DE3687255D1 - Einen gewebe-plasminogen-aktivator enthaltende zusammensetzung. - Google Patents
Einen gewebe-plasminogen-aktivator enthaltende zusammensetzung.Info
- Publication number
- DE3687255D1 DE3687255D1 DE8686112489T DE3687255T DE3687255D1 DE 3687255 D1 DE3687255 D1 DE 3687255D1 DE 8686112489 T DE8686112489 T DE 8686112489T DE 3687255 T DE3687255 T DE 3687255T DE 3687255 D1 DE3687255 D1 DE 3687255D1
- Authority
- DE
- Germany
- Prior art keywords
- composition containing
- plasminogen activator
- tissue plasminogen
- tpa
- diisocyanate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP60198629A JPS6259221A (ja) | 1985-09-10 | 1985-09-10 | 組織プラスミノ−ゲン活性化因子含有組成物 |
JP60261397A JPH0669960B2 (ja) | 1985-11-22 | 1985-11-22 | 水溶性を増加したtPA含有医薬組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3687255D1 true DE3687255D1 (de) | 1993-01-21 |
DE3687255T2 DE3687255T2 (de) | 1993-05-06 |
Family
ID=26511088
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8686112489T Expired - Fee Related DE3687255T2 (de) | 1985-09-10 | 1986-09-09 | Einen gewebe-plasminogen-aktivator enthaltende zusammensetzung. |
Country Status (5)
Country | Link |
---|---|
US (1) | US4837022A (de) |
EP (1) | EP0218112B1 (de) |
AT (1) | ATE83153T1 (de) |
CA (1) | CA1267602A (de) |
DE (1) | DE3687255T2 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0672105B2 (ja) * | 1985-10-02 | 1994-09-14 | 持田製薬株式会社 | 血栓溶解剤及びその製法 |
US4777043A (en) * | 1985-12-17 | 1988-10-11 | Genentech, Inc. | Stabilized human tissue plasminogen activator compositions |
DE3718889A1 (de) * | 1987-06-05 | 1988-12-22 | Behringwerke Ag | Verfahren zur herstellung einer loesung hoher spezifischer volumenaktivitaet von einem protein mit gewebe-plasminogenaktivator (t-pa)-aktivitaet, loesung, enthaltend protein mit t-pa-aktivitaet und verwendung der loesung in der human- und veterinaermedizin |
US5270198A (en) * | 1988-05-20 | 1993-12-14 | Genentech, Inc. | DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells |
US5342616A (en) * | 1988-06-20 | 1994-08-30 | The Wellcome Foundation Limited | Method of administering tissue plasminogen activator |
GB8814604D0 (en) * | 1988-06-20 | 1988-07-27 | Wellcome Found | Medicaments |
US5262170A (en) * | 1988-09-02 | 1993-11-16 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells |
US5714145A (en) * | 1988-09-02 | 1998-02-03 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
US6207151B1 (en) * | 1989-09-21 | 2001-03-27 | Mitsui Chemicals Inc. | Aqueous solution of t-PA |
JP2520975B2 (ja) * | 1989-09-21 | 1996-07-31 | 三井東圧化学株式会社 | 組織プラスミノ―ゲンアクチベ―タ―若しくはその誘導体を含有する血栓溶解剤 |
DE3942143A1 (de) * | 1989-12-20 | 1991-06-27 | Boehringer Mannheim Gmbh | T-pa pro stabilisierung |
DE3942141A1 (de) * | 1989-12-20 | 1991-06-27 | Boehringer Mannheim Gmbh | K2p pro-stabilisierung |
FR2661920B1 (fr) * | 1990-05-10 | 1995-10-06 | Serbio | Procede de determination d'un activateur du plasminogene et de son inhibiteur. |
DE10199044I2 (de) * | 1992-06-03 | 2006-02-09 | Genentech Inc | Varianten des Gewebeplasminogenaktivators mit verbesserter Therapeutischer wirkung |
WO2007139553A1 (en) * | 2006-05-31 | 2007-12-06 | Genzyme Corporation | Use of polysaccharides for promotion of enzymatic activity |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59196824A (ja) * | 1983-04-21 | 1984-11-08 | Kowa Co | 吸着防止剤 |
DE3584902D1 (de) * | 1984-02-29 | 1992-01-30 | Asahi Chemical Ind | Waessrige loesung eines darin in erhoehter konzentration aufgeloesten gewebe-plasminogen-aktivators und herstellungsverfahren. |
US4530905A (en) * | 1984-10-25 | 1985-07-23 | The Dow Chemical Company | Crosslinked gelatin foams |
JPS60228422A (ja) * | 1984-04-26 | 1985-11-13 | Suntory Ltd | 安定化された生理活性物質製剤 |
US4604379A (en) * | 1984-06-18 | 1986-08-05 | Curators Of The University Of Missouri | Dialysis solutions containing cross-linked gelatin |
US4661469A (en) * | 1984-08-08 | 1987-04-28 | Survival Technology, Inc. | t-PA composition capable of being absorbed into the blood stream and method of administration |
JPS61122222A (ja) * | 1984-11-19 | 1986-06-10 | Koken:Kk | コラ−ゲン又はゼラチンとプロタミンとよりなる止血剤 |
DE3500268A1 (de) * | 1985-01-05 | 1986-07-10 | Hoechst Ag, 6230 Frankfurt | Praeparate mit verzoegerter wirkung, verfahren zu deren herstellung sowie entsprechende mittel zur human- bzw. veterinaermedizinischen anwendung |
US4777043A (en) * | 1985-12-17 | 1988-10-11 | Genentech, Inc. | Stabilized human tissue plasminogen activator compositions |
US4714754A (en) * | 1986-11-10 | 1987-12-22 | General Electric Company | Polyetherimide esters |
-
1986
- 1986-09-09 EP EP86112489A patent/EP0218112B1/de not_active Expired - Lifetime
- 1986-09-09 AT AT86112489T patent/ATE83153T1/de not_active IP Right Cessation
- 1986-09-09 DE DE8686112489T patent/DE3687255T2/de not_active Expired - Fee Related
- 1986-09-09 CA CA000517801A patent/CA1267602A/en not_active Expired - Fee Related
- 1986-09-10 US US06/905,402 patent/US4837022A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE83153T1 (de) | 1992-12-15 |
US4837022A (en) | 1989-06-06 |
CA1267602A (en) | 1990-04-10 |
EP0218112B1 (de) | 1992-12-09 |
DE3687255T2 (de) | 1993-05-06 |
EP0218112A1 (de) | 1987-04-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |