IT1234977B - Espressione in e. coli polipeptidi ibridi contenenti la sequenza del fattore di rilascio dell'ormone della crescita - Google Patents

Espressione in e. coli polipeptidi ibridi contenenti la sequenza del fattore di rilascio dell'ormone della crescita

Info

Publication number
IT1234977B
IT1234977B IT8547856A IT4785685A IT1234977B IT 1234977 B IT1234977 B IT 1234977B IT 8547856 A IT8547856 A IT 8547856A IT 4785685 A IT4785685 A IT 4785685A IT 1234977 B IT1234977 B IT 1234977B
Authority
IT
Italy
Prior art keywords
expression
sequence
growth hormone
polypeptides containing
hormone release
Prior art date
Application number
IT8547856A
Other languages
English (en)
Other versions
IT8547856A0 (it
Inventor
De Fazio Gabriele
Canosi Umberto
Villa Stefano
Donini Silvia
Original Assignee
Serono Ist Farm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serono Ist Farm filed Critical Serono Ist Farm
Publication of IT8547856A0 publication Critical patent/IT8547856A0/it
Priority to IT8547856A priority Critical patent/IT1234977B/it
Priority to AT86102447T priority patent/ATE84548T1/de
Priority to EP86102447A priority patent/EP0199018B1/en
Priority to DE8686102447T priority patent/DE3687470T2/de
Priority to ZA861644A priority patent/ZA861644B/xx
Priority to IL78044A priority patent/IL78044A/xx
Priority to DK122486A priority patent/DK122486A/da
Priority to AU54843/86A priority patent/AU600891B2/en
Priority to JP61058448A priority patent/JPH0779701B2/ja
Priority to AR86303426A priority patent/AR242056A1/es
Priority to FI861217A priority patent/FI93125C/fi
Priority to ES553274A priority patent/ES8800722A1/es
Priority to NO861142A priority patent/NO175318C/no
Application granted granted Critical
Publication of IT1234977B publication Critical patent/IT1234977B/it
Priority to JP6029632A priority patent/JPH0816120B2/ja
Priority to JP7143597A priority patent/JP2537029B2/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
IT8547856A 1985-03-22 1985-03-22 Espressione in e. coli polipeptidi ibridi contenenti la sequenza del fattore di rilascio dell'ormone della crescita IT1234977B (it)

Priority Applications (15)

Application Number Priority Date Filing Date Title
IT8547856A IT1234977B (it) 1985-03-22 1985-03-22 Espressione in e. coli polipeptidi ibridi contenenti la sequenza del fattore di rilascio dell'ormone della crescita
AT86102447T ATE84548T1 (de) 1985-03-22 1986-02-25 Expression in e.coli von hybridpolypeptiden, die die sequenz des wachstumshormons ausloesenden faktors enthalten.
EP86102447A EP0199018B1 (en) 1985-03-22 1986-02-25 Expression in e.coli of hybrid polypeptides containing the growth hormone releasing factor sequence
DE8686102447T DE3687470T2 (de) 1985-03-22 1986-02-25 Expression in e.coli von hybridpolypeptiden, die die sequenz des wachstumshormons ausloesenden faktors enthalten.
ZA861644A ZA861644B (en) 1985-03-22 1986-03-05 Expression in e.coli of hybrid polypeptides containing the growth hormone releasing factor sequence
IL78044A IL78044A (en) 1985-03-22 1986-03-05 Expression in a microorganism of hybrid polypeptides containing the growth hormone releasing factor sequence preceded by a tryptophan amino acid
DK122486A DK122486A (da) 1985-03-22 1986-03-17 Ekspression af hybride polypeptider
AU54843/86A AU600891B2 (en) 1985-03-22 1986-03-18 Expression in E. coli of hybrid polypeptides containing the growth hormone releasing factor sequence
JP61058448A JPH0779701B2 (ja) 1985-03-22 1986-03-18 成長ホルモン放出因子を含むハイブリドポリペプチドをコ−ドする遺伝子
AR86303426A AR242056A1 (es) 1985-03-22 1986-03-19 Un gene estructural codificante de un polipeptido hibrido que contiene la secuencia de dna de trp-grf, dicho polipeptido como intermediario para la preparacion de grf44, grf40, grf37 y grf29.
FI861217A FI93125C (fi) 1985-03-22 1986-03-21 Kasvuhormonia vapauttavan tekijän sekvenssin sisältävien hybridipolypeptidien ilmentäminen E. colissa
ES553274A ES8800722A1 (es) 1985-03-22 1986-03-21 Metodo de produccion de un factor liberador de la hormona del crecimiento por la expresion en e. coli de polipeptidos hibridos
NO861142A NO175318C (no) 1985-03-22 1986-03-21 Hybridgen for veksthormonfrigjörende faktor, replikerbar mikrobiell ekspresjonsvektor inneholdende et slikt gen, samt mikroorganisme transformert med en slik vektor og hybridpolypeptid som inneholder en Trp-GRF
JP6029632A JPH0816120B2 (ja) 1985-03-22 1994-02-28 成長ホルモン放出因子を含むハイブリドポリペプチド
JP7143597A JP2537029B2 (ja) 1985-03-22 1995-06-09 成長ホルモン放出因子の製造方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8547856A IT1234977B (it) 1985-03-22 1985-03-22 Espressione in e. coli polipeptidi ibridi contenenti la sequenza del fattore di rilascio dell'ormone della crescita

Publications (2)

Publication Number Publication Date
IT8547856A0 IT8547856A0 (it) 1985-03-22
IT1234977B true IT1234977B (it) 1992-06-09

Family

ID=11262958

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8547856A IT1234977B (it) 1985-03-22 1985-03-22 Espressione in e. coli polipeptidi ibridi contenenti la sequenza del fattore di rilascio dell'ormone della crescita

Country Status (13)

Country Link
EP (1) EP0199018B1 (it)
JP (3) JPH0779701B2 (it)
AR (1) AR242056A1 (it)
AT (1) ATE84548T1 (it)
AU (1) AU600891B2 (it)
DE (1) DE3687470T2 (it)
DK (1) DK122486A (it)
ES (1) ES8800722A1 (it)
FI (1) FI93125C (it)
IL (1) IL78044A (it)
IT (1) IT1234977B (it)
NO (1) NO175318C (it)
ZA (1) ZA861644B (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1200162B (it) * 1985-12-18 1989-01-05 Serono Ist Farm Protezione della metionina in una catena polipeptidica dalla ossidazione irreversibile
US4828988A (en) * 1986-05-15 1989-05-09 Smith Kline - Rit Hybrid polypeptides comprising somatocrinine and alpha1 -antitrypsin, method for their production from bacterial clones and use thereof for the production of somatocrinine
US5565606A (en) * 1986-10-21 1996-10-15 Hoechst Aktiengesellschaft Synthesis of peptide aminoalkylamides and peptide hydrazides by the solid-phase method
NZ237857A (en) 1990-04-24 1992-05-26 Lilly Co Eli Polypeptide compounds with growth hormone releasing factor activity
US5512459A (en) * 1993-07-20 1996-04-30 Bionebraska, Inc. Enzymatic method for modification or recombinant polypeptides
DE4435960C2 (de) * 1994-10-07 1998-05-20 Goodwell Int Ltd Snowboardbindung
US6759393B1 (en) 1999-04-12 2004-07-06 Pfizer Inc. Growth hormone and growth hormone releasing hormone compositions
JP2000350590A (ja) * 1999-04-12 2000-12-19 Pfizer Prod Inc 成長ホルモン及び成長ホルモン放出ホルモン組成物
EP1205551A1 (en) * 2000-11-09 2002-05-15 Pfizer Products Inc. Growth hormone and growth hormone releasing hormone compositions

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA811368B (en) * 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
JPS58201796A (ja) * 1982-05-19 1983-11-24 Takeda Chem Ind Ltd 組換えｄｎａおよびその用途
GB2102006B (en) * 1981-06-16 1984-11-28 Takeda Chemical Industries Ltd Deoxyribonucleic acids, their production and use
US4499188A (en) * 1982-05-05 1985-02-12 Cetus Corporation Bacterial production of heterologous polypeptides under the control of a repressible promoter-operator
EP0108387B1 (en) * 1982-11-04 1990-05-16 F. Hoffmann-La Roche Ag Preparation of recombinant growth releasing factors
JPS59154989A (ja) * 1983-02-23 1984-09-04 Mitsubishi Chem Ind Ltd プラスミド
JPS59227899A (ja) * 1983-05-25 1984-12-21 チロン・コ−ポレイシヨン 成長ホルモン放出因子の製造方法
DE3327007A1 (de) * 1983-07-27 1985-02-07 Hoechst Ag, 6230 Frankfurt Herstellung von polypeptiden mit einem saeureamid-carboxyterminus
IT1198443B (it) * 1984-03-30 1988-12-21 Serono Ist Farm Espressione genetica di polipeptidi ibridi contenenti la sequenza della somatostatina
FR2587359B1 (fr) * 1985-05-28 1987-12-24 Sanofi Sa Derives non amides de la somatocrinine et procede de preparation par genie genetique

Also Published As

Publication number Publication date
ES553274A0 (es) 1987-12-01
JPH07316197A (ja) 1995-12-05
IL78044A0 (en) 1986-07-31
DK122486A (da) 1986-09-23
FI861217A0 (fi) 1986-03-21
FI93125C (fi) 1995-02-27
FI861217L (fi) 1986-09-23
JPH0710900A (ja) 1995-01-13
NO175318B (no) 1994-06-20
IT8547856A0 (it) 1985-03-22
JPH0816120B2 (ja) 1996-02-21
NO175318C (no) 1994-09-28
DE3687470D1 (de) 1993-02-25
IL78044A (en) 1991-07-18
ZA861644B (en) 1986-10-29
AU5484386A (en) 1986-09-25
DE3687470T2 (de) 1993-05-19
EP0199018A2 (en) 1986-10-29
JP2537029B2 (ja) 1996-09-25
FI93125B (fi) 1994-11-15
DK122486D0 (da) 1986-03-17
JPH0779701B2 (ja) 1995-08-30
AR242056A1 (es) 1993-02-26
EP0199018A3 (en) 1987-07-22
EP0199018B1 (en) 1993-01-13
ES8800722A1 (es) 1987-12-01
ATE84548T1 (de) 1993-01-15
AU600891B2 (en) 1990-08-30
NO861142L (no) 1986-09-23
JPS61274686A (ja) 1986-12-04

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Effective date: 19970321