DE19956568A1 - Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens - Google Patents

Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens

Info

Publication number
DE19956568A1
DE19956568A1 DE19956568A DE19956568A DE19956568A1 DE 19956568 A1 DE19956568 A1 DE 19956568A1 DE 19956568 A DE19956568 A DE 19956568A DE 19956568 A DE19956568 A DE 19956568A DE 19956568 A1 DE19956568 A1 DE 19956568A1
Authority
DE
Germany
Prior art keywords
dsrna
complementary
target gene
virus
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19956568A
Other languages
German (de)
English (en)
Inventor
Roland Kreutzer
Stephan Limmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26051592&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE19956568(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Priority to DE19956568A priority Critical patent/DE19956568A1/de
Priority to DK02003683.6T priority patent/DK1214945T4/da
Priority to DE10066235.8A priority patent/DE10066235C5/de
Priority to EP15194718.1A priority patent/EP3018207A1/de
Priority to EP00910510A priority patent/EP1144623B9/de
Priority to AT00910510T priority patent/ATE222953T1/de
Priority to CA002359180A priority patent/CA2359180C/en
Priority to DK06025389.5T priority patent/DK1798285T3/en
Priority to JP2000596137A priority patent/JP2003502012A/ja
Priority to PCT/DE2000/000244 priority patent/WO2000044895A1/de
Priority to PT05002454T priority patent/PT1550719E/pt
Priority to ES10011217.6T priority patent/ES2597953T3/es
Priority to AT05002454T priority patent/ATE418610T1/de
Priority to EP06025389.5A priority patent/EP1798285B1/de
Priority to EP10011217.6A priority patent/EP2363479B1/de
Priority to ES02003683T priority patent/ES2243608T5/es
Priority to DK05002454T priority patent/DK1550719T3/da
Priority to EP02003683.6A priority patent/EP1214945B2/de
Priority to DK10011217.6T priority patent/DK2363479T3/en
Priority to AT02003683T priority patent/ATE297463T1/de
Priority to DE50015501T priority patent/DE50015501D1/de
Priority to PT60253895T priority patent/PT1798285T/pt
Priority to DE50010528T priority patent/DE50010528D1/de
Priority to PT100112176T priority patent/PT2363479T/pt
Priority to DE20023125U priority patent/DE20023125U1/de
Priority to EP05002454A priority patent/EP1550719B1/de
Priority to PT02003683T priority patent/PT1214945E/pt
Priority to ES05002454T priority patent/ES2321409T3/es
Priority to DE50000414T priority patent/DE50000414D1/de
Priority to ES06025389.5T priority patent/ES2628535T3/es
Priority to DE10080167T priority patent/DE10080167B4/de
Priority to AU2000032713A priority patent/AU778474B2/en
Priority to ES00910510T priority patent/ES2182791T3/es
Publication of DE19956568A1 publication Critical patent/DE19956568A1/de
Priority to ZA200105909A priority patent/ZA200105909B/en
Priority to US10/382,768 priority patent/US8168776B2/en
Priority to US10/383,099 priority patent/US8119608B2/en
Priority to US10/382,395 priority patent/US8101584B2/en
Priority to US10/384,339 priority patent/US7829693B2/en
Priority to US10/612,179 priority patent/US8202980B2/en
Priority to AU2005201044A priority patent/AU2005201044B2/en
Priority to JP2006248529A priority patent/JP2006340732A/ja
Priority to JP2006248528A priority patent/JP2007031443A/ja
Priority to JP2007186340A priority patent/JP2007314555A/ja
Priority to JP2007186341A priority patent/JP2007312784A/ja
Priority to JP2007186339A priority patent/JP2008005844A/ja
Priority to US11/982,425 priority patent/US8183362B2/en
Priority to US11/982,345 priority patent/US8729037B2/en
Priority to US11/982,305 priority patent/US8101742B2/en
Priority to US11/982,441 priority patent/US8114981B2/en
Priority to US11/982,434 priority patent/US8114851B2/en
Priority to US11/982,325 priority patent/US20080171862A1/en
Priority to JP2009002826A priority patent/JP2009100758A/ja
Priority to JP2009002824A priority patent/JP2009100757A/ja
Priority to JP2009002825A priority patent/JP2009102380A/ja
Priority to CY20091100310T priority patent/CY1108896T1/el
Priority to JP2009285705A priority patent/JP2010057514A/ja
Priority to JP2009285706A priority patent/JP2010057515A/ja
Priority to HK12100861.2A priority patent/HK1160487B/xx
Priority to US13/656,513 priority patent/US8877726B2/en
Priority to US13/656,548 priority patent/US9902954B2/en
Priority to US13/656,540 priority patent/US20130164366A1/en
Priority to JP2013006076A priority patent/JP5990468B2/ja
Priority to US13/753,438 priority patent/US20130177631A1/en
Priority to US14/218,489 priority patent/US9902955B2/en
Priority to US14/218,476 priority patent/US9133454B2/en
Priority to JP2015098123A priority patent/JP6471901B2/ja
Priority to CY20161101011T priority patent/CY1118264T1/el
Priority to CY20171100634T priority patent/CY1119221T1/el
Priority to US15/870,380 priority patent/US20180179526A1/en
Priority to JP2018174668A priority patent/JP2019017390A/ja
Withdrawn legal-status Critical Current

