ATE241012T1 - Verfahren zur herstellung von humanen relaxin - Google Patents
Verfahren zur herstellung von humanen relaxinInfo
- Publication number
- ATE241012T1 ATE241012T1 AT94920786T AT94920786T ATE241012T1 AT E241012 T1 ATE241012 T1 AT E241012T1 AT 94920786 T AT94920786 T AT 94920786T AT 94920786 T AT94920786 T AT 94920786T AT E241012 T1 ATE241012 T1 AT E241012T1
- Authority
- AT
- Austria
- Prior art keywords
- producing human
- human relaxin
- relaxin
- prorelaxin
- naturally occurring
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- BJRCFZKVYNDCJE-WBSNEMHCSA-N 99489-95-9 Chemical compound C([C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@H](C(N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)NCC(=O)N2)[C@@H](C)CC)=O)CSSC[C@@H](C(NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC1=O)C(O)=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O)[C@@H](C)CC)[C@@H](C)CC)C(C)C)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CCCCN)C(C)C)[C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C1=CC=C(O)C=C1 BJRCFZKVYNDCJE-WBSNEMHCSA-N 0.000 title 1
- 108010087851 prorelaxin Proteins 0.000 abstract 2
- 108090000103 Relaxin Proteins 0.000 abstract 1
- 102000003743 Relaxin Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8035493A | 1993-06-21 | 1993-06-21 | |
| PCT/US1994/006997 WO1995000645A2 (en) | 1993-06-21 | 1994-06-20 | Process for producing relaxin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE241012T1 true ATE241012T1 (de) | 2003-06-15 |
Family
ID=22156855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94920786T ATE241012T1 (de) | 1993-06-21 | 1994-06-20 | Verfahren zur herstellung von humanen relaxin |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5759807A (de) |
| EP (1) | EP0707650B1 (de) |
| JP (2) | JP3954091B2 (de) |
| AT (1) | ATE241012T1 (de) |
| AU (1) | AU691189B2 (de) |
| CA (1) | CA2165781C (de) |
| DE (1) | DE69432704T2 (de) |
| WO (1) | WO1995000645A2 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0150565B1 (ko) * | 1995-02-15 | 1998-08-17 | 김정재 | 유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법 |
| US5612051A (en) * | 1995-11-17 | 1997-03-18 | Yue; Samuel K. | Method of treating involuntary muscle dysfunction with relaxin hormone |
| US5959075A (en) * | 1996-08-02 | 1999-09-28 | Zymogenetics, Inc. | Testis-specific insulin homolog polypeptides |
| US6709659B1 (en) | 1996-08-02 | 2004-03-23 | Zymogenetics, Inc. | Antibodies that bind testis-specific insulin homolog polypeptides |
| US6251863B1 (en) | 1998-09-08 | 2001-06-26 | Samuel K. Yue | Method of preventing and treating symptoms of aging and neurodegenerative dysfunctions with relaxin |
| JP2003514532A (ja) * | 1999-11-19 | 2003-04-22 | トランスカーヨティック セラピーズ インコーポレイテッド | 生成物の産生量を最適化するための核酸構築体 |
| US20050032683A1 (en) | 2000-10-04 | 2005-02-10 | Amento Edward P. | Methods of modulating apoptosis by administration of relaxin agonists or antagonists |
| US20040006205A1 (en) * | 2001-04-03 | 2004-01-08 | Li Li | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| US20050186526A1 (en) * | 2002-11-01 | 2005-08-25 | Bas Medical, Inc. | Methods and systems for enabling and stabilizing tooth movement |
| US7878978B2 (en) * | 2004-03-18 | 2011-02-01 | University Of Pittsburgh- Of The Commonwealth System Of Higher Education | Use of relaxin to increase arterial compliance |
| US20050287519A1 (en) * | 2004-05-12 | 2005-12-29 | Merchiers Pascal G | Methods, compositions and compound assays for inhibiting amyloid-beta protein production |
| CA2576030A1 (en) * | 2004-08-09 | 2006-02-23 | Alios Biopharma Inc. | Synthetic hyperglycosylated, protease-resistant polypeptide variants, oral formulations and methods of using the same |
| US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
| US20060052304A1 (en) * | 2004-09-02 | 2006-03-09 | Bas Medical, Inc. | Method for remodeling bone and related sutures |
| US20080260820A1 (en) * | 2007-04-19 | 2008-10-23 | Gilles Borrelly | Oral dosage formulations of protease-resistant polypeptides |
| MX336145B (es) | 2008-05-16 | 2016-01-08 | Corthera Inc | Metodo para el tratamiento de insuficiencia cardiaca cronica. |
| WO2009140659A2 (en) | 2008-05-16 | 2009-11-19 | Corthera, Inc. | Method of treating dyspnea associated with acute heart failure |
| US8293100B2 (en) | 2009-03-13 | 2012-10-23 | Terrasep, Llc | Methods and apparatus for centrifugal liquid chromatography |
| GR1006941B (el) | 2009-06-01 | 2010-08-27 | Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), | Πεπτιδικη συνθεση (peptide synthesis) |
| US20130053318A1 (en) | 2010-03-10 | 2013-02-28 | Parry Laura | Modulating aquaporins with relaxin |
| SMT201900495T1 (it) | 2010-08-17 | 2019-11-13 | Ambrx Inc | Polipeptidi di relaxina modificati e loro usi |
| EP2739647B1 (de) | 2011-08-04 | 2016-07-20 | Relaxera GmbH & Co. KG i.G. c/o Immundiagnostik AG | Verfahren zur herstellung von humanem relaxin-2 |
| CN102643825A (zh) * | 2011-11-18 | 2012-08-22 | 上海佑科生物技术有限公司 | 松弛素野生型和突变体的制备方法及其所制备的松弛素野生型和突变体 |
| EP2630964A1 (de) | 2012-02-22 | 2013-08-28 | Immundiagnostik AG | Verfahren und Medikation zur Behandlung von Patienten mit Risiko für Prädiabetes und Typ-2-Diabetes |
| CN102603888B (zh) * | 2012-04-11 | 2013-11-20 | 黑龙江八一农垦大学 | 一种人松弛素2前体及其制备方法 |
| US9393288B2 (en) | 2012-05-29 | 2016-07-19 | The University Of Vermont And State Agricultural College | Methods of treating diseases associated with PPARγ |
| US9907833B2 (en) | 2013-07-25 | 2018-03-06 | University Of Florida Research Foundation, Incorporated | Use of relaxin to treat placental syndromes |
| AU2014318579A1 (en) | 2013-09-13 | 2016-04-14 | The California Institute For Biomedical Research | Modified therapeutic agents and compositions thereof |
| WO2015073727A1 (en) | 2013-11-13 | 2015-05-21 | Aequus Biopharma, Inc. | Engineered glycoproteins and uses thereof |
| KR102455171B1 (ko) | 2013-12-18 | 2022-10-14 | 더 스크립스 리서치 인스티튜트 | 변형된 치료제, 스테이플드 펩티드 지질 접합체, 및 이의 조성물 |
| SG11201605273XA (en) * | 2014-02-03 | 2016-08-30 | Novartis Ag | Filters for infusion sets |
| WO2016054792A1 (en) * | 2014-10-09 | 2016-04-14 | Cathay R&D Center Co., Ltd. | Expression of recombinant tetracycline efflux pumps for the production of lysine or lysine-derived products, and methods and applications thereof |
| CN107417787B (zh) * | 2016-05-23 | 2020-11-17 | 江苏恒瑞医药股份有限公司 | 一种人松弛素2类似物的制备方法 |
| US10266578B2 (en) | 2017-02-08 | 2019-04-23 | Bristol-Myers Squibb Company | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
| CA3163507A1 (en) | 2019-12-04 | 2021-06-10 | The Scripps Research Institute | Peptide conjugates and methods of use |
| IL309067A (en) | 2021-06-09 | 2024-02-01 | Scripps Research Inst | Long-acting dual gip/glp-1 peptide conjugates and methods of use |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0068375A3 (de) * | 1981-06-22 | 1983-04-13 | G.D. Searle & Co. | Rekombinante DNS Technik zur Herstellung von Relaxin |
| US4656249A (en) * | 1982-06-10 | 1987-04-07 | Howard Florey Institute Of Experimental Physiology And Medicine | Peptides with relaxin activity |
| AU561670B2 (en) * | 1982-06-10 | 1987-05-14 | Howard Florey Institute Of Experimental Physiology And Medicine | Peptides with relaxin activity |
| IL69469A (en) * | 1982-08-12 | 1991-06-10 | Florey Howard Inst | Polypeptide having human h1-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors |
| US5145962A (en) * | 1982-08-12 | 1992-09-08 | Howard Florey Institute Of Experimental Physiology And Medicine | Human pro relaxin polypeptides |
| US5023321A (en) * | 1982-12-13 | 1991-06-11 | Howard Florey Institute Of Experimental Physiology & Medicine | Molecular cloning and characterization of a further gene sequence coding for human relaxin |
| US5179195A (en) * | 1982-12-13 | 1993-01-12 | Howard Florey Institute Of Experimental Physiology And Medicine | Human relaxin polypeptides |
| IL70414A (en) * | 1982-12-13 | 1991-06-10 | Florey Howard Inst | Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors |
| US4518526A (en) * | 1982-12-22 | 1985-05-21 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| JPS63230089A (ja) * | 1987-03-18 | 1988-09-26 | Takeda Chem Ind Ltd | 分泌発現による蛋白質の製造法 |
| US5304473A (en) * | 1991-06-11 | 1994-04-19 | Eli Lilly And Company | A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production |
| US5166191A (en) * | 1991-08-19 | 1992-11-24 | Genentech, Inc. | Use of relaxin in cardiovascular therapy |
-
1994
- 1994-06-20 EP EP94920786A patent/EP0707650B1/de not_active Expired - Lifetime
- 1994-06-20 AU AU71765/94A patent/AU691189B2/en not_active Expired
- 1994-06-20 AT AT94920786T patent/ATE241012T1/de active
- 1994-06-20 WO PCT/US1994/006997 patent/WO1995000645A2/en not_active Ceased
- 1994-06-20 CA CA002165781A patent/CA2165781C/en not_active Expired - Lifetime
- 1994-06-20 JP JP50303695A patent/JP3954091B2/ja not_active Expired - Lifetime
- 1994-06-20 DE DE69432704T patent/DE69432704T2/de not_active Expired - Lifetime
-
1995
- 1995-05-22 US US08/443,568 patent/US5759807A/en not_active Expired - Lifetime
-
2006
- 2006-07-31 JP JP2006208539A patent/JP2007014342A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0707650A1 (de) | 1996-04-24 |
| US5759807A (en) | 1998-06-02 |
| WO1995000645A3 (en) | 1995-02-09 |
| CA2165781C (en) | 2007-02-13 |
| EP0707650B1 (de) | 2003-05-21 |
| DE69432704T2 (de) | 2004-02-26 |
| AU691189B2 (en) | 1998-05-14 |
| DE69432704D1 (de) | 2003-06-26 |
| AU7176594A (en) | 1995-01-17 |
| CA2165781A1 (en) | 1995-01-05 |
| JP2007014342A (ja) | 2007-01-25 |
| JP3954091B2 (ja) | 2007-08-08 |
| JPH09501911A (ja) | 1997-02-25 |
| WO1995000645A2 (en) | 1995-01-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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