AU2081788A - Novel thrombolytic proteins - Google Patents
Novel thrombolytic proteinsInfo
- Publication number
- AU2081788A AU2081788A AU20817/88A AU2081788A AU2081788A AU 2081788 A AU2081788 A AU 2081788A AU 20817/88 A AU20817/88 A AU 20817/88A AU 2081788 A AU2081788 A AU 2081788A AU 2081788 A AU2081788 A AU 2081788A
- Authority
- AU
- Australia
- Prior art keywords
- novel thrombolytic
- thrombolytic proteins
- proteins
- novel
- thrombolytic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7001287A | 1987-07-06 | 1987-07-06 | |
US18412188A | 1988-04-20 | 1988-04-20 | |
US184121 | 1988-04-20 | ||
US070012 | 1997-12-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2081788A true AU2081788A (en) | 1989-01-30 |
Family
ID=26750667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU20817/88A Abandoned AU2081788A (en) | 1987-07-06 | 1988-07-06 | Novel thrombolytic proteins |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0394261A4 (en) |
JP (1) | JPH03500002A (en) |
AU (1) | AU2081788A (en) |
WO (1) | WO1989000191A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU627475B2 (en) * | 1988-06-24 | 1992-08-27 | British Bio-Technology Limited | Tissue plasminogen activator analogues having improved activity |
AU645344B2 (en) * | 1990-07-31 | 1994-01-13 | Genentech Inc. | Tissue plasminogen activator variants with decreased clearance |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5108901A (en) * | 1988-09-02 | 1992-04-28 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
US5258180A (en) * | 1988-09-02 | 1993-11-02 | Genetech, Inc. | Tissue plasminogen activator having fibrin specific properties and deletion of amino acids 466-970, compositions and methods of treatment |
US5714145A (en) * | 1988-09-02 | 1998-02-03 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
US5262170A (en) * | 1988-09-02 | 1993-11-16 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells |
AU664469B2 (en) * | 1992-06-03 | 1995-11-16 | Genentech Inc. | Tissue plasminogen activator glycosylation variants with improved therapeutic properties |
US6706504B1 (en) | 1996-11-12 | 2004-03-16 | The Scripps Research Institute | Tissue type plasminogen activator (t-PA) variants: compositions and methods of use |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR79202B (en) * | 1982-05-05 | 1984-10-22 | Genentech Inc | |
GB8334498D0 (en) * | 1983-12-24 | 1984-02-01 | Beecham Group Plc | Compounds |
US4753879A (en) * | 1984-08-27 | 1988-06-28 | Biogen N.V. | Modified tissue plasminogen activators |
GR860875B (en) * | 1985-04-04 | 1986-07-29 | Beecham Group Plc | Novel compounds |
US4916071A (en) * | 1985-08-14 | 1990-04-10 | American Home Products Corporation | Poly-kringle plasminogen activator |
GB8528321D0 (en) * | 1985-11-18 | 1985-12-24 | Ciba Geigy Ag | Modified fibrinolytic agents |
DE3789664T3 (en) * | 1986-01-31 | 2004-09-16 | Genetics Institute, LLC, Cambridge | NEW THROMBOLYTIC PROTEINS. |
-
1988
- 1988-07-06 EP EP19880906509 patent/EP0394261A4/en not_active Withdrawn
- 1988-07-06 WO PCT/US1988/002263 patent/WO1989000191A1/en not_active Application Discontinuation
- 1988-07-06 AU AU20817/88A patent/AU2081788A/en not_active Abandoned
- 1988-07-06 JP JP63506135A patent/JPH03500002A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU627475B2 (en) * | 1988-06-24 | 1992-08-27 | British Bio-Technology Limited | Tissue plasminogen activator analogues having improved activity |
AU645344B2 (en) * | 1990-07-31 | 1994-01-13 | Genentech Inc. | Tissue plasminogen activator variants with decreased clearance |
Also Published As
Publication number | Publication date |
---|---|
WO1989000191A1 (en) | 1989-01-12 |
EP0394261A1 (en) | 1990-10-31 |
EP0394261A4 (en) | 1991-09-11 |
JPH03500002A (en) | 1991-01-10 |
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