NO993709L - Stabilisert blanding omfattende fibrinogen - Google Patents
Stabilisert blanding omfattende fibrinogenInfo
- Publication number
- NO993709L NO993709L NO993709A NO993709A NO993709L NO 993709 L NO993709 L NO 993709L NO 993709 A NO993709 A NO 993709A NO 993709 A NO993709 A NO 993709A NO 993709 L NO993709 L NO 993709L
- Authority
- NO
- Norway
- Prior art keywords
- fibrinogen
- solution
- arginine
- lysine
- stabilized composition
- Prior art date
Links
- 102000008946 Fibrinogen Human genes 0.000 title abstract 3
- 108010049003 Fibrinogen Proteins 0.000 title abstract 3
- 229940012952 fibrinogen Drugs 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000000243 solution Substances 0.000 abstract 3
- 239000004475 Arginine Substances 0.000 abstract 2
- 239000004472 Lysine Substances 0.000 abstract 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 2
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 239000008366 buffered solution Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 210000002381 plasma Anatomy 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 abstract 1
- 229960000401 tranexamic acid Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/363—Fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Det beskrives en stabilisert løsning av fibrinogenholdige prøver, særlig en stabilisert løsning av den biologisk aktive komponent (BAC) som er en løsning av proteiner som skriver seg fra blodplasma omfattende fibrinogen, tranexamsyre, samt arginin eller lysin eller blandinger av arginin og lysin, deres farmasøytisk akseptable salter, og eventuelt substanser som danner en buffret løsning i et vandig medium.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97101569A EP0856317A1 (en) | 1997-01-31 | 1997-01-31 | A stabilized mixture comprising fibrinogen |
PCT/EP1998/000502 WO1998033533A1 (en) | 1997-01-31 | 1998-01-30 | A stabilized mixture comprising fibrinogen |
Publications (2)
Publication Number | Publication Date |
---|---|
NO993709D0 NO993709D0 (no) | 1999-07-30 |
NO993709L true NO993709L (no) | 1999-09-28 |
Family
ID=8226433
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO993709A NO993709L (no) | 1997-01-31 | 1999-07-30 | Stabilisert blanding omfattende fibrinogen |
Country Status (13)
Country | Link |
---|---|
US (1) | US6121232A (no) |
JP (1) | JP3825055B2 (no) |
KR (1) | KR100345570B1 (no) |
CN (1) | CN1182879C (no) |
AT (1) | ATE218365T1 (no) |
AU (1) | AU724715B2 (no) |
BR (1) | BR9807043A (no) |
CA (1) | CA2279419A1 (no) |
DE (1) | DE69805772T2 (no) |
ES (1) | ES2178153T3 (no) |
HU (1) | HUP0000908A3 (no) |
NO (1) | NO993709L (no) |
PL (1) | PL194316B1 (no) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10025001A1 (de) * | 2000-05-22 | 2001-11-29 | Aventis Behring Gmbh | Gewebekleber mit verbesserten anti-adhäsiven Eigenschaften |
US7276235B2 (en) * | 1998-11-18 | 2007-10-02 | Zlb Behring Gmbh | Tissue glue with improved antiadhesive properties |
CN100345591C (zh) * | 2003-08-01 | 2007-10-31 | 上海新兴医药股份有限公司 | 耐干热处理的速溶冻干纤维蛋白原制剂 |
US7186684B2 (en) * | 2003-08-07 | 2007-03-06 | Ethicon, Inc. | Hemostatic device containing a protein precipitate |
US20060093655A1 (en) * | 2004-10-20 | 2006-05-04 | Lillian Bar | Method for making a reinforced absorbable multilayered hemostatic wound dressing |
US9358318B2 (en) * | 2004-10-20 | 2016-06-07 | Ethicon, Inc. | Method of making a reinforced absorbable multilayered hemostatic wound dressing |
