PT87562B - Processo para expressao de proapolipoproteina a-i humana - Google Patents
Processo para expressao de proapolipoproteina a-i humana Download PDFInfo
- Publication number
- PT87562B PT87562B PT87562A PT8756288A PT87562B PT 87562 B PT87562 B PT 87562B PT 87562 A PT87562 A PT 87562A PT 8756288 A PT8756288 A PT 8756288A PT 87562 B PT87562 B PT 87562B
- Authority
- PT
- Portugal
- Prior art keywords
- human
- proapo
- dna sequence
- sequence
- apo
- Prior art date
Links
- 0 C*CCC=CCC=CCCC(C)C*(C)CCCNI Chemical compound C*CCC=CCC=CCCC(C)C*(C)CCCNI 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878712540A GB8712540D0 (en) | 1987-05-28 | 1987-05-28 | Expression of human proapolipoprotein a-i |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT87562A PT87562A (pt) | 1989-05-31 |
| PT87562B true PT87562B (pt) | 1992-09-30 |
Family
ID=10618034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT87562A PT87562B (pt) | 1987-05-28 | 1988-05-24 | Processo para expressao de proapolipoproteina a-i humana |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US5059528A (de) |
| EP (1) | EP0293357B1 (de) |
| JP (1) | JP2634193B2 (de) |
| KR (1) | KR970000808B1 (de) |
| CN (1) | CN1031892C (de) |
| AT (1) | ATE89006T1 (de) |
| AU (1) | AU615654B2 (de) |
| CA (1) | CA1323851C (de) |
| CY (1) | CY1809A (de) |
| CZ (1) | CZ283648B6 (de) |
| DD (1) | DD291093A5 (de) |
| DE (1) | DE3880739T2 (de) |
| DK (1) | DK175686B1 (de) |
| EG (1) | EG19101A (de) |
| ES (1) | ES2054878T3 (de) |
| FI (1) | FI100056B (de) |
| GB (1) | GB8712540D0 (de) |
| HK (1) | HK137794A (de) |
| HU (1) | HU204562B (de) |
| IE (1) | IE62422B1 (de) |
| IL (1) | IL86480A (de) |
| LT (1) | LT3600B (de) |
| LV (1) | LV5288A3 (de) |
| NO (1) | NO179253C (de) |
| NZ (1) | NZ224808A (de) |
| PL (1) | PL158064B1 (de) |
| PT (1) | PT87562B (de) |
| RU (1) | RU2009198C1 (de) |
| SG (1) | SG131594G (de) |
| SK (1) | SK363888A3 (de) |
| SU (1) | SU1834904A3 (de) |
| UA (1) | UA19765A (de) |
| ZA (1) | ZA883824B (de) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU587989B2 (en) * | 1984-10-16 | 1989-09-07 | Mitsubishi Chemical Corporation | DMA fragments, expression vectors, proteins, hosts, and process for production of the proteins |
| JP2606228B2 (ja) * | 1987-09-18 | 1997-04-30 | 三菱化学株式会社 | ヒトプロアポリポプロテインａ−ｉ様蛋白の産生法 |
| DE68917379T2 (de) * | 1988-05-31 | 1994-12-01 | Mitsubishi Chem Ind | Verfahren zur Herstellung von Proteinen, die ähnlich dem natürlich-menschlichen Apolipoprotein-E sind. |
| US5846799A (en) * | 1988-06-14 | 1998-12-08 | La Region Wallone | Human myeloperoxidase and its therapeutic application |
| US5460961A (en) * | 1988-06-14 | 1995-10-24 | La Region Wallonne | Human myeloperoxidase and its therapeutic application |
| IT1229996B (it) * | 1989-04-20 | 1991-09-20 | Cesare Sirtori | Espressione di apolipoproteina ai e apolipoproteina ai-milano in lievito e composizioni farmaceutiche che contengono dette apolipoproteine. |
| IE914102A1 (en) * | 1990-11-26 | 1992-06-03 | Genetics Inst | Expression of pace in host cells and methods of use thereof |
| US5844097A (en) * | 1990-11-30 | 1998-12-01 | Monoclonetics International, Inc. | Methods for the diagnosis of peripheral nerve damage |
| JPH06503418A (ja) * | 1990-11-30 | 1994-04-14 | モノクロネティックス インターナショナル、インコーポレーテッド | 慢性下位脊椎痛および頚部痛の診断法 |
| SE9500778D0 (sv) | 1995-03-03 | 1995-03-03 | Pharmacia Ab | Process for producing a protein |
| US5994061A (en) * | 1995-09-29 | 1999-11-30 | Queen's University At Kingston | DNA constructs and methods for screening for increased expression of human apo AI gene |
| SE9603068D0 (sv) | 1996-08-23 | 1996-08-23 | Pharmacia & Upjohn Ab | Process for purifying a protein |
| SE9603303D0 (sv) | 1996-09-11 | 1996-09-11 | Pharmacia & Upjohn Ab | Process for purifying a protein |
| SE9603304D0 (sv) | 1996-09-11 | 1996-09-11 | Pharmacia & Upjohn Ab | Process for purifying a compound |
| KR100330355B1 (ko) * | 1999-06-04 | 2002-04-01 | 장인순 | 회전유동발생 날개를 가진 덕트형 핵연료 집합체 지지격자 |
| US20040047853A1 (en) * | 2000-06-09 | 2004-03-11 | Dahl Soren W | Purified proenzyme of dipeptidyl peptidase i (pro-dppi) |
| AU3264202A (en) * | 2000-12-12 | 2002-06-24 | Lexicon Genetics Inc | Novel human kinases and polynucleotides encoding the same |
| KR100560102B1 (ko) * | 2004-06-25 | 2006-03-13 | 한국생명공학연구원 | 프로아포리포단백질 ａ－ⅰ 변이체와, 이를 포함하는고지혈증 또는 동맥경화증 예방 및 치료제 |
| US7427662B2 (en) * | 2005-02-01 | 2008-09-23 | Baord Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Inhibition of angiogenesis and destruction of angiogenic vessels by apolipoprotein A-I and high density lipoprotein |
| US8206750B2 (en) | 2005-03-24 | 2012-06-26 | Cerenis Therapeutics Holding S.A. | Charged lipoprotein complexes and their uses |
| CA2619943A1 (en) * | 2005-08-26 | 2007-03-01 | Cerenis Therapeutics Holding Sa | Compositions and methods for producing apolipoprotein gene products in lactic acid bacteria |
| WO2008104890A2 (en) * | 2007-02-28 | 2008-09-04 | Cerenis Therapeutics Holding Sa | Compositions and methods for producing apolipoprotein |
| CN102239260B (zh) * | 2008-10-03 | 2017-04-12 | 库尔纳公司 | 通过抑制针对载脂蛋白‑a1的天然反义转录物治疗载脂蛋白‑a1相关疾病 |
| KR101967417B1 (ko) | 2008-11-10 | 2019-04-10 | 알닐람 파마슈티칼스 인코포레이티드 | 치료제 운반용 신규 지질 및 조성물 |
| EP3243504A1 (de) | 2009-01-29 | 2017-11-15 | Arbutus Biopharma Corporation | Verbesserte lipidformulierung |
| NZ594995A (en) | 2009-03-12 | 2013-06-28 | Alnylam Pharmaceuticals Inc | LIPID FORMULATED COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF HUMAN KINESIN FAMILY MEMBER 11 (Eg5) AND VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) GENES |
| NZ621981A (en) | 2009-05-05 | 2015-09-25 | Tekmira Pharmaceuticals Corp | Lipid compositions |
| US9155754B2 (en) | 2009-05-06 | 2015-10-13 | Curna, Inc. | Treatment of ABCA1 gene related diseases by inhibition of a natural antisense transcript to ABCA1 |
| CA2764609C (en) | 2009-06-10 | 2018-10-02 | Alnylam Pharmaceuticals, Inc. | Improved cationic lipid of formula i |
| AP2015008874A0 (en) | 2009-08-14 | 2015-11-30 | Alnylam Pharmaceuticals Inc | Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus |
| US10525152B2 (en) | 2009-10-09 | 2020-01-07 | Signablok, Inc. | Methods and compositions for targeted imaging |
| US10894098B2 (en) | 2012-04-09 | 2021-01-19 | Signablok, Inc. | Methods and compositions for targeted imaging |
| EP2509636B1 (de) | 2009-12-07 | 2017-07-19 | Arbutus Biopharma Corporation | Zusammensetzungen für nukleinsäurefreisetzung |
| CA2784568A1 (en) | 2009-12-18 | 2011-06-23 | Martin A. Maier | Lipid particles for delivery of nucleic acids |
| US20130156845A1 (en) | 2010-04-29 | 2013-06-20 | Alnylam Pharmaceuticals, Inc. | Lipid formulated single stranded rna |
| WO2011143362A1 (en) | 2010-05-11 | 2011-11-17 | Esperion Therapeutics, Inc. | Dimeric oxidation-resistant apolipoprotein a1 variants |
| SG186085A1 (en) | 2010-06-03 | 2013-01-30 | Alnylam Pharmaceuticals Inc | Biodegradable lipids for the delivery of active agents |
| WO2012016188A2 (en) | 2010-07-30 | 2012-02-02 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for delivery of active agents |
| WO2012016184A2 (en) | 2010-07-30 | 2012-02-02 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for delivery of active agents |
| US9339513B2 (en) | 2010-11-09 | 2016-05-17 | Alnylam Pharmaceuticals, Inc. | Lipid formulated compositions and methods for inhibiting expression of Eg5 and VEGF genes |
| AU2012207606B2 (en) | 2011-01-11 | 2017-02-23 | Alnylam Pharmaceuticals, Inc. | Pegylated lipids and their use for drug delivery |
| RU2627173C2 (ru) | 2011-02-07 | 2017-08-03 | Серени Терапеутикс Холдинг С.А. | Липопротеиновые комплексы и их получение и применения |
| EP3456317A1 (de) | 2011-09-27 | 2019-03-20 | Alnylam Pharmaceuticals, Inc. | Substituierte di-aliphatic pegylierte lipide |
| US9610324B2 (en) * | 2012-07-11 | 2017-04-04 | Esperion Therapeutics, Inc. | Apolipoprotein mixtures |
| DK3524680T3 (da) * | 2013-05-01 | 2020-12-14 | Ionis Pharmaceuticals Inc | Sammensætninger og fremgangsmåder til modulation af ttr-ekspression |
| EP2853259A1 (de) | 2013-09-30 | 2015-04-01 | Université Pierre et Marie Curie (Paris 6) | Rekonstituierte hochdichte Lipoproteinzusammensetzung und Verwendungen davon |
| CN106488987A (zh) | 2014-05-02 | 2017-03-08 | 塞勒尼斯医疗控股公司 | Hdl疗法标志物 |
| EP3533872A4 (de) * | 2016-10-27 | 2020-09-09 | Institute Of Microbiology, Chinese Academy Of Sciences | Verfahren zur modifizierung eines aminosäuredämpfungsglieds und verwendung davon in der herstellung |
| EP3668549B1 (de) | 2017-08-10 | 2024-05-15 | Abionyx Pharma SA | Apomere |
| TW201919712A (zh) | 2017-08-10 | 2019-06-01 | 法商塞勒尼斯醫療控股公司 | 運送子(cargomers) |
| US11461863B2 (en) | 2018-08-24 | 2022-10-04 | Bright Marbles, Inc. | Idea assessment and landscape mapping |
| US11164065B2 (en) | 2018-08-24 | 2021-11-02 | Bright Marbles, Inc. | Ideation virtual assistant tools |
| US11081113B2 (en) | 2018-08-24 | 2021-08-03 | Bright Marbles, Inc. | Idea scoring for creativity tool selection |
| US11189267B2 (en) | 2018-08-24 | 2021-11-30 | Bright Marbles, Inc. | Intelligence-driven virtual assistant for automated idea documentation |
| CA3177243A1 (en) | 2020-04-16 | 2021-10-21 | Abionyx Pharma Sa | Methods for treating acute conditions using lipid binding protein-based complexes |
| AU2021354095A1 (en) | 2020-10-01 | 2023-06-08 | Abionyx Pharma Sa | Compositions comprising lipid binding protein-based complexes for use for treating eye diseases |
| IL307670A (en) | 2021-04-15 | 2023-12-01 | Abionyx Pharma Sa | Use of lipid-binding protein-based complexes in organ preservation solutions |
| WO2023194798A1 (en) | 2022-04-06 | 2023-10-12 | Abionyx Pharma Sa | Methods for treating leukocytosis, endothelial dysfunction and carditis using lipid binding protein-based complexes |
| WO2023194797A1 (en) | 2022-04-06 | 2023-10-12 | Abionyx Pharma Sa | Methods for treating eye diseases using lipid binding protein-based complexes |
| WO2023237935A2 (en) | 2022-06-10 | 2023-12-14 | Abionyx Pharma Sa | Methods for treating acute conditions using lipid binding protein-based complexes |
| WO2023237927A2 (en) | 2022-06-10 | 2023-12-14 | Abionyx Pharma Sa | Methods for treating hyperinflammatory conditions using lipid binding protein -based complexes |
| WO2024150064A1 (en) | 2023-01-13 | 2024-07-18 | Abionyx Pharma Sa | Lipid binding protein molecule therapy |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU587989B2 (en) * | 1984-10-16 | 1989-09-07 | Mitsubishi Chemical Corporation | DMA fragments, expression vectors, proteins, hosts, and process for production of the proteins |
| JPS6198998A (ja) | 1984-10-18 | 1986-05-17 | Matsushita Electric Ind Co Ltd | 電動送風機 |
| BE901119A (fr) | 1984-11-23 | 1985-03-15 | Wallone Region | Procede de preparation de plasmides vecteurs capables de transformer un hote bacterien escherichia coli et d'y promouvoir et controler l'expression d'un adn heterologue. |
| ATE89314T1 (de) | 1985-02-13 | 1993-05-15 | Scios Nova Inc | Menschlicher metallothionein ii-promotor in saeugetierexpressionssystemen. |
| GB8507833D0 (en) * | 1985-03-26 | 1985-05-01 | Biogen Nv | Production of human somatomedin c |
| AU6522486A (en) | 1985-10-04 | 1987-04-24 | Biotechnology Research Partners Limited | Recombinant apolipoproteins and methods |
| GB8625435D0 (en) * | 1986-10-23 | 1986-11-26 | Erba Farmitalia | Human apolipoprotein ai |
| WO1988003175A1 (en) * | 1986-10-29 | 1988-05-05 | Biotechnology Research Partners, Ltd. | Apoai-ciii-aiv, apoaii, apob, apoci, and ldl receptor polymorphisms for genetic fingerprinting and predictive of atherosclerosis |
-
1987
- 1987-05-28 GB GB878712540A patent/GB8712540D0/en active Pending
-
1988
- 1988-05-16 CA CA000566894A patent/CA1323851C/en not_active Expired - Fee Related
- 1988-05-24 AT AT88870095T patent/ATE89006T1/de not_active IP Right Cessation
- 1988-05-24 PT PT87562A patent/PT87562B/pt not_active IP Right Cessation
- 1988-05-24 EP EP88870095A patent/EP0293357B1/de not_active Expired - Lifetime
- 1988-05-24 ES ES88870095T patent/ES2054878T3/es not_active Expired - Lifetime
- 1988-05-24 DE DE8888870095T patent/DE3880739T2/de not_active Expired - Lifetime
- 1988-05-24 IL IL86480A patent/IL86480A/xx not_active IP Right Cessation
- 1988-05-25 FI FI882456A patent/FI100056B/fi not_active IP Right Cessation
- 1988-05-26 EG EG28288A patent/EG19101A/xx active
- 1988-05-26 DD DD88316110A patent/DD291093A5/de not_active IP Right Cessation
- 1988-05-26 UA UA4613079A patent/UA19765A/uk unknown
- 1988-05-26 NZ NZ224808A patent/NZ224808A/en unknown
- 1988-05-26 US US07/198,830 patent/US5059528A/en not_active Expired - Lifetime
- 1988-05-26 SU SU884356123A patent/SU1834904A3/ru active
- 1988-05-26 PL PL1988272698A patent/PL158064B1/pl unknown
- 1988-05-27 CN CN88103118A patent/CN1031892C/zh not_active Expired - Fee Related
- 1988-05-27 IE IE159788A patent/IE62422B1/en not_active IP Right Cessation
- 1988-05-27 NO NO882341A patent/NO179253C/no not_active IP Right Cessation
- 1988-05-27 HU HU882707A patent/HU204562B/hu not_active IP Right Cessation
- 1988-05-27 DK DK198802896A patent/DK175686B1/da not_active IP Right Cessation
- 1988-05-27 ZA ZA883824A patent/ZA883824B/xx unknown
- 1988-05-27 CZ CS883638A patent/CZ283648B6/cs not_active IP Right Cessation
- 1988-05-27 SK SK3638-88A patent/SK363888A3/sk unknown
- 1988-05-27 JP JP63130033A patent/JP2634193B2/ja not_active Expired - Fee Related
- 1988-05-27 AU AU16723/88A patent/AU615654B2/en not_active Ceased
- 1988-05-28 KR KR88006286A patent/KR970000808B1/ko not_active IP Right Cessation
- 1988-12-20 RU SU884613079A patent/RU2009198C1/ru active
-
1993
- 1993-06-01 LV LV930445A patent/LV5288A3/xx unknown
- 1993-08-03 LT LTIP828A patent/LT3600B/lt not_active IP Right Cessation
-
1994
- 1994-09-12 SG SG131594A patent/SG131594G/en unknown
- 1994-12-08 HK HK137794A patent/HK137794A/xx not_active IP Right Cessation
-
1995
- 1995-10-20 CY CY180995A patent/CY1809A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19920310 |
|
| PC3A | Transfer or assignment |
Free format text: 20010108 MINISTERE DE LA REGION WALLONNE BE |
|
| TE3A | Change of address (patent) |
Owner name: UCB, S.A. Effective date: 20010126 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20030930 |