AU589896B2 - A genetic engineering process for the preparation of human interleukin-2 and means for carrying out this process - Google Patents

A genetic engineering process for the preparation of human interleukin-2 and means for carrying out this process

Info

Publication number
AU589896B2
AU589896B2 AU43070/85A AU4307085A AU589896B2 AU 589896 B2 AU589896 B2 AU 589896B2 AU 43070/85 A AU43070/85 A AU 43070/85A AU 4307085 A AU4307085 A AU 4307085A AU 589896 B2 AU589896 B2 AU 589896B2
Authority
AU
Australia
Prior art keywords
genetic engineering
human interleukin
preparation
carrying
sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU43070/85A
Other versions
AU4307085A (en
Inventor
Joachim Engels
Ronald Mertz
Hubert Mullner
Hiroshi Okazaki
Eugen Uhlmann
Friedrich Wengenmayer
Ernst-Ludwig Winnacker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU4307085A publication Critical patent/AU4307085A/en
Application granted granted Critical
Publication of AU589896B2 publication Critical patent/AU589896B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

A synthetic DNA sequence can be used to obtain human interleukin-2 in a genetic engineering process. The gene is advantageously synthesised in the form of a plurality of fragments which are ligated enzymatically to give larger part-sequences which are incorporated into hybrid plasmids and amplified in host organisms. The part-sequences are reisolated and then combined to give the complete gene and incorporated into a hybrid plasmid, and the latter is expressed in a host organism.
AU43070/85A 1984-05-29 1985-05-28 A genetic engineering process for the preparation of human interleukin-2 and means for carrying out this process Ceased AU589896B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19843419995 DE3419995A1 (en) 1984-05-29 1984-05-29 GENE TECHNOLOGICAL METHOD FOR PRODUCING HUMAN INTERLEUKIN-2 AND MEANS FOR CARRYING OUT THIS METHOD
DE3419995 1984-05-29

Publications (2)

Publication Number Publication Date
AU4307085A AU4307085A (en) 1985-12-05
AU589896B2 true AU589896B2 (en) 1989-10-26

Family

ID=6237111

Family Applications (1)

Application Number Title Priority Date Filing Date
AU43070/85A Ceased AU589896B2 (en) 1984-05-29 1985-05-28 A genetic engineering process for the preparation of human interleukin-2 and means for carrying out this process

Country Status (11)

Country Link
EP (1) EP0163249B1 (en)
JP (1) JPS6199A (en)
AT (1) ATE65797T1 (en)
AU (1) AU589896B2 (en)
DE (2) DE3419995A1 (en)
DK (1) DK166681B1 (en)
ES (1) ES8605813A1 (en)
GR (1) GR851291B (en)
IE (1) IE57996B1 (en)
PT (1) PT80542B (en)
ZA (1) ZA854031B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK174501B1 (en) * 1983-12-23 2003-04-28 Hoffmann La Roche Process for Preparation of Interleukin-2
CA1340265C (en) * 1985-01-18 1998-12-15 Kirston E. Koths Oxidation resistant muteins
DE3537461A1 (en) * 1985-10-22 1987-04-23 Hoechst Ag DERIVATIVE OF INTERLEUKIN-2, ITS PRODUCTION AND USE
US5496924A (en) * 1985-11-27 1996-03-05 Hoechst Aktiengesellschaft Fusion protein comprising an interleukin-2 fragment ballast portion
DE3712985A1 (en) * 1987-04-16 1988-11-03 Hoechst Ag BIFUNCTIONAL PROTEINS
JPS62185098A (en) * 1986-02-10 1987-08-13 Otsuka Pharmaceut Co Ltd Polypeptide having interleukin ii activity
US5831022A (en) * 1986-02-18 1998-11-03 Hoffmann-La Roche Inc. Purification of recombinant human IL-1α
US4992367A (en) * 1986-05-12 1991-02-12 Hoffmann-La Roche Inc. Enhanced expression of human interleukin-2 in mammalian cells
US5017692A (en) * 1986-09-04 1991-05-21 Schering Corporation Truncated human interleukin-a alpha
CA1339757C (en) * 1987-04-16 1998-03-17 Robert F. Halenbeck Production of purified biologically active, bacterially produced recombinant human csf-1
US4929700A (en) * 1987-04-16 1990-05-29 Cetus Corporation Production of purified, biologically active, bacterially produced recombinant human CSF-1
US5162507A (en) * 1987-05-11 1992-11-10 Cetus Corporation Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
FR2643646B1 (en) * 1989-02-27 1993-09-17 Pasteur Institut EXPRESSION OF NUCLEOTIDES SEQUENCES ENCODING FOR GAS VESICLES
US6008319A (en) * 1996-12-23 1999-12-28 University Of Southern California Vasopermeability enhancing peptide of human interleukin-2 and immunoconjugates thereof
US6955807B1 (en) 1998-05-15 2005-10-18 Bayer Pharmaceuticals Corporation IL-2 selective agonists and antagonists

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2590684A (en) * 1983-03-21 1984-09-27 F. Hoffmann-La Roche Ag Interleukin-2
EP0163603A1 (en) * 1984-05-08 1985-12-04 Genetics Institute, Inc. A human T-Cell growth factor
AU579089B2 (en) * 1983-02-08 1988-11-17 Biogen, Inc. Human interleukin-2-like polypeptides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2483592A1 (en) * 1980-06-02 1981-12-04 Stein Industrie DEVICE FOR REDUCING THERMAL CONSTRAINTS ON A HEAT EXCHANGER
EP0091539B2 (en) * 1982-03-31 1996-11-27 Ajinomoto Co., Inc. Gene coding for interleukin-2 polypeptide, recombinant DNA carrying said gene, cell lines possessing the recombinant DNA,and method for producing interleukin-2 using said cells
CA1341562C (en) * 1982-03-31 2007-11-27 Tadatsugu Taniguchi Gene coded for interleukin-2 polypeptide, recombinant dna carrying the said gene, a living cell line possessing the recombinant dna, and method for producing interleukin-2 using the said cell
WO1985000817A1 (en) * 1983-08-10 1985-02-28 Amgen Microbial expression of interleukin ii
FR2559782B1 (en) * 1984-02-16 1986-07-18 Transgene Sa EXPRESSION VECTOR IN INTERLEUKIN-2 YEASTS, PROCESSED YEASTS AND PROCESS FOR PREPARING INTERLEUKIN-2

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU579089B2 (en) * 1983-02-08 1988-11-17 Biogen, Inc. Human interleukin-2-like polypeptides
AU2590684A (en) * 1983-03-21 1984-09-27 F. Hoffmann-La Roche Ag Interleukin-2
EP0163603A1 (en) * 1984-05-08 1985-12-04 Genetics Institute, Inc. A human T-Cell growth factor

Also Published As

Publication number Publication date
DE3583634D1 (en) 1991-09-05
EP0163249B1 (en) 1991-07-31
JPS6199A (en) 1986-01-06
IE851319L (en) 1985-11-29
EP0163249A2 (en) 1985-12-04
PT80542A (en) 1985-06-01
ZA854031B (en) 1986-01-29
ATE65797T1 (en) 1991-08-15
ES543508A0 (en) 1986-01-16
DK237985D0 (en) 1985-05-28
ES8605813A1 (en) 1986-01-16
DK237985A (en) 1985-11-30
DK166681B1 (en) 1993-06-28
EP0163249A3 (en) 1988-05-11
GR851291B (en) 1985-11-25
DE3419995A1 (en) 1985-12-05
AU4307085A (en) 1985-12-05
PT80542B (en) 1987-09-30
IE57996B1 (en) 1993-06-02

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