FR2887883B1 (fr) | 2005-06-29 | 2007-08-31 | Lab Francais Du Fractionnement | Procede de separation des proteines fibrinogene, facteur xiii et colle biologique d'une fraction plasmatique solubilisee et de preparation de concentres lyophilises desdites proteines |
CN101678086B (zh) * | 2007-03-22 | 2013-07-10 | 财团法人化学及血清疗法研究所 | 固体纤维蛋白原制剂 |
EP2011524A1 (en) * | 2007-07-02 | 2009-01-07 | Omrix Biopharmaceuticals Ltd. | Fibrin glue with a visualization agent |
EP2034010A1 (en) | 2007-08-30 | 2009-03-11 | Omrix Biopharmaceuticals Ltd. | Compositions suitable for repair and/or treatment of injured spinal tissue |
ES2438491T3 (es) * | 2008-09-22 | 2014-01-17 | Omrix Biopharmaceuticals Ltd. | Dispositivo implantable que comprende un sustrato pre-recubierto con fibrina estabilizada |
JP5805542B2 (ja) * | 2009-02-20 | 2015-11-04 | オムリックス・バイオファーマシューティカルズ・リミテッドOmrix Biopharmaceuticals Ltd. | 少なくとも2成分の薬物を投与する装置 |
DK2528631T3 (da) | 2010-01-28 | 2014-09-15 | Omrix Biopharmaceuticals Ltd | Fremgangsmåde til forbedret fibrintætning |
IL207586A0 (en) | 2010-08-12 | 2010-12-30 | Omrix Biopharmaceuticals Ltd | A fibrin based therapeutic preparation and use thereof |
JP5999776B2 (ja) * | 2010-09-15 | 2016-09-28 | デビオファーマ インターナショナル ソシエテ アノニムDebiopharm International Sa | 血液成分を含むフィブリノゲン含有サンプルからターゲット分子又は粒子を分離する方法 |
ES2951828T3 (es) | 2010-09-23 | 2023-10-25 | Leading Biosciences Inc | Administración de inhibidores de serina proteasa al estómago |
IL210162A0 (en) | 2010-12-21 | 2011-03-31 | Omrix Biopharmaceuticals | Viral inactivated platelet extract, use and preparation thereof |
IL213375A0 (en) | 2011-06-05 | 2011-07-31 | Omrix Biopharmaceuticals | Device for spraying fluids in proximity to a surface |
US20150064141A1 (en) | 2012-04-05 | 2015-03-05 | The Regents Of The University Of California | Regenerative sera cells and mesenchymal stem cells |
US10130346B2 (en) | 2012-07-24 | 2018-11-20 | Omrix Biopharmaceuticals Ltd. | Device and method for the application of a curable fluid composition to a bodily organ |
CN104994886B (zh) | 2012-12-20 | 2017-10-03 | 奥姆里克斯生物药品有限公司 | 病毒灭活的生物混合物 |
CN105007829B (zh) | 2012-12-30 | 2018-06-01 | 奥姆里克斯生物药品有限公司 | 用于将可固化流体组合物施用到身体器官的一部分的装置和方法 |
USD754325S1 (en) | 2013-06-06 | 2016-04-19 | Omrix Biopharmaceuticals Ltd. | Device of a curable fluid composition to a bodily organ |
IL230150A0 (en) | 2013-12-24 | 2014-09-30 | Omrix Biopharmaceuticals Ltd | One-component fibrin glue containing zymogens |
IL230151A0 (en) | 2013-12-24 | 2014-09-30 | Omrix Biopharmaceuticals Ltd | One-component fibrin glue containing a polymerization inhibitor |
KR102397379B1 (ko) | 2014-03-25 | 2022-05-13 | 리딩 바이오사이언시즈, 인크. | 자가소화의 치료용의 조성물 |
IL231792A0 (en) | 2014-03-27 | 2014-08-31 | Omrix Biopharmaceuticals Ltd | Device and method for the preparation and administration of one-component fibrin glue |
IL234246A0 (en) | 2014-08-21 | 2014-11-30 | Omrix Biopharmaceuticals Ltd | Stabilized thrombin |
IL235751A0 (en) | 2014-11-18 | 2015-02-26 | Omrix Biopharmaceuticals Ltd | An addition to the spray dryer |
BR112017010250A2 (pt) | 2014-11-18 | 2018-01-02 | Omrix Biopharmaceuticals Ltd | aparelho para secagem por aspersão e método de uso do mesmo |
EP3262409B1 (en) | 2015-02-25 | 2020-03-25 | Omrix Biopharmaceuticals Ltd. | Method for purifying and quantifying thrombin and its degradation polypeptides |
IL242984A0 (en) | 2015-12-08 | 2016-02-29 | Omrix Biopharmaceuticals Ltd | Thrombin microcapsules, their preparation and how to use them |
US10159720B2 (en) | 2015-12-08 | 2018-12-25 | Omrix Biopharmaceuticals Ltd | Thrombin microcapsules, preparation and uses thereof |
IL242924A0 (en) | 2015-12-03 | 2016-04-21 | Omrix Biopharmaceuticals Ltd | Syringe system for storing and mixing two ingredients |
CN113908281B (zh) | 2016-01-11 | 2023-09-15 | 恒翼生物医药(上海)股份有限公司 | 用于治疗和预防粘连及肠梗阻的组合物和方法 |
JP2017177073A (ja) * | 2016-03-31 | 2017-10-05 | テルモ株式会社 | 塗布具 |
IL247821A0 (en) * | 2016-09-14 | 2017-01-31 | Omrix Biopharmaceuticals Ltd | Adhesive preparations and their use |
CN109081789B (zh) * | 2017-06-13 | 2021-01-01 | 首都医科大学 | 氨基正己酰氨基甲环酰氨基正己酰脂肪氨基酸,其合成,活性和应用 |
IL261190A (en) | 2018-08-16 | 2019-01-31 | Omrix Biopharmaceuticals Ltd | Stable liquid preparations of thrombin |
WO2020121289A1 (en) | 2018-12-12 | 2020-06-18 | Omrix Biopharmaceuticals Ltd. | Low concentrated protein compositions for preventing tissue adhesion |
IL263679A (en) | 2018-12-12 | 2019-03-31 | Omrix Biopharmaceuticals Ltd | Kits, methods, and ingredients for preventing tissue adhesion |
EP4401801A1 (en) | 2021-09-16 | 2024-07-24 | Ethicon, Inc. | Kit for composition for tissue tract sealing |
WO2023119277A1 (en) | 2021-12-21 | 2023-06-29 | Omrix Biopharmaceuticals Ltd. | Highly soluble fibrinogen compositions |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT359653B (de) * | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
DK475386D0 (da) * | 1986-10-03 | 1986-10-03 | Weis Fogh Ulla Sivertsen | Fremgangsmaade og apparat til fremstilling af biologiske stoffer |
US5278189A (en) * | 1990-06-04 | 1994-01-11 | Rath Matthias W | Prevention and treatment of occlusive cardiovascular disease with ascorbate and substances that inhibit the binding of lipoprotein (A) |
EP0691858B1 (en) * | 1993-03-30 | 1999-12-15 | Omrix Biopharmaceuticals S.A. | Two component fibrin glue |
-
1997
- 1997-02-10 US US08/797,328 patent/US6121232A/en not_active Expired - Lifetime
-
1998
- 1998-01-30 PL PL98334547A patent/PL194316B1/pl unknown
- 1998-01-30 AT AT98904163T patent/ATE218365T1/de active
- 1998-01-30 AU AU62145/98A patent/AU724715B2/en not_active Ceased
- 1998-01-30 CA CA002279419A patent/CA2279419A1/en not_active Abandoned
- 1998-01-30 BR BR9807043-6A patent/BR9807043A/pt not_active IP Right Cessation
- 1998-01-30 JP JP53253698A patent/JP3825055B2/ja not_active Expired - Fee Related
- 1998-01-30 CN CNB988021757A patent/CN1182879C/zh not_active Expired - Fee Related
- 1998-01-30 HU HU0000908A patent/HUP0000908A3/hu unknown
- 1998-01-30 ES ES98904163T patent/ES2178153T3/es not_active Expired - Lifetime
- 1998-01-30 DE DE69805772T patent/DE69805772T2/de not_active Expired - Lifetime
- 1998-01-30 KR KR1019997006883A patent/KR100345570B1/ko not_active IP Right Cessation
-
1999
- 1999-07-30 NO NO993709A patent/NO993709L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
BR9807043A (pt) | 2000-03-28 |
CA2279419A1 (en) | 1998-08-06 |
JP3825055B2 (ja) | 2006-09-20 |
NO993709D0 (no) | 1999-07-30 |
KR20000070634A (ko) | 2000-11-25 |
AU6214598A (en) | 1998-08-25 |
DE69805772D1 (de) | 2002-07-11 |
HUP0000908A3 (en) | 2001-05-28 |
JP2000509630A (ja) | 2000-08-02 |
CN1182879C (zh) | 2005-01-05 |
DE69805772T2 (de) | 2003-01-30 |
HUP0000908A2 (hu) | 2000-08-28 |
ATE218365T1 (de) | 2002-06-15 |
PL334547A1 (en) | 2000-03-13 |
CN1246069A (zh) | 2000-03-01 |
KR100345570B1 (ko) | 2002-07-26 |
US6121232A (en) | 2000-09-19 |
ES2178153T3 (es) | 2002-12-16 |
AU724715B2 (en) | 2000-09-28 |
PL194316B1 (pl) | 2007-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |