NO176921C - Genteknologisk fremgangsmåte for fremstilling av et tPA-lignende protein, samt vertscelle som er i stand til å uttrykke et slikt protein - Google Patents

Genteknologisk fremgangsmåte for fremstilling av et tPA-lignende protein, samt vertscelle som er i stand til å uttrykke et slikt protein

Info

Publication number
NO176921C
NO176921C NO873517A NO873517A NO176921C NO 176921 C NO176921 C NO 176921C NO 873517 A NO873517 A NO 873517A NO 873517 A NO873517 A NO 873517A NO 176921 C NO176921 C NO 176921C
Authority
NO
Norway
Prior art keywords
tpa
protein
analogs
expressing
producing
Prior art date
Application number
NO873517A
Other languages
English (en)
Other versions
NO176921B (no
NO873517D0 (no
NO873517L (no
Inventor
Keith R Marotti
Edward F Rehberg
Nicole Y Theriault
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of NO873517D0 publication Critical patent/NO873517D0/no
Publication of NO873517L publication Critical patent/NO873517L/no
Publication of NO176921B publication Critical patent/NO176921B/no
Publication of NO176921C publication Critical patent/NO176921C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NO873517A 1985-12-20 1987-08-20 Genteknologisk fremgangsmåte for fremstilling av et tPA-lignende protein, samt vertscelle som er i stand til å uttrykke et slikt protein NO176921C (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81160785A 1985-12-20 1985-12-20
US90948286A 1986-09-19 1986-09-19
PCT/US1986/002684 WO1987003906A1 (en) 1985-12-20 1986-12-12 Tissue plasminogen activator (tpa) analogs

Publications (4)

Publication Number Publication Date
NO873517D0 NO873517D0 (no) 1987-08-20
NO873517L NO873517L (no) 1987-08-20
NO176921B NO176921B (no) 1995-03-13
NO176921C true NO176921C (no) 1995-06-21

Family

ID=27123502

Family Applications (1)

Application Number Title Priority Date Filing Date
NO873517A NO176921C (no) 1985-12-20 1987-08-20 Genteknologisk fremgangsmåte for fremstilling av et tPA-lignende protein, samt vertscelle som er i stand til å uttrykke et slikt protein

Country Status (12)

