DK237985A - GENETIC TECHNOLOGY PROCEDURE FOR MANUFACTURING HUMAN-INTERLEUKIN-2 AND METHOD FOR IMPLEMENTING THE PROCEDURE - Google Patents

GENETIC TECHNOLOGY PROCEDURE FOR MANUFACTURING HUMAN-INTERLEUKIN-2 AND METHOD FOR IMPLEMENTING THE PROCEDURE Download PDF

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Publication number
DK237985A
DK237985A DK237985A DK237985A DK237985A DK 237985 A DK237985 A DK 237985A DK 237985 A DK237985 A DK 237985A DK 237985 A DK237985 A DK 237985A DK 237985 A DK237985 A DK 237985A
Authority
DK
Denmark
Prior art keywords
procedure
interleukin
implementing
genetic technology
manufacturing human
Prior art date
Application number
DK237985A
Other languages
Danish (da)
Other versions
DK166681B1 (en
DK237985D0 (en
Inventor
Joachim Engels
Eugen Uhlmann
Friedrich Wegenmayer
Hubert Muellner
Ernst-Ludwig Winnacker
Ronald Mertz
Hiroshi Okazaki
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK237985D0 publication Critical patent/DK237985D0/en
Publication of DK237985A publication Critical patent/DK237985A/en
Application granted granted Critical
Publication of DK166681B1 publication Critical patent/DK166681B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

A synthetic DNA sequence can be used to obtain human interleukin-2 in a genetic engineering process. The gene is advantageously synthesised in the form of a plurality of fragments which are ligated enzymatically to give larger part-sequences which are incorporated into hybrid plasmids and amplified in host organisms. The part-sequences are reisolated and then combined to give the complete gene and incorporated into a hybrid plasmid, and the latter is expressed in a host organism.
DK237985A 1984-05-29 1985-05-28 DNA SEQUENCES, DNA SEQUENCES AND DNA OLIGONUCLEOTIDES FOR USE IN THE PREPARATION OF THE FIRST DNA SEQUENCES, HYBRID PLASMIDS CONTAINING DNA SEQUENCE, HOUSE CELLS WITH 2 DK166681B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3419995 1984-05-29
DE19843419995 DE3419995A1 (en) 1984-05-29 1984-05-29 GENE TECHNOLOGICAL METHOD FOR PRODUCING HUMAN INTERLEUKIN-2 AND MEANS FOR CARRYING OUT THIS METHOD

Publications (3)

Publication Number Publication Date
DK237985D0 DK237985D0 (en) 1985-05-28
DK237985A true DK237985A (en) 1985-11-30
DK166681B1 DK166681B1 (en) 1993-06-28

Family

ID=6237111

Family Applications (1)

Application Number Title Priority Date Filing Date
DK237985A DK166681B1 (en) 1984-05-29 1985-05-28 DNA SEQUENCES, DNA SEQUENCES AND DNA OLIGONUCLEOTIDES FOR USE IN THE PREPARATION OF THE FIRST DNA SEQUENCES, HYBRID PLASMIDS CONTAINING DNA SEQUENCE, HOUSE CELLS WITH 2

Country Status (11)

Country Link
EP (1) EP0163249B1 (en)
JP (1) JPS6199A (en)
AT (1) ATE65797T1 (en)
AU (1) AU589896B2 (en)
DE (2) DE3419995A1 (en)
DK (1) DK166681B1 (en)
ES (1) ES8605813A1 (en)
GR (1) GR851291B (en)
IE (1) IE57996B1 (en)
PT (1) PT80542B (en)
ZA (1) ZA854031B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ210634A (en) * 1983-12-23 1989-05-29 Hoffmann La Roche Purification of recombinant human interleukin - 2; pharmaceutical compositions
CA1340265C (en) * 1985-01-18 1998-12-15 Kirston E. Koths Oxidation resistant muteins
DE3537461A1 (en) * 1985-10-22 1987-04-23 Hoechst Ag DERIVATIVE OF INTERLEUKIN-2, ITS PRODUCTION AND USE
US5496924A (en) * 1985-11-27 1996-03-05 Hoechst Aktiengesellschaft Fusion protein comprising an interleukin-2 fragment ballast portion
DE3712985A1 (en) * 1987-04-16 1988-11-03 Hoechst Ag BIFUNCTIONAL PROTEINS
JPS62185098A (en) * 1986-02-10 1987-08-13 Otsuka Pharmaceut Co Ltd Polypeptide having interleukin ii activity
US5831022A (en) * 1986-02-18 1998-11-03 Hoffmann-La Roche Inc. Purification of recombinant human IL-1α
US4992367A (en) * 1986-05-12 1991-02-12 Hoffmann-La Roche Inc. Enhanced expression of human interleukin-2 in mammalian cells
US5017692A (en) * 1986-09-04 1991-05-21 Schering Corporation Truncated human interleukin-a alpha
CA1339757C (en) * 1987-04-16 1998-03-17 Robert F. Halenbeck Production of purified biologically active, bacterially produced recombinant human csf-1
US4929700A (en) * 1987-04-16 1990-05-29 Cetus Corporation Production of purified, biologically active, bacterially produced recombinant human CSF-1
US5162507A (en) * 1987-05-11 1992-11-10 Cetus Corporation Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
FR2643646B1 (en) * 1989-02-27 1993-09-17 Pasteur Institut EXPRESSION OF NUCLEOTIDES SEQUENCES ENCODING FOR GAS VESICLES
US6008319A (en) 1996-12-23 1999-12-28 University Of Southern California Vasopermeability enhancing peptide of human interleukin-2 and immunoconjugates thereof
US6955807B1 (en) 1998-05-15 2005-10-18 Bayer Pharmaceuticals Corporation IL-2 selective agonists and antagonists

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2483592A1 (en) * 1980-06-02 1981-12-04 Stein Industrie DEVICE FOR REDUCING THERMAL CONSTRAINTS ON A HEAT EXCHANGER
CA1341562C (en) * 1982-03-31 2007-11-27 Tadatsugu Taniguchi Gene coded for interleukin-2 polypeptide, recombinant dna carrying the said gene, a living cell line possessing the recombinant dna, and method for producing interleukin-2 using the said cell
EP0091539B2 (en) * 1982-03-31 1996-11-27 Ajinomoto Co., Inc. Gene coding for interleukin-2 polypeptide, recombinant DNA carrying said gene, cell lines possessing the recombinant DNA,and method for producing interleukin-2 using said cells
AU579089B2 (en) * 1983-02-08 1988-11-17 Biogen, Inc. Human interleukin-2-like polypeptides
ZA842025B (en) * 1983-03-21 1984-11-28 Hoffmann La Roche Interleuken-2
WO1985000817A1 (en) * 1983-08-10 1985-02-28 Amgen Microbial expression of interleukin ii
FR2559782B1 (en) * 1984-02-16 1986-07-18 Transgene Sa EXPRESSION VECTOR IN INTERLEUKIN-2 YEASTS, PROCESSED YEASTS AND PROCESS FOR PREPARING INTERLEUKIN-2
DE3574731D1 (en) * 1984-05-08 1990-01-18 Genetics Inst A HUMAN T-CELL GROWTH FACTOR.

Also Published As

Publication number Publication date
DE3583634D1 (en) 1991-09-05
ES543508A0 (en) 1986-01-16
EP0163249A2 (en) 1985-12-04
DK166681B1 (en) 1993-06-28
AU589896B2 (en) 1989-10-26
EP0163249A3 (en) 1988-05-11
JPS6199A (en) 1986-01-06
GR851291B (en) 1985-11-25
PT80542A (en) 1985-06-01
DE3419995A1 (en) 1985-12-05
AU4307085A (en) 1985-12-05
DK237985D0 (en) 1985-05-28
EP0163249B1 (en) 1991-07-31
ZA854031B (en) 1986-01-29
IE851319L (en) 1985-11-29
IE57996B1 (en) 1993-06-02
ES8605813A1 (en) 1986-01-16
ATE65797T1 (en) 1991-08-15
PT80542B (en) 1987-09-30

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed