IT1198443B - Espressione genetica di polipeptidi ibridi contenenti la sequenza della somatostatina - Google Patents

Espressione genetica di polipeptidi ibridi contenenti la sequenza della somatostatina

Info

Publication number
IT1198443B
IT1198443B IT47976/84A IT4797684A IT1198443B IT 1198443 B IT1198443 B IT 1198443B IT 47976/84 A IT47976/84 A IT 47976/84A IT 4797684 A IT4797684 A IT 4797684A IT 1198443 B IT1198443 B IT 1198443B
Authority
IT
Italy
Prior art keywords
genetic expression
polypeptides containing
hybrid polypeptides
somatostatin sequence
somatostatin
Prior art date
Application number
IT47976/84A
Other languages
English (en)
Other versions
IT8447976A0 (it
Inventor
Fazio Gabriele De
Umberto Canosi
Stefano Villa
Silvia Donini
Original Assignee
Serono Ist Farm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serono Ist Farm filed Critical Serono Ist Farm
Publication of IT8447976A0 publication Critical patent/IT8447976A0/it
Priority to IT47976/84A priority Critical patent/IT1198443B/it
Priority to EP85102891A priority patent/EP0160190A3/en
Priority to IL74620A priority patent/IL74620A/xx
Priority to ZA852035A priority patent/ZA852035B/xx
Priority to DK131285A priority patent/DK131285A/da
Priority to AU40461/85A priority patent/AU4046185A/en
Priority to FI851288A priority patent/FI851288L/fi
Priority to CA000477979A priority patent/CA1301676C/en
Priority to NO851308A priority patent/NO851308L/no
Priority to ES541782A priority patent/ES8605284A1/es
Priority to JP60065088A priority patent/JPS615788A/ja
Priority to US07/193,202 priority patent/US5268278A/en
Application granted granted Critical
Publication of IT1198443B publication Critical patent/IT1198443B/it
Priority to AU39547/89A priority patent/AU611048B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT47976/84A 1984-03-30 1984-03-30 Espressione genetica di polipeptidi ibridi contenenti la sequenza della somatostatina IT1198443B (it)

Priority Applications (13)

Application Number Priority Date Filing Date Title
IT47976/84A IT1198443B (it) 1984-03-30 1984-03-30 Espressione genetica di polipeptidi ibridi contenenti la sequenza della somatostatina
EP85102891A EP0160190A3 (en) 1984-03-30 1985-03-13 Genetic expression of somatostatin as hybrid polypeptide
IL74620A IL74620A (en) 1984-03-30 1985-03-15 Genetic expression of somatostatin as hybrid polypeptide
ZA852035A ZA852035B (en) 1984-03-30 1985-03-19 Genetic expression of somatostatin as hybrid polypeptide
DK131285A DK131285A (da) 1984-03-30 1985-03-22 Plasmidvektor til udtrykkelse af et hybridpolypeptid
AU40461/85A AU4046185A (en) 1984-03-30 1985-03-28 Genetic expression of somatostatin as hybrid polypeptide
FI851288A FI851288L (fi) 1984-03-30 1985-03-29 Genetisk expression av somatostatin som hybridpolypeptid.
CA000477979A CA1301676C (en) 1984-03-30 1985-03-29 Genetic expression of somatostatin as hybrid polypeptide
NO851308A NO851308L (no) 1984-03-30 1985-03-29 Genetisk ekspresjon av somatostatin som hybridpolypeptid
ES541782A ES8605284A1 (es) 1984-03-30 1985-03-29 Metodo de produccion de somatostatina como polipeptido hi- brido
JP60065088A JPS615788A (ja) 1984-03-30 1985-03-30 ソマトスタチン雑種ポリペプチド遺伝子
US07/193,202 US5268278A (en) 1984-03-30 1988-05-09 Genetic expression of somatostatin as hybrid polypeptide
AU39547/89A AU611048B2 (en) 1984-03-30 1989-08-11 Genetic expression of somatostatin as hybrid polypeptide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT47976/84A IT1198443B (it) 1984-03-30 1984-03-30 Espressione genetica di polipeptidi ibridi contenenti la sequenza della somatostatina

Publications (2)

Publication Number Publication Date
IT8447976A0 IT8447976A0 (it) 1984-03-30
IT1198443B true IT1198443B (it) 1988-12-21

Family

ID=11263727

Family Applications (1)

Application Number Title Priority Date Filing Date
IT47976/84A IT1198443B (it) 1984-03-30 1984-03-30 Espressione genetica di polipeptidi ibridi contenenti la sequenza della somatostatina

Country Status (11)

Country Link
EP (1) EP0160190A3 (it)
JP (1) JPS615788A (it)
AU (2) AU4046185A (it)
CA (1) CA1301676C (it)
DK (1) DK131285A (it)
ES (1) ES8605284A1 (it)
FI (1) FI851288L (it)
IL (1) IL74620A (it)
IT (1) IT1198443B (it)
NO (1) NO851308L (it)
ZA (1) ZA852035B (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1234977B (it) 1985-03-22 1992-06-09 Serono Ist Farm Espressione in e. coli polipeptidi ibridi contenenti la sequenza del fattore di rilascio dell'ormone della crescita
JPS63304996A (ja) * 1987-06-04 1988-12-13 Toray Ind Inc 融合タンパク質およびその製造方法
JPH0722517B2 (ja) * 1989-08-24 1995-03-15 株式会社三和化学研究所 モチリン様ポリペプチドの製法並びにそのための組換えｄｎａ及び発現用プラスミド

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU257278A (en) * 1977-11-08 1984-02-29 Genentech Inc Process for obtaining a recombinat clone carrier
GB2052516B (en) * 1979-06-01 1983-06-29 Searle & Co Plasmid vectors production and use thereof
IE52122B1 (en) * 1980-08-25 1987-06-24 Univ California Somatostatin or somatostatin precursors
GB2102006B (en) * 1981-06-16 1984-11-28 Takeda Chemical Industries Ltd Deoxyribonucleic acids, their production and use
JPS59203495A (ja) * 1983-04-28 1984-11-17 Kyowa Hakko Kogyo Co Ltd 外来遺伝子の新規な発現方法

Also Published As

Publication number Publication date
FI851288L (fi) 1985-10-01
CA1301676C (en) 1992-05-26
DK131285D0 (da) 1985-03-22
ES541782A0 (es) 1986-04-01
FI851288A0 (fi) 1985-03-29
IT8447976A0 (it) 1984-03-30
IL74620A0 (en) 1985-06-30
EP0160190A3 (en) 1987-07-15
AU611048B2 (en) 1991-05-30
ES8605284A1 (es) 1986-04-01
DK131285A (da) 1985-10-01
JPS615788A (ja) 1986-01-11
AU3954789A (en) 1989-11-30
EP0160190A2 (en) 1985-11-06
AU4046185A (en) 1985-10-31
IL74620A (en) 1990-12-23
ZA852035B (en) 1985-11-27
NO851308L (no) 1985-10-01

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