DK171827B1 - Dobbeltstrenget DNA-fragment, der koder for human-H1-præprorelaxin, human-H1-prorelaxin eller A- og B-kæderne i human-H1-relaxin, samt DNA-transfervektor, der indeholder en cDNA-deoxynukleotidsekvens, som svarer til et sådant DNA-fragment, celle transformeret med en sådan DNA-transfervektor, og fremgangsmåde til fremstilling af human-H1-prorelaxin eller -H1-relaxin ved dyrkning af en sådan celle - Google Patents

Dobbeltstrenget DNA-fragment, der koder for human-H1-præprorelaxin, human-H1-prorelaxin eller A- og B-kæderne i human-H1-relaxin, samt DNA-transfervektor, der indeholder en cDNA-deoxynukleotidsekvens, som svarer til et sådant DNA-fragment, celle transformeret med en sådan DNA-transfervektor, og fremgangsmåde til fremstilling af human-H1-prorelaxin eller -H1-relaxin ved dyrkning af en sådan celle Download PDF

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Publication number
DK171827B1
DK171827B1 DK366483A DK366483A DK171827B1 DK 171827 B1 DK171827 B1 DK 171827B1 DK 366483 A DK366483 A DK 366483A DK 366483 A DK366483 A DK 366483A DK 171827 B1 DK171827 B1 DK 171827B1
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DK
Denmark
Prior art keywords
human
relaxin
chain
lys
dna fragment
Prior art date
Application number
DK366483A
Other languages
Danish (da)
English (en)
Other versions
DK366483A (da
DK366483D0 (da
Inventor
Peter John Hudson
John Shine
Hugh David Niall
Geoffrey William Tregear
Original Assignee
Florey Howard Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Florey Howard Inst filed Critical Florey Howard Inst
Publication of DK366483D0 publication Critical patent/DK366483D0/da
Publication of DK366483A publication Critical patent/DK366483A/da
Application granted granted Critical
Publication of DK171827B1 publication Critical patent/DK171827B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/30—Signal or leader sequence

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DK366483A 1982-08-12 1983-08-11 Dobbeltstrenget DNA-fragment, der koder for human-H1-præprorelaxin, human-H1-prorelaxin eller A- og B-kæderne i human-H1-relaxin, samt DNA-transfervektor, der indeholder en cDNA-deoxynukleotidsekvens, som svarer til et sådant DNA-fragment, celle transformeret med en sådan DNA-transfervektor, og fremgangsmåde til fremstilling af human-H1-prorelaxin eller -H1-relaxin ved dyrkning af en sådan celle DK171827B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPF535282 1982-08-12
AUPF535282 1982-08-12

Publications (3)

Publication Number Publication Date
DK366483D0 DK366483D0 (da) 1983-08-11
DK366483A DK366483A (da) 1984-02-13
DK171827B1 true DK171827B1 (da) 1997-06-23

Family

ID=3769689

Family Applications (2)

Application Number Title Priority Date Filing Date
DK366483A DK171827B1 (da) 1982-08-12 1983-08-11 Dobbeltstrenget DNA-fragment, der koder for human-H1-præprorelaxin, human-H1-prorelaxin eller A- og B-kæderne i human-H1-relaxin, samt DNA-transfervektor, der indeholder en cDNA-deoxynukleotidsekvens, som svarer til et sådant DNA-fragment, celle transformeret med en sådan DNA-transfervektor, og fremgangsmåde til fremstilling af human-H1-prorelaxin eller -H1-relaxin ved dyrkning af en sådan celle
DK156592A DK171683B1 (da) 1982-08-12 1992-12-28 Analogifremgangsmåde til fremstilling af human-H1-relaxinanalog

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK156592A DK171683B1 (da) 1982-08-12 1992-12-28 Analogifremgangsmåde til fremstilling af human-H1-relaxinanalog

Country Status (14)

Country Link
US (1) US4871670A (de)
EP (2) EP0287820B1 (de)
JP (3) JP2537477B2 (de)
KR (1) KR930003515B1 (de)
AT (1) ATE78042T1 (de)
CA (1) CA1340542C (de)
DE (1) DE3382117D1 (de)
DK (2) DK171827B1 (de)
ES (5) ES524885A0 (de)
HU (1) HU197350B (de)
IE (1) IE58682B1 (de)
IL (1) IL69469A (de)
NZ (1) NZ205241A (de)
ZA (1) ZA835963B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5320953A (en) * 1982-08-12 1994-06-14 Howard Florey Institute Of Experimental Physiology And Medicine Process for synthesizing human H1-prorelaxin, H1-relaxin and fusion proteins thereof
US5023321A (en) * 1982-12-13 1991-06-11 Howard Florey Institute Of Experimental Physiology & Medicine Molecular cloning and characterization of a further gene sequence coding for human relaxin
NZ206534A (en) * 1982-12-13 1988-05-30 Florey Howard Inst Molecular cloning and characterisation of gene sequence coding for human relaxin
US4835251A (en) * 1986-06-23 1989-05-30 Genetech, Inc. Method of chain combination
WO1989007945A1 (en) * 1988-02-26 1989-09-08 Genentech, Inc. Human relaxin formulation
JP2857684B2 (ja) * 1989-05-04 1999-02-17 ジェネンテク，インコーポレイテッド ヒトリラキシンの単離のための方法および組成物
US5089419A (en) * 1989-08-07 1992-02-18 International Canine Genetics Detection of pregnancy by identification of the c peptide of relaxin in the urine of animals
US5166191A (en) * 1991-08-19 1992-11-24 Genentech, Inc. Use of relaxin in cardiovascular therapy
US5478807A (en) * 1991-08-19 1995-12-26 Genentech, Inc. Use of relaxin in the treatment of bradycardia
US6348327B1 (en) * 1991-12-06 2002-02-19 Genentech, Inc. Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells
AU691189B2 (en) * 1993-06-21 1998-05-14 Genentech Inc. Process for producing relaxin
US5911997A (en) * 1995-06-07 1999-06-15 Connetics Corporation Relaxin-like factor and methods and uses thereof
US20070021360A1 (en) * 2001-04-24 2007-01-25 Nyce Jonathan W Compositions, formulations and kit with anti-sense oligonucleotide and anti-inflammatory steroid and/or obiquinone for treatment of respiratory and lung disesase
US20030088884A1 (en) * 2001-08-17 2003-05-08 Hsu Sheau Yu Mammalian relaxin receptors
AU2003903124A0 (en) * 2003-06-20 2003-07-10 Mark Del Borgo Analogues of heteromeric proteins
WO2005115435A2 (en) * 2004-04-30 2005-12-08 Bas Medical, Inc. Methods and compositions for control of fetal growth via modulation of relaxin
US20060052304A1 (en) * 2004-09-02 2006-03-09 Bas Medical, Inc. Method for remodeling bone and related sutures
US8389475B2 (en) 2009-08-10 2013-03-05 The Board Of Trustees Of The Leland Stanford Junior University Relaxin analogs
FI3572091T3 (fi) * 2010-08-17 2024-03-01 Ambrx Inc Muokattuja relaksiinipolypeptidejä ja niiden käyttötapoja
CA2821711C (en) 2010-12-15 2017-10-10 Baxter International Inc. Eluate collection using conductivity gradient
EP2630964A1 (de) 2012-02-22 2013-08-28 Immundiagnostik AG Verfahren und Medikation zur Behandlung von Patienten mit Risiko für Prädiabetes und Typ-2-Diabetes
EP3068891A1 (de) 2013-11-13 2016-09-21 Aequus Biopharma Inc. Manipulierte glycoproteine und verwendungen davon
EP2946788A1 (de) 2014-05-23 2015-11-25 Immundiagnostik AG Verfahren und Zusammensetzung zur Behandlung von Herzversagen mit erhaltener Austreibungsfraktion
CN109640962B (zh) 2016-05-18 2022-07-19 摩登纳特斯有限公司 编码松弛素的多核苷酸

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267101A (en) * 1980-02-01 1981-05-12 Serono Laboratories Inc. Process for obtaining human relaxin from fetal membranes
IE55479B1 (en) * 1982-02-12 1990-09-26 Florey Howard Inst Molecular cloning and characterization of the gene sequence coding for porcine relaxin
NZ206534A (en) * 1982-12-13 1988-05-30 Florey Howard Inst Molecular cloning and characterisation of gene sequence coding for human relaxin

Also Published As

Publication number Publication date
JP2892596B2 (ja) 1999-05-17
US4871670A (en) 1989-10-03
DK366483A (da) 1984-02-13
IL69469A0 (en) 1983-11-30
DK156592D0 (da) 1992-12-28
NZ205241A (en) 1991-01-29
EP0101309A2 (de) 1984-02-22
ES557505A0 (es) 1988-02-16
DK171683B1 (da) 1997-03-10
ES540886A0 (es) 1988-04-01
ES8603579A1 (es) 1985-12-16
ATE78042T1 (de) 1992-07-15
JP2670001B2 (ja) 1997-10-29
DK156592A (da) 1992-12-28
ES8801671A1 (es) 1988-02-16
CA1340542C (en) 1999-05-18
EP0101309B1 (de) 1991-01-16
ES8801676A1 (es) 1988-02-16
ZA835963B (en) 1984-04-25
EP0287820B1 (de) 1992-07-08
HU197350B (en) 1989-03-28
ES8802394A1 (es) 1988-05-16
JP2537477B2 (ja) 1996-09-25
JPS5985292A (ja) 1984-05-17
IL69469A (en) 1991-06-10
ES550943A0 (es) 1988-05-16
ES557506A0 (es) 1988-02-16
KR930003515B1 (ko) 1993-05-01
JPH07215998A (ja) 1995-08-15
JPH0690780A (ja) 1994-04-05
EP0101309A3 (en) 1984-12-27
DK366483D0 (da) 1983-08-11
IE58682B1 (en) 1993-11-03
DE3382117D1 (de) 1991-02-21
EP0287820A1 (de) 1988-10-26
ES524885A0 (es) 1985-12-16
IE831909L (en) 1984-02-12
KR840005739A (ko) 1984-11-16
ES8802160A1 (es) 1988-04-01

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Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired