DE3687470D1 - Expression in e.coli von hybridpolypeptiden, die die sequenz des wachstumshormons ausloesenden faktors enthalten. - Google Patents

Expression in e.coli von hybridpolypeptiden, die die sequenz des wachstumshormons ausloesenden faktors enthalten.

Info

Publication number
DE3687470D1
DE3687470D1 DE8686102447T DE3687470T DE3687470D1 DE 3687470 D1 DE3687470 D1 DE 3687470D1 DE 8686102447 T DE8686102447 T DE 8686102447T DE 3687470 T DE3687470 T DE 3687470T DE 3687470 D1 DE3687470 D1 DE 3687470D1
Authority
DE
Germany
Prior art keywords
coli
expression
sequence
growth hormone
polypeptides containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686102447T
Other languages
English (en)
Other versions
DE3687470T2 (de
Inventor
Umberto Canosi
Fazio Gabriele De
Stefano Villa
Silvia Donini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Serono SpA
Original Assignee
Istituto di Ricerca Cesare Serono SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto di Ricerca Cesare Serono SpA filed Critical Istituto di Ricerca Cesare Serono SpA
Application granted granted Critical
Publication of DE3687470D1 publication Critical patent/DE3687470D1/de
Publication of DE3687470T2 publication Critical patent/DE3687470T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
DE8686102447T 1985-03-22 1986-02-25 Expression in e.coli von hybridpolypeptiden, die die sequenz des wachstumshormons ausloesenden faktors enthalten. Expired - Fee Related DE3687470T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8547856A IT1234977B (it) 1985-03-22 1985-03-22 Espressione in e. coli polipeptidi ibridi contenenti la sequenza del fattore di rilascio dell'ormone della crescita

Publications (2)

Publication Number Publication Date
DE3687470D1 true DE3687470D1 (de) 1993-02-25
DE3687470T2 DE3687470T2 (de) 1993-05-19

Family

ID=11262958

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686102447T Expired - Fee Related DE3687470T2 (de) 1985-03-22 1986-02-25 Expression in e.coli von hybridpolypeptiden, die die sequenz des wachstumshormons ausloesenden faktors enthalten.

Country Status (13)

Country Link
EP (1) EP0199018B1 (de)
JP (3) JPH0779701B2 (de)
AR (1) AR242056A1 (de)
AT (1) ATE84548T1 (de)
AU (1) AU600891B2 (de)
DE (1) DE3687470T2 (de)
DK (1) DK122486A (de)
ES (1) ES8800722A1 (de)
FI (1) FI93125C (de)
IL (1) IL78044A (de)
IT (1) IT1234977B (de)
NO (1) NO175318C (de)
ZA (1) ZA861644B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1200162B (it) * 1985-12-18 1989-01-05 Serono Ist Farm Protezione della metionina in una catena polipeptidica dalla ossidazione irreversibile
US4828988A (en) * 1986-05-15 1989-05-09 Smith Kline - Rit Hybrid polypeptides comprising somatocrinine and alpha1 -antitrypsin, method for their production from bacterial clones and use thereof for the production of somatocrinine
US5565606A (en) * 1986-10-21 1996-10-15 Hoechst Aktiengesellschaft Synthesis of peptide aminoalkylamides and peptide hydrazides by the solid-phase method
NZ237857A (en) 1990-04-24 1992-05-26 Lilly Co Eli Polypeptide compounds with growth hormone releasing factor activity
US5512459A (en) * 1993-07-20 1996-04-30 Bionebraska, Inc. Enzymatic method for modification or recombinant polypeptides
DE4435960C2 (de) * 1994-10-07 1998-05-20 Goodwell Int Ltd Snowboardbindung
EP1052286A3 (de) * 1999-04-12 2001-07-25 Pfizer Products Inc. Wachstumshormon- (GH) und Wachstumshormon-freisetzenden Hormon (GHRH) enthaltende Zusammensetzungen
US6759393B1 (en) 1999-04-12 2004-07-06 Pfizer Inc. Growth hormone and growth hormone releasing hormone compositions
EP1205551A1 (de) * 2000-11-09 2002-05-15 Pfizer Products Inc. Wachstumshormon- (GH) und Wachstumshormon-freisetzenden Hormon (GHRH) enthaltende Zusammensetzungen

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA811368B (en) * 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
EP0068719A3 (de) * 1981-06-16 1984-03-28 Takeda Chemical Industries, Ltd. Desoxyribonukleine Säuren, deren Herstellung und Verwendung
JPS58201796A (ja) * 1982-05-19 1983-11-24 Takeda Chem Ind Ltd 組換えｄｎａおよびその用途
US4499188A (en) * 1982-05-05 1985-02-12 Cetus Corporation Bacterial production of heterologous polypeptides under the control of a repressible promoter-operator
EP0108387B1 (de) * 1982-11-04 1990-05-16 F. Hoffmann-La Roche Ag Hestellung von rekombinanten wachstumsauslösenden Faktoren
JPS59154989A (ja) * 1983-02-23 1984-09-04 Mitsubishi Chem Ind Ltd プラスミド
JPS59227899A (ja) * 1983-05-25 1984-12-21 チロン・コ−ポレイシヨン 成長ホルモン放出因子の製造方法
DE3327007A1 (de) * 1983-07-27 1985-02-07 Hoechst Ag, 6230 Frankfurt Herstellung von polypeptiden mit einem saeureamid-carboxyterminus
IT1198443B (it) * 1984-03-30 1988-12-21 Serono Ist Farm Espressione genetica di polipeptidi ibridi contenenti la sequenza della somatostatina
FR2587359B1 (fr) * 1985-05-28 1987-12-24 Sanofi Sa Derives non amides de la somatocrinine et procede de preparation par genie genetique

Also Published As

Publication number Publication date
FI861217A0 (fi) 1986-03-21
EP0199018A3 (en) 1987-07-22
DK122486D0 (da) 1986-03-17
AU600891B2 (en) 1990-08-30
JPH0710900A (ja) 1995-01-13
AR242056A1 (es) 1993-02-26
IL78044A0 (en) 1986-07-31
NO175318B (no) 1994-06-20
IT8547856A0 (it) 1985-03-22
EP0199018A2 (de) 1986-10-29
FI93125B (fi) 1994-11-15
NO861142L (no) 1986-09-23
FI861217A (fi) 1986-09-23
IL78044A (en) 1991-07-18
DE3687470T2 (de) 1993-05-19
JPH0779701B2 (ja) 1995-08-30
ES8800722A1 (es) 1987-12-01
ES553274A0 (es) 1987-12-01
FI93125C (fi) 1995-02-27
EP0199018B1 (de) 1993-01-13
IT1234977B (it) 1992-06-09
NO175318C (no) 1994-09-28
JPH07316197A (ja) 1995-12-05
JP2537029B2 (ja) 1996-09-25
ZA861644B (en) 1986-10-29
JPH0816120B2 (ja) 1996-02-21
ATE84548T1 (de) 1993-01-15
DK122486A (da) 1986-09-23
JPS61274686A (ja) 1986-12-04
AU5484386A (en) 1986-09-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee