ES541782A0 - Metodo de produccion de somatostatina como polipeptido hi- brido - Google Patents

Metodo de produccion de somatostatina como polipeptido hi- brido

Info

Publication number
ES541782A0
ES541782A0 ES541782A ES541782A ES541782A0 ES 541782 A0 ES541782 A0 ES 541782A0 ES 541782 A ES541782 A ES 541782A ES 541782 A ES541782 A ES 541782A ES 541782 A0 ES541782 A0 ES 541782A0
Authority
ES
Spain
Prior art keywords
somatostatin
production method
hybrid polypeptide
polypeptide
hybrid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES541782A
Other languages
English (en)
Other versions
ES8605284A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Serono SpA
Original Assignee
Istituto Farmacologico Serono SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Farmacologico Serono SpA filed Critical Istituto Farmacologico Serono SpA
Publication of ES8605284A1 publication Critical patent/ES8605284A1/es
Publication of ES541782A0 publication Critical patent/ES541782A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES541782A 1984-03-30 1985-03-29 Metodo de produccion de somatostatina como polipeptido hi- brido Expired ES8605284A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT47976/84A IT1198443B (it) 1984-03-30 1984-03-30 Espressione genetica di polipeptidi ibridi contenenti la sequenza della somatostatina

Publications (2)

Publication Number Publication Date
ES8605284A1 ES8605284A1 (es) 1986-04-01
ES541782A0 true ES541782A0 (es) 1986-04-01

Family

ID=11263727

Family Applications (1)

Application Number Title Priority Date Filing Date
ES541782A Expired ES8605284A1 (es) 1984-03-30 1985-03-29 Metodo de produccion de somatostatina como polipeptido hi- brido

Country Status (11)

Country Link
EP (1) EP0160190A3 (es)
JP (1) JPS615788A (es)
AU (2) AU4046185A (es)
CA (1) CA1301676C (es)
DK (1) DK131285A (es)
ES (1) ES8605284A1 (es)
FI (1) FI851288L (es)
IL (1) IL74620A (es)
IT (1) IT1198443B (es)
NO (1) NO851308L (es)
ZA (1) ZA852035B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1234977B (it) 1985-03-22 1992-06-09 Serono Ist Farm Espressione in e. coli polipeptidi ibridi contenenti la sequenza del fattore di rilascio dell'ormone della crescita
JPS63304996A (ja) * 1987-06-04 1988-12-13 Toray Ind Inc 融合タンパク質およびその製造方法
JPH0722517B2 (ja) * 1989-08-24 1995-03-15 株式会社三和化学研究所 モチリン様ポリペプチドの製法並びにそのための組換えｄｎａ及び発現用プラスミド

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES474852A1 (es) * 1977-11-08 1979-12-01 Genentech Inc Un metodo para la expresion,en un huesped bacteriano trans- formado de un polipeptido heterologo con respecto al huespeden su estado no transformado
GB2052516B (en) * 1979-06-01 1983-06-29 Searle & Co Plasmid vectors production and use thereof
IE52122B1 (en) * 1980-08-25 1987-06-24 Univ California Somatostatin or somatostatin precursors
EP0068719A3 (en) * 1981-06-16 1984-03-28 Takeda Chemical Industries, Ltd. Deoxyribonucleic acids, their production and use
JPS59203495A (ja) * 1983-04-28 1984-11-17 Kyowa Hakko Kogyo Co Ltd 外来遺伝子の新規な発現方法

Also Published As

Publication number Publication date
IL74620A0 (en) 1985-06-30
IT1198443B (it) 1988-12-21
ES8605284A1 (es) 1986-04-01
CA1301676C (en) 1992-05-26
AU4046185A (en) 1985-10-31
DK131285D0 (da) 1985-03-22
AU611048B2 (en) 1991-05-30
JPS615788A (ja) 1986-01-11
EP0160190A2 (en) 1985-11-06
FI851288A0 (fi) 1985-03-29
ZA852035B (en) 1985-11-27
DK131285A (da) 1985-10-01
EP0160190A3 (en) 1987-07-15
FI851288L (fi) 1985-10-01
AU3954789A (en) 1989-11-30
IL74620A (en) 1990-12-23
IT8447976A0 (it) 1984-03-30
NO851308L (no) 1985-10-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960102