DE10199044I2 - Varianten des Gewebeplasminogenaktivators mit verbesserter Therapeutischer wirkung - Google Patents
Varianten des Gewebeplasminogenaktivators mit verbesserter Therapeutischer wirkungInfo
- Publication number
- DE10199044I2 DE10199044I2 DE2001199044 DE10199044C DE10199044I2 DE 10199044 I2 DE10199044 I2 DE 10199044I2 DE 2001199044 DE2001199044 DE 2001199044 DE 10199044 C DE10199044 C DE 10199044C DE 10199044 I2 DE10199044 I2 DE 10199044I2
- Authority
- DE
- Germany
- Prior art keywords
- variants
- plasminogen activator
- tissue plasminogen
- therapeutic effect
- improved therapeutic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89421392A | 1992-06-03 | 1992-06-03 | |
PCT/US1993/005109 WO1993024635A1 (en) | 1992-06-03 | 1993-05-28 | Tissue plasminogen activator glycosylation variants with improved therapeutic properties |
Publications (2)
Publication Number | Publication Date |
---|---|
DE10199044I1 DE10199044I1 (de) | 2002-02-21 |
DE10199044I2 true DE10199044I2 (de) | 2006-02-09 |
Family
ID=25402765
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69333127T Expired - Lifetime DE69333127T2 (de) | 1992-06-03 | 1993-05-28 | Varianten des Gewebeplasminogenaktivators mit verbesserter therapeutischer Wirkung |
DE69312493T Expired - Lifetime DE69312493T2 (de) | 1992-06-03 | 1993-05-28 | Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung |
DE2001199044 Active DE10199044I2 (de) | 1992-06-03 | 1993-05-28 | Varianten des Gewebeplasminogenaktivators mit verbesserter Therapeutischer wirkung |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69333127T Expired - Lifetime DE69333127T2 (de) | 1992-06-03 | 1993-05-28 | Varianten des Gewebeplasminogenaktivators mit verbesserter therapeutischer Wirkung |
DE69312493T Expired - Lifetime DE69312493T2 (de) | 1992-06-03 | 1993-05-28 | Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung |
Country Status (20)
Country | Link |
---|---|
US (1) | US5612029A (de) |
EP (2) | EP0786257B1 (de) |
JP (1) | JP3559559B2 (de) |
AT (2) | ATE155816T1 (de) |
AU (1) | AU664469B2 (de) |
CA (1) | CA2129660C (de) |
DE (3) | DE69333127T2 (de) |
DK (2) | DK0786257T3 (de) |
EE (1) | EE03128B1 (de) |
ES (2) | ES2107041T3 (de) |
FI (1) | FI117940B (de) |
GE (1) | GEP20012448B (de) |
GR (1) | GR3024806T3 (de) |
HK (2) | HK1000449A1 (de) |
IL (1) | IL105883A (de) |
LU (1) | LU90800I2 (de) |
NL (1) | NL300050I2 (de) |
NZ (1) | NZ253556A (de) |
PT (1) | PT786257E (de) |
WO (1) | WO1993024635A1 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7060484B1 (en) | 1993-11-12 | 2006-06-13 | Gilead Sciences, Inc. | Polypeptides and coagulation therapy |
EP0728210B1 (de) * | 1993-11-12 | 2005-04-13 | Gilead Sciences, Inc. | Thrombin mutanten |
US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
US5510330A (en) † | 1994-03-25 | 1996-04-23 | Boehringer Mannheim Gmbh | Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof. |
DE4423574A1 (de) * | 1994-07-05 | 1996-01-11 | Boehringer Mannheim Gmbh | Nicht-glykosylierte Plasminogenaktivator-Derivate und ihre Verwendung bei erhöhtem Blutungsrisiko |
US5945432A (en) * | 1995-12-22 | 1999-08-31 | The University Of Vermont And State Agricultural College | Thrombolytic agents and thienopyridine derivatives in acute stroke |
AU2660397A (en) * | 1996-04-05 | 1997-10-29 | Board Of Regents, The University Of Texas System | Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells |
US6083715A (en) * | 1997-06-09 | 2000-07-04 | Board Of Regents, The University Of Texas System | Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells |
WO1999023115A1 (en) * | 1997-10-31 | 1999-05-14 | Eli Lilly And Company | Glycosylated obesity protein analogs |
US6242473B1 (en) | 1999-01-08 | 2001-06-05 | Maxim Pharmaceuticals, Inc. | Treatment and prevention of reactive oxygen metabolite-mediated cellular damage |
CZ302023B6 (cs) | 1999-11-04 | 2010-09-08 | Genentech, Inc. | Zpusob sledování úcinnosti purifikacního postupu |
US20030036181A1 (en) * | 2000-06-30 | 2003-02-20 | Okkels Jens Sigurd | Peptide extended glycosylated polypeptides |
JP2005508366A (ja) * | 2001-11-06 | 2005-03-31 | マキシム ファーマシューティカルス,インコーポレイテッド | 感染性疾患の治療用組成物 |
AU2002365408B2 (en) * | 2001-11-26 | 2008-04-24 | Genentech, Inc. | Catheter composition and uses thereof |
US7084118B2 (en) | 2002-02-22 | 2006-08-01 | Genentech, Inc. | Combination treatment with t-PA variant and low molecular weight heparin |
US20060105387A1 (en) * | 2002-08-30 | 2006-05-18 | Prior Christopher P | Transferrin fusion proteins libraries |
US20070014779A1 (en) * | 2002-11-14 | 2007-01-18 | Genentech, Inc. | Plasminogen activator variant formulations |
US7553930B2 (en) | 2003-01-06 | 2009-06-30 | Xencor, Inc. | BAFF variants and methods thereof |
US20060104969A1 (en) * | 2004-08-16 | 2006-05-18 | Massachusetts Institute Of Technology | Compositions and methods for enhancing structural and functional nervous system reorganization and recovery |
WO2006129191A2 (en) * | 2005-06-02 | 2006-12-07 | Avestha Gengraine Technologies Pvt Ltd. | A method for optimized production of a recombinant form of tissue plasminogen activator |
WO2007030652A2 (en) * | 2005-09-08 | 2007-03-15 | University Of Virginia Patent Foundation | Methods and compositions for growing adipose stem cells |
US20080069857A1 (en) * | 2006-04-12 | 2008-03-20 | Yoon Yeo | Compositions And Methods For Inhibiting Adhesions |
WO2007120847A2 (en) * | 2006-04-14 | 2007-10-25 | Massachusetts Institute Of Technology | Identifying and modulating molecular pathways that mediate nervous system plasticity |
US20080107641A1 (en) | 2006-08-29 | 2008-05-08 | Genentech, Inc. | Method of treating stroke with thrombolytic agent |
WO2008060374A2 (en) * | 2006-10-06 | 2008-05-22 | University Of Virginia Patent Foundation | Methods and compositions useful for diabetic wound healing |
WO2008070353A2 (en) | 2006-11-07 | 2008-06-12 | Genentech, Inc. | Tissue plasminogen activator variant uses |
KR100834561B1 (ko) | 2006-12-08 | 2008-06-02 | 가톨릭대학교 산학협력단 | 크링글 도메인 1 및 2로 이루어진 비-글리코실화 재조합단백질, 그 제조 방법 및 이를 포함하는 조성물 |
EP2289541A1 (de) | 2009-08-31 | 2011-03-02 | PAION Deutschland GmbH | Behandlung von neurologischen und neurodegenerativen Erkrankungen |
EP2289542A1 (de) | 2009-08-31 | 2011-03-02 | PAION Deutschland GmbH | Behandlung von neurologischen und neurodegenerativen Erkrankungen |
US20130122076A1 (en) * | 2011-11-11 | 2013-05-16 | Mathew Gelfand | Transdermal Patch Having Ultrasound Transducer for Administering Thrombolytic Reagents to Patients Having a Protein Misfolding Disease |
IN2015MN00047A (de) * | 2012-07-05 | 2015-10-16 | Hadasit Med Res Service | |
CA2931172C (en) | 2012-12-05 | 2022-11-15 | National Jewish Health | Treatment for airway cast obstruction |
CN103159860B (zh) * | 2013-04-07 | 2014-09-24 | 旭华(上海)生物研发中心有限公司 | 重组组织型纤溶酶原激活剂及其制备方法与用途 |
WO2015023830A1 (en) | 2013-08-14 | 2015-02-19 | Stc.Unm | Treatment and prevention of stroke and other neurological disorders |
ES2788697T3 (es) * | 2014-11-03 | 2020-10-22 | Thrombolytic Science Llc | Métodos y composiciones para trombólisis segura y eficaz |
KR102633644B1 (ko) | 2017-02-03 | 2024-02-05 | 액티코어 바이오테크 | 항-인간 gpvi 항체를 이용한 혈소판 응집의 억제 |
