WO1997023611A3 - Nukleinsäuresequenzen von genen der high mobility group proteine sowie verwendungen derselben - Google Patents

Nukleinsäuresequenzen von genen der high mobility group proteine sowie verwendungen derselben Download PDF

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Publication number
WO1997023611A3
WO1997023611A3 PCT/DE1996/002494 DE9602494W WO9723611A3 WO 1997023611 A3 WO1997023611 A3 WO 1997023611A3 DE 9602494 W DE9602494 W DE 9602494W WO 9723611 A3 WO9723611 A3 WO 9723611A3
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Prior art keywords
genes
high mobility
agents
mobility group
procedures
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PCT/DE1996/002494
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English (en)
French (fr)
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WO1997023611A2 (de
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Joern Bullerdiek
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Joern Bullerdiek
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Publication date
Application filed by Joern Bullerdiek filed Critical Joern Bullerdiek
Priority to EP96946114A priority Critical patent/EP0870024A2/de
Priority to JP9523225A priority patent/JP2000504933A/ja
Priority to AU18705/97A priority patent/AU1870597A/en
Publication of WO1997023611A2 publication Critical patent/WO1997023611A2/de
Publication of WO1997023611A3 publication Critical patent/WO1997023611A3/de
Priority to US09/105,542 priority patent/US6323329B1/en
Priority to US09/951,107 priority patent/US20020120120A1/en
Priority to US11/024,522 priority patent/US7790454B2/en
Priority to US12/857,456 priority patent/US20100311161A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Ophthalmology & Optometry (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Steroid Compounds (AREA)

Abstract

Die vorliegende Erfindung betrifft DNA-Sequenzen, deren Verwendung sowie die Verwendung von DNA-Sequenzen der MAG-Gene bzw. von Genen der High Mobility Group Proteine, Mittel zur Behandlung verschiedener Krankheiten, einschließlich Tumorerkrankungen, zur Beeinflussung der Gefäßentwicklung sowie zur Kontrazeption und Geweberegeneration und entsprechende Kits und Verfahren. Mit den genannten Sequenzen, Mitteln, Verwendungen, Kits und Verfahren wird eine spezifische Beeinflussung von molekularen Mechanismen möglich, die verschiedenen Krankheiten, der Gefäßentwicklung, der Kontrazeption und der Geweberegeneration gemeinsam zugrundeliegen. Damit verringern sich die bei entsprechenden Mitteln oder Verfahren sonst zu beobachtenden Nachteile.
PCT/DE1996/002494 1995-12-21 1996-12-20 Nukleinsäuresequenzen von genen der high mobility group proteine sowie verwendungen derselben WO1997023611A2 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP96946114A EP0870024A2 (de) 1995-12-21 1996-12-20 Nukleinsäuresequenzen von genen der high mobility group proteine sowie verwendungen derselben
JP9523225A JP2000504933A (ja) 1995-12-21 1996-12-20 ＨＭＧ蛋白質（ｈｉｇｈ ｍｏｂｉｌｉｔｙ ｇｒｏｕｐ ｐｒｏｔｅｉｎ）遺伝子の核酸配列およびそれらの使用
AU18705/97A AU1870597A (en) 1995-12-21 1996-12-20 Nucleic acid sequences of genes of the high mobility group proteins and uses thereof
US09/105,542 US6323329B1 (en) 1995-12-21 1998-06-26 Nucleic acid sequences of genes encoding high mobility group proteins
US09/951,107 US20020120120A1 (en) 1995-12-21 2001-09-10 Nucleic acid sequences of genes encoding high mobility group proteins and uses thereof
US11/024,522 US7790454B2 (en) 1995-12-21 2004-12-29 Method for tissue regeneration
US12/857,456 US20100311161A1 (en) 1995-12-21 2010-08-16 Method for tissue regeneration

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19548122.4 1995-12-21
DE19548122A DE19548122A1 (de) 1995-12-21 1995-12-21 Nukleinsäuresequenzen von Genen der High Mobility Group Proteine sowie Verwendungen derselben

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10232198A Continuation 1995-12-21 1998-06-22

Publications (2)

Publication Number Publication Date
WO1997023611A2 WO1997023611A2 (de) 1997-07-03
WO1997023611A3 true WO1997023611A3 (de) 1997-10-02

Family

ID=7781000

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1996/002494 WO1997023611A2 (de) 1995-12-21 1996-12-20 Nukleinsäuresequenzen von genen der high mobility group proteine sowie verwendungen derselben

Country Status (7)

Country Link
EP (1) EP0870024A2 (de)
JP (3) JP2000504933A (de)
AU (1) AU1870597A (de)
CA (1) CA2239682A1 (de)
DE (1) DE19548122A1 (de)
NZ (1) NZ504445A (de)
WO (1) WO1997023611A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19824230A1 (de) * 1998-05-29 1999-12-02 Starzinski Powitz Anna Neues Endometriose-assoziiertes Gen
DE19904514A1 (de) * 1999-02-04 2000-08-10 Joern Bullerdiek Mittel zur Prävention und/oder Behandlung von Leiomyomen
US7151082B2 (en) 1999-02-11 2006-12-19 The Feinstein Institute For Medical Research Antagonists of HMG1 for treating inflammatory conditions
US6303321B1 (en) 1999-02-11 2001-10-16 North Shore-Long Island Jewish Research Institute Methods for diagnosing sepsis
AU7899300A (en) * 1999-10-18 2001-04-30 Shanghai Bio Road Gene Technology Ltd. A novel polypeptide - human high mobility group protein 13 and a polynucleotide encoding the same
CN1300762A (zh) * 1999-12-23 2001-06-27 复旦大学 一种新的多肽－高迁移率组分蛋白家族11和编码这种多肽的多核苷酸
US7304034B2 (en) 2001-05-15 2007-12-04 The Feinstein Institute For Medical Research Use of HMGB fragments as anti-inflammatory agents
WO2003051383A2 (de) * 2001-12-19 2003-06-26 Alcedo Biotech Gmbh Verwendung von hmgb-proteinen und dafür codierenden nukleinsäuren
EP1519957B1 (de) * 2002-07-03 2009-03-04 Fondazione Centro San Raffaele Del Monte Tabor Die verwendung von hmgb1 zur behandlung von gewebeverletzungen und/oder zur unterstützung der gewebewiederherstellung
EP1579221A2 (de) * 2003-01-03 2005-09-28 Alcedo Biotech GmbH Verwendungen von hmgb, hmgn, hmga proteinen
US7696169B2 (en) 2003-06-06 2010-04-13 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
CA2538763C (en) 2003-09-11 2015-05-05 Critical Therapeutics, Inc. Monoclonal antibodies against hmgb1
US8129130B2 (en) 2004-10-22 2012-03-06 The Feinstein Institute For Medical Research High affinity antibodies against HMGB1 and methods of use thereof
WO2007001422A2 (en) 2004-10-22 2007-01-04 Medimmune, Inc. High affinity antibodies against hmgb1 and methods of use thereof
WO2007076200A2 (en) 2005-11-28 2007-07-05 Medimmune, Inc. Antagonists of hmgb1 and/or rage and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0727487A1 (de) * 1995-02-17 1996-08-21 K.U. Leuven Research & Development Multi-Tumor abweichende Wachstumsgene

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5279941A (en) * 1992-06-12 1994-01-18 Trustees Of The University Of Pennsylvania Determination of endometrial receptivity toward embryo implantation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0727487A1 (de) * 1995-02-17 1996-08-21 K.U. Leuven Research & Development Multi-Tumor abweichende Wachstumsgene

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ASHAR H. ET AL.: "Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains", CELL, vol. 82, 14 July 1995 (1995-07-14), pages 57 - 65, XP002033203 *
CHAU K. ET AL.: "The gene for the human architectural transcription factor HMGI-C consists of five exons each coding for a distinct functional element", NUCLEIC ACIDS RESEARCH, vol. 23, no. 21, 11 November 1995 (1995-11-11), pages 4262 - 4266, XP002033205 *
PATEL U. ET AL.: "Expression and cDNA cloning of human HMGI-C phosphoprotein", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 201, no. 1, 30 May 1994 (1994-05-30), pages 63 - 70, XP002033206 *
SCHOENMAKERS E. ET AL.: "Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours", NATURE GENETICS, vol. 10, August 1995 (1995-08-01), pages 436 - 443, XP002033204 *

Also Published As

Publication number Publication date
JP2000504933A (ja) 2000-04-25
NZ504445A (en) 2002-08-28
JP2007312778A (ja) 2007-12-06
AU1870597A (en) 1997-07-17
EP0870024A2 (de) 1998-10-14
CA2239682A1 (en) 1997-07-03
WO1997023611A2 (de) 1997-07-03
JP2010029207A (ja) 2010-02-12
DE19548122A1 (de) 1997-06-26

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