YU174490A - Novi estri tienil-karboksilne kiseline sa aminoalkoholima, njihova kvaterna jedinjenja kao i pripremanje i primena tih jedinjenja - Google Patents

Novi estri tienil-karboksilne kiseline sa aminoalkoholima, njihova kvaterna jedinjenja kao i pripremanje i primena tih jedinjenja

Info

Publication number
YU174490A
YU174490A YU174490A YU174490A YU174490A YU 174490 A YU174490 A YU 174490A YU 174490 A YU174490 A YU 174490A YU 174490 A YU174490 A YU 174490A YU 174490 A YU174490 A YU 174490A
Authority
YU
Yugoslavia
Prior art keywords
compounds
quateral
preparation
well
carboxylic acid
Prior art date
Application number
YU174490A
Other languages
English (en)
Other versions
YU47800B (sr
Inventor
R. Banholzer
R. Bauer
R. Reichl
Original Assignee
Boehringer Ingelheim Kg.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6389619&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU174490(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Kg. filed Critical Boehringer Ingelheim Kg.
Priority to SI9011744A priority Critical patent/SI9011744B/sl
Publication of YU174490A publication Critical patent/YU174490A/sh
Priority to HRP-1744/90A priority patent/HRP940723B1/xx
Publication of YU47800B publication Critical patent/YU47800B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Abstract

Novi estri tienil-karboksilne kisline z aminoalkoholi, njihovi kvaternirni produkti kot tudi priprava in uporaba teh spojin Opisane so nove spojine s formulo I v kateri A stoji za skupino v kateri m in n neodvisno drug od drugega pomenita 1 ali 2, Q eno izmed dvoveznih skupin in Q' predstavlja skupino = NR ali skupino = NRR', pri čemer R pomeni H ali v danem primeru s halogenom ali hidroksi substituiran C1-C4 alkilni ostanek, R' pa C1-C1-alkilni ostanek in R in R' lahko skupaj tvorita tudi C4-C6-alkilenski ostanek in pri čemer pri kvarternih spojinah stoji nasproti pozitivnega naboja N-atoma ekvivalent aniona (X-), R1 stoji za tienilni, fenilni, furilni, ciklopentilni ali cikloheksilni ostanek, pri čemer so ti ostanki lahko tudi substituirani z metilom, tienil in fenil pa tudi s fluorom ali klorom, R2 stoji za vodik, OH, C1C4-alkoksi ali C1-C4-alkil, Ra stoji za H, F, Cl ali CH3, in v kolikor = NR pomeni sekundarno ali terciarno amino skupino, tudi njihove kislinske adicijske soli, ki se dajo pripraviti po samih po sebi znanih metodah in so uporabne kot učinkovine za zdravila.
YU174490A 1989-09-16 1990-09-13 Estri tienil-karboksilne kiseline sa aminoalkoholima, njihova kvaterna jedinjenja kao i pripremanje tih jedinjenja YU47800B (sr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI9011744A SI9011744B (sl) 1989-09-16 1990-09-13 Novi estri karboksilne kisline z amino-alkoholi, njihovi kvarternirni produkti kot tudi priprava in uporaba teh spojin
HRP-1744/90A HRP940723B1 (en) 1989-09-16 1994-10-21 New thienylcarboxylic acid esters of aminoalcohols, their quarternary products, their preparation and use of the compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3931041A DE3931041C2 (de) 1989-09-16 1989-09-16 Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel

Publications (2)

Publication Number Publication Date
YU174490A true YU174490A (sh) 1993-10-20
YU47800B YU47800B (sr) 1996-01-09

Family

ID=6389619

Family Applications (1)

Application Number Title Priority Date Filing Date
YU174490A YU47800B (sr) 1989-09-16 1990-09-13 Estri tienil-karboksilne kiseline sa aminoalkoholima, njihova kvaterna jedinjenja kao i pripremanje tih jedinjenja

Country Status (33)

Country Link
US (1) USRE39820E1 (sh)
EP (1) EP0418716B1 (sh)
JP (1) JPH0730074B2 (sh)
KR (1) KR0168432B1 (sh)
AT (1) ATE103914T1 (sh)
AU (1) AU642913B2 (sh)
BG (1) BG61295B2 (sh)
CA (1) CA2066248C (sh)
CZ (1) CZ284589B6 (sh)
DD (1) DD297647A5 (sh)
DE (3) DE3931041C2 (sh)
DK (1) DK0418716T3 (sh)
ES (1) ES2052125T3 (sh)
FI (1) FI114395B (sh)
HR (1) HRP940723B1 (sh)
HU (2) HU208823B (sh)
IE (1) IE65528B1 (sh)
IL (1) IL95691A (sh)
LU (1) LU90949I2 (sh)
MX (1) MX9203150A (sh)
NL (1) NL300084I2 (sh)
NO (2) NO301478B1 (sh)
NZ (1) NZ235306A (sh)
PH (1) PH31617A (sh)
PL (1) PL168468B1 (sh)
PT (1) PT95312B (sh)
RU (1) RU2073677C1 (sh)
SI (1) SI9011744B (sh)
SK (1) SK452390A3 (sh)
UA (1) UA41272C2 (sh)
WO (1) WO1991004252A1 (sh)
YU (1) YU47800B (sh)
ZA (1) ZA907338B (sh)

Families Citing this family (148)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE4108393A1 (de) * 1991-03-15 1992-09-17 Boehringer Ingelheim Kg Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln
US5770738A (en) * 1992-03-05 1998-06-23 Boehringer Ingelheim Kg Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions
DE19921693A1 (de) 1999-05-12 2000-11-16 Boehringer Ingelheim Pharma Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
US7214687B2 (en) 1999-07-14 2007-05-08 Almirall Ag Quinuclidine derivatives and medicinal compositions containing the same
GB0009606D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Therapeutic combinations
GB0009592D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Respiratory combinations
GB0009583D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Respiratory formulations
GB0009605D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Medicaments
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
AR032361A1 (es) 2000-08-05 2003-11-05 Glaxo Group Ltd Derivados de androstano y sales y solvatos de los mismos, su uso para la fabricacion de medicamentos, composiciones farmaceuticas que comprenden tales compuestos, proceso para la preparacion de dichos compuestos, e intermediarios utiles en la preparacion de tales compuestos
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
BR0107304A (pt) 2000-10-12 2002-08-13 Boehringer Ingelheim Pharma Pó para inalação contendo tiotrópio
DK1326862T3 (da) * 2000-10-12 2004-11-22 Boehringer Ingelheim Pharma Krystallinsk monohydrat af tiotropiumbromid, fremgangsmåde til fremstilling deraf og anvendelse deraf til fremstilling af et lægemiddel
US6908928B2 (en) 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
NZ526023A (en) * 2000-10-31 2005-05-27 Boehringer Ingelheim Pharma Inhalable formulation of a solution containing a tiotropium salt
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
BR0116624A (pt) 2000-12-28 2003-12-23 Almirall Prodesfarma Ag Composto, processo para produzir o mesmo, composição farmacêutica, uso do composto ou da composição farmacêutica, e, produto de combinação
US6506900B1 (en) 2001-01-31 2003-01-14 Boehringer Ingelheim Pharma Ag Process for preparing a scopine ester intermediate
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
JP4446661B2 (ja) 2001-04-30 2010-04-07 グラクソ グループ リミテッド 抗炎症性の、１７α位に環状エステル基を有するアンドロスタンの１７β−カルボチオ酸エステル誘導体
DE10126924A1 (de) * 2001-06-01 2002-12-05 Boehringer Ingelheim Pharma Inhalationskapseln
US6608055B2 (en) 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
DK1401445T3 (da) * 2001-06-22 2006-11-27 Boehringer Ingelheim Pharma Krystallinsk anticholinergikum, fremgangsmåde til fremstilling af dette og anvendelse af dette til fremstilling af et lægemiddel
US6610849B2 (en) * 2001-06-28 2003-08-26 Boehringer Ingelheim Pharma Kg Process for the manufacture of tropenol
DE10141377A1 (de) 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
MXPA04003865A (es) 2001-10-26 2004-07-08 Upjohn Co Compuestos de amonio cuaternario y sus usos como agentes antimuscarinicos.
DE10200943A1 (de) 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
US6696462B2 (en) 2002-01-31 2004-02-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics, processes for the preparation thereof, and pharmaceutical compositions
DE10203749A1 (de) * 2002-01-31 2003-08-14 Boehringer Ingelheim Pharma Neue Anticholinergika, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
GB0203193D0 (en) * 2002-02-11 2002-03-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
WO2003068233A1 (en) * 2002-02-11 2003-08-21 Pfizer Limited Nicotinamide derivatives and a tiotropium salt in combination for the treatment of e.g. inflammatory, allergic and respiratory diseases
US7309707B2 (en) * 2002-03-20 2007-12-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
DE10212264A1 (de) * 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
DE10214264A1 (de) * 2002-03-28 2003-10-16 Boehringer Ingelheim Pharma HFA-Suspensionsformulierungen eines Anhydrats
US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
UA80123C2 (en) 2002-04-09 2007-08-27 Boehringer Ingelheim Pharma Inhalation kit comprising inhalable powder of tiotropium
DE10216036A1 (de) 2002-04-11 2003-10-23 Boehringer Ingelheim Pharma Aerosolformulierung für die Inhalation enthaltend ein Tiotropiumsalz
DE10224091A1 (de) * 2002-05-31 2003-12-11 Boehringer Ingelheim Pharma Technisches Verfahren zur Herstellung von Tropenol
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
US7763280B2 (en) 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
CA2513188A1 (en) * 2003-01-16 2004-08-05 University Of Rochester Quaternary antimuscarinic compounds for the treatment of bladder diseases
US20040226556A1 (en) 2003-05-13 2004-11-18 Deem Mark E. Apparatus for treating asthma using neurotoxin
WO2004106333A1 (en) 2003-05-28 2004-12-09 Theravance, Inc. Azabicycloalkane compounds as muscarinic receptor antagonists
DK2083007T3 (da) 2003-11-03 2013-07-29 Boehringer Ingelheim Int Tiotropiumsalte, fremgangsmåder til deres fremstilling og lægemiddelformuleringer indeholdende disse
SI1682542T1 (sl) * 2003-11-03 2010-04-30 Boehringer Ingelheim Int Nov kristaliniŽŤen anhidrat z antiholinergiŽŤno uŽŤinkovitostjo
US7968717B2 (en) 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
DK1682541T3 (da) * 2003-11-03 2010-06-28 Boehringer Ingelheim Int Fremgangsmåde til fremstilling af tiotropiumsalte
SE0303570L (sv) 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
EP1785421A1 (en) * 2004-08-30 2007-05-16 Ono Pharmaceutical Co., Ltd. Tropan compound
SI1881980T1 (sl) 2005-05-02 2012-12-31 Boehringer Ingelheim International Gmbh Nove kristalinične oblike tiotropijevega bromida
AU2006243239A1 (en) * 2005-05-02 2006-11-09 Boehringer Ingelheim International Gmbh Crystalline forms of tiotropium bromide
DE102005035112A1 (de) 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
EP2281813A1 (en) 2005-08-08 2011-02-09 Pulmagen Therapeutics (Synergy) Limited Bicyclo[2.2.1]hept-7-ylamine derivatives and their uses
TWI389692B (zh) 2005-10-10 2013-03-21 Boehringer Ingelheim Int 用以吸入β-共效劑的氣溶膠調配物
DE102005059602A1 (de) * 2005-12-14 2007-06-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Mikronisierung
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
ES2384486T3 (es) * 2005-12-19 2012-07-05 Sicor, Inc. Nueva forma de bromuro de tiotropio y procedimiento para su preparación
US20070167480A1 (en) * 2005-12-19 2007-07-19 Sicor Inc. Pure and stable tiotropium bromide
MY146362A (en) * 2006-01-04 2012-08-15 Boehringer Ingelheim Int Use of tiotropium salts in the treatment of moderate persistent asthma
ES2298049B1 (es) 2006-07-21 2009-10-20 Laboratorios Almirall S.A. Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano.
NZ574533A (en) 2006-08-01 2011-05-27 Glaxo Group Ltd Pyrazolo[3,4-b]pyridine compounds, and their use as pde4 inhibitors
EP1923393A1 (en) * 2006-11-17 2008-05-21 Boehringer Ingelheim Pharma GmbH & Co. KG Crystalline form of tiotropium bromide and urea
EP1925295A1 (de) * 2006-11-22 2008-05-28 Boehringer Ingelheim Pharma GmbH & Co. KG Stabile Pulverformulierung enthaltend ein Anticholinergikum
GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
CA2608561A1 (en) * 2007-10-29 2009-04-29 Carl Paluszkiewicz Motorcycle wind deflector accessory support
WO2009087419A1 (en) * 2008-01-10 2009-07-16 Generics [Uk] Limited Novel process for the preparation of scopine esters
US8483831B1 (en) 2008-02-15 2013-07-09 Holaira, Inc. System and method for bronchial dilation
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2662046B1 (en) 2008-05-09 2023-03-15 Nuvaira, Inc. Systems and assemblies for treating a bronchial tree
EP2172190A1 (en) 2008-10-02 2010-04-07 Laboratorios Liconsa, S.A. Inhalable particles comprising tiotropium
WO2010101538A2 (en) 2009-03-06 2010-09-10 Bilgic Mahmut New crystal forms
US8815258B2 (en) 2009-05-29 2014-08-26 Pearl Therapeutics, Inc. Compositions, methods and systems for respiratory delivery of two or more active agents
AR076621A1 (es) 2009-05-29 2011-06-22 Pearl Therapeutics Inc Composiciones para el suministro de antagonistas muscarinicos de accion prolongada y agonista del receptor adrenergico b2 de accion prolongada. metodo de tratamiento. sistemas asociados. inhalador dosificador
WO2011015884A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Process to prepare scopine esters
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use
IN2012DN00968A (sh) * 2009-08-07 2015-04-10 Generics Uk Ltd
TR200907237A2 (tr) 2009-09-23 2011-04-21 Bi̇lgi̇ç Mahmut Tiotropyum kuru toz kombinasyonu
TR200907236A2 (tr) 2009-09-23 2011-04-21 Bi̇lgi̇ç Mahmut Tiotropyum kuru toz formülasyonunun blister ambalajda taşınması.
CN107049479B (zh) 2009-10-27 2020-10-16 努瓦拉公司 具有可冷却的能量发射组件的递送装置
US8911439B2 (en) 2009-11-11 2014-12-16 Holaira, Inc. Non-invasive and minimally invasive denervation methods and systems for performing the same
KR101820542B1 (ko) 2009-11-11 2018-01-19 호라이라 인코포레이티드 조직을 치료하고 협착을 제어하기 위한 방법, 기구 및 장치
WO2011093809A2 (en) 2010-01-28 2011-08-04 Mahmut Bilgic Dry powder pharmaceutical composition comprising tiotropium and ciclesonide
TR200909793A2 (tr) 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Tiotropyum, mometazon ve bir kromoglisik asit türevi kombinasyonu içeren kuru toz kombinasyonu.
WO2011093810A2 (en) 2010-01-28 2011-08-04 Bilgic Mahmut Dry powder pharmaceutical composition comprising tiotropium and mometasone
TR201000681A2 (tr) * 2010-01-29 2011-08-22 B�Lg�� Mahmut İnhalasyon yoluyla alınan kuru toz formülasyonları.
TR200909790A2 (tr) 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Tiotropyum, formoterol ve bir kromoglisik asit türevi kombinasyonu içeren kuru toz kombinasyonu.
TR200909788A2 (tr) 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Tiotropyum içeren inhalasyona uygun kuru toz formülasyonu
TR200909789A2 (tr) 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Tiotropyum, budesonid ve bir kromoglisik asit türevi kombinasyonu içeren kuru toz kombinasyonu
US8834931B2 (en) 2009-12-25 2014-09-16 Mahmut Bilgic Dry powder formulation containing tiotropium for inhalation
TR201000679A2 (tr) * 2010-01-29 2011-08-22 B�Lg�� Mahmut Farmasötik bir kombinasyon içeren kuru toz formülasyonları.
WO2011093812A2 (en) 2010-01-28 2011-08-04 Mahmut Bilgic Pharmaceutical formulation comprising tiotropium and budesonide in dry powder form
TR200909792A2 (tr) 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Tiotropyum, kortikosteroid ve bir kromoglisik asit türevi kombinasyonu içeren kuru toz kombinasyonu
EP2528600B1 (en) 2010-01-28 2016-06-29 Mahmut Bilgic Dry powder pharmaceutical composition comprising tiotropium and fluticasone
TR201000733A2 (tr) 2010-02-02 2011-08-22 Bi̇lgi̇ç Mahmut Flutikazon, tiotropyum ve sodyum kromoglikat içeren farmasötik bileşimler.
TR201002520A2 (tr) 2010-04-01 2010-05-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür imalat metodu.
TR201005222A2 (tr) 2010-04-01 2011-10-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür sentez yöntemi
US8957209B2 (en) 2010-04-01 2015-02-17 Mahmut Bilgic Methods for the synthesis of tiotropium bromide
TR201005221A2 (tr) 2010-04-01 2012-01-23 Bi̇lgi̇ç Mahmut Geliştirilmiş sentez metodu.
TR201007108A2 (tr) 2010-08-25 2012-03-21 B�Lg�� Mahmut Yeni tiotropyum bromür kristali ve üretim yöntemi.@
TR201101897A2 (tr) 2011-02-28 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal madde
TR201111589A2 (tr) 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür susuz kristal formu.
TR201102068A2 (tr) 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal maddeler
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
ITRM20110508A1 (it) 2011-09-27 2013-03-28 Lusochimica Spa Processo per la preparazione degli esteri della scopina.
US8680297B2 (en) 2011-10-06 2014-03-25 Drug Process Licensing Assoc., LLC Manufacturing process for tiotropium bromide
CZ304368B6 (cs) 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
EP2607351B1 (en) * 2011-12-22 2017-03-15 Cerbios-Pharma S.A. Continuous process for the alkylation of cyclic tertiary amines
WO2013109216A2 (en) 2012-01-16 2013-07-25 Mahmut Bilgic Preparation of dry powder formulations comprising tiotropium
CZ201241A3 (cs) 2012-01-20 2013-07-31 Zentiva, K.S. Nové polymorfní formy tiotropium jodidu a zpusob jejich prípravy
WO2014007773A1 (en) 2012-07-05 2014-01-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Compositions comprising muscarinic receptor antagonist and sorbitol
PT106142B (pt) * 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
WO2013127738A1 (de) 2012-02-28 2013-09-06 Boehringer Ingelheim International Gmbh Neue treibgashaltige tiotropium-formulierung
CZ304808B6 (cs) 2012-03-16 2014-11-05 Zentiva, K.S. Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu a jeho nová forma
CZ305012B6 (cs) * 2012-03-30 2015-03-25 Zentiva, K.S. Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu
WO2014007771A2 (en) 2012-07-05 2014-01-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Inhalation compositions comprising muscarinic receptor antagonist
US20150174064A1 (en) 2012-07-05 2015-06-25 Arven IIac Sanayi Ve Ticaret A.S. Compositions comprising muscarinic receptor antagonist and glucose anhydrous
EP2705838A1 (en) 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium preparations
RS55919B1 (sr) 2012-11-05 2017-09-29 Zentiva As Stabilizacija solvata tiotropijuma
US9398933B2 (en) 2012-12-27 2016-07-26 Holaira, Inc. Methods for improving drug efficacy including a combination of drug administration and nerve modulation
CN105188679B (zh) 2013-03-15 2018-10-16 珍珠治疗公司 用于微粒晶体材料的状态调节的方法和系统
CA2907566C (en) 2013-04-01 2023-08-22 Pulmatrix, Inc. Tiotropium dry powders
EP2913332A1 (en) * 2014-02-27 2015-09-02 Euticals S.P.A. Crystalline form of tiotropium bromide with lactose
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
US9987260B2 (en) 2015-05-18 2018-06-05 Glenmark Specialty S.A. Tiotropium inhalation solution for nebulization
EP3297607B1 (en) 2015-05-18 2020-07-22 Glenmark Specialty S.A. Tiotropium inhalation solution for nebulization
US10653683B2 (en) 2015-05-18 2020-05-19 Glenmark Specialty S.A. Tiotropium inhalation solution for nebulization
KR101748796B1 (ko) 2015-09-30 2017-06-19 한미약품 주식회사 활성성분의 전달량이 향상된 흡입용 캡슐제
EP3159278A1 (en) 2015-10-23 2017-04-26 Arven Ilac Sanayi Ve Ticaret A.S. Blister for tiotropium bromide inhalable formulation
PT3159277T (pt) 2015-10-23 2019-09-11 Arven Ilac Sanayi Ve Ticaret As Blister para formulação inalável de brometo de tiotrópio
WO2017138896A1 (en) 2016-02-11 2017-08-17 Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti Crystalline form of tiotropium bromide anhydrate
CN106467535A (zh) * 2016-08-28 2017-03-01 杭州百诚医药科技股份有限公司 一种制备2,2‑双(2‑噻吩基)乙醇酸东莨菪酯的纯化工艺
WO2018055642A1 (en) * 2016-09-23 2018-03-29 Gbr Laboratories Pvt. Ltd. A process for preparing tiotropium bromide and intermediates thereof
US10555903B2 (en) 2016-10-14 2020-02-11 Glenmark Specialty S.A. Nebulizable compositions of tiotropium and formoterol
US20200215051A1 (en) 2019-01-03 2020-07-09 Glenmark Specialty S.A. Nebulization composition comprising tiotropium and indacaterol
CA3226153A1 (en) 2021-07-09 2023-01-12 Astrazeneca Pharmaceuticals Lp Compositions, methods and systems for aerosol drug delivery
CN114213408B (zh) * 2021-12-15 2023-03-31 台州仙琚药业有限公司 一种噻托溴铵的制备方法
WO2023119093A1 (en) 2021-12-20 2023-06-29 Astrazeneca Ab Compositions, methods and systems for aerosol drug delivery

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB845056A (en) 1957-07-05 1960-08-17 Egyt Gyogyszervegyeszeti Gyar Improvements in or relating to tropane derivatives
DE1166787B (de) * 1960-07-09 1964-04-02 Boehringer & Soehne Gmbh Verfahren zur Herstellung von neuen Granatanol-(3ª‰)-estern und ihren Hydrohalogeniden
GB955535A (en) * 1962-10-22 1964-04-15 Boehringer & Soehne Gmbh New n-substituted norgranatanol-(3ª‰)-esters
DE2046659A1 (sh) 1970-01-28 1972-03-23
US3808263A (en) * 1970-05-12 1974-04-30 Tanabe Seiyaku Co 6,6-dimethyl-9-alkyl-9-azabicyclo(3.3.1)nonan-3-ols
US3673195A (en) * 1970-05-25 1972-06-27 Tanabe Seiyaku Co Derivatives of 6,6,9-tri-lower alkyl-9-azabicyclo(3.3.1) nonan-3{60 -or 3{62 -ol
US4353922A (en) * 1981-03-13 1982-10-12 Syntex (U.S.A.) Inc. Anticholinergic bronchodilators
DE3546218A1 (de) 1985-12-27 1987-07-02 Madaus & Co Dr Azoniaspironortropanolester, verfahren zu deren herstellung und pharmazeutisches mittel
DE3931041C2 (de) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel

Also Published As

Publication number Publication date
DE59005250D1 (de) 1994-05-11
CA2066248A1 (en) 1991-03-17
FI921087A0 (fi) 1992-03-13
DE10299026I1 (de) 2002-11-07
NO2002009I2 (no) 2004-10-11
EP0418716A1 (de) 1991-03-27
AU642913B2 (en) 1993-11-04
HRP940723A2 (en) 1997-06-30
UA41272C2 (uk) 2001-09-17
ATE103914T1 (de) 1994-04-15
HU208823B (en) 1994-01-28
CZ452390A3 (cs) 1998-11-11
WO1991004252A1 (de) 1991-04-04
DE3931041A1 (de) 1991-03-28
HUT60740A (en) 1992-10-28
HRP940723B1 (en) 1999-10-31
PL168468B1 (pl) 1996-02-29
NO921002D0 (no) 1992-03-13
LU90949I2 (fr) 2002-10-30
SI9011744B (sl) 1999-12-31
DD297647A5 (de) 1992-01-16
DE10299026I2 (de) 2004-07-01
SK279453B6 (sk) 1998-11-04
JPH05502438A (ja) 1993-04-28
DK0418716T3 (da) 1994-05-02
BG61295B2 (bg) 1997-04-30
ZA907338B (en) 1992-08-26
HU210612A9 (en) 1995-05-29
IL95691A0 (en) 1991-06-30
RU2073677C1 (ru) 1997-02-20
NO921002L (no) 1992-03-13
HU9200857D0 (en) 1992-05-28
NL300084I1 (nl) 2002-05-01
JPH0730074B2 (ja) 1995-04-05
FI114395B (fi) 2004-10-15
AU6431890A (en) 1991-04-18
PT95312B (pt) 1997-06-30
NO301478B1 (no) 1997-11-03
IE903342A1 (en) 1991-04-10
KR910006272A (ko) 1991-04-29
DE3931041C2 (de) 2000-04-06
USRE39820E1 (en) 2007-09-04
MX9203150A (es) 1992-07-01
NZ235306A (en) 1997-06-24
SI9011744A (en) 1997-10-31
PT95312A (pt) 1991-05-22
ES2052125T3 (es) 1994-07-01
KR0168432B1 (ko) 1999-01-15
PL286900A1 (en) 1991-12-02
IE65528B1 (en) 1995-11-01
SK452390A3 (en) 1998-11-04
NL300084I2 (nl) 2002-08-01
PH31617A (en) 1999-01-12
IL95691A (en) 1996-07-23
YU47800B (sr) 1996-01-09
EP0418716B1 (de) 1994-04-06
CA2066248C (en) 1998-08-04
CZ284589B6 (cs) 1999-01-13

Similar Documents

Publication Publication Date Title
YU174490A (sh) Novi estri tienil-karboksilne kiseline sa aminoalkoholima, njihova kvaterna jedinjenja kao i pripremanje i primena tih jedinjenja
DK581185A (da) Farmaceutisk praeparat indeholdende 13-cis-a-vitaminsyre
IL109578A0 (en) Nor-bile acid derivatives, processes for their preparation and the use of these compounds as medicaments
DE69010139D1 (de) Haarkräftigungsmittel.
PL262105A1 (en) The method of manufacture of new derivatives of benzimidazole
DE69025920T2 (de) Glykosaminoglykan-modifiertes Protein, Verfahren zu dessen Herstellung und pharmazeutische Zubereitungen, die es enthalten
FR2601259B1 (fr) Nouvelles compositions tensio-actives a base d&#39;esters phosphoriques leur procede de preparation et leur application a la formulation de matieres actives.
ATE58292T1 (de) L-dopa enthaltendes arzneimittel.
MY117090A (en) Substituted benzamidines, their preparation and their use as pharmaceutical compounds
ATE38991T1 (de) In 2-stellung substituierte 1,3propyledendephosphonat-derivate, ihre herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
IT1228288B (it) Composti ad attivita&#39; antiserotoninica
SE8404065D0 (sv) Novel biologically active compounds
IT1224405B (it) Composti attivi sul sistema cardiovascolare
HUT46214A (en) Process for producing medical preparation suitable for treatment of peptic ulcer
SE8101963L (sv) Monohydrerad isoftalsyrapikolylamid, forfarande for dess framstellning samt farmaceutisk anvendning derav
ES8606248A1 (es) Un procedimiento para la produccion de una dihidroxifenil- glicina opticamente activa
IT8622051A1 (it) Composizioni farmaceutiche ad attivita&#39; cicatrizzante
ATE53384T1 (de) 3-mercapto-2-oxo-1-pyrrolidinessigsaeurederivate verfahren zur herstellung und pharmazeutische zusammensetzungen die sie enthalten.
ES2053034T3 (es) Un procedimiento para la preparacion de butalactina y su empleo como producto farmaceutico.