
WO2007059082A1 (en) 2005-11-10 2007-05-24 Curagen Corporation Method of treating ovarian and renal cancer using antibodies against t cell immunoglobulin domain and mucin domain 1 (tim-1) antigen
US20070037232A1 (en) * 2005-03-31 2007-02-15 Barasch Jonathan M Detection of NGAL in chronic renal disease
US20080090304A1 (en) * 2006-10-13 2008-04-17 Barasch Jonathan Matthew Diagnosis and monitoring of chronic renal disease using ngal
WO2007137584A1 (en) 2006-05-30 2007-12-06 Antibodyshop A/S Methods and devices for rapid assessment of severity of injury
EP2064553B2 (en) * 2006-08-07 2023-06-07 Antibodyshop A/S Diagnostic test to exclude significant renal injury
CN101680903A (zh) * 2007-03-21 2010-03-24 比奥波托诊断股份公司 肾损伤的诊断试验
US8846036B2 (en) 2007-10-19 2014-09-30 Abbott Laboratories Antibodies that bind to mammalian NGAL and uses thereof
US20090297479A1 (en) * 2008-03-28 2009-12-03 Kiyoshi Ariizumi Dc-hil conjugates for treatment of t-cell disorders
BRPI0917711A2 (pt) * 2008-08-28 2017-06-20 Astute Medical Inc método para avaliar o estado renal em um paciente, e, uso de um ou mais marcadores de lesão renal
EP2324354B1 (en) * 2008-08-29 2014-07-16 Astute Medical, Inc. Methods for prognosis of acute renal failure
EP3783363A1 (en) * 2008-10-21 2021-02-24 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN102246038B (zh) * 2008-10-21 2014-06-18 阿斯图特医药公司 用于诊断和预后肾损伤和肾衰竭的方法和组合物
MX2011004767A (es) 2008-11-10 2011-09-06 Astute Medical Inc Metodos y composiciones para diagnosis y prognosis de lesion renal y falla renal.
BRPI0921921A2 (pt) * 2008-11-22 2019-09-24 Astute Medical Inc método para avaliar a condição renal em um indivíduo, e, uso de um ou mais marcadores de lesão renal.
JP5524241B2 (ja) * 2009-01-28 2014-06-18 インダストリアル テクノロジー リサーチ インスティテュート 腎症と関連するバイオマーカー
US9229010B2 (en) 2009-02-06 2016-01-05 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
NZ598035A (en) * 2009-08-07 2014-06-27 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CA2770393A1 (en) 2009-08-07 2011-02-10 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN104793000A (zh) 2009-11-07 2015-07-22 阿斯图特医药公司 用于肾损伤和肾衰竭的诊断及预后的方法和组合物
EA201290387A1 (ru) 2009-12-20 2013-02-28 Астьют Медикал, Инк. Способы и композиции для диагностики и прогнозирования повреждений почек и почечной недостаточности
PT2666872T (pt) 2010-02-05 2016-07-08 Astute Medical Inc Processos e composições para o diagnóstico e o prognóstico de lesões renais e de insuficiência renal
KR20140051754A (ko) 2010-02-26 2014-05-02 아스튜트 메디컬 인코포레이티드 신장 손상 및 신부전의 진단 및 예후를 위한 방법 및 조성물
AU2011269847A1 (en) 2010-02-26 2013-01-31 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
ES2667066T3 (es) 2010-05-24 2018-05-09 The Trustees Of Columbia University In The City Of New York Proteínas NGAL mutantes y usos de las mismas
EP2585827A4 (en) 2010-06-23 2013-12-04 Astute Medical Inc METHOD AND COMPOSITIONS FOR DIAGNOSIS AND FORECASTING kidney injury and kidney insufficiency
US8927252B2 (en) * 2011-02-09 2015-01-06 Lavivo Ab Synbiotic compositions for restoration and reconstitution of gut microbiota
EP2788759B1 (en) 2011-12-08 2019-02-20 Astute Medical, Inc. Methods and uses for diagnosis of renal injury and renal failure
EP2925337B1 (en) 2012-11-21 2019-07-03 The Trustees of Columbia University in the City of New York Mutant ngal proteins and uses thereof
EP3734280B8 (en) 2013-01-17 2022-08-24 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US10420337B2 (en) * 2013-03-15 2019-09-24 Lifeline Scientific, Inc. Transporter with a glucose sensor for determining viability of an organ or tissue
US10265424B2 (en) * 2014-03-04 2019-04-23 Trust-Biosonics, Inc. Molecular imaging contrast agents and uses thereof
EP3465201A4 (en) 2016-06-06 2020-08-26 Astute Medical, Inc. MANAGEMENT OF ACUTE KIDNEY DAMAGE USING INSULINOMIMETIC GROWTH FACTOR BINDING PROTEIN 7 AND TISSUE METALLOPROTEINASE 2 INHIBITOR

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2003A (en) * 1841-03-12 Improvement in horizontal windivhlls
US5019368A (en) * 1989-02-23 1991-05-28 Cancer Biologics, Inc. Detection of necrotic malignant tissue and associated therapy
GB9122820D0 (en) * 1991-10-28 1991-12-11 Wellcome Found Stabilised antibodies
AU4116793A (en) * 1992-04-24 1993-11-29 Board Of Regents, The University Of Texas System Recombinant production of immunoglobulin-like domains in prokaryotic cells
CA2166313A1 (en) * 1994-02-14 1995-08-17 John N. Simons Non-a, non-b, non-c, non-d, non-e hepatitis reagents and methods for their use
US5622861A (en) * 1994-08-05 1997-04-22 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA encoding hepatitis A virus receptor
JPH10508461A (ja) * 1994-08-18 1998-08-25 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク 独特の関連したカポシ肉腫ウイルス配列およびその使用
US6069230A (en) * 1994-11-10 2000-05-30 Promega Corporation High level expression and facile purification of proteins, peptides and conjugates for immunization, purification and detection applications
US6066322A (en) * 1995-03-03 2000-05-23 Millennium Pharmaceuticals, Inc. Methods for the treatment of immune disorders
ES2258793T5 (es) * 1996-05-24 2010-01-25 Biogen Idec Ma Inc. Moduladores de la regeneracion tisular.
NZ523475A (en) * 2000-06-16 2004-09-24 Biogen Inc Renal regulatory elements and methods of use thereof
ATE382060T1 (de) * 2001-06-01 2008-01-15 Biogen Idec Inc Moleküle und verfahren zur inhibierung der freisetzung von kim-1
WO2003002722A2 (en) * 2001-06-29 2003-01-09 The Board Of Trustees Of The Leland Stanford Junior University T cell regulatory genes and methods of use thereof
US7838220B2 (en) * 2001-06-29 2010-11-23 The Board Of Trustees Of The Leland Stanford Junior University T cell regulatory genes associated with immune disease
US7215871B2 (en) * 2001-07-27 2007-05-08 Thomson Licensing Changing a playback speed for video presentation recorded in a field structure format
US7687454B2 (en) * 2001-12-03 2010-03-30 The University Of British Columbia Effectors of innate immunity determination
AU2003303082B2 (en) * 2002-01-30 2009-07-02 Dana-Farber Cancer Institute, Inc. Compositions and methods related to TIM-3, a Th1-specific cell surface molecule
US20050014687A1 (en) * 2002-03-19 2005-01-20 Anderson David W. Therapeutic polypeptides, nucleic acids encoding same, and methods of use
CN1835769B (zh) * 2002-12-30 2011-06-29 比奥根艾迪克Ma公司 Kim-1拮抗剂及其在免疫系统调节中的应用
TW200539890A (en) * 2004-03-12 2005-12-16 Brigham & Womens Hospital Methods of modulating immune responses by modulating tim-1, tim-2 and tim-4 function
EA200601761A1 (ru) * 2004-03-24 2007-06-29 Телос Фармасьютикалз, Инк. Композиции в качестве адъювантов для усиления иммунных ответов на вакцины и способы их применения

Also Published As

Publication number Publication date
SK285461B6 (sk) 2007-02-01
EP0907735A1 (en) 1999-04-14
US20070141590A1 (en) 2007-06-21
ES2258793T3 (es) 2006-09-01
NZ336467A (en) 2000-10-27
BG64678B1 (bg) 2005-11-30
EE9800409A (et) 1999-06-15
NO20090945L (no) 1999-01-25
HK1021746A1 (en) 2000-06-30
EP0907735B9 (en) 2010-05-19
EP1655367A1 (en) 2006-05-10
NO985427L (no) 1999-01-25
AU712289B2 (en) 1999-11-04
CN1223685A (zh) 1999-07-21
CA2257851C (en) 2011-11-15
JP2009039111A (ja) 2009-02-26
HU226205B1 (en) 2008-06-30
IS2636B (is) 2010-06-15
SI0907735T2 (sl) 2010-01-29
ES2258793T5 (es) 2010-01-25
EP0907735B1 (en) 2006-03-01
EE04817B1 (et) 2007-04-16
DK0907735T4 (da) 2009-12-21
ATE318903T1 (de) 2006-03-15
HUP9902770A3 (en) 2001-09-28
JP2001505761A (ja) 2001-05-08
US20050089868A1 (en) 2005-04-28
NO327597B1 (no) 2009-08-31
NO985427D0 (no) 1998-11-20
AU3567697A (en) 1997-12-09
SK160998A3 (en) 1999-07-12
HUP9902770A2 (hu) 1999-12-28
JP2008067701A (ja) 2008-03-27
JP4602482B2 (ja) 2010-12-22
PL330313A1 (en) 1999-05-10
DE69735364T3 (de) 2010-05-06
US6664385B1 (en) 2003-12-16
BR9709115A (pt) 1999-08-03
PT907735E (pt) 2006-06-30
CN1147584C (zh) 2004-04-28
PL188826B1 (pl) 2005-04-29
US20060286031A1 (en) 2006-12-21
DK0907735T3 (da) 2006-06-26
IL127162A0 (en) 1999-09-22
WO1997044460A1 (en) 1997-11-27
EA004402B1 (ru) 2004-04-29
CA2257851A1 (en) 1997-11-27
EA199801044A1 (ru) 1999-04-29
TR199802421T2 (xx) 1999-02-22
DE69735364D1 (de) 2006-04-27
DK0907735T5 (da) 2010-06-14
JP4316640B2 (ja) 2009-08-19
SI0907735T1 (sl) 2006-08-31
EP0907735B2 (en) 2009-10-07
CZ381398A3 (cs) 1999-05-12
CZ295936B6 (cs) 2005-12-14
IL127162A (en) 2007-07-24
DE69735364T2 (de) 2006-11-30
BG102967A (bg) 2000-05-31

Similar Documents

Publication Publication Date Title
IS4902A (is) Stilliefni fyrir endurmyndun vefja
ATE280826T1 (de) Cc-chemokinzeptor c-c ckr-5, dessen derivate und verwendungen
ATE252639T1 (de) Modifizierter, das dorsalgewebe beeinflussender faktor
FI972333L (fi) Entsymaattiset DNA-molekyylit
DE69736068D1 (de) Faktor viii vom schwein und hybriden
FI951612A7 (fi) Menetelmiä synteettisten oligonukleotidien sekvensoimiseksi, jotka sis ältävät nukleotidien välisiä ei-fosfodiesterisidoksia
DE69707849D1 (de) Verfahren zur reinigung von 1,4-butandiol
DK0960127T3 (da) Isoleret dimert fibroblastaktiverende protein-alfa og anvendelser deraf
HUT77049A (hu) Katepszin-02-fehérjék, -nukleinsavak és -ellenanyagok
DE69715234D1 (de) Verfahren zur reinigung von 1,1-difluorethan
DE69527803D1 (de) Aufgereinigte dna-polymerase von thermococcus barossii
FI962087L (fi) Olefiinien polymerointiin tarkoitettu stereospesifinen katalyyttisysteemi ja monivaiheiset polymerointiprosessit, joissa tätä systeemiä käytetään
ITMI941969A0 (it) Processo per la purificazione di 2,6-diisopropilfenolo
ZA9710163B (en) Novel carboxylesterase nucleic acid molecules, proteins and uses thereof.
BR9706702A (pt) Purificação de 1,1,1,3,3-pentafluorpropano
PE20399A1 (es) Muteina ob
FR2698102B1 (fr) Composition destinée au lavage de la peau ou des muqueuses.
FR2717185B1 (fr) Microfiltration de la bière.
ITTO940070V0 (it) Filtro aria con supporto in poliuterano, particolarmente per l'abita- colo di autoveicoli.
DE69414375D1 (de) Verfahren zur herstellung von 1,1,1,2,2-pentafluoroethan, verfahren zur herstellung von 2,2-dichloro-1,1,1-trifluoroethan und verfahren zur reinigung von 1,1,1,2,2-pentafluoroethan
DE3777359D1 (de) Aminosaeuresequenz des menschlichen alpha 2-plasmininhibitors und cdns sowie diese aminosaeuresequenz codierende genomische dns.
DE69607582D1 (de) Verfahren zur Herstellung und Reinigung von 1,1,1-Tris(4-hydroxyphenyl)ethan
DE69721065D1 (de) Verfahren zur reiningung von 1,3,5-triisopropylbenzol
DE59708626D1 (de) Verfahren zur herstellung von 4,5,6-trichlor- und 2,4,5,6-tetrachlorpyrimidin