ATE62507T1 - Molekulare klonierung und charakterisierung einer anderen gensequenz die fuer menschliches relaxin kodiert. - Google Patents
Molekulare klonierung und charakterisierung einer anderen gensequenz die fuer menschliches relaxin kodiert.Info
- Publication number
- ATE62507T1 ATE62507T1 AT83307553T AT83307553T ATE62507T1 AT E62507 T1 ATE62507 T1 AT E62507T1 AT 83307553 T AT83307553 T AT 83307553T AT 83307553 T AT83307553 T AT 83307553T AT E62507 T1 ATE62507 T1 AT E62507T1
- Authority
- AT
- Austria
- Prior art keywords
- characterization
- sequence encoding
- molecular cloning
- gene sequence
- encoding human
- Prior art date
Links
- BJRCFZKVYNDCJE-WBSNEMHCSA-N 99489-95-9 Chemical compound C([C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@H](C(N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)NCC(=O)N2)[C@@H](C)CC)=O)CSSC[C@@H](C(NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC1=O)C(O)=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O)[C@@H](C)CC)[C@@H](C)CC)C(C)C)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CCCCN)C(C)C)[C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C1=CC=C(O)C=C1 BJRCFZKVYNDCJE-WBSNEMHCSA-N 0.000 title 1
- 238000012512 characterization method Methods 0.000 title 1
- 238000010369 molecular cloning Methods 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 101001091088 Homo sapiens Prorelaxin H2 Proteins 0.000 abstract 2
- 102000049116 human RLN2 Human genes 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPF724782 | 1982-12-13 | ||
| EP83307553A EP0112149B1 (de) | 1982-12-13 | 1983-12-12 | Molekulare Klonierung und Charakterisierung einer anderen Gensequenz die für menschliches Relaxin kodiert |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE62507T1 true ATE62507T1 (de) | 1991-04-15 |
Family
ID=3769889
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT83307553T ATE62507T1 (de) | 1982-12-13 | 1983-12-12 | Molekulare klonierung und charakterisierung einer anderen gensequenz die fuer menschliches relaxin kodiert. |
| AT88110103T ATE90360T1 (de) | 1982-12-13 | 1983-12-12 | Molekulare klonierung und charakterisierung einer weiteren gen-sequenz, die fuer menschliches relaxin kodiert. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88110103T ATE90360T1 (de) | 1982-12-13 | 1983-12-12 | Molekulare klonierung und charakterisierung einer weiteren gen-sequenz, die fuer menschliches relaxin kodiert. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4758516A (de) |
| EP (2) | EP0112149B1 (de) |
| JP (3) | JP2545055B2 (de) |
| KR (1) | KR940002536B1 (de) |
| AT (2) | ATE62507T1 (de) |
| CA (1) | CA1220735A (de) |
| DE (1) | DE3382249D1 (de) |
| DK (2) | DK171684B1 (de) |
| ES (6) | ES527964A0 (de) |
| HU (1) | HU197767B (de) |
| IE (1) | IE63902B1 (de) |
| IL (1) | IL70414A (de) |
| NZ (1) | NZ206534A (de) |
| ZA (1) | ZA839231B (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0101309B1 (de) * | 1982-08-12 | 1991-01-16 | Howard Florey Institute Of Experimental Physiology And Medicine | Molekulare Klonierung und Charakterisierung der das menschliche Relaxin kodierenden Gen-Sequenz |
| US5179195A (en) * | 1982-12-13 | 1993-01-12 | Howard Florey Institute Of Experimental Physiology And Medicine | Human relaxin polypeptides |
| US4835251A (en) * | 1986-06-23 | 1989-05-30 | Genetech, Inc. | Method of chain combination |
| NZ221789A (en) * | 1986-09-12 | 1991-05-28 | Genentech Inc | Recombinant prorelaxin, its preparation and pharmaceutical compositions comprising it |
| AU626840B2 (en) * | 1988-02-26 | 1992-08-13 | Genentech Inc. | Human relaxin formulation |
| CA2051375C (en) * | 1989-05-04 | 2000-09-12 | Dennis J. Henner | Process and compositions for the isolation of human relaxin |
| US5089419A (en) * | 1989-08-07 | 1992-02-18 | International Canine Genetics | Detection of pregnancy by identification of the c peptide of relaxin in the urine of animals |
| US5478807A (en) * | 1991-08-19 | 1995-12-26 | Genentech, Inc. | Use of relaxin in the treatment of bradycardia |
| US5166191A (en) * | 1991-08-19 | 1992-11-24 | Genentech, Inc. | Use of relaxin in cardiovascular therapy |
| JPH07508341A (ja) * | 1991-10-28 | 1995-09-14 | ボード・オヴ・リージェンツ，ザ・ユニヴァーシティ・オヴ・テキサス・システム | 生物サンプルおよび体液中の正常細胞と悪性腫瘍細胞とにおける分化マーカーの検出方法 |
| US6348327B1 (en) | 1991-12-06 | 2002-02-19 | Genentech, Inc. | Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells |
| WO1995000645A2 (en) * | 1993-06-21 | 1995-01-05 | Genentech, Inc. | Process for producing relaxin |
| US20050032683A1 (en) * | 2000-10-04 | 2005-02-10 | Amento Edward P. | Methods of modulating apoptosis by administration of relaxin agonists or antagonists |
| US20040006205A1 (en) * | 2001-04-03 | 2004-01-08 | Li Li | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| AU2002324727A1 (en) * | 2001-08-17 | 2003-03-03 | The Board Of Trustees Of The Leland Stanford Junior University | Mammalian relaxin receptors |
| AU2003903124A0 (en) * | 2003-06-20 | 2003-07-10 | Mark Del Borgo | Analogues of heteromeric proteins |
| AU2005247332A1 (en) * | 2004-04-30 | 2005-12-08 | Corthera, Inc. | Methods and compositions for control of fetal growth via modulation of relaxin |
| US20060052304A1 (en) * | 2004-09-02 | 2006-03-09 | Bas Medical, Inc. | Method for remodeling bone and related sutures |
| EP2288367B1 (de) * | 2008-05-16 | 2015-10-07 | Corthera, Inc. | H2-Relaxin zur Verwendung bei der Behandlung von vorzeitiger Zervixdilatation |
| GR1006941B (el) | 2009-06-01 | 2010-08-27 | Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), | Πεπτιδικη συνθεση (peptide synthesis) |
| US8389475B2 (en) | 2009-08-10 | 2013-03-05 | The Board Of Trustees Of The Leland Stanford Junior University | Relaxin analogs |
| EP3572091B1 (de) * | 2010-08-17 | 2023-12-13 | Ambrx, Inc. | Modifizierte relaxinpolypeptide und deren verwendungen |
| RU2014103288A (ru) | 2011-07-01 | 2015-08-10 | Байер Интеллектчуал Проперти Гмбх | Слитые полипептиды релаксина и их применение |
| EP2630964A1 (de) | 2012-02-22 | 2013-08-28 | Immundiagnostik AG | Verfahren und Medikation zur Behandlung von Patienten mit Risiko für Prädiabetes und Typ-2-Diabetes |
| US20160296632A1 (en) | 2013-11-13 | 2016-10-13 | Aequus Biopharma, Inc. | Engineered glycoproteins and uses thereof |
| EP2946788A1 (de) | 2014-05-23 | 2015-11-25 | Immundiagnostik AG | Verfahren und Zusammensetzung zur Behandlung von Herzversagen mit erhaltener Austreibungsfraktion |
| KR102533456B1 (ko) | 2016-05-18 | 2023-05-17 | 모더나티엑스, 인크. | 릴랙신을 인코딩하는 폴리뉴클레오타이드 |
| PE20191716A1 (es) | 2017-02-08 | 2019-12-05 | Bristol Myers Squibb Co | Polipeptidos de relaxina modificada que comprenden un mejorador farmacocinetico y sus usos |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4468464A (en) * | 1974-11-04 | 1984-08-28 | The Board Of Trustees Of The Leland Stanford Junior University | Biologically functional molecular chimeras |
| GR70279B (de) * | 1979-09-12 | 1982-09-03 | Univ California | |
| US4267101A (en) * | 1980-02-01 | 1981-05-12 | Serono Laboratories Inc. | Process for obtaining human relaxin from fetal membranes |
| EP0068375A3 (de) * | 1981-06-22 | 1983-04-13 | G.D. Searle & Co. | Rekombinante DNS Technik zur Herstellung von Relaxin |
| IE55479B1 (en) * | 1982-02-12 | 1990-09-26 | Florey Howard Inst | Molecular cloning and characterization of the gene sequence coding for porcine relaxin |
| EP0101309B1 (de) * | 1982-08-12 | 1991-01-16 | Howard Florey Institute Of Experimental Physiology And Medicine | Molekulare Klonierung und Charakterisierung der das menschliche Relaxin kodierenden Gen-Sequenz |
-
1983
- 1983-12-09 IL IL70414A patent/IL70414A/xx not_active IP Right Cessation
- 1983-12-09 NZ NZ206534A patent/NZ206534A/en unknown
- 1983-12-12 AT AT83307553T patent/ATE62507T1/de not_active IP Right Cessation
- 1983-12-12 DE DE8383307553T patent/DE3382249D1/de not_active Expired - Lifetime
- 1983-12-12 ZA ZA839231A patent/ZA839231B/xx unknown
- 1983-12-12 ES ES527964A patent/ES527964A0/es active Granted
- 1983-12-12 IE IE290883A patent/IE63902B1/en not_active IP Right Cessation
- 1983-12-12 EP EP83307553A patent/EP0112149B1/de not_active Expired - Lifetime
- 1983-12-12 CA CA000443049A patent/CA1220735A/en not_active Expired
- 1983-12-12 EP EP88110103A patent/EP0303033B1/de not_active Expired - Lifetime
- 1983-12-12 AT AT88110103T patent/ATE90360T1/de not_active IP Right Cessation
- 1983-12-13 JP JP58233744A patent/JP2545055B2/ja not_active Expired - Lifetime
- 1983-12-13 DK DK573783A patent/DK171684B1/da not_active IP Right Cessation
- 1983-12-13 HU HU834243A patent/HU197767B/hu unknown
- 1983-12-13 KR KR1019830005905A patent/KR940002536B1/ko not_active Expired - Lifetime
- 1983-12-13 US US06/560,790 patent/US4758516A/en not_active Expired - Lifetime
-
1985
- 1985-06-17 ES ES544293A patent/ES8802249A1/es not_active Expired
-
1986
- 1986-02-17 ES ES552095A patent/ES8801373A1/es not_active Expired
- 1986-02-17 ES ES552094A patent/ES8708015A1/es not_active Expired
- 1986-02-17 ES ES552093A patent/ES8708016A1/es not_active Expired
-
1987
- 1987-05-11 ES ES557531A patent/ES8801675A1/es not_active Expired
-
1992
- 1992-11-30 DK DK143492A patent/DK172012B1/da not_active IP Right Cessation
-
1993
- 1993-03-22 JP JP5061747A patent/JP2677332B2/ja not_active Expired - Lifetime
-
1994
- 1994-10-26 JP JP6262254A patent/JP2891882B2/ja not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |