ATE241012T1 - Verfahren zur herstellung von humanen relaxin - Google Patents

Verfahren zur herstellung von humanen relaxin

Info

Publication number
ATE241012T1
ATE241012T1 AT94920786T AT94920786T ATE241012T1 AT E241012 T1 ATE241012 T1 AT E241012T1 AT 94920786 T AT94920786 T AT 94920786T AT 94920786 T AT94920786 T AT 94920786T AT E241012 T1 ATE241012 T1 AT E241012T1
Authority
AT
Austria
Prior art keywords
producing human
human relaxin
relaxin
prorelaxin
naturally occurring
Prior art date
Application number
AT94920786T
Other languages
English (en)
Inventor
Tim Breece
Kirk Hayenga
Ernst Rinderknecht
Richard Vandlen
Daniel Yansura
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE241012T1 publication Critical patent/ATE241012T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT94920786T 1993-06-21 1994-06-20 Verfahren zur herstellung von humanen relaxin ATE241012T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8035493A 1993-06-21 1993-06-21
PCT/US1994/006997 WO1995000645A2 (en) 1993-06-21 1994-06-20 Process for producing relaxin

Publications (1)

Publication Number Publication Date
ATE241012T1 true ATE241012T1 (de) 2003-06-15

Family

ID=22156855

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94920786T ATE241012T1 (de) 1993-06-21 1994-06-20 Verfahren zur herstellung von humanen relaxin

Country Status (8)

Country Link
US (1) US5759807A (de)
EP (1) EP0707650B1 (de)
JP (2) JP3954091B2 (de)
AT (1) ATE241012T1 (de)
AU (1) AU691189B2 (de)
CA (1) CA2165781C (de)
DE (1) DE69432704T2 (de)
WO (1) WO1995000645A2 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0150565B1 (ko) * 1995-02-15 1998-08-17 김정재 유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법
US5612051A (en) * 1995-11-17 1997-03-18 Yue; Samuel K. Method of treating involuntary muscle dysfunction with relaxin hormone
US6709659B1 (en) 1996-08-02 2004-03-23 Zymogenetics, Inc. Antibodies that bind testis-specific insulin homolog polypeptides
JP2000503860A (ja) 1996-08-02 2000-04-04 ザイモジェネティクス，インコーポレイティド 精巣―特異的インシュリン同族体ポリペプチド
US6251863B1 (en) 1998-09-08 2001-06-26 Samuel K. Yue Method of preventing and treating symptoms of aging and neurodegenerative dysfunctions with relaxin
AU784477B2 (en) * 1999-11-19 2006-04-13 Shire Human Genetic Therapies, Inc. Nucleic acid construct for optimized production of products
US20050032683A1 (en) 2000-10-04 2005-02-10 Amento Edward P. Methods of modulating apoptosis by administration of relaxin agonists or antagonists
US20040006205A1 (en) * 2001-04-03 2004-01-08 Li Li Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US20050186526A1 (en) * 2002-11-01 2005-08-25 Bas Medical, Inc. Methods and systems for enabling and stabilizing tooth movement
US7878978B2 (en) * 2004-03-18 2011-02-01 University Of Pittsburgh- Of The Commonwealth System Of Higher Education Use of relaxin to increase arterial compliance
WO2005109002A2 (en) * 2004-05-12 2005-11-17 Galapagos N.V. Methods, compositions and compound assays for inhibiting amyloid-beta protein production
JP2008513356A (ja) * 2004-08-09 2008-05-01 アリオス バイオファーマ インク． 合成高度糖鎖付加プロテアーゼ耐性ポリペプチド変異体、それを使用する経口製剤および方法
US7597884B2 (en) * 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
US20060052304A1 (en) * 2004-09-02 2006-03-09 Bas Medical, Inc. Method for remodeling bone and related sutures
US20080260820A1 (en) * 2007-04-19 2008-10-23 Gilles Borrelly Oral dosage formulations of protease-resistant polypeptides
MX2010012502A (es) 2008-05-16 2011-04-11 Corthera Inc Metodo para el tratamiento de insuficiencia cardiaca cronica.
GB2462221B (en) 2008-05-16 2010-09-01 Corthera Inc Administration of relaxin to reduce diuretic use in humans with acute decompensated heart failure
US9052304B2 (en) 2009-03-13 2015-06-09 Terrasep, Llc Methods and apparatus for centrifugal liquid chromatography
GR1006941B (el) 2009-06-01 2010-08-27 Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), Πεπτιδικη συνθεση (peptide synthesis)
RU2564900C2 (ru) 2010-03-10 2015-10-10 Дзе Юниверсити Оф Флорида Рисерч Фаундейшн, Инк. Модулирование аквапоринов релаксином
MY162837A (en) 2010-08-17 2017-07-31 Ambrx Inc Modified relaxin polypeptides and their uses
JP6276690B2 (ja) 2011-08-04 2018-02-07 ファリス バイオテック ゲーエムベーハー ヒトリラキシン−２を調製する方法
CN102643825A (zh) * 2011-11-18 2012-08-22 上海佑科生物技术有限公司 松弛素野生型和突变体的制备方法及其所制备的松弛素野生型和突变体
EP2630964A1 (de) 2012-02-22 2013-08-28 Immundiagnostik AG Verfahren und Medikation zur Behandlung von Patienten mit Risiko für Prädiabetes und Typ-2-Diabetes
CN102603888B (zh) * 2012-04-11 2013-11-20 黑龙江八一农垦大学 一种人松弛素2前体及其制备方法
US9393288B2 (en) 2012-05-29 2016-07-19 The University Of Vermont And State Agricultural College Methods of treating diseases associated with PPARγ
US9907833B2 (en) 2013-07-25 2018-03-06 University Of Florida Research Foundation, Incorporated Use of relaxin to treat placental syndromes
JP6822839B2 (ja) 2013-09-13 2021-01-27 ザ・スクリップス・リサーチ・インスティテュート 修飾された治療剤、及びその組成物
US20160296632A1 (en) 2013-11-13 2016-10-13 Aequus Biopharma, Inc. Engineered glycoproteins and uses thereof
AU2014364589B2 (en) 2013-12-18 2020-02-27 The California Institute For Biomedical Research Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof
EP3204405B1 (de) * 2014-10-09 2020-12-02 Cathay Biotech Inc. Expression von rekombinanten tetrazyklin-effluxpumpen zur herstellung von lysin oder lysin-abgeleiteten produkten sowie verfahren und anwendungen davon
CN107417787B (zh) * 2016-05-23 2020-11-17 江苏恒瑞医药股份有限公司 一种人松弛素2类似物的制备方法
ES2963839T3 (es) 2017-02-08 2024-04-02 Bristol Myers Squibb Co Polipéptidos de relaxina modificados que comprenden un potenciador farmacocinético y usos de los mismos

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0068375A3 (de) * 1981-06-22 1983-04-13 G.D. Searle & Co. Rekombinante DNS Technik zur Herstellung von Relaxin
AU561670B2 (en) * 1982-06-10 1987-05-14 Howard Florey Institute Of Experimental Physiology And Medicine Peptides with relaxin activity
US4656249A (en) * 1982-06-10 1987-04-07 Howard Florey Institute Of Experimental Physiology And Medicine Peptides with relaxin activity
ATE78042T1 (de) * 1982-08-12 1992-07-15 Florey Howard Inst Analoge des humanen relaxins.
US5145962A (en) * 1982-08-12 1992-09-08 Howard Florey Institute Of Experimental Physiology And Medicine Human pro relaxin polypeptides
US5023321A (en) * 1982-12-13 1991-06-11 Howard Florey Institute Of Experimental Physiology & Medicine Molecular cloning and characterization of a further gene sequence coding for human relaxin
NZ206534A (en) * 1982-12-13 1988-05-30 Florey Howard Inst Molecular cloning and characterisation of gene sequence coding for human relaxin
US5179195A (en) * 1982-12-13 1993-01-12 Howard Florey Institute Of Experimental Physiology And Medicine Human relaxin polypeptides
US4518526A (en) * 1982-12-22 1985-05-21 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
JPS63230089A (ja) * 1987-03-18 1988-09-26 Takeda Chem Ind Ltd 分泌発現による蛋白質の製造法
US5304473A (en) * 1991-06-11 1994-04-19 Eli Lilly And Company A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production
US5166191A (en) * 1991-08-19 1992-11-24 Genentech, Inc. Use of relaxin in cardiovascular therapy

Also Published As

Publication number Publication date
DE69432704T2 (de) 2004-02-26
CA2165781C (en) 2007-02-13
JPH09501911A (ja) 1997-02-25
WO1995000645A2 (en) 1995-01-05
DE69432704D1 (de) 2003-06-26
AU691189B2 (en) 1998-05-14
US5759807A (en) 1998-06-02
JP3954091B2 (ja) 2007-08-08
WO1995000645A3 (en) 1995-02-09
AU7176594A (en) 1995-01-17
EP0707650A1 (de) 1996-04-24
EP0707650B1 (de) 2003-05-21
CA2165781A1 (en) 1995-01-05
JP2007014342A (ja) 2007-01-25

Similar Documents

Publication Publication Date Title
ATE241012T1 (de) Verfahren zur herstellung von humanen relaxin
DE69716767D1 (de) Verfahren zur herstellung von tolterodin
DE69101775D1 (de) Verfahren zur Herstellung von Wasserstoffperoxid.
DE69610433T2 (de) Verfahren zur herstellung von halogenierten alkanen
DE58908534D1 (de) Verfahren zur Herstellung von doppelt-haploiden Gurken.
DE69409148D1 (de) Verfahren zur Herstellung von Wasserstoffperoxid
DE69606495D1 (de) Verfahren zur Herstellung von depolymerisiertem Naturkautschuk
DE69407653T2 (de) Verfahren zur Herstellung von Wasserstoffsuperoxyd
DE69424024D1 (de) Verfahren zur Herstellung von Laktamen
DE59003282D1 (de) Verfahren zur Herstellung von Dawsonit.
DE59300418D1 (de) Verfahren zur Herstellung von natürlichen Antioxidantien.
DE69314445T2 (de) Verfahren zur Herstellung von Wasserstoffperoxyd
DE69605064D1 (de) Verfahren zur Herstellung von Wasserstoffperoxid
DE69015814D1 (de) Verfahren zur Herstellung von Calciumhypochlorit.
DE69023991D1 (de) Verfahren zur Herstellung von Chlortrifluorethylen.
ATE115514T1 (de) Verfahren zur herstellung von chlordioxyd.
DE69611331D1 (de) Verfahren zur Herstellung von S-Phenyl-L-Cystein
DE69611505T2 (de) Verfahren zur Herstellung von all-trans Polyprenolen
DE69014042D1 (de) Verfahren zur Herstellung von menschlichem Osteocalcin.
DE69603243T2 (de) Verfahren zur Herstellung von Ethenylamiden
ATE185134T1 (de) Verbessertes verfahren zur herstellung von sulfonyl isocyanaten
ATE108486T1 (de) Verfahren zur herstellung von tocopherolen.
DE69609804D1 (de) Verfahren zur Herstellung von Fluorenon
ATE201196T1 (de) Verfahren zur herstellung von weitgehend isomerenreinen alpha-bisoximen
DE69419676T2 (de) Verfahren zur Herstellung von Bohnenpüree

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0707650

Country of ref document: EP