DE3687255T2 - Einen gewebe-plasminogen-aktivator enthaltende zusammensetzung. - Google Patents

Einen gewebe-plasminogen-aktivator enthaltende zusammensetzung.

Info

Publication number
DE3687255T2
DE3687255T2 DE8686112489T DE3687255T DE3687255T2 DE 3687255 T2 DE3687255 T2 DE 3687255T2 DE 8686112489 T DE8686112489 T DE 8686112489T DE 3687255 T DE3687255 T DE 3687255T DE 3687255 T2 DE3687255 T2 DE 3687255T2
Authority
DE
Germany
Prior art keywords
composition containing
plasminogen activator
tissue plasminogen
tpa
diisocyanate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686112489T
Other languages
English (en)
Other versions
DE3687255D1 (de
Inventor
Fumio Kakimoto
Naoki Asakawa
Yasuo Ishibashi
Yasuo Miyake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP60198629A external-priority patent/JPS6259221A/ja
Priority claimed from JP60261397A external-priority patent/JPH0669960B2/ja
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of DE3687255D1 publication Critical patent/DE3687255D1/de
Publication of DE3687255T2 publication Critical patent/DE3687255T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
DE8686112489T 1985-09-10 1986-09-09 Einen gewebe-plasminogen-aktivator enthaltende zusammensetzung. Expired - Fee Related DE3687255T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP60198629A JPS6259221A (ja) 1985-09-10 1985-09-10 組織プラスミノ−ゲン活性化因子含有組成物
JP60261397A JPH0669960B2 (ja) 1985-11-22 1985-11-22 水溶性を増加したｔＰＡ含有医薬組成物

Publications (2)

Publication Number Publication Date
DE3687255D1 DE3687255D1 (de) 1993-01-21
DE3687255T2 true DE3687255T2 (de) 1993-05-06

Family

ID=26511088

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686112489T Expired - Fee Related DE3687255T2 (de) 1985-09-10 1986-09-09 Einen gewebe-plasminogen-aktivator enthaltende zusammensetzung.

Country Status (5)

Country Link
US (1) US4837022A (de)
EP (1) EP0218112B1 (de)
AT (1) ATE83153T1 (de)
CA (1) CA1267602A (de)
DE (1) DE3687255T2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0672105B2 (ja) * 1985-10-02 1994-09-14 持田製薬株式会社 血栓溶解剤及びその製法
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
DE3718889A1 (de) * 1987-06-05 1988-12-22 Behringwerke Ag Verfahren zur herstellung einer loesung hoher spezifischer volumenaktivitaet von einem protein mit gewebe-plasminogenaktivator (t-pa)-aktivitaet, loesung, enthaltend protein mit t-pa-aktivitaet und verwendung der loesung in der human- und veterinaermedizin
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5342616A (en) * 1988-06-20 1994-08-30 The Wellcome Foundation Limited Method of administering tissue plasminogen activator
GB8814604D0 (en) * 1988-06-20 1988-07-27 Wellcome Found Medicaments
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
JP2520975B2 (ja) * 1989-09-21 1996-07-31 三井東圧化学株式会社 組織プラスミノ―ゲンアクチベ―タ―若しくはその誘導体を含有する血栓溶解剤
US6207151B1 (en) * 1989-09-21 2001-03-27 Mitsui Chemicals Inc. Aqueous solution of t-PA
DE3942143A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh T-pa pro stabilisierung
DE3942141A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh K2p pro-stabilisierung
FR2661920B1 (fr) * 1990-05-10 1995-10-06 Serbio Procede de determination d'un activateur du plasminogene et de son inhibiteur.
ATE155816T1 (de) * 1992-06-03 1997-08-15 Genentech Inc Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung
US9175283B2 (en) * 2006-05-31 2015-11-03 Genzyme Corporation Use polysaccharides for promotion of enzymatic activity

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59196824A (ja) * 1983-04-21 1984-11-08 Kowa Co 吸着防止剤
DE3584902D1 (de) * 1984-02-29 1992-01-30 Asahi Chemical Ind Waessrige loesung eines darin in erhoehter konzentration aufgeloesten gewebe-plasminogen-aktivators und herstellungsverfahren.
US4530905A (en) * 1984-10-25 1985-07-23 The Dow Chemical Company Crosslinked gelatin foams
JPS60228422A (ja) * 1984-04-26 1985-11-13 Suntory Ltd 安定化された生理活性物質製剤
US4604379A (en) * 1984-06-18 1986-08-05 Curators Of The University Of Missouri Dialysis solutions containing cross-linked gelatin
US4661469A (en) * 1984-08-08 1987-04-28 Survival Technology, Inc. t-PA composition capable of being absorbed into the blood stream and method of administration
JPS61122222A (ja) * 1984-11-19 1986-06-10 Koken:Kk コラ−ゲン又はゼラチンとプロタミンとよりなる止血剤
DE3500268A1 (de) * 1985-01-05 1986-07-10 Hoechst Ag, 6230 Frankfurt Praeparate mit verzoegerter wirkung, verfahren zu deren herstellung sowie entsprechende mittel zur human- bzw. veterinaermedizinischen anwendung
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
US4714754A (en) * 1986-11-10 1987-12-22 General Electric Company Polyetherimide esters

Also Published As

Publication number Publication date
US4837022A (en) 1989-06-06
CA1267602A (en) 1990-04-10
ATE83153T1 (de) 1992-12-15
EP0218112A1 (de) 1987-04-15
DE3687255D1 (de) 1993-01-21
EP0218112B1 (de) 1992-12-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee