NO963806L - Rekombinante viruser som koder for en glutamat-dekarboksylase (GAD)aktivitet - Google Patents

Rekombinante viruser som koder for en glutamat-dekarboksylase (GAD)aktivitet

Info

Publication number
NO963806L
NO963806L NO963806A NO963806A NO963806L NO 963806 L NO963806 L NO 963806L NO 963806 A NO963806 A NO 963806A NO 963806 A NO963806 A NO 963806A NO 963806 L NO963806 L NO 963806L
Authority
NO
Norway
Prior art keywords
gad
activity
virus
glutamate decarboxylase
contg
Prior art date
Application number
NO963806A
Other languages
English (en)
Other versions
NO963806D0 (no
Inventor
Alexis Bemelmans
Marc-Claude Geoffroy
Philippe Horellou
Jean-Francois Julien
Jacques Mallet
Michel Perricaudet
Jean-Jacques Robert
Emmanuelle Vigne
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9403411A external-priority patent/FR2717823B1/fr
Priority claimed from FR9413487A external-priority patent/FR2726575B1/fr
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of NO963806D0 publication Critical patent/NO963806D0/no
Publication of NO963806L publication Critical patent/NO963806L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/025—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a parvovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/028—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a herpesvirus
NO963806A 1994-03-23 1996-09-11 Rekombinante viruser som koder for en glutamat-dekarboksylase (GAD)aktivitet NO963806L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9403411A FR2717823B1 (fr) 1994-03-23 1994-03-23 Virus recombinants, préparation et utilisation en thérapie génique.
FR9413487A FR2726575B1 (fr) 1994-11-09 1994-11-09 Virus recombinants, preparation et utilisation en therapie genique
PCT/FR1995/000342 WO1995025805A1 (fr) 1994-03-23 1995-03-21 Virus recombinants codant pour une activite glutamate decarboxylase (gad)

Publications (2)

Publication Number Publication Date
NO963806D0 NO963806D0 (no) 1996-09-11
NO963806L true NO963806L (no) 1996-09-11

Family

ID=26231035

Family Applications (1)

Application Number Title Priority Date Filing Date
NO963806A NO963806L (no) 1994-03-23 1996-09-11 Rekombinante viruser som koder for en glutamat-dekarboksylase (GAD)aktivitet

Country Status (13)

Country Link
US (1) US20020028212A1 (no)
EP (2) EP1681354A3 (no)
JP (1) JPH09511394A (no)
KR (1) KR100403893B1 (no)
AT (1) ATE320502T1 (no)
AU (1) AU2140695A (no)
CA (1) CA2184297C (no)
DE (1) DE69534873T2 (no)
FI (1) FI963755A (no)
IL (1) IL113052A0 (no)
MX (1) MX9604026A (no)
NO (1) NO963806L (no)
WO (1) WO1995025805A1 (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001213773A (ja) * 2000-01-31 2001-08-07 Yaegaki Hakko Giken Kk 高血圧および糖尿病改善剤とγ−アミノ酪酸の製造方法
ATE280590T1 (de) 2000-05-23 2004-11-15 Neurologix Inc Glutaminsäure decarboxylase (gad) abgabesystem zur behandlung neurodegeneraliver erkrankungen
US7695959B2 (en) * 2000-05-23 2010-04-13 Neurologix, Inc. Glutamic acid decarboxylase (GAD) based delivery systems
US20160136095A1 (en) * 2014-11-18 2016-05-19 PixarBio Corporation Methods for treating epilepsy or seizure disorders
WO2017123676A1 (en) 2016-01-11 2017-07-20 Synlogic, Inc. Recombinant bacteria engineered to treat diseases and disorders associated with amino acid metabolism and methods of use thereof

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8424757D0 (en) 1984-10-01 1984-11-07 Pasteur Institut Retroviral vector
FR2573436B1 (fr) 1984-11-20 1989-02-17 Pasteur Institut Adn recombinant comportant une sequence nucleotidique codant pour un polypeptide determine sous le controle d'un promoteur d'adenovirus, vecteurs contenant cet adn recombinant, cellules eucaryotes transformees par cet adn recombinant, produits d'excretion de ces cellules transformees et leurs applications, notamment a la constitution de vaccins
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
WO1987000201A1 (en) 1985-07-05 1987-01-15 Whitehead Institute For Biomedical Research Epithelial cells expressing foreign genetic material
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US4861719A (en) 1986-04-25 1989-08-29 Fred Hutchinson Cancer Research Center DNA constructs for retrovirus packaging cell lines
DE3855681T2 (de) 1987-05-01 1997-05-28 Gen Hospital Corp Transkaryotische Einpflanzung
DE68927996T2 (de) 1988-02-05 1997-12-04 Whitehead Biomedical Inst Modifizierte hepatozyten und deren anwendung
CA1315719C (en) 1988-02-05 1993-04-06 Arthur Bank Retroviral packaging cell lines and processes of using same
WO1990002806A1 (en) 1988-09-01 1990-03-22 Whitehead Institute For Biomedical Research Recombinant retroviruses with amphotropic and ecotropic host ranges
US5270452A (en) * 1988-11-28 1993-12-14 Rhone-Poulenc Rorer Pharmaceuticals Inc. Pure glia maturation factor
JPH04507041A (ja) 1988-12-13 1992-12-10 アメリカ合衆国 遺伝工学により修飾された内皮細胞およびその利用方法
JP2814529B2 (ja) * 1989-03-16 1998-10-22 味の素株式会社 虚血性脳障害治療薬
US5585362A (en) * 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
CA2039921A1 (en) 1990-04-16 1991-10-17 Xandra O. Breakefield Transfer and expression of gene sequences into central nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication
WO1991018088A1 (en) 1990-05-23 1991-11-28 The United States Of America, Represented By The Secretary, United States Department Of Commerce Adeno-associated virus (aav)-based eucaryotic vectors
AU646877B2 (en) * 1990-06-15 1994-03-10 Scios Nova Inc. Transgenic non-human mammal displaying the amyloid-forming pathology of alzheimer's disease
US6682906B1 (en) * 1990-09-21 2004-01-27 The Regents Of The University Of California Cloned glutamic acid decarboxylase
US5173414A (en) 1990-10-30 1992-12-22 Applied Immune Sciences, Inc. Production of recombinant adeno-associated virus vectors
US5189026A (en) * 1991-06-07 1993-02-23 Fractal Laboratories, Inc. Treatment of human diseases involving dysregulation or dysfunction of the nervous system
US5252479A (en) 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
FR2688514A1 (fr) * 1992-03-16 1993-09-17 Centre Nat Rech Scient Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant.
SK283281B6 (sk) * 1992-05-20 2003-05-02 Northwestern University Deriváty gamaaminomaslovej kyseliny, spôsoby a medziprodukty na ich výrobu, ich použitie a farmaceutické prostriedky
JPH08501686A (ja) * 1992-09-25 1996-02-27 ローン−プーラン・ロレ・ソシエテ・アノニム 中枢神経系、特に脳における細胞への外来遺伝子の転移のためのアデノウィルスベクター
FR2702152B1 (fr) * 1993-03-03 1995-05-24 Inst Nat Sante Rech Med Virus recombinants et leur utilisation en thérapie génique.
FR2705361B1 (fr) 1993-05-18 1995-08-04 Centre Nat Rech Scient Vecteurs viraux et utilisation en thérapie génique.
FR2707664B1 (fr) 1993-07-13 1995-09-29 Centre Nat Rech Scient Vecteurs viraux et utilisation en thérapie génique.
US5543328A (en) * 1993-08-13 1996-08-06 Genetic Therapy, Inc. Adenoviruses having modified fiber proteins

Also Published As

Publication number Publication date
DE69534873D1 (de) 2006-05-11
KR970701785A (ko) 1997-04-12
NO963806D0 (no) 1996-09-11
EP0752003A1 (fr) 1997-01-08
FI963755A0 (fi) 1996-09-20
CA2184297C (fr) 2009-09-29
EP1681354A3 (fr) 2010-08-11
KR100403893B1 (ko) 2004-02-19
WO1995025805A1 (fr) 1995-09-28
AU2140695A (en) 1995-10-09
DE69534873T2 (de) 2006-11-16
US20020028212A1 (en) 2002-03-07
CA2184297A1 (fr) 1995-09-28
MX9604026A (es) 1997-09-30
JPH09511394A (ja) 1997-11-18
IL113052A0 (en) 1995-06-29
FI963755A (fi) 1996-09-20
EP1681354A2 (fr) 2006-07-19
ATE320502T1 (de) 2006-04-15
EP0752003B1 (fr) 2006-03-15

Similar Documents

Publication Publication Date Title
DK1394179T3 (da) Fremgangsmåde til fremstilling af erythropoietin fri for animalske proteiner
ZA942778B (en) Recombinant viruses, and their preparation and use in gene therapy.
CA2033176A1 (en) Growth hormone fusion proteins
DK374689A (da) Dna-sekvenser, som koder for polypeptider med beta-1,3-glucanaseaktivitet
EP1005376A4 (en) METHODS AND COMPOSITIONS FOR USE IN GENE THERAPY IN THE TREATMENT OF HEMOPHILIA
NO993709L (no) Stabilisert blanding omfattende fibrinogen
DE3786321T2 (de) Expression von Protein-C.
AU3698697A (en) Method for preserving infectious recombinant viruses, aqueous viral suspension and use as medicament
ATE284954T1 (de) Hyaluronan synthase gen und seine verwendung
DE3688900D1 (de) Expression von protein c.
NO910982L (no) Uratoksydase-aktivt protein, rekombinant gen som koder for det, ekspresjonsvektor, mikroorganismer og transformerteceller.
NO963806D0 (no) Rekombinante viruser som koder for en glutamat-dekarboksylase (GAD)aktivitet
ATA3552000A (de) Xylosyltransferase-gen
DE60036555D1 (de) Polypeptidfragmente mit einem c-terminalen teil von katalase aus helicobacter
AU590861B2 (en) New human lymphotoxin (TNF-beta) polypeptides their prepartion and use
EA200401390A1 (ru) N-ацетилглюкозамин-6-фосфатдеацетилаза человека, взаимодействующая с каспазой-8, и способы ее применения
ES8605296A1 (es) Procedimiento de producir factor viii-r humano
IL108584A0 (en) Cloning of interferon - alpha beta binding protein
SE8901715L (sv) En plasmid dna-konstruktion innehaallande dna-sekvenser
NO944878L (no) Modifisert Kluyveromyces-gjær, dens fremstilling og anvendelse
EP0903147A3 (en) Use of REG-2 as a Schwann cell mitogen
NO895154D0 (no) Fremgangsmaate ved fremstilling av et protein eller polypeptid, en dna-sekvens som koder for polypeptidet, en mikroorganisme som inneholder dna-sekvensen samt polypeptidet ogdets anvendelse som et farmasoeytisk preparat.
NO941982L (no) Fremstilling av proteiner ved anvendelse av 7B2 protein

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application