ES2009238A6 - Metodo para producir proteinas de mycobacterium tuberculosis y peptidos antigenicos de las mismas. - Google Patents

Metodo para producir proteinas de mycobacterium tuberculosis y peptidos antigenicos de las mismas.

Info

Publication number
ES2009238A6
ES2009238A6 ES8800574A ES8800574A ES2009238A6 ES 2009238 A6 ES2009238 A6 ES 2009238A6 ES 8800574 A ES8800574 A ES 8800574A ES 8800574 A ES8800574 A ES 8800574A ES 2009238 A6 ES2009238 A6 ES 2009238A6
Authority
ES
Spain
Prior art keywords
peptides
disclosed
proteins
mycobacterial
recombinants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8800574A
Other languages
English (en)
Inventor
Thomas Shinnick
Richard Houghten
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Clinic and Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Clinic and Research Foundation filed Critical Scripps Clinic and Research Foundation
Publication of ES2009238A6 publication Critical patent/ES2009238A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

METODO PARA PRODUCIR PROTEINAS DE MYCOBACTERIUM TUBERCULOSIS Y PEPTIDOS ANTIGENICOS DE LAS MISMAS. LAS PROTEINAS DE INTERES TIENEN ENTRE 517 Y 540 RESTOS DE AMINOACIDOS Y SE OBTIENEN POR CULTIVO DE UN MEDIO DE REPLICACION/EXPRESION QUE CONTIENE UN PLASMIDO CON UNA SECUENCIA DE ADN EXTRAÑO QUE CONSTA DE LA SECUENCIA NUCLEOTIDICA COMPRENDIDA ENTRE LAS POSICIONES 3950 Y 2390 LEIDA DE IZQUIERDA A DERECHA Y DESDE EL EXTREMO 5'' AL 3'' DEL GENOMA DE M. TUBERCULOSIS Y POSTERIOR RECOLECCION DE LA PROTEINA EXPRESADA. LOS PEPTIDOS ANTIGENICOS CONSTAN DE UNA SECUENCIA DE 5 A 40 RESTOS AMINOACIDOS CORRESPONDIENTES A LA PROTEINA DE 540 O DE 517 AMINOACIDOS Y SE OBTIENEN POR SINTESIS QUIMICA. ESTAS PROTEINAS Y PEPTIDOS SON ADECUADOS PARA ANALIZAR LA PRESENCIA DE ANTICUERPOS FRENTE A M. TUBERCULOSIS Y PARA LA PREPARACION DE EQUIPOS DE DIAGNOSTICO.
ES8800574A 1987-02-26 1988-02-26 Metodo para producir proteinas de mycobacterium tuberculosis y peptidos antigenicos de las mismas. Expired ES2009238A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/019,529 US4952395A (en) 1987-02-26 1987-02-26 Mycobacterial recombinants and peptides

Publications (1)

Publication Number Publication Date
ES2009238A6 true ES2009238A6 (es) 1989-09-16

Family

ID=21793686

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8800574A Expired ES2009238A6 (es) 1987-02-26 1988-02-26 Metodo para producir proteinas de mycobacterium tuberculosis y peptidos antigenicos de las mismas.

Country Status (8)

Country Link
US (1) US4952395A (es)
CA (1) CA1340423C (es)
ES (1) ES2009238A6 (es)
GR (1) GR1000083B (es)
NZ (1) NZ223632A (es)
PT (1) PT86838B (es)
WO (1) WO1988006591A1 (es)
ZA (1) ZA881344B (es)

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FR2694754B1 (fr) * 1992-08-12 1994-09-16 Bio Merieux Fragments d'ADN de mycobactéries, amorces d'amplification, sondes d'hybridation, réactifs et procédé de détection de détection de mycobactéries.
JPH08510756A (ja) 1993-06-04 1996-11-12 ホワイトヘッド インスティチュート フォー バイオメディカル リサーチ ストレス蛋白質とその使用
US5955077A (en) * 1993-07-02 1999-09-21 Statens Seruminstitut Tuberculosis vaccine
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CA2177249C (en) 1993-11-23 2010-10-19 Marcus A. Horwitz Abundant extracellular products and methods for their production and use
US7300660B2 (en) * 1993-11-23 2007-11-27 The Regents Of The University Of California Abundant extracellular products and methods for their production and use
US6752993B1 (en) 1993-11-23 2004-06-22 The Regents Of The University Of California Abundant extracellular product vaccines and methods for their production and use
PT751957E (pt) * 1994-03-21 2004-07-30 Univ Utrecht Fragmentos peptidicos de proteinas de stress microbianas e composicao farmaceutica a base destes fragmentos para o tratamento e a prevencao de doencas inflamatorias
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US6338852B1 (en) 1995-09-01 2002-01-15 Corixa Corporation Compounds and methods for diagnosis of tuberculosis
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US6592877B1 (en) * 1995-09-01 2003-07-15 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
US6013660A (en) * 1996-10-02 2000-01-11 The Regents Of The University Of California Externally targeted prophylactic and chemotherapeutic method and agents
US7157089B1 (en) 1996-11-26 2007-01-02 Stressgen Biotechnologies Corporation Immune responses using compositions containing stress proteins
US6982085B2 (en) * 1997-04-02 2006-01-03 Statens Serum Institut TB diagnostic based on antigens from M. tuberculosis
US7037510B2 (en) 1997-04-18 2006-05-02 Statens Serum Institut Hybrids of M. tuberculosis antigens
US6613881B1 (en) 1997-05-20 2003-09-02 Corixa Corporation Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use
US7087713B2 (en) * 2000-02-25 2006-08-08 Corixa Corporation Compounds and methods for diagnosis and immunotherapy of tuberculosis
US6555653B2 (en) 1997-05-20 2003-04-29 Corixa Corporation Compounds for diagnosis of tuberculosis and methods for their use
CN1915425A (zh) 1997-08-05 2007-02-21 斯特思吉生物技术公司 包含hpv抗原和应激蛋白或者其表达载体的组合物激发的抗hpv抗原免疫应答
US20040013685A1 (en) * 1997-11-10 2004-01-22 Peter Andersen Nucleic acid fragments and polypeptide fragments derived from M. tuberculosis
US6497880B1 (en) 1998-12-08 2002-12-24 Stressgen Biotechnologies Corporation Heat shock genes and proteins from Neisseria meningitidis, Candida glabrata and Aspergillus fumigatus
US6465633B1 (en) 1998-12-24 2002-10-15 Corixa Corporation Compositions and methods of their use in the treatment, prevention and diagnosis of tuberculosis
US8143386B2 (en) * 1999-04-07 2012-03-27 Corixa Corporation Fusion proteins of mycobacterium tuberculosis antigens and their uses
CA2378097A1 (en) 1999-07-08 2001-01-18 Stressgen Biotechnologies Corporation Induction of a th1-like response in vitro
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US7632803B2 (en) * 1999-10-01 2009-12-15 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
US7592304B2 (en) 1999-10-01 2009-09-22 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
US7311922B1 (en) * 1999-10-07 2007-12-25 Corixa Corporation Fusion proteins of mycobacterium tuberculosis
DE60042704D1 (de) 2000-01-14 2009-09-17 Whitehead Biomedical Inst Induktion zytotoxischer lymphozyten durch hitzeschockprotein-fusionsproteine hängt von der atp-bindungsdomäne in hsp ab und is cd4+ unabhängig
DE60139963D1 (de) * 2000-06-20 2009-10-29 Corixa Corp Fusionsproteine aus mycobakterium tuberculosis
CZ20024154A3 (cs) 2000-06-26 2003-08-13 Stressgen Biotechnologies Corporation Použití prostředku obsahujícího napojený protein pro výrobu farmaceutického přípravku pro léčení bradavic a chorob a stavů souvisejících s papiloma virem
AU2001271963A1 (en) * 2000-07-10 2002-01-21 Colorado State University Research Foundation Mid-life vaccine and methods for boosting anti-mycobacterial immunity
AU2002227406A1 (en) * 2000-12-13 2002-06-24 Argonex Pharmaceuticals Mhc class i associated peptides for prevention and treatment of tuberculosis
CN1264572C (zh) 2001-02-05 2006-07-19 斯特雷斯根生物技术公司 治疗hbv的融合蛋白及其应用
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AU2003295579A1 (en) * 2002-11-15 2004-06-15 Regents Of The University Of California Anti-microbial agents derived from methionine sulfoximine analogues
PL239045B1 (pl) * 2018-01-09 2021-11-02 Inst Immunologii I Terapii Doswiadczalnej Polskiej Akademii Nauk Epitop specyficzny dla zakaźnych Streptococcus agalactiae oraz sposób wykrywania zakażenia pacjenta szczepem Streptococcus agalactiae

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US4689397A (en) * 1985-08-12 1987-08-25 Scripps Clinic And Research Foundation Synthetic polypeptides for detecting mycobacterial infections
NL8701163A (nl) * 1986-09-09 1988-04-05 Nederlanden Staat Gebruik van een peptide voor de bereiding van preparaten voor het verlichten, het behandelen en de diagnose van autoimmuunziekten, in het bijzonder arthritische toestanden, verbindingen die met dit peptide verwant zijn, alsmede farmaceutische en diagnostische preparaten en testkits.
WO1988005823A2 (en) * 1987-02-02 1988-08-11 Whitehead Institute For Biomedical Research Mycobacterium tuberculosis genes encoding protein antigens

Also Published As

Publication number Publication date
PT86838B (pt) 1992-05-29
GR1000083B (el) 1990-11-29
GR880100104A (en) 1988-12-16
ZA881344B (en) 1988-08-26
WO1988006591A1 (en) 1988-09-07
US4952395A (en) 1990-08-28
PT86838A (pt) 1988-03-01
NZ223632A (en) 1991-03-26
CA1340423C (en) 1999-03-09

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