DE69805772D1 - Stabilisierte mischung auf fibrinogenbasis - Google Patents

Stabilisierte mischung auf fibrinogenbasis

Info

Publication number
DE69805772D1
DE69805772D1 DE69805772T DE69805772T DE69805772D1 DE 69805772 D1 DE69805772 D1 DE 69805772D1 DE 69805772 T DE69805772 T DE 69805772T DE 69805772 T DE69805772 T DE 69805772T DE 69805772 D1 DE69805772 D1 DE 69805772D1
Authority
DE
Germany
Prior art keywords
fibrinogen
solution
mixture based
arginine
lysine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69805772T
Other languages
English (en)
Other versions
DE69805772T2 (de
Inventor
Israel Nur
Lilliana Bar
Oded Lieberman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omrix Biopharmaceuticals SA
Original Assignee
Omrix Biopharmaceuticals SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP97101569A external-priority patent/EP0856317A1/de
Application filed by Omrix Biopharmaceuticals SA filed Critical Omrix Biopharmaceuticals SA
Publication of DE69805772D1 publication Critical patent/DE69805772D1/de
Application granted granted Critical
Publication of DE69805772T2 publication Critical patent/DE69805772T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/363—Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69805772T 1997-01-31 1998-01-30 Stabilisierte mischung auf fibrinogenbasis Expired - Lifetime DE69805772T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97101569A EP0856317A1 (de) 1997-01-31 1997-01-31 Fibrinogen enthaltende stabilisierte Mischung
PCT/EP1998/000502 WO1998033533A1 (en) 1997-01-31 1998-01-30 A stabilized mixture comprising fibrinogen

Publications (2)

Publication Number Publication Date
DE69805772D1 true DE69805772D1 (de) 2002-07-11
DE69805772T2 DE69805772T2 (de) 2003-01-30

Family

ID=8226433

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69805772T Expired - Lifetime DE69805772T2 (de) 1997-01-31 1998-01-30 Stabilisierte mischung auf fibrinogenbasis

Country Status (13)

Country Link
US (1) US6121232A (de)
JP (1) JP3825055B2 (de)
KR (1) KR100345570B1 (de)
CN (1) CN1182879C (de)
AT (1) ATE218365T1 (de)
AU (1) AU724715B2 (de)
BR (1) BR9807043A (de)
CA (1) CA2279419A1 (de)
DE (1) DE69805772T2 (de)
ES (1) ES2178153T3 (de)
HU (1) HUP0000908A3 (de)
NO (1) NO993709L (de)
PL (1) PL194316B1 (de)

Families Citing this family (43)

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DE10025001A1 (de) * 2000-05-22 2001-11-29 Aventis Behring Gmbh Gewebekleber mit verbesserten anti-adhäsiven Eigenschaften
US7276235B2 (en) * 1998-11-18 2007-10-02 Zlb Behring Gmbh Tissue glue with improved antiadhesive properties
CN100345591C (zh) * 2003-08-01 2007-10-31 上海新兴医药股份有限公司 耐干热处理的速溶冻干纤维蛋白原制剂
US7186684B2 (en) * 2003-08-07 2007-03-06 Ethicon, Inc. Hemostatic device containing a protein precipitate
EP1809343B1 (de) * 2004-10-20 2012-08-15 Ethicon, Inc. Verstärkter resorbierbarer mehrschichtiger hämostatischer wundverband und herstellungsverfahren
US9358318B2 (en) * 2004-10-20 2016-06-07 Ethicon, Inc. Method of making a reinforced absorbable multilayered hemostatic wound dressing
FR2887883B1 (fr) * 2005-06-29 2007-08-31 Lab Francais Du Fractionnement Procede de separation des proteines fibrinogene, facteur xiii et colle biologique d'une fraction plasmatique solubilisee et de preparation de concentres lyophilises desdites proteines
CN101678086B (zh) * 2007-03-22 2013-07-10 财团法人化学及血清疗法研究所 固体纤维蛋白原制剂
EP2011524A1 (de) * 2007-07-02 2009-01-07 Omrix Biopharmaceuticals Ltd. Fibrinleim mit Visualisierungsmittel
EP2034010A1 (de) 2007-08-30 2009-03-11 Omrix Biopharmaceuticals Ltd. Zusammensetzungen zur Reparatur und/oder Behandlung von verletztem Rückenmarksgewebe
WO2010032246A2 (en) * 2008-09-22 2010-03-25 Omrix Biopharmaceuticals Ltd. Implantable device comprising a substrate pre-coated with stabilized fibrin
EP2398394B1 (de) * 2009-02-20 2021-08-04 Omrix Biopharmaceuticals Ltd. Vorrichtung zur verabreichung einer aus mindestens zwei komponenten bestehenden substanz
KR101786786B1 (ko) 2010-01-28 2017-10-18 옴릭스 바이오파머슈티컬스 리미티드 개선된 피브린 밀봉 방법
IL207586A0 (en) 2010-08-12 2010-12-30 Omrix Biopharmaceuticals Ltd A fibrin based therapeutic preparation and use thereof
JP5999776B2 (ja) * 2010-09-15 2016-09-28 デビオファーマ インターナショナル ソシエテ アノニムＤｅｂｉｏｐｈａｒｍ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｓａ 血液成分を含むフィブリノゲン含有サンプルからターゲット分子又は粒子を分離する方法
ES2951828T3 (es) 2010-09-23 2023-10-25 Leading Biosciences Inc Administración de inhibidores de serina proteasa al estómago
IL210162A0 (en) 2010-12-21 2011-03-31 Omrix Biopharmaceuticals Viral inactivated platelet extract, use and preparation thereof
IL213375A0 (en) 2011-06-05 2011-07-31 Omrix Biopharmaceuticals Device for spraying fluids in proximity to a surface
US20150064141A1 (en) 2012-04-05 2015-03-05 The Regents Of The University Of California Regenerative sera cells and mesenchymal stem cells
US10130346B2 (en) 2012-07-24 2018-11-20 Omrix Biopharmaceuticals Ltd. Device and method for the application of a curable fluid composition to a bodily organ
AU2013365623B2 (en) 2012-12-20 2017-08-24 Omrix Biopharmaceuticals Ltd. Viral inactivated biological mixture
CN105007829B (zh) 2012-12-30 2018-06-01 奥姆里克斯生物药品有限公司 用于将可固化流体组合物施用到身体器官的一部分的装置和方法
USD754325S1 (en) 2013-06-06 2016-04-19 Omrix Biopharmaceuticals Ltd. Device of a curable fluid composition to a bodily organ
IL230151A0 (en) 2013-12-24 2014-09-30 Omrix Biopharmaceuticals Ltd One-component fibrin glue containing a polymerization inhibitor
IL230150A0 (en) 2013-12-24 2014-09-30 Omrix Biopharmaceuticals Ltd One-component fibrin glue containing zymogens
CN112641771B (zh) 2014-03-25 2022-04-15 恒翼生物医药科技(上海)有限公司 用于治疗自身消化的组合物
IL231792A0 (en) 2014-03-27 2014-08-31 Omrix Biopharmaceuticals Ltd Device and method for the preparation and administration of one-component fibrin glue
IL234246A0 (en) 2014-08-21 2014-11-30 Omrix Biopharmaceuticals Ltd Stabilized thrombin
IL235751A0 (en) 2014-11-18 2015-02-26 Omrix Biopharmaceuticals Ltd An addition to the spray dryer
BR112017010250A2 (pt) 2014-11-18 2018-01-02 Omrix Biopharmaceuticals Ltd aparelho para secagem por aspersão e método de uso do mesmo
BR112017017628A2 (pt) 2015-02-25 2018-05-08 Omrix Biopharmaceuticals Ltd. método para a purificação e quantificação de trombina e seus polipeptídeos de degradação
US10159720B2 (en) 2015-12-08 2018-12-25 Omrix Biopharmaceuticals Ltd Thrombin microcapsules, preparation and uses thereof
IL242984A0 (en) 2015-12-08 2016-02-29 Omrix Biopharmaceuticals Ltd Thrombin microcapsules, their preparation and how to use them
IL242924A0 (en) 2015-12-03 2016-04-21 Omrix Biopharmaceuticals Ltd Syringe system for storing and mixing two ingredients
WO2017123653A1 (en) 2016-01-11 2017-07-20 Leading BioSciences, Inc. Compositions and methods for treating and preventing adhesions and ileus
JP2017177073A (ja) * 2016-03-31 2017-10-05 テルモ株式会社 塗布具
IL247821A0 (en) * 2016-09-14 2017-01-31 Omrix Biopharmaceuticals Ltd Adhesive preparations and their use
CN109081789B (zh) * 2017-06-13 2021-01-01 首都医科大学 氨基正己酰氨基甲环酰氨基正己酰脂肪氨基酸，其合成，活性和应用
IL261190A (en) 2018-08-16 2019-01-31 Omrix Biopharmaceuticals Ltd Stable liquid preparations of thrombin
WO2020121289A1 (en) 2018-12-12 2020-06-18 Omrix Biopharmaceuticals Ltd. Low concentrated protein compositions for preventing tissue adhesion
IL263679A (en) 2018-12-12 2019-03-31 Omrix Biopharmaceuticals Ltd Kits, methods, and ingredients for preventing tissue adhesion
EP4401801A1 (de) 2021-09-16 2024-07-24 Ethicon, Inc. Kit für zusammensetzung zur gewebetraktabdichtung
WO2023119277A1 (en) 2021-12-21 2023-06-29 Omrix Biopharmaceuticals Ltd. Highly soluble fibrinogen compositions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT359653B (de) * 1979-02-15 1980-11-25 Immuno Ag Verfahren zur herstellung eines gewebekleb- stoffes
DK475386D0 (da) * 1986-10-03 1986-10-03 Weis Fogh Ulla Sivertsen Fremgangsmaade og apparat til fremstilling af biologiske stoffer
US5278189A (en) * 1990-06-04 1994-01-11 Rath Matthias W Prevention and treatment of occlusive cardiovascular disease with ascorbate and substances that inhibit the binding of lipoprotein (A)
ES2139740T3 (es) * 1993-03-30 2000-02-16 Omrix Biopharm Sa Cola de fibrina de dos componentes.

Also Published As

Publication number Publication date
HUP0000908A2 (hu) 2000-08-28
KR20000070634A (ko) 2000-11-25
NO993709D0 (no) 1999-07-30
KR100345570B1 (ko) 2002-07-26
CN1182879C (zh) 2005-01-05
ATE218365T1 (de) 2002-06-15
JP2000509630A (ja) 2000-08-02
CA2279419A1 (en) 1998-08-06
JP3825055B2 (ja) 2006-09-20
ES2178153T3 (es) 2002-12-16
CN1246069A (zh) 2000-03-01
PL334547A1 (en) 2000-03-13
BR9807043A (pt) 2000-03-28
PL194316B1 (pl) 2007-05-31
US6121232A (en) 2000-09-19
NO993709L (no) 1999-09-28
DE69805772T2 (de) 2003-01-30
HUP0000908A3 (en) 2001-05-28
AU724715B2 (en) 2000-09-28
AU6214598A (en) 1998-08-25

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