ES8700691A1 - Un metodo para sintetizar por adn recombinante un inhibidor de serin-proteasa con una unica cadena polipeptidica - Google Patents

Un metodo para sintetizar por adn recombinante un inhibidor de serin-proteasa con una unica cadena polipeptidica

Info

Publication number
ES8700691A1
ES8700691A1 ES549630A ES549630A ES8700691A1 ES 8700691 A1 ES8700691 A1 ES 8700691A1 ES 549630 A ES549630 A ES 549630A ES 549630 A ES549630 A ES 549630A ES 8700691 A1 ES8700691 A1 ES 8700691A1
Authority
ES
Spain
Prior art keywords
serine protease
recombinant dna
polypeptide chain
protease inhibitor
dna synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES549630A
Other languages
English (en)
Other versions
ES549630A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Boulder Inc
Original Assignee
Synergen Biologicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24724427&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8700691(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synergen Biologicals Inc filed Critical Synergen Biologicals Inc
Publication of ES8700691A1 publication Critical patent/ES8700691A1/es
Publication of ES549630A0 publication Critical patent/ES549630A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

SINTESIS POR ADN RECOMBINANTE DE UN INHIBIDOR DE SERINA-PROTEASA CON UNA UNICA CADENA POLIPEPTIDICA. SE PREPARA UNA SECUENCIA DE ADN CAPAS DE DIRIGIR A UN MICROORGANISMO HOSPEDANTE PARA PRODUCIR UNA PROTEINA QUE TIENE ACTIVIDAD DE INHIBIDOR DE SERINA-PROTEASAS; SE CLONA LA SECUENCIA DE ADN EN UN VECTOR CAPAZ DE SER TRANSFERIO A, Y DE REPLICARSE EN, UN MICROORGANISMO HOSPEDANTE CONTENIENDO TAL VECTOR ELEMENTOS OPERACIONALES PARA LA SECUENCIA DE ADN; SE TRANSFIERE EL VECTOR QUE CONTIENE LA SECUENCIA DE ADN Y LOS ELEMENTOS OPERACIONALES A UN MICROORGANISMO HOSPEDANTE CAPAZ DE EXPRESAR LA PROTEINA INHIBIDORA DE PROTEASAS; SE CULTIVA EL MICROORGANISMO HOSPEDANTE EN CONDICIONES APROPIADAS PARA MULTIPLICAR EL VECTOR Y EXPRESAR EL INHIBIDOR; SE RECOGE EL INHIBIDOR; SE PERMITE QUE EL INHIBIDOR ADOPTE UNA ESTRUCTURA TERCIARIA ACTIVA POR LA QUE POSEA ACTIVIDAD DE INHIBIDOR DE SERINA-PROTEASAS; Y SE PURIFICA ESTE. SON APLICABLES EN COMPOSICIONES FARMACEUTICAS PARA LA TERAPIA DE DIVERSAS ENFERMEDADES.
ES549630A 1984-12-06 1985-12-05 Un metodo para sintetizar por adn recombinante un inhibidor de serin-proteasa con una unica cadena polipeptidica Expired ES8700691A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67882284A 1984-12-06 1984-12-06

Publications (2)

Publication Number Publication Date
ES8700691A1 true ES8700691A1 (es) 1986-10-16
ES549630A0 ES549630A0 (es) 1986-10-16

Family

ID=24724427

Family Applications (1)

Application Number Title Priority Date Filing Date
ES549630A Expired ES8700691A1 (es) 1984-12-06 1985-12-05 Un metodo para sintetizar por adn recombinante un inhibidor de serin-proteasa con una unica cadena polipeptidica

Country Status (4)

Country Link
JP (1) JP2672088B2 (es)
KR (1) KR940011339B1 (es)
ES (1) ES8700691A1 (es)
ZA (1) ZA859363B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340877C (en) * 1987-12-28 2000-01-18 Takashi Sugiyama Elastase inhibitory polypeptide and process for production thereof by recombinant gene technology

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5318398A (en) * 1976-08-03 1978-02-20 Sumitomo Bakelite Co Liquid crystal display unit
JPS5848698U (ja) * 1981-09-24 1983-04-01 津田　勝一 高所作業用バスケツト

Also Published As

Publication number Publication date
KR940011339B1 (ko) 1994-12-05
JP2672088B2 (ja) 1997-11-05
JPS62501262A (ja) 1987-05-21
ZA859363B (en) 1987-04-29
ES549630A0 (es) 1986-10-16
KR870700093A (ko) 1987-02-28

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Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20040628