MX336145B - Metodo para el tratamiento de insuficiencia cardiaca cronica. - Google Patents
Metodo para el tratamiento de insuficiencia cardiaca cronica.Info
- Publication number
- MX336145B MX336145B MX2012010249A MX2012010249A MX336145B MX 336145 B MX336145 B MX 336145B MX 2012010249 A MX2012010249 A MX 2012010249A MX 2012010249 A MX2012010249 A MX 2012010249A MX 336145 B MX336145 B MX 336145B
- Authority
- MX
- Mexico
- Prior art keywords
- heart failure
- chronic heart
- treating chronic
- methods
- relaxin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2221—Relaxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
La presente invención se refiere a métodos para el tratamiento de los sujetos humanos que padecen insuficiencia cardiaca crónica. Los métodos descritos en la presente emplean la administración de relaxina. Una relaxina humana H2 farmacéuticamente activa para usarse en el tratamiento de insuficiencia cardiaca crónica en donde la relaxina está adaptada para ser administrable a un sujeto que tiene insuficiencia cardiaca clase II o clase III de acuerdo con la clasificación de la Asociación Cardiaca de Nueva York de insuficiencia cardiaca, al inicio de la administración a una cantidad terapéuticamente efectiva para reducir la frecuencia o duración de la hospitalización del sujeto, comparado a un tratamiento sin dicha relaxina, donde la frecuencia de descompensaciones es reducida a comparación de un tratamiento sin relaxina, y en donde dicha relaxina está formulada por una dosis fija de 10 a 960 µg/kg/día.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12788908P | 2008-05-16 | 2008-05-16 | |
US19054508P | 2008-08-28 | 2008-08-28 | |
US20124008P | 2008-12-08 | 2008-12-08 | |
PCT/US2009/044247 WO2009140657A2 (en) | 2008-05-16 | 2009-05-15 | Method of treating chronic heart failure |
Publications (1)
Publication Number | Publication Date |
---|---|
MX336145B true MX336145B (es) | 2016-01-08 |
Family
ID=41319370
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010012502A MX2010012502A (es) | 2008-05-16 | 2009-05-15 | Metodo para el tratamiento de insuficiencia cardiaca cronica. |
MX2012010249A MX336145B (es) | 2008-05-16 | 2009-05-15 | Metodo para el tratamiento de insuficiencia cardiaca cronica. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010012502A MX2010012502A (es) | 2008-05-16 | 2009-05-15 | Metodo para el tratamiento de insuficiencia cardiaca cronica. |
Country Status (10)
Country | Link |
---|---|
US (3) | US20110144019A1 (es) |
EP (2) | EP3150219A1 (es) |
JP (3) | JP2011520917A (es) |
CN (2) | CN102026649A (es) |
AU (1) | AU2009246112B2 (es) |
BR (1) | BRPI0912559A2 (es) |
CA (1) | CA2724535A1 (es) |
MX (2) | MX2010012502A (es) |
RU (1) | RU2512933C2 (es) |
WO (1) | WO2009140657A2 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ598709A (en) | 2008-05-16 | 2013-09-27 | Corthera Inc | Treating acute decompensated heart failure with relaxin |
JP5970380B2 (ja) | 2010-03-10 | 2016-08-17 | ザ ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド | リラキシンによるアクアポリンの調節 |
EP2646572B1 (en) * | 2010-12-01 | 2017-02-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Diagnostic and treatment of chronic heart failure |
BR112014000474A2 (pt) * | 2011-07-08 | 2017-02-21 | Bayer Ip Gmbh | proteínas de fusão libertadoras de relaxina e suas utilizações |
CN103764674A (zh) * | 2011-08-04 | 2014-04-30 | 法瑞斯生物技术有限公司 | 制备人松弛素-2的方法 |
WO2013033324A2 (en) | 2011-08-31 | 2013-03-07 | University Of Florida Research Foundation, Inc. | Materials and methods for modulating activity of bone marrow derived cells |
EP2795338A4 (en) * | 2011-12-21 | 2015-11-04 | Nuclea Biotechnologies Inc | BIOMARKERS OF CONGESTIVE HEART FAILURE |
PT2814513T (pt) * | 2012-02-14 | 2018-03-02 | Univ California | Entrega sistémica e expressão regulada de genes parácrinos para doenças cardiovasculares e outras doenças |
WO2014115033A2 (en) * | 2013-01-25 | 2014-07-31 | Cardiorentis Ltd. | Methods of treating cardiovascular indications |
WO2015067113A1 (zh) * | 2013-11-07 | 2015-05-14 | 上海恒瑞医药有限公司 | 人松驰素类似物、其药物组合物及其在医药上的应用 |
US10500227B2 (en) * | 2014-12-03 | 2019-12-10 | University Of Cincinnati | Bioactive gas-encapsulated echogenic liposomes and methods for treating cardiovascular disease |
EP3387019B1 (en) | 2015-12-09 | 2021-10-20 | The Scripps Research Institute | Relaxin immunoglobulin fusion proteins and methods of use |
CN110637027A (zh) | 2017-02-08 | 2019-12-31 | 百时美施贵宝公司 | 包含药代动力学增强子的修饰的松弛素多肽及其用途 |
CN107335051A (zh) * | 2017-08-18 | 2017-11-10 | 温州医科大学附属第医院 | 一种保护慢性心衰肾功能的药物组合物 |
EP4058048A1 (en) * | 2019-11-16 | 2022-09-21 | Relaxera Pharmazeutische Gesellschaft mbH & Co. KG | Medical composition for treating cardiac wasting and cachexia |
CN116406297A (zh) * | 2020-08-05 | 2023-07-07 | 阿斯克肋匹奥生物制药公司 | 治疗心脏疾患和充血性心力衰竭以及施用aav载体的方法 |
RU2748529C1 (ru) * | 2020-09-01 | 2021-05-26 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр кардиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ кардиологии" Минздрава России) | Способ определения этиологии хронической сердечной недостаточности |
WO2024121362A1 (en) * | 2022-12-09 | 2024-06-13 | Astrazeneca Ab | Dosing regimens using heterodimeric relaxin fusions |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5023321A (en) | 1982-12-13 | 1991-06-11 | Howard Florey Institute Of Experimental Physiology & Medicine | Molecular cloning and characterization of a further gene sequence coding for human relaxin |
US5166191A (en) * | 1991-08-19 | 1992-11-24 | Genentech, Inc. | Use of relaxin in cardiovascular therapy |
DE69432704T2 (de) | 1993-06-21 | 2004-02-26 | Genentech, Inc., South San Francisco | Verfahren zur Herstellung von humanen Relaxin |
US5811395A (en) | 1995-06-07 | 1998-09-22 | Medical University Of South Carolina | Relaxin analogs and derivatives methods and uses thereof |
RU2213559C2 (ru) * | 2000-01-26 | 2003-10-10 | Тюменская государственная медицинская академия | Способ лечения больных хронической сердечной недостаточностью на фоне ишемической болезни сердца |
DE10155843A1 (de) * | 2000-11-16 | 2003-01-30 | Immundiagnostik Ag | Verfahren zur Prognose und Diagnose von Herzinsuffizienz |
US20050113286A1 (en) * | 2002-03-18 | 2005-05-26 | Schreiner George F. | Methods for treating congestive heart failure |
EP1729817B1 (en) * | 2004-03-30 | 2014-03-05 | Industry-Academic Cooperation Foundation | Gene delivery system containing relaxin gene and pharmaceutical composition using relaxin |
US20080077025A1 (en) * | 2005-07-11 | 2008-03-27 | Leticia Delgado-Herrera | Methods for determining how to treat congestive heart failure |
US8492329B2 (en) | 2007-07-12 | 2013-07-23 | Compugen Ltd. | Bioactive peptides and methods of using same |
NZ598709A (en) * | 2008-05-16 | 2013-09-27 | Corthera Inc | Treating acute decompensated heart failure with relaxin |
-
2009
- 2009-05-15 MX MX2010012502A patent/MX2010012502A/es active IP Right Grant
- 2009-05-15 EP EP16174665.6A patent/EP3150219A1/en not_active Withdrawn
- 2009-05-15 CA CA2724535A patent/CA2724535A1/en not_active Abandoned
- 2009-05-15 JP JP2011509781A patent/JP2011520917A/ja not_active Withdrawn
- 2009-05-15 CN CN2009801176516A patent/CN102026649A/zh active Pending
- 2009-05-15 RU RU2010151470/14A patent/RU2512933C2/ru not_active IP Right Cessation
- 2009-05-15 EP EP09747738A patent/EP2288366A4/en not_active Ceased
- 2009-05-15 US US12/992,667 patent/US20110144019A1/en not_active Abandoned
- 2009-05-15 WO PCT/US2009/044247 patent/WO2009140657A2/en active Application Filing
- 2009-05-15 MX MX2012010249A patent/MX336145B/es unknown
- 2009-05-15 AU AU2009246112A patent/AU2009246112B2/en not_active Ceased
- 2009-05-15 BR BRPI0912559A patent/BRPI0912559A2/pt not_active Application Discontinuation
- 2009-05-15 CN CN201510202983.1A patent/CN104815319A/zh active Pending
-
2013
- 2013-07-11 US US13/939,648 patent/US20140005112A1/en not_active Abandoned
-
2014
- 2014-06-25 JP JP2014129744A patent/JP2014237648A/ja not_active Withdrawn
-
2016
- 2016-04-25 US US15/137,054 patent/US20160287672A1/en not_active Abandoned
- 2016-09-29 JP JP2016190522A patent/JP2017061453A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2014237648A (ja) | 2014-12-18 |
CN102026649A (zh) | 2011-04-20 |
EP3150219A1 (en) | 2017-04-05 |
WO2009140657A3 (en) | 2010-01-07 |
US20110144019A1 (en) | 2011-06-16 |
CA2724535A1 (en) | 2009-11-19 |
CN104815319A (zh) | 2015-08-05 |
US20160287672A1 (en) | 2016-10-06 |
BRPI0912559A2 (pt) | 2015-10-13 |
AU2009246112B2 (en) | 2013-05-02 |
JP2017061453A (ja) | 2017-03-30 |
AU2009246112A1 (en) | 2009-11-19 |
US20140005112A1 (en) | 2014-01-02 |
JP2011520917A (ja) | 2011-07-21 |
RU2010151470A (ru) | 2012-06-27 |
MX2010012502A (es) | 2011-04-11 |
RU2512933C2 (ru) | 2014-04-10 |
EP2288366A2 (en) | 2011-03-02 |
EP2288366A4 (en) | 2012-05-02 |
WO2009140657A2 (en) | 2009-11-19 |
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