DK143492A - Human-h2-praeprorelaxin, -prorelaxin og -relaxin samt polypeptid med relaxinaktivitet - Google Patents

Human-h2-praeprorelaxin, -prorelaxin og -relaxin samt polypeptid med relaxinaktivitet Download PDF

Info

Publication number
DK143492A
DK143492A DK143492A DK143492A DK143492A DK 143492 A DK143492 A DK 143492A DK 143492 A DK143492 A DK 143492A DK 143492 A DK143492 A DK 143492A DK 143492 A DK143492 A DK 143492A
Authority
DK
Denmark
Prior art keywords
relaxin
human
praeprorelaxin
prorelaxin
polypeptide
Prior art date
Application number
DK143492A
Other languages
English (en)
Other versions
DK143492D0 (da
DK172012B1 (da
Inventor
Peter John Hudson
Hugh David Niall
Geoffrey William Tregar
Original Assignee
Florey Howard Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3769889&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK143492(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Florey Howard Inst filed Critical Florey Howard Inst
Publication of DK143492A publication Critical patent/DK143492A/da
Publication of DK143492D0 publication Critical patent/DK143492D0/da
Application granted granted Critical
Publication of DK172012B1 publication Critical patent/DK172012B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Reproductive Health (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK143492A 1982-12-13 1992-11-30 Rekombinant human-H2-præprorelaxin, -prorelaxin og -relaxin samt polypeptid med relaxinaktivitet. DK172012B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPF724782 1982-12-13
AUPF724782 1982-12-13

Publications (3)

Publication Number Publication Date
DK143492A true DK143492A (da) 1992-11-30
DK143492D0 DK143492D0 (da) 1992-11-30
DK172012B1 DK172012B1 (da) 1997-09-15

Family

ID=3769889

Family Applications (2)

Application Number Title Priority Date Filing Date
DK573783A DK171684B1 (da) 1982-12-13 1983-12-13 Dobbeltstrenget DNA-fragment, der koder for human-H2-præprorelaxin, human-H2-prorelaxin eller A- og B-kæderne i human-H2-relaxin, samt DNA-transfervektor, der indeholder en cDNA-deoxynukleotidsekvens, som svarer til et sådant DNA-fragment, celle transformeret med en sådan DNA-transfervektor, og fremgangsmåde til fremstilling af human-H2-prorelaxin eller -H2-relaxin ved dyrkning af en sådan celle
DK143492A DK172012B1 (da) 1982-12-13 1992-11-30 Rekombinant human-H2-præprorelaxin, -prorelaxin og -relaxin samt polypeptid med relaxinaktivitet.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK573783A DK171684B1 (da) 1982-12-13 1983-12-13 Dobbeltstrenget DNA-fragment, der koder for human-H2-præprorelaxin, human-H2-prorelaxin eller A- og B-kæderne i human-H2-relaxin, samt DNA-transfervektor, der indeholder en cDNA-deoxynukleotidsekvens, som svarer til et sådant DNA-fragment, celle transformeret med en sådan DNA-transfervektor, og fremgangsmåde til fremstilling af human-H2-prorelaxin eller -H2-relaxin ved dyrkning af en sådan celle

Country Status (14)

