DE3680271D1 - Thrombolytische zusammensetzung und verfahren zu deren herstellung. - Google Patents

Thrombolytische zusammensetzung und verfahren zu deren herstellung.

Info

Publication number
DE3680271D1
DE3680271D1 DE8686113507T DE3680271T DE3680271D1 DE 3680271 D1 DE3680271 D1 DE 3680271D1 DE 8686113507 T DE8686113507 T DE 8686113507T DE 3680271 T DE3680271 T DE 3680271T DE 3680271 D1 DE3680271 D1 DE 3680271D1
Authority
DE
Germany
Prior art keywords
production
thrombolytic composition
plasminogen activator
tissue plasminogen
thrombolytic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686113507T
Other languages
English (en)
Inventor
Michio Ichimura
Hidemi Ohta
Kiyoshi Sakai
Yasuyuki Kunihiro
Takehisa Nakashiro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Mochida Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16738163&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3680271(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mochida Pharmaceutical Co Ltd filed Critical Mochida Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE3680271D1 publication Critical patent/DE3680271D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8686113507T 1985-10-02 1986-10-01 Thrombolytische zusammensetzung und verfahren zu deren herstellung. Expired - Lifetime DE3680271D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP60219606A JPH0672105B2 (ja) 1985-10-02 1985-10-02 血栓溶解剤及びその製法

Publications (1)

Publication Number Publication Date
DE3680271D1 true DE3680271D1 (de) 1991-08-22

Family

ID=16738163

Family Applications (2)

Application Number Title Priority Date Filing Date
DE198686113507T Pending DE217379T1 (de) 1985-10-02 1986-10-01 Thrombolytische zusammensetzung und verfahren zu deren herstellung.
DE8686113507T Expired - Lifetime DE3680271D1 (de) 1985-10-02 1986-10-01 Thrombolytische zusammensetzung und verfahren zu deren herstellung.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE198686113507T Pending DE217379T1 (de) 1985-10-02 1986-10-01 Thrombolytische zusammensetzung und verfahren zu deren herstellung.

Country Status (5)

Country Link
EP (1) EP0217379B1 (de)
JP (1) JPH0672105B2 (de)
AT (1) ATE65185T1 (de)
CA (1) CA1340270C (de)
DE (2) DE217379T1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8601354A (nl) * 1985-05-28 1986-12-16 Wellcome Found Nieuwe samenstelling.
US4929444A (en) * 1985-05-28 1990-05-29 Burroughs Wellcome Co. Low pH pharmaceutical formulation containing t-PA
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
JPS62120321A (ja) * 1985-11-20 1987-06-01 Eisai Co Ltd ｔＰＡ含有医薬組成物
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
US5034225A (en) * 1985-12-17 1991-07-23 Genentech Inc. Stabilized human tissue plasminogen activator compositions
US4857320A (en) * 1987-02-19 1989-08-15 Monsanto Company Method of enhancing the solubility of tissue plasminogen activator
DE3718889A1 (de) * 1987-06-05 1988-12-22 Behringwerke Ag Verfahren zur herstellung einer loesung hoher spezifischer volumenaktivitaet von einem protein mit gewebe-plasminogenaktivator (t-pa)-aktivitaet, loesung, enthaltend protein mit t-pa-aktivitaet und verwendung der loesung in der human- und veterinaermedizin
JP2708749B2 (ja) * 1987-08-10 1998-02-04 エーザイ株式会社 修飾型ｔＰＡ含有注射用組成物
US4898826A (en) * 1987-12-10 1990-02-06 Invitron Corporation Method to solubilize tissue plasminogen activator
DE3832898A1 (de) * 1988-09-28 1990-04-12 Boehringer Mannheim Gmbh Praeparat von in prokaryonten exprimiertem plasminogenaktivator
EP0448605A4 (en) * 1988-12-15 1991-11-21 Invitron Corporation Use of basic amino acids to solubilize immunoglobulins
US4980165A (en) * 1989-01-27 1990-12-25 Genetics Institute, Inc. Pharmaceutical formulations of plasminogen activator proteins
DE3903581A1 (de) * 1989-02-07 1990-08-16 Boehringer Mannheim Gmbh Gewebs-plasminogenaktivator-derivat
JP2520975B2 (ja) * 1989-09-21 1996-07-31 三井東圧化学株式会社 組織プラスミノ―ゲンアクチベ―タ―若しくはその誘導体を含有する血栓溶解剤
DE3942142A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh Stabilisierung von glykosyliertem t-pa
DE3942143A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh T-pa pro stabilisierung
DE69433133T2 (de) * 1993-12-17 2004-04-01 Mochida Pharmaceutical Co. Ltd. Lösliches thrombomodulin enthaltende zubereitung
FR2729972B1 (fr) * 1995-01-31 1997-04-18 Sanofi Sa Procede d'extraction de proteines periplasmiques de microorganismes procaryotes en presence d'arginine
US6139838A (en) * 1996-09-06 2000-10-31 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Tissue plasminogen activator medicinal composition
US6767892B1 (en) 1997-11-07 2004-07-27 Chrion Corporation Compositions providing for increased IGF-I solubility
JP2001522814A (ja) * 1997-11-07 2001-11-20 カイロン コーポレイション 増大されたｉｇｆ−ｉ溶解性を提供する組成物
AU4013900A (en) * 1999-03-19 2000-10-09 Enos Pharmaceuticals, Inc. Increasing cerebral bioavailability of drugs
JP4800739B2 (ja) * 2005-10-20 2011-10-26 デンカ生研株式会社 アッセイ用媒体及びアッセイ方法
EP3233111B1 (de) * 2014-12-19 2024-08-07 Kedrion Biopharma Inc. Pharmazeutische zusammensetzung mit plasminogen und verwendungen davon
EP4125851A1 (de) * 2020-10-27 2023-02-08 Gosbert Weth Antivirale thrombosehemmende und tumorschädigende zusammensetzung mit arginin und thiocyanat

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK98833C (da) * 1961-04-25 1964-05-25 Novo Terapeutisk Labor As Fremgangsmåde til stabilisering af terapeutisk anvendelige plasminopløsninger.
DE3203775A1 (de) * 1982-02-04 1983-08-11 Behringwerke Ag, 3550 Marburg Fibrinogenzubereitung, verfahen zu ihrer herstellungund ihre verwendung
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
JPS6051119A (ja) * 1983-08-30 1985-03-22 Green Cross Corp:The ウロキナ−ゼ乾燥製剤
JPS60184026A (ja) * 1984-03-01 1985-09-19 Asahi Chem Ind Co Ltd 組織プラスミノ−ゲン・アクチベ−タ−の溶解補助方法
JPS60181028A (ja) * 1984-02-29 1985-09-14 Asahi Chem Ind Co Ltd 組織プラスミノ−ゲン・アクチベ−タ−の溶解補助法
JPS61124383A (ja) * 1984-11-16 1986-06-12 Unitika Ltd 固定化線維素溶解活性酵素の安定化法
DE3687255T2 (de) * 1985-09-10 1993-05-06 Eisai Co Ltd Einen gewebe-plasminogen-aktivator enthaltende zusammensetzung.
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
JP3035023B2 (ja) * 1991-09-13 2000-04-17 住友ベークライト株式会社 密封容器

Also Published As

Publication number Publication date
DE217379T1 (de) 1989-01-26
JPH0672105B2 (ja) 1994-09-14
EP0217379A3 (en) 1988-08-31
JPS6281326A (ja) 1987-04-14
ATE65185T1 (de) 1991-08-15
CA1340270C (en) 1998-12-15
EP0217379A2 (de) 1987-04-08
EP0217379B1 (de) 1991-07-17

Similar Documents

Publication Publication Date Title
DE3680271D1 (de) Thrombolytische zusammensetzung und verfahren zu deren herstellung.
ATE94754T1 (de) Verfahren und zusammensetzung zur herstellung von liposomen.
DE3584902D1 (de) Waessrige loesung eines darin in erhoehter konzentration aufgeloesten gewebe-plasminogen-aktivators und herstellungsverfahren.
ATE156355T1 (de) Stabile zusammensetzungen von askorbinsäure
MX9203338A (es) Nuevos derivados del oxico a_nor-esteroide-3-carboxilico.
DE69019084D1 (de) Methoden zur Verhinderung von Schimmel.
DE3675717D1 (de) Verfahren zur sulphatierung von glykosaminoglykanen, daraus hergestellte glykosaminoglykane und ihre biologischen verwendungen.
DE3881364D1 (de) Verfahren zur herstellung und zusammensetzungen von kollagen-derivaten.
DE69224124D1 (de) Verfahren zur Herstellung von Dihomo-Gamma-Linolensäure und das in dieser enthaltende Lipid
DE69407272D1 (de) Verfahren zum reinigen von 20 cs)-camptothecin
DE3587230D1 (de) Enzymatisches verfahren.
BG35465A3 (en) Method for preparing derivatives of 1-(cyclohexyl)-4-aryl-4- piperidine carbonic acid
DE3869230D1 (de) Verfahren zur herstellung einer loesung hoher spezifischer volumenaktivitaet von einem protein mit gewebe-plasminogenaktivator (t-pa)-aktivitaet, loesung, enthaltend protein mit t-pa-aktivitaet und verwendung der loesung in der human- und veterinaermedizin.
GR1001218B (el) Μεθοδος παρασκευης αλατων κεφαλοσπορινης και ενεσιμων συνθεσεων
DE68928756D1 (de) Topische Zubereitungen enthaltend aliphatische Amine zur Behandlung von Hautkrankheiten
ATE113939T1 (de) Verfahren zur herstellung von cephalosporin und zwischenverbindungen.
DE3854266D1 (de) Verfahren zur Modifizierung eines Molekularsiebes.
DE59401990D1 (de) Imidazolyl-substituierte Phenylessigsäureprolinamide
DE3876361D1 (de) Herstellungsverfahren von carbonsaeureestern.
DE3467340D1 (en) Process for purification of 1,2-unsaturated carboxylic acids and/or esters thereof
ATE117313T1 (de) Stabile lösungen von rebeccamycinderivaten sowie deren herstellung.
DE68921051D1 (de) Pyridin-3-percarboxylsäure monopersulfat.
KR890701732A (ko) 개량형 조직 플라스미노겐 활성화 인자
ATE103974T1 (de) Verfahren zur stabilisierung des lactoperoxidase- enzyms in produkten.
ES2000764A6 (es) Procedimiento para el desencalado de pieles

Legal Events

Date Code Title Description
8363 Opposition against the patent
8327 Change in the person/name/address of the patent owner

Owner name: BOEHRINGER INGELHEIM INTERNATIONAL GMBH, 55218 ING

8310 Action for declaration of annulment
8364 No opposition during term of opposition
8313 Request for invalidation rejected/withdrawn