ES8802394A1 - Un procedimiento para preparar una proteina de fusion derivada de la secuencia de aminoacidos de la preprorrelaxina humana. - Google Patents

Un procedimiento para preparar una proteina de fusion derivada de la secuencia de aminoacidos de la preprorrelaxina humana.

Info

Publication number
ES8802394A1
ES8802394A1 ES550943A ES550943A ES8802394A1 ES 8802394 A1 ES8802394 A1 ES 8802394A1 ES 550943 A ES550943 A ES 550943A ES 550943 A ES550943 A ES 550943A ES 8802394 A1 ES8802394 A1 ES 8802394A1
Authority
ES
Spain
Prior art keywords
characterization
molecular cloning
gene sequence
sequence coding
human relaxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES550943A
Other languages
English (en)
Other versions
ES550943A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Florey Institute of Neuroscience and Mental Health
Original Assignee
Howard Florey Institute of Experimental Physiology and Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Howard Florey Institute of Experimental Physiology and Medicine filed Critical Howard Florey Institute of Experimental Physiology and Medicine
Publication of ES550943A0 publication Critical patent/ES550943A0/es
Publication of ES8802394A1 publication Critical patent/ES8802394A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/30—Signal or leader sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

PROCEDIMIENTO PARA PRODUCIR UNA PROTEINA DE FUSION QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE LA PREPRORRELAXINA HUMANA Y QUE COMPRENDE LOS PEPTIDOS A Y B DE RELAXINA HUMANA, SEPARADOS UNO DEL OTRO POR UN PEPTIDO C COMO SECUENCIA C-TERMINAL, Y UNA PORCION DE PROTEINA PROCARIOTICA O EUCARIOTICA COMO SECUENCIA N-TERMINAL. CONSISTENTE EN: A) ESCINDIR UN VECTOR DE TRANSFERENCIA DE ADN CON UNA ENZIMA DE RESTRICCION PARA OBTENER UNA MOLECULA DE ADN; B) LISAR UNA SECUENCIA DE DESOXINUCLEOTIDOS CODIFICADORES DE PREPRORRELAXINA HIMANA; CARACTERIZADA PORQUE DICHA SECUENCIA ES UNA CADENA CODIFICADORA Y UNA CADENA COMPLEMENTARIA DE ARNM, A LA CADENA DE ADN OBTENIDA EN LA ETAPA A) PARA OBTENER UN VECTOR DE TRANSFERENCIA; C) INCUBAR EL MICROORGANISMO TRANSFORMADO, RECUPERAR Y PURIFICAR LA PROTEINA DE FUSION ASI PRODUCIDA, A PARTIR DEL LISADO O DEL MEDIO DE CULTIVO DEL MICROORGANISMO. LA RELAXINA ES DE UTILIDAD EN EL TRATAMIENTO DURANTE EL PROCESO DE NACIMIENTO.
ES550943A 1982-08-12 1986-01-16 Un procedimiento para preparar una proteina de fusion derivada de la secuencia de aminoacidos de la preprorrelaxina humana. Expired ES8802394A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPF535282 1982-08-12

Publications (2)

Publication Number Publication Date
ES550943A0 ES550943A0 (es) 1988-05-16
ES8802394A1 true ES8802394A1 (es) 1988-05-16

Family

ID=3769689

Family Applications (5)

Application Number Title Priority Date Filing Date
ES524885A Granted ES524885A0 (es) 1982-08-12 1983-08-11 Un procedimiento para producir un vector de transferencia de adn.
ES540886A Expired ES8802160A1 (es) 1982-08-12 1985-03-01 Un procedimiento para aislar un gen de relaxina cromosomica de un ser humano o de otro primate o una especie afin
ES550943A Expired ES8802394A1 (es) 1982-08-12 1986-01-16 Un procedimiento para preparar una proteina de fusion derivada de la secuencia de aminoacidos de la preprorrelaxina humana.
ES557506A Expired ES8801671A1 (es) 1982-08-12 1987-04-15 Un procedimiento para preparar relaxina humana o sus analogos
ES557505A Expired ES8801676A1 (es) 1982-08-12 1987-04-15 Un procedimiento para preparar relaxina humana o sus analogos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES524885A Granted ES524885A0 (es) 1982-08-12 1983-08-11 Un procedimiento para producir un vector de transferencia de adn.
ES540886A Expired ES8802160A1 (es) 1982-08-12 1985-03-01 Un procedimiento para aislar un gen de relaxina cromosomica de un ser humano o de otro primate o una especie afin

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES557506A Expired ES8801671A1 (es) 1982-08-12 1987-04-15 Un procedimiento para preparar relaxina humana o sus analogos
ES557505A Expired ES8801676A1 (es) 1982-08-12 1987-04-15 Un procedimiento para preparar relaxina humana o sus analogos

Country Status (14)

Country Link
US (1) US4871670A (es)
EP (2) EP0287820B1 (es)
JP (3) JP2537477B2 (es)
KR (1) KR930003515B1 (es)
AT (1) ATE78042T1 (es)
CA (1) CA1340542C (es)
DE (1) DE3382117D1 (es)
DK (2) DK171827B1 (es)
ES (5) ES524885A0 (es)
HU (1) HU197350B (es)
IE (1) IE58682B1 (es)
IL (1) IL69469A (es)
NZ (1) NZ205241A (es)
ZA (1) ZA835963B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5320953A (en) * 1982-08-12 1994-06-14 Howard Florey Institute Of Experimental Physiology And Medicine Process for synthesizing human H1-prorelaxin, H1-relaxin and fusion proteins thereof
US5023321A (en) * 1982-12-13 1991-06-11 Howard Florey Institute Of Experimental Physiology & Medicine Molecular cloning and characterization of a further gene sequence coding for human relaxin
NZ206534A (en) * 1982-12-13 1988-05-30 Florey Howard Inst Molecular cloning and characterisation of gene sequence coding for human relaxin
US4835251A (en) * 1986-06-23 1989-05-30 Genetech, Inc. Method of chain combination
DE68906153T2 (de) * 1988-02-26 1993-10-28 Genentech Inc Humanes relaxinpräparat.
AU623518B2 (en) * 1989-05-04 1992-05-14 Genentech Inc. Processes and compositions for the isolation of human relaxin
US5089419A (en) * 1989-08-07 1992-02-18 International Canine Genetics Detection of pregnancy by identification of the c peptide of relaxin in the urine of animals
US5166191A (en) * 1991-08-19 1992-11-24 Genentech, Inc. Use of relaxin in cardiovascular therapy
US5478807A (en) * 1991-08-19 1995-12-26 Genentech, Inc. Use of relaxin in the treatment of bradycardia
US6348327B1 (en) * 1991-12-06 2002-02-19 Genentech, Inc. Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells
EP0707650B1 (en) * 1993-06-21 2003-05-21 Genentech, Inc. Process for producing human relaxin
US5911997A (en) * 1995-06-07 1999-06-15 Connetics Corporation Relaxin-like factor and methods and uses thereof
WO2002085308A2 (en) * 2001-04-24 2002-10-31 Epigenesis Pharmaceuticals, Inc. Antisense and anti-inflammatory based compositions to treat respiratory disorders
CA2456753A1 (en) * 2001-08-17 2003-02-27 The Board Of Trustees Of The Leland Stanford Junior University Mammalian relaxin receptors
AU2003903124A0 (en) * 2003-06-20 2003-07-10 Mark Del Borgo Analogues of heteromeric proteins
WO2005115435A2 (en) * 2004-04-30 2005-12-08 Bas Medical, Inc. Methods and compositions for control of fetal growth via modulation of relaxin
US20060052304A1 (en) * 2004-09-02 2006-03-09 Bas Medical, Inc. Method for remodeling bone and related sutures
US8389475B2 (en) * 2009-08-10 2013-03-05 The Board Of Trustees Of The Leland Stanford Junior University Relaxin analogs
PL2605789T3 (pl) 2010-08-17 2019-11-29 Ambrx Inc Zmodyfikowane polipeptydy relaksyny i ich zastosowania
WO2012082933A1 (en) * 2010-12-15 2012-06-21 Baxter International, Inc. Eluate collection using conductivity gradient
EP2630964A1 (en) 2012-02-22 2013-08-28 Immundiagnostik AG Method and medicament for treating patients in risk of prediabetes and type-2 diabetes
US20160296632A1 (en) 2013-11-13 2016-10-13 Aequus Biopharma, Inc. Engineered glycoproteins and uses thereof
EP2946788A1 (en) 2014-05-23 2015-11-25 Immundiagnostik AG Method and composition for treating heart failure with preserved ejection fraction
BR112018073683A2 (pt) 2016-05-18 2019-02-26 Modernatx, Inc. polinucleotídeos codificadores de relaxina

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267101A (en) * 1980-02-01 1981-05-12 Serono Laboratories Inc. Process for obtaining human relaxin from fetal membranes
IE55479B1 (en) * 1982-02-12 1990-09-26 Florey Howard Inst Molecular cloning and characterization of the gene sequence coding for porcine relaxin
NZ206534A (en) * 1982-12-13 1988-05-30 Florey Howard Inst Molecular cloning and characterisation of gene sequence coding for human relaxin

Also Published As

Publication number Publication date
ES8603579A1 (es) 1985-12-16
EP0101309A2 (en) 1984-02-22
CA1340542C (en) 1999-05-18
DK156592A (da) 1992-12-28
JPS5985292A (ja) 1984-05-17
ES550943A0 (es) 1988-05-16
IL69469A0 (en) 1983-11-30
ES557505A0 (es) 1988-02-16
JP2537477B2 (ja) 1996-09-25
ES540886A0 (es) 1988-04-01
ES524885A0 (es) 1985-12-16
EP0287820A1 (en) 1988-10-26
IL69469A (en) 1991-06-10
ES8801671A1 (es) 1988-02-16
EP0287820B1 (en) 1992-07-08
JP2670001B2 (ja) 1997-10-29
DK156592D0 (da) 1992-12-28
DK366483A (da) 1984-02-13
IE831909L (en) 1984-02-12
EP0101309A3 (en) 1984-12-27
ES8802160A1 (es) 1988-04-01
DE3382117D1 (de) 1991-02-21
US4871670A (en) 1989-10-03
IE58682B1 (en) 1993-11-03
JP2892596B2 (ja) 1999-05-17
KR930003515B1 (ko) 1993-05-01
ES8801676A1 (es) 1988-02-16
JPH07215998A (ja) 1995-08-15
ATE78042T1 (de) 1992-07-15
DK171827B1 (da) 1997-06-23
HU197350B (en) 1989-03-28
EP0101309B1 (en) 1991-01-16
JPH0690780A (ja) 1994-04-05
DK366483D0 (da) 1983-08-11
KR840005739A (ko) 1984-11-16
DK171683B1 (da) 1997-03-10
ZA835963B (en) 1984-04-25
ES557506A0 (es) 1988-02-16
NZ205241A (en) 1991-01-29

Similar Documents

Publication Publication Date Title
ES8801675A1 (es) Un procedimiento para preparar relaxina-h2 humana
ES8802394A1 (es) Un procedimiento para preparar una proteina de fusion derivada de la secuencia de aminoacidos de la preprorrelaxina humana.
NO885659L (no) Mycobakterielle rekombinanter og peptider.
ES2009238A6 (es) Metodo para producir proteinas de mycobacterium tuberculosis y peptidos antigenicos de las mismas.
DK0932678T3 (da) En familie af gener kodende for apoptoserelaterede peptider, peptider kodet deraf og fremgangsmåde til anvendelse deraf
DK0882130T5 (da) Humant cancerantigen i tyrosinase-beslægtet protein 1 og gen, der koder dette
FI941048A (fi) Geloniinipolypeptidin koodaavia DNA-sekvenssejä
DE3686579D1 (en) Prokaryotisches expressionssystem.
ES8503373A1 (es) Un procedimiento de preparacion de un vector de transferencia de adn.
DK595187A (da) Minactivin og fremgangsmaade til fremstilling deraf
SE8100238L (sv) Syntetisk gen, plasmidvektor innehallande denna gen, forfaranden for genens och vektorns framstellning och anvendning samt salunda erhallna celler och peptider
ES2008391A6 (es) Un metodo para producir isopenicilina n sintetasa.
WO2000053789A3 (de) Retrovirale expressionsvektoren auf der basis von herv-ltr-sequenzen
HUP9903075A2 (hu) Sejtciklus ellenőrzőpont gének