DK0454898T3 - Glycosaminoglycan-modificeret protein, fremgangsmåde til fremstilling af proteinet, farmaceutiske præparater indeholdende proteinet samt anvendelse af proteinet - Google Patents
Glycosaminoglycan-modificeret protein, fremgangsmåde til fremstilling af proteinet, farmaceutiske præparater indeholdende proteinet samt anvendelse af proteinetInfo
- Publication number
- DK0454898T3 DK0454898T3 DK90119607.1T DK90119607T DK0454898T3 DK 0454898 T3 DK0454898 T3 DK 0454898T3 DK 90119607 T DK90119607 T DK 90119607T DK 0454898 T3 DK0454898 T3 DK 0454898T3
- Authority
- DK
- Denmark
- Prior art keywords
- protein
- glycosaminoglycan
- producing
- pharmaceutical preparations
- preparations containing
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 6
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 229920002683 Glycosaminoglycan Polymers 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 102000035118 modified proteins Human genes 0.000 title 1
- 108091005573 modified proteins Proteins 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 125000003172 aldehyde group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 230000001766 physiological effect Effects 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2081163A JP2975632B2 (ja) | 1990-03-30 | 1990-03-30 | グリコサミノグリカン修飾プロテイン |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0454898T3 true DK0454898T3 (da) | 1996-04-15 |
Family
ID=13738789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90119607.1T DK0454898T3 (da) | 1990-03-30 | 1990-10-12 | Glycosaminoglycan-modificeret protein, fremgangsmåde til fremstilling af proteinet, farmaceutiske præparater indeholdende proteinet samt anvendelse af proteinet |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5310881A (da) |
| EP (1) | EP0454898B1 (da) |
| JP (1) | JP2975632B2 (da) |
| KR (1) | KR100188382B1 (da) |
| AT (1) | ATE135375T1 (da) |
| AU (1) | AU649416B2 (da) |
| CA (1) | CA2027447A1 (da) |
| DE (1) | DE69025920T2 (da) |
| DK (1) | DK0454898T3 (da) |
| ES (1) | ES2083989T3 (da) |
| FI (1) | FI102836B1 (da) |
| NO (1) | NO179044C (da) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0502550B1 (en) * | 1991-03-07 | 1995-01-04 | Mect Corporation | Colominic acid and partial hydrolysis products of colominic acid for the preparation of medicaments for the treatment of hepatitis, nephritis and arthritis |
| US5846951A (en) * | 1991-06-06 | 1998-12-08 | The School Of Pharmacy, University Of London | Pharmaceutical compositions |
| GB9112212D0 (en) * | 1991-06-06 | 1991-07-24 | Gregoriadis Gregory | Pharmaceutical compositions |
| GB2266239B (en) * | 1992-03-25 | 1996-03-06 | Jevco Ltd | Wound healing compositions containing chondroitin sulphate oligosaccharides |
| CA2091544A1 (en) * | 1992-03-26 | 1993-09-27 | Shing F. Kwan | Stabilization of functional proteins |
| DK0744409T3 (da) * | 1994-02-23 | 2008-11-10 | Kyowa Hakko Kogyo Kk | Accelerator for vækst af blodplader |
| JPH09503001A (ja) * | 1994-05-09 | 1997-03-25 | ベーリンガー マンハイム ゲゼルシャフト ミット ベシュレンクテル ハフツング | ニューロンを保護するためのコンドロイチン硫酸プロテオグリカンの使用 |
| US6228998B1 (en) | 1994-07-22 | 2001-05-08 | Seikagaku Kogyo Kabushiki Kaisha | Amino spacered glycosaminoglycan derivatives and their use in copolymerization with acrylamide |
| PT789590E (pt) * | 1994-09-23 | 2002-12-31 | Zonagen Inc | Imunopotenciacao induzida por quitosano |
| US5912000A (en) * | 1994-09-23 | 1999-06-15 | Zonagen, Inc. | Chitosan induced immunopotentiation |
| US5677276A (en) * | 1994-12-23 | 1997-10-14 | La Jolla Cancer Research Foundation | Immobilization of peptides to hyaluronate |
| RU2176509C2 (ru) * | 1995-09-19 | 2001-12-10 | Сейкагаку Корпорейшн | Средство, усиливающее противовоспалительное действие иммунодепрессанта (варианты), способ усиления противовоспалительного действия иммунодепрессанта, способ лечения воспаления |
| US7045585B2 (en) * | 1995-11-30 | 2006-05-16 | Hamilton Civic Hospital Research Development Inc. | Methods of coating a device using anti-thrombin heparin |
| US6491965B1 (en) * | 1995-11-30 | 2002-12-10 | Hamilton Civic Hospitals Research Development, Inc. | Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
| US6562781B1 (en) | 1995-11-30 | 2003-05-13 | Hamilton Civic Hospitals Research Development Inc. | Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
| WO1998013519A1 (en) * | 1996-09-25 | 1998-04-02 | Universal Healthwatch, Inc. | Diagnostic test devices with improved fluid movement and resistance to interferences |
| WO2001005434A2 (en) * | 1999-07-20 | 2001-01-25 | Amgen Inc. | Hyaluronic acid-protein conjugates |
| JP5232352B2 (ja) * | 2001-10-10 | 2013-07-10 | ノボ ノルデイスク エイ エス | ペプチドの改造および複合糖質化 |
| DK2279755T3 (da) * | 2001-10-10 | 2014-05-26 | Ratiopharm Gmbh | Remodellering og glycokonjugering af fibroblastvækstfaktor (FGF) |
| DE10209822A1 (de) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid |
| DE10209821A1 (de) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung von Proteinen an ein modifiziertes Polysaccharid |
| WO2004024761A1 (en) | 2002-09-11 | 2004-03-25 | Fresenius Kabi Deutschland Gmbh | Hasylated polypeptides, especially hasylated erythropoietin |
| US8673333B2 (en) * | 2002-09-25 | 2014-03-18 | The Johns Hopkins University | Cross-linked polymer matrices, and methods of making and using same |
| US7862831B2 (en) * | 2002-10-09 | 2011-01-04 | Synthasome, Inc. | Method and material for enhanced tissue-biomaterial integration |
| AU2003288911B8 (en) * | 2002-09-25 | 2009-12-24 | Johns Hopkins University | Cross-linked polymer matrices, and methods of making and using same |
| WO2005014655A2 (en) | 2003-08-08 | 2005-02-17 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
| RU2333223C2 (ru) | 2003-08-12 | 2008-09-10 | Лайпоксен Текнолоджиз Лимитед | Альдегидные производные сиаловой кислоты, способы их получения, конъюгаты альдегидных производных сиаловой кислоты и фармацевтическая композиция на их основе |
| WO2006089119A2 (en) * | 2005-02-18 | 2006-08-24 | Cartilix, Inc. | Biological adhesive |
| CN103626884B (zh) | 2005-02-23 | 2016-05-18 | 利普生技术有限公司 | 用于蛋白质衍生和缀合的活化的唾液酸衍生物 |
| EP1886696A1 (en) * | 2006-08-03 | 2008-02-13 | Endotis Pharma | Conjugates of antithrombin binding oligosaccharide derivatives and therapeutic proteins |
| US8658593B2 (en) | 2011-06-06 | 2014-02-25 | The Cleveland Clinic Foundation | Treatment of extracellular matrix to reduce inflammation |
| WO2015046602A1 (ja) | 2013-09-30 | 2015-04-02 | 生化学工業株式会社 | タンパク質の血中滞留性の増強方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2824092A (en) * | 1955-01-04 | 1958-02-18 | Robert E Thompson | Process of preparation of a gelatincarboxymethyl cellulose complex |
| GB1479268A (en) * | 1973-07-05 | 1977-07-13 | Beecham Group Ltd | Pharmaceutical compositions |
| US4301153A (en) * | 1977-03-21 | 1981-11-17 | Riker Laboratories, Inc. | Heparin preparation |
| CA1171375A (en) * | 1980-09-15 | 1984-07-24 | Ulf P.F. Lindahl | Oligosaccharides having selective anticoagulation activity |
| US4356170A (en) * | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
| US4526714A (en) * | 1982-12-13 | 1985-07-02 | Cordis Europa N.V. | Conjugates of anticoagulant and protein |
| NL188622C (nl) * | 1981-12-15 | 1992-08-17 | Cordis Europ | Werkwijze ter verbetering van de bloedcompatibiliteit van een materiaaloppervlak door bekleding daarvan met een heparine of heparine-analoga en een eiwit houdende film, alsmede voorwerp, omvattende een oppervlak met verbeterde bloedcompatibiliteit verkregen onder toepassing van een op het oppervlak aangebrachte heparine of heparine-analoga en een eiwit houdende film. |
| SE8200751L (sv) * | 1982-02-09 | 1983-08-10 | Olle Larm | Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter |
| US4585754A (en) * | 1984-01-09 | 1986-04-29 | Valcor Scientific, Ltd. | Stabilization of proteins and peptides by chemical binding with chondroitin |
| US4863907A (en) * | 1984-06-29 | 1989-09-05 | Seikagaku Kogyo Co., Ltd. | Crosslinked glycosaminoglycans and their use |
| ATE65506T1 (de) * | 1986-04-22 | 1991-08-15 | Valcor Scient Ltd | Verfahren zur stabilisierung von proteinen. |
| US4745180A (en) * | 1986-06-27 | 1988-05-17 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using heparin fragments |
| DE3636590A1 (de) * | 1986-10-28 | 1988-05-26 | Braun Melsungen Ag | Blutersatzmittel |
| FR2631970B1 (fr) * | 1988-05-24 | 1993-12-24 | Sanofi | N-polyosyl-polypeptides |
| DE3819079A1 (de) * | 1988-06-04 | 1989-12-07 | Hoechst Ag | Hirudin-derivate mit verzoegerter wirkung |
| WO1990001332A1 (en) * | 1988-08-10 | 1990-02-22 | Cetus Corporation | Plasminogen activator-heparin conjugates |
-
1990
- 1990-03-30 JP JP2081163A patent/JP2975632B2/ja not_active Expired - Lifetime
- 1990-10-10 AU AU64506/90A patent/AU649416B2/en not_active Ceased
- 1990-10-10 NO NO904378A patent/NO179044C/no unknown
- 1990-10-11 FI FI905003A patent/FI102836B1/fi not_active IP Right Cessation
- 1990-10-12 CA CA002027447A patent/CA2027447A1/en not_active Abandoned
- 1990-10-12 DK DK90119607.1T patent/DK0454898T3/da active
- 1990-10-12 EP EP90119607A patent/EP0454898B1/en not_active Expired - Lifetime
- 1990-10-12 DE DE69025920T patent/DE69025920T2/de not_active Expired - Fee Related
- 1990-10-12 ES ES90119607T patent/ES2083989T3/es not_active Expired - Lifetime
- 1990-10-12 KR KR1019900016160A patent/KR100188382B1/ko not_active IP Right Cessation
- 1990-10-12 AT AT90119607T patent/ATE135375T1/de active
-
1992
- 1992-07-02 US US07/908,910 patent/US5310881A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2975632B2 (ja) | 1999-11-10 |
| EP0454898B1 (en) | 1996-03-13 |
| DE69025920T2 (de) | 1996-08-14 |
| JPH03284698A (ja) | 1991-12-16 |
| US5310881A (en) | 1994-05-10 |
| KR100188382B1 (ko) | 1999-06-01 |
| NO179044C (no) | 1996-07-24 |
| KR910016770A (ko) | 1991-11-05 |
| CA2027447A1 (en) | 1991-10-01 |
| DE69025920D1 (de) | 1996-04-18 |
| NO904378L (no) | 1991-10-01 |
| AU6450690A (en) | 1991-10-31 |
| EP0454898A1 (en) | 1991-11-06 |
| FI102836B (fi) | 1999-02-26 |
| ATE135375T1 (de) | 1996-03-15 |
| FI905003A0 (fi) | 1990-10-11 |
| NO904378D0 (no) | 1990-10-10 |
| AU649416B2 (en) | 1994-05-26 |
| NO179044B (no) | 1996-04-15 |
| FI102836B1 (fi) | 1999-02-26 |
| ES2083989T3 (es) | 1996-05-01 |
| FI905003A (fi) | 1991-10-01 |
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