DE3382117D1 - Molekulare klonierung und charakterisierung der das menschliche relaxin kodierenden gen-sequenz. - Google Patents

Molekulare klonierung und charakterisierung der das menschliche relaxin kodierenden gen-sequenz.

Info

Publication number
DE3382117D1
DE3382117D1 DE8383304662T DE3382117T DE3382117D1 DE 3382117 D1 DE3382117 D1 DE 3382117D1 DE 8383304662 T DE8383304662 T DE 8383304662T DE 3382117 T DE3382117 T DE 3382117T DE 3382117 D1 DE3382117 D1 DE 3382117D1
Authority
DE
Germany
Prior art keywords
characterization
molecular cloning
human relaxin
gene sequence
encoding gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8383304662T
Other languages
English (en)
Inventor
Peter John Hudson
John Shine
Hugh David Niall
Geoffrey William Tregear
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Florey Institute of Neuroscience and Mental Health
Original Assignee
Howard Florey Institute of Experimental Physiology and Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Howard Florey Institute of Experimental Physiology and Medicine filed Critical Howard Florey Institute of Experimental Physiology and Medicine
Application granted granted Critical
Publication of DE3382117D1 publication Critical patent/DE3382117D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/30—Signal or leader sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DE8383304662T 1982-08-12 1983-08-11 Molekulare klonierung und charakterisierung der das menschliche relaxin kodierenden gen-sequenz. Expired - Lifetime DE3382117D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPF535282 1982-08-12

Publications (1)

Publication Number Publication Date
DE3382117D1 true DE3382117D1 (de) 1991-02-21

Family

ID=3769689

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383304662T Expired - Lifetime DE3382117D1 (de) 1982-08-12 1983-08-11 Molekulare klonierung und charakterisierung der das menschliche relaxin kodierenden gen-sequenz.

Country Status (14)

Country Link
US (1) US4871670A (de)
EP (2) EP0287820B1 (de)
JP (3) JP2537477B2 (de)
KR (1) KR930003515B1 (de)
AT (1) ATE78042T1 (de)
CA (1) CA1340542C (de)
DE (1) DE3382117D1 (de)
DK (2) DK171827B1 (de)
ES (5) ES8603579A1 (de)
HU (1) HU197350B (de)
IE (1) IE58682B1 (de)
IL (1) IL69469A (de)
NZ (1) NZ205241A (de)
ZA (1) ZA835963B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5320953A (en) * 1982-08-12 1994-06-14 Howard Florey Institute Of Experimental Physiology And Medicine Process for synthesizing human H1-prorelaxin, H1-relaxin and fusion proteins thereof
US5023321A (en) * 1982-12-13 1991-06-11 Howard Florey Institute Of Experimental Physiology & Medicine Molecular cloning and characterization of a further gene sequence coding for human relaxin
IL70414A (en) * 1982-12-13 1991-06-10 Florey Howard Inst Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors
US4835251A (en) * 1986-06-23 1989-05-30 Genetech, Inc. Method of chain combination
JP2815649B2 (ja) * 1988-02-26 1998-10-27 ジェネンテク，インコーポレイテッド ヒトレラキシン製剤
EP0470976B1 (de) * 1989-05-04 1993-03-31 Genentech, Inc. Verfahren und zusammensetzungen zur isolation von menschlichem relaxin
US5089419A (en) * 1989-08-07 1992-02-18 International Canine Genetics Detection of pregnancy by identification of the c peptide of relaxin in the urine of animals
US5166191A (en) * 1991-08-19 1992-11-24 Genentech, Inc. Use of relaxin in cardiovascular therapy
US5478807A (en) * 1991-08-19 1995-12-26 Genentech, Inc. Use of relaxin in the treatment of bradycardia
US6348327B1 (en) * 1991-12-06 2002-02-19 Genentech, Inc. Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells
EP0707650B1 (de) * 1993-06-21 2003-05-21 Genentech, Inc. Verfahren zur Herstellung von humanen Relaxin
US5911997A (en) * 1995-06-07 1999-06-15 Connetics Corporation Relaxin-like factor and methods and uses thereof
AU2002256359A1 (en) * 2001-04-24 2002-11-05 Epigenesis Pharmaceuticals, Inc. Antisense and anti-inflammatory based compositions to treat respiratory disorders
AU2002324727A1 (en) * 2001-08-17 2003-03-03 The Board Of Trustees Of The Leland Stanford Junior University Mammalian relaxin receptors
AU2003903124A0 (en) * 2003-06-20 2003-07-10 Mark Del Borgo Analogues of heteromeric proteins
JP4836942B2 (ja) * 2004-04-30 2011-12-14 コーセラ， インコーポレイテッド リラキシンの調節による胎仔の発育の制御のための方法および組成物
US20060052304A1 (en) * 2004-09-02 2006-03-09 Bas Medical, Inc. Method for remodeling bone and related sutures
US8389475B2 (en) * 2009-08-10 2013-03-05 The Board Of Trustees Of The Leland Stanford Junior University Relaxin analogs
CA2808596C (en) * 2010-08-17 2020-12-15 Ambrx, Inc. Modified relaxin polypeptides and their uses
EP2652491B1 (de) * 2010-12-15 2017-11-29 Baxalta GmbH Eluatsammlung mit leitfähigkeitsgradient
EP2630964A1 (de) 2012-02-22 2013-08-28 Immundiagnostik AG Verfahren und Medikation zur Behandlung von Patienten mit Risiko für Prädiabetes und Typ-2-Diabetes
EP3068891A1 (de) 2013-11-13 2016-09-21 Aequus Biopharma Inc. Manipulierte glycoproteine und verwendungen davon
EP2946788A1 (de) 2014-05-23 2015-11-25 Immundiagnostik AG Verfahren und Zusammensetzung zur Behandlung von Herzversagen mit erhaltener Austreibungsfraktion
WO2017201340A2 (en) 2016-05-18 2017-11-23 Modernatx, Inc. Polynucleotides encoding relaxin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267101A (en) * 1980-02-01 1981-05-12 Serono Laboratories Inc. Process for obtaining human relaxin from fetal membranes
IE55479B1 (en) * 1982-02-12 1990-09-26 Florey Howard Inst Molecular cloning and characterization of the gene sequence coding for porcine relaxin
IL70414A (en) * 1982-12-13 1991-06-10 Florey Howard Inst Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors

Also Published As

Publication number Publication date
ES524885A0 (es) 1985-12-16
JP2892596B2 (ja) 1999-05-17
JPS5985292A (ja) 1984-05-17
IE831909L (en) 1984-02-12
DK366483D0 (da) 1983-08-11
KR930003515B1 (ko) 1993-05-01
ES8603579A1 (es) 1985-12-16
DK171827B1 (da) 1997-06-23
JPH07215998A (ja) 1995-08-15
JP2537477B2 (ja) 1996-09-25
DK366483A (da) 1984-02-13
IE58682B1 (en) 1993-11-03
DK156592A (da) 1992-12-28
NZ205241A (en) 1991-01-29
IL69469A (en) 1991-06-10
EP0287820A1 (de) 1988-10-26
US4871670A (en) 1989-10-03
ES8802394A1 (es) 1988-05-16
ATE78042T1 (de) 1992-07-15
EP0101309A2 (de) 1984-02-22
CA1340542C (en) 1999-05-18
JPH0690780A (ja) 1994-04-05
ES8802160A1 (es) 1988-04-01
KR840005739A (ko) 1984-11-16
DK171683B1 (da) 1997-03-10
ES550943A0 (es) 1988-05-16
JP2670001B2 (ja) 1997-10-29
ES557506A0 (es) 1988-02-16
HU197350B (en) 1989-03-28
ES8801671A1 (es) 1988-02-16
ES8801676A1 (es) 1988-02-16
EP0101309A3 (en) 1984-12-27
ES557505A0 (es) 1988-02-16
DK156592D0 (da) 1992-12-28
IL69469A0 (en) 1983-11-30
EP0101309B1 (de) 1991-01-16
EP0287820B1 (de) 1992-07-08
ES540886A0 (es) 1988-04-01
ZA835963B (en) 1984-04-25

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