ATE155816T1 - Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung - Google Patents

Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung

Info

Publication number
ATE155816T1
ATE155816T1 AT93914240T AT93914240T ATE155816T1 AT E155816 T1 ATE155816 T1 AT E155816T1 AT 93914240 T AT93914240 T AT 93914240T AT 93914240 T AT93914240 T AT 93914240T AT E155816 T1 ATE155816 T1 AT E155816T1
Authority
AT
Austria
Prior art keywords
variants
plasminogen activator
tissue plasminogen
therapeutic effects
improved therapeutic
Prior art date
Application number
AT93914240T
Other languages
English (en)
Inventor
William F Bennett
Bruce Alan Keyt
Nicholas F Paoni
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE155816T1 publication Critical patent/ATE155816T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT93914240T 1992-06-03 1993-05-28 Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung ATE155816T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89421392A 1992-06-03 1992-06-03

Publications (1)

Publication Number Publication Date
ATE155816T1 true ATE155816T1 (de) 1997-08-15

Family

ID=25402765

Family Applications (2)

Application Number Title Priority Date Filing Date
AT93914240T ATE155816T1 (de) 1992-06-03 1993-05-28 Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung
AT96117264T ATE246000T1 (de) 1992-06-03 1993-05-28 Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT96117264T ATE246000T1 (de) 1992-06-03 1993-05-28 Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung

Country Status (20)

Country Link
US (1) US5612029A (de)
EP (2) EP0643772B1 (de)
JP (1) JP3559559B2 (de)
AT (2) ATE155816T1 (de)
AU (1) AU664469B2 (de)
CA (1) CA2129660C (de)
DE (3) DE69333127T2 (de)
DK (2) DK0643772T3 (de)
EE (1) EE03128B1 (de)
ES (2) ES2203668T3 (de)
FI (1) FI117940B (de)
GE (1) GEP20012448B (de)
GR (1) GR3024806T3 (de)
HK (2) HK1000449A1 (de)
IL (1) IL105883A (de)
LU (1) LU90800I2 (de)
NL (1) NL300050I2 (de)
NZ (1) NZ253556A (de)
PT (1) PT786257E (de)
WO (1) WO1993024635A1 (de)

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US6083715A (en) * 1997-06-09 2000-07-04 Board Of Regents, The University Of Texas System Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
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US8835170B2 (en) * 2006-10-06 2014-09-16 University Of Virginia Patent Foundation Methods and compositions useful for diabetic wound healing
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KR100834561B1 (ko) 2006-12-08 2008-06-02 가톨릭대학교 산학협력단 크링글 도메인 1 및 2로 이루어진 비-글리코실화 재조합단백질, 그 제조 방법 및 이를 포함하는 조성물
EP2289542A1 (de) 2009-08-31 2011-03-02 PAION Deutschland GmbH Behandlung von neurologischen und neurodegenerativen Erkrankungen
EP2289541A1 (de) 2009-08-31 2011-03-02 PAION Deutschland GmbH Behandlung von neurologischen und neurodegenerativen Erkrankungen
US20130122076A1 (en) * 2011-11-11 2013-05-16 Mathew Gelfand Transdermal Patch Having Ultrasound Transducer for Administering Thrombolytic Reagents to Patients Having a Protein Misfolding Disease
US10188706B2 (en) 2012-07-05 2019-01-29 Hadasit Medical Research Services & Development Limited Plasminogen activator mutants as anti-fibrinolytic agents
WO2014089327A1 (en) 2012-12-05 2014-06-12 National Jewish Health Treatment for airway cast obstruction
CN103159860B (zh) * 2013-04-07 2014-09-24 旭华（上海）生物研发中心有限公司 重组组织型纤溶酶原激活剂及其制备方法与用途
US10220008B2 (en) 2013-08-14 2019-03-05 Stc.Unm Treatment and prevention of stroke and other neurological disorders
EP3708226A1 (de) * 2014-11-03 2020-09-16 Thrombolytic Science, LLC Verfahren und zusammensetzungen zur sicheren und wirksamen thrombolyse
WO2018141909A1 (en) 2017-02-03 2018-08-09 Acticor Biotech Inhibition of platelet aggregation using anti-human gpvi antibodies
CN110913890A (zh) 2017-05-16 2020-03-24 国家医疗保健研究所 用于治疗急性缺血性中风的方法和药物组合物
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EP3806833A1 (de) 2018-06-15 2021-04-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Verwendung von pi3kc2b-inhibitoren zur erhaltung der integrität der vaskulären endothelialen zellbarriere
WO2021148439A1 (en) 2020-01-21 2021-07-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for stimulating cerebrovascular function
WO2021249974A1 (en) 2020-06-09 2021-12-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Fucoidan-functionalized polysaccharide particles with t-pa for targeted thrombolytic therapy
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Also Published As

Publication number Publication date
AU4397393A (en) 1993-12-30
DK0643772T3 (da) 1998-02-02
US5612029A (en) 1997-03-18
ES2107041T3 (es) 1997-11-16
JP3559559B2 (ja) 2004-09-02
FI117940B (fi) 2007-04-30
EP0643772A1 (de) 1995-03-22
DE69312493D1 (de) 1997-09-04
FI943632A (fi) 1994-10-04
ATE246000T1 (de) 2003-08-15
EP0643772B1 (de) 1997-07-23
ES2203668T3 (es) 2004-04-16
LU90800I2 (fr) 2001-10-08
AU664469B2 (en) 1995-11-16
HK1001190A1 (en) 1998-05-29
JPH07507448A (ja) 1995-08-24
WO1993024635A1 (en) 1993-12-09
NZ253556A (en) 1995-11-27
DE10199044I1 (de) 2002-02-21
DE10199044I2 (de) 2006-02-09
DE69333127D1 (de) 2003-09-04
IL105883A0 (en) 1993-10-20
FI943632A0 (fi) 1994-08-04
IL105883A (en) 2003-04-10
DK0786257T3 (da) 2003-10-06
NL300050I2 (nl) 2001-11-01
PT786257E (pt) 2003-12-31
EP0786257B1 (de) 2003-07-30
EE03128B1 (et) 1998-10-15
CA2129660C (en) 2005-06-28
EP0786257A1 (de) 1997-07-30
NL300050I1 (nl) 2001-10-01
GR3024806T3 (en) 1998-01-30
DE69312493T2 (de) 1998-01-15
DE69333127T2 (de) 2004-05-06
HK1000449A1 (en) 2004-03-05
CA2129660A1 (en) 1993-12-09
GEP20012448B (en) 2001-05-25

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