WO2018210860A1 (en) | 2017-05-16 | 2018-11-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of acute ischemic stroke |
US11154596B2 (en) | 2017-06-16 | 2021-10-26 | Thrombolytic Science, Llc | Methods for thrombolysis |
WO2019238933A1 (en) | 2018-06-15 | 2019-12-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of pi3kc2b inhibitors for the preservation of vascular endothelial cell barrier integrity |
WO2021148439A1 (en) | 2020-01-21 | 2021-07-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for stimulating cerebrovascular function |
EP4161579A1 (de) | 2020-06-09 | 2023-04-12 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Fucoidanfunktionalisierte polysaccharidpartikel mit t-pa zur gezielten thrombolytischen therapie |
WO2023156683A1 (en) | 2022-02-21 | 2023-08-24 | Acticor Biotech | Treatment of cardiovascular diseases using anti-human gpvi antibodies |
Family Cites Families (78)
Publication number | Priority date | Publication date | Assignee | Title |
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USRE30985E (en) | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
NL8003402A (nl) | 1980-06-11 | 1982-01-04 | Leuven Res & Dev Vzw | Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking. |
US4766075A (en) | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
AR241654A1 (es) | 1982-05-05 | 1992-10-30 | Genentech Inc | Procedimiento para producir activador de plasminogeno de tejido humano. |
US4943529A (en) | 1982-05-19 | 1990-07-24 | Gist-Brocades Nv | Kluyveromyces as a host strain |
WO1984001960A1 (en) * | 1982-11-11 | 1984-05-24 | Beecham Group Plc | Pharmaceutically active compounds |
DE3382389D1 (de) * | 1982-12-14 | 1991-10-02 | South African Inventions | Plasminogenaktivator. |
US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
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DE3537176C2 (de) * | 1984-10-18 | 1994-06-09 | Zymogenetics Inc | Gewebeplasminogenaktivator und Verfahren zu seiner Herstellung |
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FR2581652B1 (fr) * | 1985-04-22 | 1989-12-22 | Genentech Inc | Nouveaux mutants de l'activateur tissulaire du plasminogene humain |
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FI85334C (fi) * | 1985-05-28 | 1992-04-10 | Wellcome Found | Foerfarande foer framstaellning av en vattenbaserad, vaevnadsplasminogenaktivator (t-pa) innehaollande, koncentrerad parenterad loesning. |
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ZW14486A1 (en) * | 1985-07-29 | 1986-10-22 | Smithkline Beckman Corp | Pharmaceutical dosage unit |
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DE3687255T2 (de) * | 1985-09-10 | 1993-05-06 | Eisai Co Ltd | Einen gewebe-plasminogen-aktivator enthaltende zusammensetzung. |
GB8528321D0 (en) * | 1985-11-18 | 1985-12-24 | Ciba Geigy Ag | Modified fibrinolytic agents |
WO1987003906A1 (en) * | 1985-12-20 | 1987-07-02 | The Upjohn Company | Tissue plasminogen activator (tpa) analogs |
DK623186A (da) | 1985-12-23 | 1987-08-26 | Chiron Corp | Polypeptid med vaevsplasminogen-aktivator-virkning |
DK43387A (da) * | 1986-01-29 | 1987-07-30 | Beecham Group Plc | Fibrinolytisk enzym |
JP2527454B2 (ja) * | 1986-01-31 | 1996-08-21 | ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド | 新しい血栓溶解タンパク質 |
IE81073B1 (en) * | 1986-03-18 | 2000-01-12 | Genentech Inc | Modified human tissue-type plasminogen activator and its preparation |
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PT84589B (en) * | 1986-04-02 | 1989-05-09 | Beecham Group Plc | Process for preparing a fibrinolytic enzyme |
NZ219829A (en) | 1986-04-02 | 1990-05-28 | Beecham Group Plc | Tissue-type plasminogen activator modified in the region of amino acids 67-69 and pharmaceutical compositions thereof |
PT84588B (en) | 1986-04-02 | 1989-05-09 | Beecham Group Plc | Process for preparing a fibrinolytic enzyme |
DE3643158A1 (de) * | 1986-04-21 | 1987-11-19 | Boehringer Mannheim Gmbh | Gewebs-plasminogen-aktivator(tpa) - derivat und seine herstellung |
JPH0761266B2 (ja) * | 1986-07-03 | 1995-07-05 | 株式会社ミドリ十字 | 変異ヒトプロウロキナ−ゼ |
DK345087A (da) * | 1986-07-11 | 1988-01-12 | Novo Industri As | Modificeret vaevsplasminogenaktivator |
GB8619098D0 (en) * | 1986-08-05 | 1986-09-17 | Wellcome Found | Combination |
EP0266032A1 (de) * | 1986-08-29 | 1988-05-04 | Beecham Group Plc | Modifiziertes fibrinolytisches Enzym |
WO1988005081A2 (en) * | 1986-12-30 | 1988-07-14 | Cetus Corporation | Novel plasminogen activator |
GB8705377D0 (en) * | 1987-03-07 | 1987-04-08 | Beecham Group Plc | Compounds |
NO882226L (no) * | 1987-05-22 | 1988-11-23 | Zymogenetics Inc | Fibrinolytiske proteiner. |
IE67036B1 (en) * | 1987-06-04 | 1996-05-15 | Zymogenetics Inc | Tissue plasminogen activator analogs having modified growth factor domains |
ATE110772T1 (de) * | 1987-06-04 | 1994-09-15 | Zymogenetics Inc | Mutierter t-pa mit kringle-ersatz. |
SE8702562L (sv) * | 1987-06-18 | 1988-12-19 | Kabigen Ab | Nya fibrinolytiska enzymer |
WO1988010119A1 (en) * | 1987-06-22 | 1988-12-29 | Genetics Institute, Inc. | Novel thrombolytic proteins |
US4935237A (en) | 1988-03-21 | 1990-06-19 | Genentech, Inc. | Processes for the preparation of t-PA mutants |
WO1989000197A1 (en) * | 1987-06-30 | 1989-01-12 | Genentech, Inc. | Improved processes for the treatment of vascular disease |
AU2081788A (en) * | 1987-07-06 | 1989-01-30 | Genetics Institute Inc. | Novel thrombolytic proteins |
AU1893988A (en) * | 1987-07-13 | 1989-01-19 | Collaborative Research Inc. | Nonglycosylated plasminogen activator and method of preparation |
DK468388A (da) | 1987-08-21 | 1989-02-22 | Wellcome Found | Kompleks af polyethylenglycol og vaevplasminogen-aktivator, fremgangsmaade til dets fremstilling og farmaceutiske kompositioner indeholdende komplekset |
IL88247A0 (en) | 1987-11-06 | 1989-06-30 | Genentech Inc | Novel human tissue-type plasminogen activator variant |
US5225540A (en) | 1988-04-26 | 1993-07-06 | Du Pont Merck Pharmaceutical Company | Monoclonal antibodies to tissue plasminogen activator (t-pa) which prolong its functional half-life |
IL90146A (en) | 1988-05-20 | 1994-10-07 | Genentech Inc | Glycosylation derivatives of tissue plasminogen activator |
US5270198A (en) * | 1988-05-20 | 1993-12-14 | Genentech, Inc. | DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells |
US5342616A (en) * | 1988-06-20 | 1994-08-30 | The Wellcome Foundation Limited | Method of administering tissue plasminogen activator |
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DK395288D0 (da) * | 1988-07-15 | 1988-07-15 | Novo Industri As | Proteiner |
US5108901A (en) * | 1988-09-02 | 1992-04-28 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
US5262170A (en) * | 1988-09-02 | 1993-11-16 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells |
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US5041376A (en) * | 1988-12-09 | 1991-08-20 | The Board Of Regents Of The University Of Texas System | Method for identifying or shielding functional sites or epitopes of proteins that enter the exocytotic pathway of eukaryotic cells, the mutant proteins so produced and genes encoding said mutant proteins |
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DE69034013T2 (de) * | 1989-03-06 | 2003-07-31 | Univ Texas | Serpin-resistenter T-PA; Mutanten; Gene |
US5304482A (en) * | 1989-03-06 | 1994-04-19 | The Board Of Regents Of The University Of Texas System | Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors |
EP0394538B1 (de) | 1989-04-28 | 1996-10-16 | Rhein Biotech Gesellschaft Für Neue Biotechnologische Prozesse Und Produkte Mbh | Hefezellen der Gattung-Schwanniomyces |
FR2649120B1 (fr) | 1989-06-30 | 1994-01-28 | Cayla | Nouvelle souche et ses mutants de champignons filamenteux, procede de production de proteines recombinantes a l'aide de ladite souche et souches et proteines obtenues selon ce procede |
US5087572A (en) | 1989-12-01 | 1992-02-11 | Genentech, Inc. | Dna encoding human plasminogen modified at the cleavage site |
US5366730A (en) * | 1989-12-20 | 1994-11-22 | Boehringer Mannheim Gmbh | Stabilized compositions having human tissue type plasminogen activator enzymatic activity |
DE3942142A1 (de) * | 1989-12-20 | 1991-06-27 | Boehringer Mannheim Gmbh | Stabilisierung von glykosyliertem t-pa |
US5246850A (en) * | 1990-07-31 | 1993-09-21 | Genentech, Inc. | DNA molecules encoding human tissue plasminogen activator variants with decreased clearance, vectors, and host cells |
AU645344B2 (en) * | 1990-07-31 | 1994-01-13 | Genentech Inc. | Tissue plasminogen activator variants with decreased clearance |
US5242688A (en) * | 1990-12-24 | 1993-09-07 | Eli Lilly And Company | Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants |
-
1993
- 1993-05-28 JP JP50080394A patent/JP3559559B2/ja not_active Expired - Lifetime
- 1993-05-28 EP EP96117264A patent/EP0786257B1/de not_active Expired - Lifetime
- 1993-05-28 GE GEAP19932383A patent/GEP20012448B/en unknown
- 1993-05-28 AT AT93914240T patent/ATE155816T1/de active
- 1993-05-28 DE DE69333127T patent/DE69333127T2/de not_active Expired - Lifetime
- 1993-05-28 CA CA002129660A patent/CA2129660C/en not_active Expired - Lifetime
- 1993-05-28 ES ES93914240T patent/ES2107041T3/es not_active Expired - Lifetime
- 1993-05-28 PT PT96117264T patent/PT786257E/pt unknown
- 1993-05-28 DK DK96117264T patent/DK0786257T3/da active
- 1993-05-28 NZ NZ253556A patent/NZ253556A/en not_active IP Right Cessation
- 1993-05-28 ES ES96117264T patent/ES2203668T3/es not_active Expired - Lifetime
- 1993-05-28 EP EP93914240A patent/EP0643772B1/de not_active Expired - Lifetime
- 1993-05-28 AT AT96117264T patent/ATE246000T1/de active
- 1993-05-28 DE DE69312493T patent/DE69312493T2/de not_active Expired - Lifetime
- 1993-05-28 WO PCT/US1993/005109 patent/WO1993024635A1/en active IP Right Grant
- 1993-05-28 AU AU43973/93A patent/AU664469B2/en not_active Ceased
- 1993-05-28 DK DK93914240.2T patent/DK0643772T3/da active
- 1993-05-28 DE DE2001199044 patent/DE10199044I2/de active Active
- 1993-06-02 IL IL10588393A patent/IL105883A/xx not_active IP Right Cessation
-
1994
- 1994-08-04 FI FI943632A patent/FI117940B/fi not_active IP Right Cessation
- 1994-11-17 EE EE9400401A patent/EE03128B1/xx unknown
-
1995
- 1995-05-08 US US08/436,697 patent/US5612029A/en not_active Expired - Lifetime
-
1997
- 1997-09-22 GR GR970402440T patent/GR3024806T3/el unknown
- 1997-09-23 HK HK97101814A patent/HK1000449A1/xx not_active IP Right Cessation
-
1998
- 1998-01-07 HK HK98100124A patent/HK1001190A1/xx not_active IP Right Cessation
-
2001
- 2001-07-24 NL NL300050C patent/NL300050I2/nl unknown
- 2001-08-06 LU LU90800C patent/LU90800I2/fr unknown
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