KR840005739A - 인체릴랙신(relaxin)을 암호하는 유전자의 분리방법 및 릴랙신 활성을 갖는 폴리펩티드의 제조방법 - Google Patents

인체릴랙신(relaxin)을 암호하는 유전자의 분리방법 및 릴랙신 활성을 갖는 폴리펩티드의 제조방법

Info

Publication number
KR840005739A
KR840005739A KR1019830003783A KR830003783A KR840005739A KR 840005739 A KR840005739 A KR 840005739A KR 1019830003783 A KR1019830003783 A KR 1019830003783A KR 830003783 A KR830003783 A KR 830003783A KR 840005739 A KR840005739 A KR 840005739A
Authority
KR
South Korea
Prior art keywords
relaxin
polypeptide
isolating
producing
gene encoding
Prior art date
Application number
KR1019830003783A
Other languages
English (en)
Other versions
KR930003515B1 (ko
Inventor
존 허드슨 피터
샤인 죤
데이비드 니얼 휴
윌리엄 트레기어 지오프리
Original Assignee
하워드 플로리 인스티튜트 오브 엑스페리멘탈 피지올로지 엔드 메디신
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 하워드 플로리 인스티튜트 오브 엑스페리멘탈 피지올로지 엔드 메디신 filed Critical 하워드 플로리 인스티튜트 오브 엑스페리멘탈 피지올로지 엔드 메디신
Publication of KR840005739A publication Critical patent/KR840005739A/ko
Application granted granted Critical
Publication of KR930003515B1 publication Critical patent/KR930003515B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/30—Signal or leader sequence
KR1019830003783A 1982-08-12 1983-08-12 인체릴랙신(relaxin)을 암호하는 유전자의 분리방법 및 릴랙신 활성을 갖는 폴리펩티드의 제조방법 KR930003515B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPF535282 1982-08-12
AU5352 1982-08-12

Publications (2)

Publication Number Publication Date
KR840005739A true KR840005739A (ko) 1984-11-16
KR930003515B1 KR930003515B1 (ko) 1993-05-01

Family

ID=3769689

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830003783A KR930003515B1 (ko) 1982-08-12 1983-08-12 인체릴랙신(relaxin)을 암호하는 유전자의 분리방법 및 릴랙신 활성을 갖는 폴리펩티드의 제조방법

Country Status (14)

Country Link
US (1) US4871670A (ko)
EP (2) EP0101309B1 (ko)
JP (3) JP2537477B2 (ko)
KR (1) KR930003515B1 (ko)
AT (1) ATE78042T1 (ko)
CA (1) CA1340542C (ko)
DE (1) DE3382117D1 (ko)
DK (2) DK171827B1 (ko)
ES (5) ES8603579A1 (ko)
HU (1) HU197350B (ko)
IE (1) IE58682B1 (ko)
IL (1) IL69469A (ko)
NZ (1) NZ205241A (ko)
ZA (1) ZA835963B (ko)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5320953A (en) * 1982-08-12 1994-06-14 Howard Florey Institute Of Experimental Physiology And Medicine Process for synthesizing human H1-prorelaxin, H1-relaxin and fusion proteins thereof
US5023321A (en) * 1982-12-13 1991-06-11 Howard Florey Institute Of Experimental Physiology & Medicine Molecular cloning and characterization of a further gene sequence coding for human relaxin
IL70414A (en) * 1982-12-13 1991-06-10 Florey Howard Inst Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors
US4835251A (en) * 1986-06-23 1989-05-30 Genetech, Inc. Method of chain combination
WO1989007945A1 (en) * 1988-02-26 1989-09-08 Genentech, Inc. Human relaxin formulation
JP2857684B2 (ja) * 1989-05-04 1999-02-17 ジェネンテク，インコーポレイテッド ヒトリラキシンの単離のための方法および組成物
US5089419A (en) * 1989-08-07 1992-02-18 International Canine Genetics Detection of pregnancy by identification of the c peptide of relaxin in the urine of animals
US5166191A (en) * 1991-08-19 1992-11-24 Genentech, Inc. Use of relaxin in cardiovascular therapy
US5478807A (en) * 1991-08-19 1995-12-26 Genentech, Inc. Use of relaxin in the treatment of bradycardia
US6348327B1 (en) 1991-12-06 2002-02-19 Genentech, Inc. Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells
JP3954091B2 (ja) * 1993-06-21 2007-08-08 ジェネンテック・インコーポレーテッド リラキシンの製造方法
US5911997A (en) * 1995-06-07 1999-06-15 Connetics Corporation Relaxin-like factor and methods and uses thereof
US20070021360A1 (en) * 2001-04-24 2007-01-25 Nyce Jonathan W Compositions, formulations and kit with anti-sense oligonucleotide and anti-inflammatory steroid and/or obiquinone for treatment of respiratory and lung disesase
WO2003016487A2 (en) * 2001-08-17 2003-02-27 The Board Of Trustees Of The Leland Stanford Junior University Mammalian relaxin receptors
AU2003903124A0 (en) * 2003-06-20 2003-07-10 Mark Del Borgo Analogues of heteromeric proteins
US7553813B2 (en) * 2004-04-30 2009-06-30 Corthera, Inc. Methods and compositions for control of fetal growth via modulation of relaxin
US20060052304A1 (en) * 2004-09-02 2006-03-09 Bas Medical, Inc. Method for remodeling bone and related sutures
US8389475B2 (en) 2009-08-10 2013-03-05 The Board Of Trustees Of The Leland Stanford Junior University Relaxin analogs
MX346786B (es) 2010-08-17 2017-03-31 Ambrx Inc Polipeptidos de relaxina modificados y sus usos.
SG191186A1 (en) 2010-12-15 2013-07-31 Baxter Int Eluate collection using conductivity gradient
EP2630964A1 (en) 2012-02-22 2013-08-28 Immundiagnostik AG Method and medicament for treating patients in risk of prediabetes and type-2 diabetes
US20160296632A1 (en) 2013-11-13 2016-10-13 Aequus Biopharma, Inc. Engineered glycoproteins and uses thereof
EP2946788A1 (en) 2014-05-23 2015-11-25 Immundiagnostik AG Method and composition for treating heart failure with preserved ejection fraction
KR102533456B1 (ko) 2016-05-18 2023-05-17 모더나티엑스, 인크. 릴랙신을 인코딩하는 폴리뉴클레오타이드

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267101A (en) * 1980-02-01 1981-05-12 Serono Laboratories Inc. Process for obtaining human relaxin from fetal membranes
IE55479B1 (en) * 1982-02-12 1990-09-26 Florey Howard Inst Molecular cloning and characterization of the gene sequence coding for porcine relaxin
IL70414A (en) * 1982-12-13 1991-06-10 Florey Howard Inst Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors

Also Published As

Publication number Publication date
CA1340542C (en) 1999-05-18
ES8802394A1 (es) 1988-05-16
JPH07215998A (ja) 1995-08-15
EP0287820A1 (en) 1988-10-26
ES540886A0 (es) 1988-04-01
ES524885A0 (es) 1985-12-16
JPS5985292A (ja) 1984-05-17
NZ205241A (en) 1991-01-29
ZA835963B (en) 1984-04-25
DK156592D0 (da) 1992-12-28
DK171683B1 (da) 1997-03-10
ES557505A0 (es) 1988-02-16
EP0101309A3 (en) 1984-12-27
IE58682B1 (en) 1993-11-03
JPH0690780A (ja) 1994-04-05
ES8802160A1 (es) 1988-04-01
DK156592A (da) 1992-12-28
ES550943A0 (es) 1988-05-16
JP2892596B2 (ja) 1999-05-17
EP0101309A2 (en) 1984-02-22
ES8801671A1 (es) 1988-02-16
IL69469A (en) 1991-06-10
IE831909L (en) 1984-02-12
ES8801676A1 (es) 1988-02-16
EP0287820B1 (en) 1992-07-08
KR930003515B1 (ko) 1993-05-01
EP0101309B1 (en) 1991-01-16
IL69469A0 (en) 1983-11-30
ATE78042T1 (de) 1992-07-15
US4871670A (en) 1989-10-03
ES8603579A1 (es) 1985-12-16
DK171827B1 (da) 1997-06-23
DK366483A (da) 1984-02-13
JP2670001B2 (ja) 1997-10-29
DK366483D0 (da) 1983-08-11
DE3382117D1 (de) 1991-02-21
HU197350B (en) 1989-03-28
ES557506A0 (es) 1988-02-16
JP2537477B2 (ja) 1996-09-25

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