Links

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE19956568A 1999-01-30 1999-11-24 Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens Withdrawn DE19956568A1 (de)

Priority Applications (70)

Application Number Priority Date Filing Date Title
DE19956568A DE19956568A1 (de) 1999-01-30 1999-11-24 Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
DK02003683.6T DK1214945T4 (da) 1999-01-30 2000-01-29 Fremgangsmåde og medikament til at hæmme ekspressionen af et defineret målgen
DE10066235.8A DE10066235C5 (de) 1999-01-30 2000-01-29 Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
EP15194718.1A EP3018207A1 (de) 1999-01-30 2000-01-29 Oligoribonukleotid zur hemmung der expression eines vorgegebenen gens
EP00910510A EP1144623B9 (de) 1999-01-30 2000-01-29 Verfahren und medikament zur hemmung der expression eines vorgegebenen gens
AT00910510T ATE222953T1 (de) 1999-01-30 2000-01-29 Verfahren und medikament zur hemmung der expression eines vorgegebenen gens
CA002359180A CA2359180C (en) 1999-01-30 2000-01-29 Method and medicament for inhibiting the expression of a given gene
DK06025389.5T DK1798285T3 (en) 1999-01-30 2000-01-29 Method and drug for inhibiting the expression of a given gene
JP2000596137A JP2003502012A (ja) 1999-01-30 2000-01-29 特定遺伝子の発現を抑制するための方法および薬剤
PCT/DE2000/000244 WO2000044895A1 (de) 1999-01-30 2000-01-29 Verfahren und medikament zur hemmung der expression eines vorgegebenen gens
PT05002454T PT1550719E (pt) 1999-01-30 2000-01-29 Arn de cadeia dupla (arncd), para a inibição da expressão de um gene previamente definido
ES10011217.6T ES2597953T3 (es) 1999-01-30 2000-01-29 Oligorribonucleótido para inhibir la expresión de un gen predeterminado
AT05002454T ATE418610T1 (de) 1999-01-30 2000-01-29 Doppelsträngige rna (dsrna) zur hemmung der expression eines vorgegebenen gens
EP06025389.5A EP1798285B1 (de) 1999-01-30 2000-01-29 Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
EP10011217.6A EP2363479B1 (de) 1999-01-30 2000-01-29 Oligoribonukleotid zur Hemmung der Expression eines vorgegebenen Gens
ES02003683T ES2243608T5 (es) 1999-01-30 2000-01-29 Procedimiento y medicamento para la inhibición de la expresión de un gen predeterminado
DK05002454T DK1550719T3 (da) 1999-01-30 2000-01-29 Dobbeltstrenget RNA (dsRNA) til inhibering af ekspressionen af et defineret gen
EP02003683.6A EP1214945B2 (de) 1999-01-30 2000-01-29 Verfahren und medikament zur hemmung der expression eines vorgegebenen gens
DK10011217.6T DK2363479T3 (en) 1999-01-30 2000-01-29 Oligoribonucleotide for inhibiting the expression of a defined gene
AT02003683T ATE297463T1 (de) 1999-01-30 2000-01-29 Verfahren und medikament zur hemmung der expression eines vorgegebenen gens
DE50015501T DE50015501D1 (de) 1999-01-30 2000-01-29 Doppelsträngige RNA (dsRNA) zur Hemmung der Expression eines vorgegebenen Gens
PT60253895T PT1798285T (pt) 1999-01-30 2000-01-29 Método e medicamento para a inibição da expressão de um determinado gene
DE50010528T DE50010528D1 (de) 1999-01-30 2000-01-29 Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
PT100112176T PT2363479T (pt) 1999-01-30 2000-01-29 Oligorribonucleótido para a inibição da expressão de um gene previamente definido
DE20023125U DE20023125U1 (de) 1999-01-30 2000-01-29 Medikament zur Hemmung der Expression eines vorgegebenen Gens
EP05002454A EP1550719B1 (de) 1999-01-30 2000-01-29 Doppelsträngige RNA (dsRNA) zur Hemmung der Expression eines vorgegebenen Gens
PT02003683T PT1214945E (pt) 1999-01-30 2000-01-29 Processo e medicamento para a inibicao da expressao de um gene alvo previamente definido
ES05002454T ES2321409T3 (es) 1999-01-30 2000-01-29 Arn (dsarn) de hebra doble para la inhibicion de la expresion de un gen predeterminado.
DE50000414T DE50000414D1 (de) 1999-01-30 2000-01-29 Verfahren und medikament zur hemmung der expression eines vorgegebenen gens
ES06025389.5T ES2628535T3 (es) 1999-01-30 2000-01-29 Procedimiento y medicamento para la inhibición de la expresión de un gen predeterminado
DE10080167T DE10080167B4 (de) 1999-01-30 2000-01-29 Medikament zur Hemmung der Expression eines vorgegebenen Gens
AU2000032713A AU778474B2 (en) 1999-01-30 2000-01-29 Method and medicament for inhibiting the expression of a defined gene
ES00910510T ES2182791T3 (es) 1999-01-30 2000-01-29 Procedimiento y medicamento para la inhibicion de la expresion de un gen predeterminado.
ZA200105909A ZA200105909B (en) 1999-01-30 2001-07-18 Method and medicament for inhibiting the expression of a defined gene.
US10/382,768 US8168776B2 (en) 1999-01-30 2003-03-06 Method for making a 21 nucleotide double stranded RNA chemically linked at one end
US10/383,099 US8119608B2 (en) 1999-01-30 2003-03-06 Method and medicament for inhibiting the expression of a given gene
US10/382,395 US8101584B2 (en) 1999-01-30 2003-03-06 Method and medicament for inhibiting the expression of a given gene
US10/384,339 US7829693B2 (en) 1999-11-24 2003-03-07 Compositions and methods for inhibiting expression of a target gene
US10/612,179 US8202980B2 (en) 1999-01-30 2003-07-02 Method and medicament for inhibiting the expression of a given gene
AU2005201044A AU2005201044B2 (en) 1999-01-30 2005-03-09 Method and medicament for inhibiting the expression of a defined gene
JP2006248529A JP2006340732A (ja) 1999-01-30 2006-09-13 特定遺伝子の発現を抑制するための方法および薬剤
JP2006248528A JP2007031443A (ja) 1999-01-30 2006-09-13 特定遺伝子の発現を抑制するための方法および薬剤
JP2007186340A JP2007314555A (ja) 1999-01-30 2007-07-17 特定遺伝子の発現を抑制するための方法および薬剤
JP2007186341A JP2007312784A (ja) 1999-01-30 2007-07-17 特定遺伝子の発現を抑制するための方法および薬剤
JP2007186339A JP2008005844A (ja) 1999-01-30 2007-07-17 特定遺伝子の発現を抑制するための方法および薬剤
US11/982,425 US8183362B2 (en) 1999-01-30 2007-10-31 Method and medicament for inhibiting the expression of a given gene
US11/982,345 US8729037B2 (en) 1999-01-30 2007-10-31 Method and medicament for inhibiting the expression of a given gene
US11/982,305 US8101742B2 (en) 1999-01-30 2007-10-31 Method and medicament for inhibiting the expression of a given gene
US11/982,441 US8114981B2 (en) 1999-01-30 2007-10-31 Method and medicament for inhibiting the expression of a given gene
US11/982,434 US8114851B2 (en) 1999-01-30 2007-10-31 Method and medicament for inhibiting the expression of a given gene
US11/982,325 US20080171862A1 (en) 1999-01-30 2007-10-31 Method and medicament for inhibiting the expression of a given gene
JP2009002826A JP2009100758A (ja) 1999-01-30 2009-01-08 特定遺伝子の発現を抑制するための方法および薬剤
JP2009002824A JP2009100757A (ja) 1999-01-30 2009-01-08 特定遺伝子の発現を抑制するための方法および薬剤
JP2009002825A JP2009102380A (ja) 1999-01-30 2009-01-08 特定遺伝子の発現を抑制するための方法および薬剤
CY20091100310T CY1108896T1 (el) 1999-01-30 2009-03-20 ΔΙΠΛΟΚΛΩΝΟ RNA (dsRNA) ΓΙΑ ΤΗΝ ΑΝΑΣΤΟΛΗ ΤΗΣ ΕΚΦΡΑΣΗΣ ΠΡΟΚΑΘΟΡΙΣΜΕΝΟΥ ΓΟΝΙΔΙΟΥ
JP2009285705A JP2010057514A (ja) 1999-01-30 2009-12-16 特定遺伝子の発現を抑制するための方法および薬剤
JP2009285706A JP2010057515A (ja) 1999-01-30 2009-12-16 特定遺伝子の発現を抑制するための方法および薬剤
HK12100861.2A HK1160487B (en) 1999-01-30 2012-01-30 Oligoribonucucleotide for inhibiting the expression of a predefined gene
US13/656,513 US8877726B2 (en) 1999-01-30 2012-10-19 Method and medicament for inhibiting the expression of a given gene
US13/656,548 US9902954B2 (en) 1999-01-30 2012-10-19 Method and medicament for inhibiting the expression of a given gene
US13/656,540 US20130164366A1 (en) 1999-01-30 2012-10-19 Method and medicament for inhibiting the expression of a given gene
JP2013006076A JP5990468B2 (ja) 1999-01-30 2013-01-17 特定遺伝子の発現を抑制するための方法および薬剤
US13/753,438 US20130177631A1 (en) 1999-01-30 2013-01-29 Method and medicament for inhibiting the expression of a given gene
US14/218,489 US9902955B2 (en) 1999-01-30 2014-03-18 Method and medicament for inhibiting the expression of a given gene
US14/218,476 US9133454B2 (en) 1999-01-30 2014-03-18 Method and medicament for inhibiting the expression of a given gene
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CY20161101011T CY1118264T1 (el) 1999-01-30 2016-10-12 Ολιγονουκλεοτιδio για την αναστολη της εκφρασης προκαθορισμενου γονιδιου
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