Country Link
EP (2) EP0289508A1 (no)
JP (1) JPH0659223B2 (no)
KR (2) KR950000303B1 (no)
AT (1) ATE85081T1 (no)
AU (1) AU600463B2 (no)
DE (1) DE3687651T2 (no)
DK (1) DK431887A (no)
ES (1) ES2053449T3 (no)
FI (1) FI97809C (no)
GR (1) GR3007280T3 (no)
NO (1) NO176921C (no)
WO (1) WO1987003906A1 (no)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA869626B (en) * 1985-12-23 1987-10-28 Chiron Corp Peptide plasminogen activators
EP0234051B1 (en) * 1986-02-17 1991-12-11 Stichting Centraal Laboratorium van de Bloedtransfusiedienst van het Nederlandse Rode Kruis Tissue-type plasminogen activator mutants; recombinant genetic information coding therefor and process for preparing said mutants; their use and pharmaceutical compositions
WO1987005934A1 (en) * 1986-03-28 1987-10-08 Roberto Crea Protein analogues of tissue plasminogen activator
US5047241A (en) * 1986-07-11 1991-09-10 American Home Products Corporation Tris-Kringle plasminogen activator with novel K2 insert
US5242819A (en) * 1986-12-05 1993-09-07 Ciba-Geigy Corporation DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
US5580559A (en) * 1986-12-05 1996-12-03 Ciba-Geigy Corporation Hybrid plasminogen activator
US5376547A (en) * 1987-01-30 1994-12-27 American Home Products Corporation Des-epidermal growth factor plasminogen activators
US5149533A (en) * 1987-06-04 1992-09-22 Zymogenetics, Inc. Modified t-PA with kringle-/replaced by another kringle
SE8702562L (sv) * 1987-06-18 1988-12-19 Kabigen Ab Nya fibrinolytiska enzymer
US5244676A (en) * 1987-10-09 1993-09-14 Monsanto Company Modified tissue plasminogen activator with modified glycosylation site
DE3888619D1 (de) * 1987-10-09 1994-04-28 Monsanto Co Modifizierter Gewebeplasminogenaktivator.
US5037752A (en) * 1987-10-09 1991-08-06 Monsanto Company Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277
US4963357A (en) * 1987-10-09 1990-10-16 Monsanto Company Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor
US5100666A (en) * 1987-10-09 1992-03-31 Monsanto Company Modified tissue plasminogen activator K2K2SP
ATE125294T1 (de) * 1987-10-29 1995-08-15 Yamanouchi Pharma Co Ltd Polypeptid-verbindungen.
US5648254A (en) * 1988-01-15 1997-07-15 Zymogenetics, Inc. Co-expression in eukaryotic cells
JPH04500752A (ja) * 1988-02-05 1992-02-13 ジェンザイム・コーポレーション 修飾ｔＰＡをコードする修飾遺伝子配列、並びにその産物
JPH03505276A (ja) * 1988-02-05 1991-11-21 ジェンザイム・コーポレーション 再配列された組織プラスミノーゲン活性化因子及びその産生方法
AU619803B2 (en) * 1988-02-05 1992-02-06 Genzyme Corporation Rearranged tissue plasminogen activators and method for producing same
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
DE3823805A1 (de) * 1988-07-14 1990-01-18 Basf Ag Neue polypeptide, ihre herstellung und verwendung
DE3825253A1 (de) * 1988-07-25 1990-02-01 Boehringer Mannheim Gmbh T-pa-derivat und seine herstellung
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
DE3836200A1 (de) * 1988-10-24 1990-04-26 Boehringer Mannheim Gmbh Domaenenduplikations-muteine des gewebsplasminogen-aktivators (t-pa)
US5275946A (en) * 1988-10-27 1994-01-04 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Thrombolytic agents with modified kringle domains
CA2007364A1 (en) * 1989-01-17 1990-07-17 David J. Livingston Gene sequences encoding modified residues situated in the protease domain of tpa
DE3927865A1 (de) * 1989-08-23 1991-02-28 Boehringer Mannheim Gmbh T-pa-mutante gk1l
ATE246000T1 (de) * 1992-06-03 2003-08-15 Genentech Inc Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung
IL104355A (en) 1993-01-10 2006-08-20 Yeda Res & Dev Tnf receptor promoter
US5795975A (en) * 1993-01-10 1998-08-18 Yeda Research And Development Co. Ltd. TNF receptor promoter
US6706504B1 (en) 1996-11-12 2004-03-16 The Scripps Research Institute Tissue type plasminogen activator (t-PA) variants: compositions and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR241654A1 (es) * 1982-05-05 1992-10-30 Genentech Inc Procedimiento para producir activador de plasminogeno de tejido humano.
ZA837173B (en) 1982-11-08 1984-05-30 Univ Case Western Reserve Genomic bovine growth hormone
US4511503A (en) 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511502A (en) 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
NZ215660A (en) 1985-04-04 1990-03-27 Beecham Group Plc Tissue plasminogen activator modified in the growth factor domain
US4916071A (en) * 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
NZ217331A (en) * 1985-08-26 1989-05-29 Lilly Co Eli Tissue plasminogen activator derivatives and genetically engineered product

Also Published As

Publication number Publication date
EP0231624B1 (en) 1993-01-27
FI882922A0 (fi) 1988-06-17
KR880700856A (ko) 1988-04-12
DK431887D0 (da) 1987-08-19
NO176921B (no) 1995-03-13
DE3687651D1 (de) 1993-03-11
WO1987003906A1 (en) 1987-07-02
AU600463B2 (en) 1990-08-16
DK431887A (da) 1987-08-19
AU6770187A (en) 1987-07-15
EP0231624A1 (en) 1987-08-12
DE3687651T2 (de) 1993-06-24
ATE85081T1 (de) 1993-02-15
FI882922A (fi) 1988-06-17
FI97809B (fi) 1996-11-15
GR3007280T3 (no) 1993-07-30
KR950000303B1 (ko) 1995-01-13
ES2053449T3 (es) 1994-08-01
NO873517D0 (no) 1987-08-20
NO873517L (no) 1987-08-20
JPH0659223B2 (ja) 1994-08-10
JPH05344892A (ja) 1993-12-27
EP0289508A1 (en) 1988-11-09
FI97809C (fi) 1997-02-25

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MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN JUNE 2001