ES8801373A1 - Un procedimiento para aislar un gen de preprorrelaxina -h2 humana o un equivalente o subunidad del mismo - Google Patents

Un procedimiento para aislar un gen de preprorrelaxina -h2 humana o un equivalente o subunidad del mismo

Info

Publication number
ES8801373A1
ES8801373A1 ES552095A ES552095A ES8801373A1 ES 8801373 A1 ES8801373 A1 ES 8801373A1 ES 552095 A ES552095 A ES 552095A ES 552095 A ES552095 A ES 552095A ES 8801373 A1 ES8801373 A1 ES 8801373A1
Authority
ES
Spain
Prior art keywords
characterization
molecular cloning
gene sequence
sequence coding
human relaxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES552095A
Other languages
English (en)
Other versions
ES552095A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Florey Institute of Neuroscience and Mental Health
Original Assignee
Howard Florey Institute of Experimental Physiology and Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3769889&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8801373(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Howard Florey Institute of Experimental Physiology and Medicine filed Critical Howard Florey Institute of Experimental Physiology and Medicine
Publication of ES8801373A1 publication Critical patent/ES8801373A1/es
Publication of ES552095A0 publication Critical patent/ES552095A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Reproductive Health (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA AISLAR UN GEN DE PREPRORRELAXINA-H2 HUMANA O UN EQUIVALENTE O SUBUNIDAD DEL MISMO. COMPRENDE LAS OPERACIONES DE FORMAR UN VECTOR DE TRANSFERENCIA RECOMBINANTE MEDIANTE LAS ACCIONES DE AISLAR MARN DE TEJIDO HUMANO QUE EXPRESA RELAXINA, DE PREPARAR ADN DE DOBLE CADENA A PARTIR DE DICHO MARN Y DE INSERTAR EL CADN EN UN VECTOR DE TRANSFERENCIA APROPIADO, PARA OBTENER UN VECTOR DE TRANSFERENCIA RECOMBINANTE; DE TRANSFORMAR CELULAS HOSPEDANTES CON EL VECTOR O VECTORES DE TRANSFERENCIA RECOMBINANTES; Y DE HIBRIDAR EL VECTOR O VECTORES DE TRANSFERENCIA RECOMBINANTES CON UNA SONDA DE HIBRIDACION MARCADA CORRESPONDIENTE A UNA SUBUNIDAD O FRAGMENTO DEL GEN DE RELAXINA-H1 HUMANA PARA IDENTIFICAR EL GEN DE PREPRORRELAXINA-H2 HUMANA.
ES552095A 1982-12-13 1986-02-17 Un procedimiento para aislar un gen de preprorrelaxina -h2 humana o un equivalente o subunidad del mismo Expired ES8801373A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPF724782 1982-12-13

Publications (2)

Publication Number Publication Date
ES8801373A1 true ES8801373A1 (es) 1987-12-16
ES552095A0 ES552095A0 (es) 1987-12-16

Family

ID=3769889

Family Applications (6)

Application Number Title Priority Date Filing Date
ES527964A Expired ES8602133A1 (es) 1982-12-13 1983-12-12 Un procedimiento para preparar un vector de transferencias de adn
ES544293A Expired ES8802249A1 (es) 1982-12-13 1985-06-17 Un procedimiento para el aislamiento de un gen de relaxina de un ser humano u otro primate o de una especie relacionada
ES552093A Expired ES8708016A1 (es) 1982-12-13 1986-02-17 Un procedimiento para sintetizar una secuencia de aminoacidos que contienen la totalidad o parte de la secuencia de aminoacidos de la preprorrelaxina -h2 humana.
ES552095A Expired ES8801373A1 (es) 1982-12-13 1986-02-17 Un procedimiento para aislar un gen de preprorrelaxina -h2 humana o un equivalente o subunidad del mismo
ES552094A Expired ES8708015A1 (es) 1982-12-13 1986-02-17 Un procedimiento para preparar relaxina -h2 humana o uno de sus analogos
ES557531A Expired ES8801675A1 (es) 1982-12-13 1987-05-11 Un procedimiento para preparar relaxina-h2 humana

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES527964A Expired ES8602133A1 (es) 1982-12-13 1983-12-12 Un procedimiento para preparar un vector de transferencias de adn
ES544293A Expired ES8802249A1 (es) 1982-12-13 1985-06-17 Un procedimiento para el aislamiento de un gen de relaxina de un ser humano u otro primate o de una especie relacionada
ES552093A Expired ES8708016A1 (es) 1982-12-13 1986-02-17 Un procedimiento para sintetizar una secuencia de aminoacidos que contienen la totalidad o parte de la secuencia de aminoacidos de la preprorrelaxina -h2 humana.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES552094A Expired ES8708015A1 (es) 1982-12-13 1986-02-17 Un procedimiento para preparar relaxina -h2 humana o uno de sus analogos
ES557531A Expired ES8801675A1 (es) 1982-12-13 1987-05-11 Un procedimiento para preparar relaxina-h2 humana

Country Status (14)

Country Link
US (1) US4758516A (es)
EP (2) EP0303033B1 (es)
JP (3) JP2545055B2 (es)
KR (1) KR940002536B1 (es)
AT (2) ATE90360T1 (es)
CA (1) CA1220735A (es)
DE (1) DE3382249D1 (es)
DK (2) DK171684B1 (es)
ES (6) ES8602133A1 (es)
HU (1) HU197767B (es)
IE (1) IE63902B1 (es)
IL (1) IL70414A (es)
NZ (1) NZ206534A (es)
ZA (1) ZA839231B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0101309B1 (en) * 1982-08-12 1991-01-16 Howard Florey Institute Of Experimental Physiology And Medicine Molecular cloning and characterization of a gene sequence coding for human relaxin
US5179195A (en) * 1982-12-13 1993-01-12 Howard Florey Institute Of Experimental Physiology And Medicine Human relaxin polypeptides
US4835251A (en) * 1986-06-23 1989-05-30 Genetech, Inc. Method of chain combination
EP0260149A1 (en) * 1986-09-12 1988-03-16 Howard Florey Institute Of Experimental Physiology And Medicine Human prorelaxin for therapeutic use
WO1989007945A1 (en) * 1988-02-26 1989-09-08 Genentech, Inc. Human relaxin formulation
CA2051375C (en) * 1989-05-04 2000-09-12 Dennis J. Henner Process and compositions for the isolation of human relaxin
US5089419A (en) * 1989-08-07 1992-02-18 International Canine Genetics Detection of pregnancy by identification of the c peptide of relaxin in the urine of animals
US5478807A (en) * 1991-08-19 1995-12-26 Genentech, Inc. Use of relaxin in the treatment of bradycardia
US5166191A (en) * 1991-08-19 1992-11-24 Genentech, Inc. Use of relaxin in cardiovascular therapy
WO1993009436A1 (en) * 1991-10-28 1993-05-13 Board Of Regents, The University Of Texas System A method for detecting a differentiation marker in normal and carcinoma cells and in biological samples and body fluid
US6348327B1 (en) 1991-12-06 2002-02-19 Genentech, Inc. Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells
ATE241012T1 (de) * 1993-06-21 2003-06-15 Genentech Inc Verfahren zur herstellung von humanen relaxin
US20050032683A1 (en) * 2000-10-04 2005-02-10 Amento Edward P. Methods of modulating apoptosis by administration of relaxin agonists or antagonists
US20040006205A1 (en) * 2001-04-03 2004-01-08 Li Li Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US20030088884A1 (en) * 2001-08-17 2003-05-08 Hsu Sheau Yu Mammalian relaxin receptors
AU2003903124A0 (en) * 2003-06-20 2003-07-10 Mark Del Borgo Analogues of heteromeric proteins
AU2005247332A1 (en) * 2004-04-30 2005-12-08 Corthera, Inc. Methods and compositions for control of fetal growth via modulation of relaxin
US20060052304A1 (en) * 2004-09-02 2006-03-09 Bas Medical, Inc. Method for remodeling bone and related sutures
PT2288367E (pt) * 2008-05-16 2016-02-09 Corthera Inc Relaxina h2 para utilização no tratamento da dilatação cervical prematura
GR1006941B (el) 2009-06-01 2010-08-27 Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), Πεπτιδικη συνθεση (peptide synthesis)
US8389475B2 (en) 2009-08-10 2013-03-05 The Board Of Trustees Of The Leland Stanford Junior University Relaxin analogs
MX346786B (es) 2010-08-17 2017-03-31 Ambrx Inc Polipeptidos de relaxina modificados y sus usos.
CN103930440A (zh) * 2011-07-01 2014-07-16 拜耳知识产权有限责任公司 松弛素融合多肽及其用途
EP2630964A1 (en) 2012-02-22 2013-08-28 Immundiagnostik AG Method and medicament for treating patients in risk of prediabetes and type-2 diabetes
WO2015073727A1 (en) 2013-11-13 2015-05-21 Aequus Biopharma, Inc. Engineered glycoproteins and uses thereof
EP2946788A1 (en) 2014-05-23 2015-11-25 Immundiagnostik AG Method and composition for treating heart failure with preserved ejection fraction
MA45051A (fr) 2016-05-18 2019-03-27 Modernatx Inc Polynucléotides codant la relaxine
CN110637027B (zh) 2017-02-08 2024-08-30 百时美施贵宝公司 包含药代动力学增强子的修饰的松弛素多肽及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4468464A (en) * 1974-11-04 1984-08-28 The Board Of Trustees Of The Leland Stanford Junior University Biologically functional molecular chimeras
GR70279B (es) * 1979-09-12 1982-09-03 Univ California
US4267101A (en) * 1980-02-01 1981-05-12 Serono Laboratories Inc. Process for obtaining human relaxin from fetal membranes
EP0068375A3 (en) * 1981-06-22 1983-04-13 G.D. Searle & Co. Recombinant dna techniques for the production of relaxin
IE55479B1 (en) * 1982-02-12 1990-09-26 Florey Howard Inst Molecular cloning and characterization of the gene sequence coding for porcine relaxin
EP0101309B1 (en) * 1982-08-12 1991-01-16 Howard Florey Institute Of Experimental Physiology And Medicine Molecular cloning and characterization of a gene sequence coding for human relaxin

Also Published As

Publication number Publication date
ES552093A0 (es) 1987-09-01
IE832908L (en) 1984-06-13
DE3382249D1 (de) 1991-05-16
DK143492A (da) 1992-11-30
IE63902B1 (en) 1995-06-14
DK143492D0 (da) 1992-11-30
ZA839231B (en) 1984-08-29
ES527964A0 (es) 1985-11-16
EP0112149A2 (en) 1984-06-27
DK171684B1 (da) 1997-03-10
JP2545055B2 (ja) 1996-10-16
ES557531A0 (es) 1988-02-16
HU197767B (en) 1989-05-29
EP0112149B1 (en) 1991-04-10
KR940002536B1 (ko) 1994-03-25
EP0303033A3 (en) 1989-10-25
NZ206534A (en) 1988-05-30
DK573783A (da) 1984-06-14
JPH06100585A (ja) 1994-04-12
JPH07173198A (ja) 1995-07-11
IL70414A (en) 1991-06-10
US4758516A (en) 1988-07-19
KR840007024A (ko) 1984-12-04
CA1220735A (en) 1987-04-21
DK172012B1 (da) 1997-09-15
ES8602133A1 (es) 1985-11-16
IL70414A0 (en) 1984-03-30
ES8708015A1 (es) 1987-09-01
EP0112149A3 (en) 1985-05-22
DK573783D0 (da) 1983-12-13
JP2677332B2 (ja) 1997-11-17
ES552094A0 (es) 1987-09-01
ES552095A0 (es) 1987-12-16
JPS59156284A (ja) 1984-09-05
ATE90360T1 (de) 1993-06-15
ATE62507T1 (de) 1991-04-15
JP2891882B2 (ja) 1999-05-17
ES544293A0 (es) 1988-04-16
ES8802249A1 (es) 1988-04-16
ES8708016A1 (es) 1987-09-01
EP0303033B1 (en) 1993-06-09
ES8801675A1 (es) 1988-02-16
EP0303033A2 (en) 1989-02-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20051028