Country Link
US (1) US4758516A (da)
EP (2) EP0112149B1 (da)
JP (3) JP2545055B2 (da)
KR (1) KR940002536B1 (da)
AT (2) ATE62507T1 (da)
CA (1) CA1220735A (da)
DE (1) DE3382249D1 (da)
DK (2) DK171684B1 (da)
ES (6) ES527964A0 (da)
HU (1) HU197767B (da)
IE (1) IE63902B1 (da)
IL (1) IL70414A (da)
NZ (1) NZ206534A (da)
ZA (1) ZA839231B (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0101309B1 (en) * 1982-08-12 1991-01-16 Howard Florey Institute Of Experimental Physiology And Medicine Molecular cloning and characterization of a gene sequence coding for human relaxin
US5179195A (en) * 1982-12-13 1993-01-12 Howard Florey Institute Of Experimental Physiology And Medicine Human relaxin polypeptides
US4835251A (en) * 1986-06-23 1989-05-30 Genetech, Inc. Method of chain combination
NZ221789A (en) * 1986-09-12 1991-05-28 Genentech Inc Recombinant prorelaxin, its preparation and pharmaceutical compositions comprising it
JP2815649B2 (ja) * 1988-02-26 1998-10-27 ジェネンテク，インコーポレイテッド ヒトレラキシン製剤
AU623518B2 (en) * 1989-05-04 1992-05-14 Genentech Inc. Processes and compositions for the isolation of human relaxin
US5089419A (en) * 1989-08-07 1992-02-18 International Canine Genetics Detection of pregnancy by identification of the c peptide of relaxin in the urine of animals
US5166191A (en) * 1991-08-19 1992-11-24 Genentech, Inc. Use of relaxin in cardiovascular therapy
US5478807A (en) * 1991-08-19 1995-12-26 Genentech, Inc. Use of relaxin in the treatment of bradycardia
WO1993009436A1 (en) * 1991-10-28 1993-05-13 Board Of Regents, The University Of Texas System A method for detecting a differentiation marker in normal and carcinoma cells and in biological samples and body fluid
US6348327B1 (en) 1991-12-06 2002-02-19 Genentech, Inc. Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells
EP0707650B1 (en) * 1993-06-21 2003-05-21 Genentech, Inc. Process for producing human relaxin
US20050032683A1 (en) 2000-10-04 2005-02-10 Amento Edward P. Methods of modulating apoptosis by administration of relaxin agonists or antagonists
US20040006205A1 (en) * 2001-04-03 2004-01-08 Li Li Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US20030088884A1 (en) * 2001-08-17 2003-05-08 Hsu Sheau Yu Mammalian relaxin receptors
AU2003903124A0 (en) * 2003-06-20 2003-07-10 Mark Del Borgo Analogues of heteromeric proteins
EP1753449A4 (en) * 2004-04-30 2009-09-23 Corthera Inc METHOD AND COMPOSITIONS FOR CONTROLLING FEDERAL GROWTH BY RELAXIN MODULATION
US20060052304A1 (en) * 2004-09-02 2006-03-09 Bas Medical, Inc. Method for remodeling bone and related sutures
US20110166070A1 (en) * 2008-05-16 2011-07-07 Stewart Dennis R Method of preventing premature delivery
GR1006941B (el) 2009-06-01 2010-08-27 Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), Πεπτιδικη συνθεση (peptide synthesis)
US8389475B2 (en) * 2009-08-10 2013-03-05 The Board Of Trustees Of The Leland Stanford Junior University Relaxin analogs
PL2605789T3 (pl) 2010-08-17 2019-11-29 Ambrx Inc Zmodyfikowane polipeptydy relaksyny i ich zastosowania
KR20140054009A (ko) 2011-07-01 2014-05-08 바이엘 인텔렉쳐 프로퍼티 게엠베하 릴랙신 융합 폴리펩타이드 및 그의 용도
EP2630964A1 (en) 2012-02-22 2013-08-28 Immundiagnostik AG Method and medicament for treating patients in risk of prediabetes and type-2 diabetes
WO2015073727A1 (en) 2013-11-13 2015-05-21 Aequus Biopharma, Inc. Engineered glycoproteins and uses thereof
EP2946788A1 (en) 2014-05-23 2015-11-25 Immundiagnostik AG Method and composition for treating heart failure with preserved ejection fraction
MA45051A (fr) 2016-05-18 2019-03-27 Modernatx Inc Polynucléotides codant la relaxine
SG10201912034UA (en) 2017-02-08 2020-02-27 Bristol Myers Squibb Co Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4468464A (en) * 1974-11-04 1984-08-28 The Board Of Trustees Of The Leland Stanford Junior University Biologically functional molecular chimeras
GR70279B (da) * 1979-09-12 1982-09-03 Univ California
US4267101A (en) * 1980-02-01 1981-05-12 Serono Laboratories Inc. Process for obtaining human relaxin from fetal membranes
EP0068375A3 (en) * 1981-06-22 1983-04-13 G.D. Searle & Co. Recombinant dna techniques for the production of relaxin
IE55479B1 (en) * 1982-02-12 1990-09-26 Florey Howard Inst Molecular cloning and characterization of the gene sequence coding for porcine relaxin
EP0101309B1 (en) * 1982-08-12 1991-01-16 Howard Florey Institute Of Experimental Physiology And Medicine Molecular cloning and characterization of a gene sequence coding for human relaxin

Also Published As

Publication number Publication date
HU197767B (en) 1989-05-29
ES8602133A1 (es) 1985-11-16
JP2677332B2 (ja) 1997-11-17
KR840007024A (ko) 1984-12-04
US4758516A (en) 1988-07-19
DK573783D0 (da) 1983-12-13
EP0112149A2 (en) 1984-06-27
EP0303033A2 (en) 1989-02-15
IE63902B1 (en) 1995-06-14
CA1220735A (en) 1987-04-21
ES552095A0 (es) 1987-12-16
JPH07173198A (ja) 1995-07-11
DK573783A (da) 1984-06-14
IL70414A (en) 1991-06-10
JP2545055B2 (ja) 1996-10-16
ATE62507T1 (de) 1991-04-15
DK171684B1 (da) 1997-03-10
EP0303033A3 (en) 1989-10-25
ATE90360T1 (de) 1993-06-15
DE3382249D1 (de) 1991-05-16
JPS59156284A (ja) 1984-09-05
ES527964A0 (es) 1985-11-16
EP0112149A3 (en) 1985-05-22
NZ206534A (en) 1988-05-30
JPH06100585A (ja) 1994-04-12
EP0112149B1 (en) 1991-04-10
ES557531A0 (es) 1988-02-16
DK143492D0 (da) 1992-11-30
ES8801675A1 (es) 1988-02-16
ES552094A0 (es) 1987-09-01
IL70414A0 (en) 1984-03-30
ES8708016A1 (es) 1987-09-01
ZA839231B (en) 1984-08-29
EP0303033B1 (en) 1993-06-09
IE832908L (en) 1984-06-13
JP2891882B2 (ja) 1999-05-17
ES544293A0 (es) 1988-04-16
DK172012B1 (da) 1997-09-15
ES8802249A1 (es) 1988-04-16
KR940002536B1 (ko) 1994-03-25
ES8801373A1 (es) 1987-12-16
ES8708015A1 (es) 1987-09-01
ES552093A0 (es) 1987-09-01

Similar Documents

Publication Publication Date Title
DK143492A (da) Human-h2-praeprorelaxin, -prorelaxin og -relaxin samt polypeptid med relaxinaktivitet
FI851336A0 (fi) Ny fysiologiskt aktiv human polypeptid.
DK156592A (da) Human-h1-praeprorelaxin, -prorelaxin og -relaxin samt polypeptid med relaxinaktivitet og fremgangsmaade til sammenfoejning af a- og b-kaederne i human-h1-relaxin
DE3789413D1 (de) Lymphokin-ähnliche Peptide.
DE3882593D1 (de) Polypeptid und dessen herstellung.
DE3579148D1 (de) Polypeptid und polypeptidzusammensetzung.
DK551287D0 (da) Polypeptid
SE8403377D0 (sv) Nya peptider
DK50987D0 (da) Polypeptid med plasminogenaktivatorvirkning
DE3886517D1 (de) Menschlicher Prourokinase ähnliches Polypeptid.
NO854903L (no) Peptidvaksine eller -diagnosemiddel, samt polypeptid for slik anvendelse.
IT8620026A0 (it) Tripeptide ad attivita'immunostimolante.
IT8620027A0 (it) Tripeptide ad attivita'immunostimolante.
DK527287D0 (da) Polypeptid med interleukin-2-aktiviteter
ATE98990T1 (de) Menschlicher prourokinase aehnliches polypeptid.
ATE92106T1 (de) Polypeptid und dessen herstellung.
NO893572D0 (no) Lunge-overflateaktivt protein og beslektet polypeptid.
IT8522187V0 (it) Dentarella per il comando dei nastri-pinze nei telai per tessitura con corpo in materiale leggero ed un riporto in acciaio, od altro materiale equivalente, a contorno dei denti.
ATE55414T1 (de) Polypeptid und polypeptidzusammensetzung.
ATE103339T1 (de) Lymphokin-aehnliche peptide.

Legal Events

Date Code Title Description
PBP Patent lapsed
B1 Patent granted (law 1993)
PUP Patent expired