DE3888619D1 - Modifizierter Gewebeplasminogenaktivator. - Google Patents

Modifizierter Gewebeplasminogenaktivator.

Info

Publication number
DE3888619D1
DE3888619D1 DE88870156T DE3888619T DE3888619D1 DE 3888619 D1 DE3888619 D1 DE 3888619D1 DE 88870156 T DE88870156 T DE 88870156T DE 3888619 T DE3888619 T DE 3888619T DE 3888619 D1 DE3888619 D1 DE 3888619D1
Authority
DE
Germany
Prior art keywords
plasminogen activator
tissue plasminogen
modified tissue
kringles
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE88870156T
Other languages
English (en)
Inventor
Leslie David Bell
Ernest Jay Mayer
Mark Oliver Palmier
Hanife Eser Tolunay
Thomas George Warren
Tze-Chein Wun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Application granted granted Critical
Publication of DE3888619D1 publication Critical patent/DE3888619D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DE88870156T 1987-10-09 1988-10-07 Modifizierter Gewebeplasminogenaktivator. Expired - Lifetime DE3888619D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10770887A 1987-10-09 1987-10-09

Publications (1)

Publication Number Publication Date
DE3888619D1 true DE3888619D1 (de) 1994-04-28

Family

ID=22318035

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88870156T Expired - Lifetime DE3888619D1 (de) 1987-10-09 1988-10-07 Modifizierter Gewebeplasminogenaktivator.

Country Status (6)

Country Link
EP (1) EP0311589B1 (de)
JP (1) JPH01132377A (de)
AT (1) ATE103332T1 (de)
AU (1) AU605364B2 (de)
DE (1) DE3888619D1 (de)
ZA (1) ZA887556B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL88247A0 (en) * 1987-11-06 1989-06-30 Genentech Inc Novel human tissue-type plasminogen activator variant
IE69054B1 (en) * 1988-07-20 1996-08-07 Schering Ag Vampire bat salivary plasminogen activators
GB9023149D0 (en) * 1990-10-24 1990-12-05 British Bio Technology Proteins and nucleic acids
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
DE19950043A1 (de) 1999-10-16 2001-07-12 Degussa Pigmentpräparationen, Verfahren zu ihrer Herstellung und Verwendung
US7553930B2 (en) 2003-01-06 2009-06-30 Xencor, Inc. BAFF variants and methods thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0289508A1 (de) * 1985-12-20 1988-11-09 The Upjohn Company Analoge des gewebespezifischen plasminogenaktivators
ATE74379T1 (de) * 1985-12-23 1992-04-15 Chiron Corp Peptidplasminogenaktivatoren.
EP0234051B1 (de) * 1986-02-17 1991-12-11 Stichting Centraal Laboratorium van de Bloedtransfusiedienst van het Nederlandse Rode Kruis Gewebeplasminogen-Aktivator-Mutant, dafür kodierende rekombinante genetische Information und Verfahren zur Herstellung dieser Mutanten, deren Verwendung und pharmazeutische Zusammensetzungen

Also Published As

Publication number Publication date
EP0311589A1 (de) 1989-04-12
JPH01132377A (ja) 1989-05-24
ATE103332T1 (de) 1994-04-15
AU2353688A (en) 1989-06-22
AU605364B2 (en) 1991-01-10
ZA887556B (en) 1989-07-26
EP0311589B1 (de) 1994-03-23

Similar Documents

Publication Publication Date Title
ES8801552A1 (es) Un procedimiento para preparar una proteina hibrida fibrinoliticamente activa.
DE69432592D1 (de) Mutanten der pro-urokinase
NO885109D0 (no) FremgangsmŸte og middel for Ÿ forhindre blodpropp.
IE892650L (en) Tissue plasminogen activator having zymogenic or fibrin¹specific properties
IL103118A0 (en) Tissue glue prepared by using cryoprecipitate
DE3888619D1 (de) Modifizierter Gewebeplasminogenaktivator.
ATE62512T1 (de) Verfahren zur bestimmung von plasminogenaktivatoren (pa).
AU4502589A (en) Thrombolytic agents with modified kringle domains
NO168055C (no) Fremgangsmaate for fremstilling av human vevplasminogenaktivator og urokinase-type plasminogenaktivator.
KR890701732A (ko) 개량형 조직 플라스미노겐 활성화 인자
IE873398L (en) New plasminogen activators.
DE59001558D1 (de) Thrombolytisch wirkendes kombinationspraeparat.
EP0292326A3 (de) Modifiziertes Enzym
EP0386240A4 (en) Novel polypeptide compounds
DK37988A (da) Fibrinolytisk vaevstype-plasminogenaktivator
Rudenskaya et al. Studying in vitro fibrinolytic and thrombolytic properties of thiol-dependent serine proteinase from Thermoactinomyces vulgaris.
IL111767A0 (en) Tissue plasminogen activator having zymogenic or fibrin specific properties
ATE100330T1 (de) Plasminogenaktivator und thrombolytischer wirkstoff.

Legal Events

Date Code Title Description
8332 No legal effect for de