ATE373083T1 - Methode und zusammensetzungen zur identifizierung von morphogen-analogen - Google Patents
Methode und zusammensetzungen zur identifizierung von morphogen-analogenInfo
- Publication number
- ATE373083T1 ATE373083T1 AT96926752T AT96926752T ATE373083T1 AT E373083 T1 ATE373083 T1 AT E373083T1 AT 96926752 T AT96926752 T AT 96926752T AT 96926752 T AT96926752 T AT 96926752T AT E373083 T1 ATE373083 T1 AT E373083T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions
- morphogen
- activating element
- transcription activating
- responsive transcription
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 102000008131 Bone Morphogenetic Protein 7 Human genes 0.000 abstract 4
- 108010049870 Bone Morphogenetic Protein 7 Proteins 0.000 abstract 4
- 230000003213 activating effect Effects 0.000 abstract 3
- 238000013518 transcription Methods 0.000 abstract 3
- 230000035897 transcription Effects 0.000 abstract 3
- 108700008625 Reporter Genes Proteins 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/507,750 US5932716A (en) | 1995-07-26 | 1995-07-26 | Morphogen-responsive regulatory elements |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE373083T1 true ATE373083T1 (de) | 2007-09-15 |
Family
ID=24019969
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96926752T ATE373083T1 (de) | 1995-07-26 | 1996-07-22 | Methode und zusammensetzungen zur identifizierung von morphogen-analogen |
Country Status (8)
Country | Link |
---|---|
US (2) | US5932716A (de) |
EP (1) | EP0842268B1 (de) |
JP (1) | JPH11510054A (de) |
AT (1) | ATE373083T1 (de) |
AU (1) | AU715772B2 (de) |
CA (1) | CA2227694A1 (de) |
DE (1) | DE69637242T2 (de) |
WO (1) | WO1997005241A2 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7306903B1 (en) | 1995-07-26 | 2007-12-11 | Curis, Inc. | Methods and compositions for identifying morphogen analogs |
US5834188A (en) * | 1995-07-26 | 1998-11-10 | Creative Biomolecule, Inc. | Methods and compositions for identifying morphogen analogs |
US6090544A (en) * | 1995-07-26 | 2000-07-18 | Creative Biomolecules, Inc. | Methods and compositions for identifying morphogen analogs |
US5932716A (en) * | 1995-07-26 | 1999-08-03 | Creative Biomolecules, Inc. | Morphogen-responsive regulatory elements |
US6103491A (en) * | 1995-07-26 | 2000-08-15 | Creative Biomolecules, Inc. | Methods and compositions for identifying morphogen analogs |
US20030185792A1 (en) * | 1996-01-22 | 2003-10-02 | Curis, Inc. | Morphogen analogs of bone morphogenic proteins |
EP0876401B1 (de) * | 1996-01-22 | 2007-06-13 | Curis, Inc. | Methoden zur herstellung von op-1 morphogen analoge |
EP1117805A2 (de) | 1998-10-07 | 2001-07-25 | STRYKER CORPORATION (a Michigan corporation) | Modifizierte proteine der tgf-beta superfamilie |
WO2000037676A1 (en) * | 1998-12-22 | 2000-06-29 | Isis Innovation Limited | Method of sequence identification |
US6368787B1 (en) | 1999-12-16 | 2002-04-09 | Stryker Corporation | Methods and compositions for identifying morphogenic protein analogs using morphogenic protein responsive inhibitory elements |
WO2002048333A2 (en) * | 2000-12-12 | 2002-06-20 | Lexicon Genetics Incorporated | Novel human kinases and uses thereof |
US7763769B2 (en) | 2001-02-16 | 2010-07-27 | Kci Licensing, Inc. | Biocompatible wound dressing |
US7700819B2 (en) | 2001-02-16 | 2010-04-20 | Kci Licensing, Inc. | Biocompatible wound dressing |
US8697139B2 (en) | 2004-09-21 | 2014-04-15 | Frank M. Phillips | Method of intervertebral disc treatment using articular chondrocyte cells |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5023179A (en) * | 1988-11-14 | 1991-06-11 | Eric Lam | Promoter enhancer element for gene expression in plant roots |
US5585237A (en) * | 1993-10-25 | 1996-12-17 | Creative Biomolecules, Inc. | Methods and compositions for high protein production from recombinant DNA |
WO1995014104A1 (en) * | 1993-11-16 | 1995-05-26 | Children's Medical Center Corporation | Method of identifying a substance capable of inducing bone formation |
CA2191583C (en) * | 1994-06-07 | 2007-03-27 | Engin Ozkaynak | Methods and compositions for modulating morphogenic protein expression |
US6083690A (en) * | 1995-06-02 | 2000-07-04 | Osteoscreen, Inc. | Methods and compositions for identifying osteogenic agents |
US5834188A (en) * | 1995-07-26 | 1998-11-10 | Creative Biomolecule, Inc. | Methods and compositions for identifying morphogen analogs |
US5932716A (en) * | 1995-07-26 | 1999-08-03 | Creative Biomolecules, Inc. | Morphogen-responsive regulatory elements |
-
1995
- 1995-07-26 US US08/507,750 patent/US5932716A/en not_active Expired - Lifetime
-
1996
- 1996-07-22 AU AU66786/96A patent/AU715772B2/en not_active Ceased
- 1996-07-22 DE DE69637242T patent/DE69637242T2/de not_active Expired - Lifetime
- 1996-07-22 AT AT96926752T patent/ATE373083T1/de not_active IP Right Cessation
- 1996-07-22 EP EP96926752A patent/EP0842268B1/de not_active Expired - Lifetime
- 1996-07-22 WO PCT/US1996/012054 patent/WO1997005241A2/en active IP Right Grant
- 1996-07-22 JP JP9507668A patent/JPH11510054A/ja not_active Withdrawn
- 1996-07-22 CA CA002227694A patent/CA2227694A1/en not_active Abandoned
-
1997
- 1997-06-11 US US08/872,859 patent/US6110460A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69637242T2 (de) | 2008-05-29 |
WO1997005241A2 (en) | 1997-02-13 |
JPH11510054A (ja) | 1999-09-07 |
AU6678696A (en) | 1997-02-26 |
EP0842268B1 (de) | 2007-09-12 |
US6110460A (en) | 2000-08-29 |
CA2227694A1 (en) | 1997-02-13 |
EP0842268A2 (de) | 1998-05-20 |
WO1997005241A3 (en) | 1997-05-22 |
DE69637242D1 (de) | 2007-10-25 |
AU715772B2 (en) | 2000-02-10 |
US5932716A (en) | 1999-08-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE373083T1 (de) | Methode und zusammensetzungen zur identifizierung von morphogen-analogen | |
DE68925083D1 (de) | Rekombinante DNS, diese rekombinante DNS enthaltender Mikroorganismus und Verfahren zur Herstellung von L-Aminosäure unter Verwendung dieses Mikroorganismus | |
ATE266723T1 (de) | Lösung die chaotropische mittel enthält und verwendung dieser lösung in verfahren zur isolierung von dna, rna und proteinen | |
DE59611371D1 (de) | Verfahren zur Herstellung von Erythropoietin frei von tierischen Proteinen | |
DE69121618D1 (de) | Mutierte Luciferase vom Leuchtkäfer, mutiertes Luciferasegen, rekombinante DNS diese Gene enthaltend, und Verfahren zur Herstellung von mutierter Luciferase | |
NO176921C (no) | Genteknologisk fremgangsmåte for fremstilling av et tPA-lignende protein, samt vertscelle som er i stand til å uttrykke et slikt protein | |
NO993709L (no) | Stabilisert blanding omfattende fibrinogen | |
DE69635864D1 (de) | Rekombinante rna-replikase von hepatitis-c-virus | |
KR850007275A (ko) | 기능성 인체인자 ⅷ의 제조방법 | |
ATE391175T1 (de) | Multidrug resistenz gen | |
DE69941701D1 (de) | Mutanten von flt3-l und ihre verwendungen | |
BR9610511B1 (pt) | construções de dna, úteis em terapia genética, compreendendo ao menos uma sequência nucléica de interesse e composição farmacêutica. | |
DE3585953D1 (de) | Dna-fragmente, expressionsvektoren, proteine, wirte und verfahren zur herstellung der proteine. | |
WO1997005285A3 (en) | Methods and compositions for identifying morphogen analogs | |
DE69723057D1 (de) | Nukleosid analogen | |
WO2000030667A3 (en) | Compositions and methods using lactadherin or variants thereof | |
ATE271607T1 (de) | Vorbeugen des graftsabstosses in transplantaten und zur herstellung von universalen gentherapie wirtszell, unter anwendung von lymphozytenaktivierungsgen-3 (lag-3) | |
DE3867017D1 (de) | Vorrichtung zur kontrolle des inhaltes und der anzeigedauer von werbeanzeigen. | |
DE3576361D1 (de) | Rekombinante dna, damit transformierter mikroorganismus, und verfahren zur herstellung von menschlicher cu-zn superoxiddismutase unter verwendung des transformierten mikroorganismus. | |
BR9811014A (pt) | "região concentrada reguladora de gene especìfica para semente precoce" | |
DE69809561D1 (de) | Zusammensetzung und verfahren zur regulierung von zellproliferation und zelltod | |
DE68922550D1 (de) | Alkohol-oxidase Enzymelektrode und Verfahren zur Bestimmung von Alkoholeinhalt. | |
ATE196165T1 (de) | Methoden zur herstellung von protein c | |
ATE233321T1 (de) | Verbesserungen in der herstellung von proteinen in wirtszellen | |
EP0985045B1 (de) | Modulatoren der expression von morphogenen und deren identifizierungsverfahren |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |