JP2003502012A - 特定遺伝子の発現を抑制するための方法および薬剤 - Google Patents

特定遺伝子の発現を抑制するための方法および薬剤

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Publication number
JP2003502012A
JP2003502012A JP2000596137A JP2000596137A JP2003502012A JP 2003502012 A JP2003502012 A JP 2003502012A JP 2000596137 A JP2000596137 A JP 2000596137A JP 2000596137 A JP2000596137 A JP 2000596137A JP 2003502012 A JP2003502012 A JP 2003502012A
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JP
Japan
Prior art keywords
double
stranded
complementary
stranded rna
rna
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Withdrawn
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JP2000596137A
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English (en)
Japanese (ja)
Inventor
ローラント・クロイツァー
シュテファン・リメル
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26051592&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2003502012(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of JP2003502012A publication Critical patent/JP2003502012A/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2000596137A 1999-01-30 2000-01-29 特定遺伝子の発現を抑制するための方法および薬剤 Withdrawn JP2003502012A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19903713.2 1999-01-30
DE19903713 1999-01-30
DE19956568A DE19956568A1 (de) 1999-01-30 1999-11-24 Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
DE19956568.6 1999-11-24
PCT/DE2000/000244 WO2000044895A1 (de) 1999-01-30 2000-01-29 Verfahren und medikament zur hemmung der expression eines vorgegebenen gens

Related Child Applications (6)

Application Number Title Priority Date Filing Date
JP2006248528A Division JP2007031443A (ja) 1999-01-30 2006-09-13 特定遺伝子の発現を抑制するための方法および薬剤
JP2006248529A Division JP2006340732A (ja) 1999-01-30 2006-09-13 特定遺伝子の発現を抑制するための方法および薬剤
JP2007186339A Division JP2008005844A (ja) 1999-01-30 2007-07-17 特定遺伝子の発現を抑制するための方法および薬剤
JP2009002825A Division JP2009102380A (ja) 1999-01-30 2009-01-08 特定遺伝子の発現を抑制するための方法および薬剤
JP2009002826A Division JP2009100758A (ja) 1999-01-30 2009-01-08 特定遺伝子の発現を抑制するための方法および薬剤
JP2009002824A Division JP2009100757A (ja) 1999-01-30 2009-01-08 特定遺伝子の発現を抑制するための方法および薬剤

Publications (1)

Publication Number Publication Date
JP2003502012A true JP2003502012A (ja) 2003-01-21

Family

ID=26051592

Family Applications (14)

Application Number Title Priority Date Filing Date
JP2000596137A Withdrawn JP2003502012A (ja) 1999-01-30 2000-01-29 特定遺伝子の発現を抑制するための方法および薬剤
JP2006248528A Withdrawn JP2007031443A (ja) 1999-01-30 2006-09-13 特定遺伝子の発現を抑制するための方法および薬剤
JP2006248529A Withdrawn JP2006340732A (ja) 1999-01-30 2006-09-13 特定遺伝子の発現を抑制するための方法および薬剤
JP2007186341A Pending JP2007312784A (ja) 1999-01-30 2007-07-17 特定遺伝子の発現を抑制するための方法および薬剤
JP2007186339A Pending JP2008005844A (ja) 1999-01-30 2007-07-17 特定遺伝子の発現を抑制するための方法および薬剤
JP2007186340A Pending JP2007314555A (ja) 1999-01-30 2007-07-17 特定遺伝子の発現を抑制するための方法および薬剤
JP2009002825A Pending JP2009102380A (ja) 1999-01-30 2009-01-08 特定遺伝子の発現を抑制するための方法および薬剤
JP2009002824A Pending JP2009100757A (ja) 1999-01-30 2009-01-08 特定遺伝子の発現を抑制するための方法および薬剤
JP2009002826A Pending JP2009100758A (ja) 1999-01-30 2009-01-08 特定遺伝子の発現を抑制するための方法および薬剤
JP2009285706A Pending JP2010057515A (ja) 1999-01-30 2009-12-16 特定遺伝子の発現を抑制するための方法および薬剤
JP2009285705A Withdrawn JP2010057514A (ja) 1999-01-30 2009-12-16 特定遺伝子の発現を抑制するための方法および薬剤
JP2013006076A Expired - Lifetime JP5990468B2 (ja) 1999-01-30 2013-01-17 特定遺伝子の発現を抑制するための方法および薬剤
JP2015098123A Expired - Lifetime JP6471901B2 (ja) 1999-01-30 2015-05-13 特定遺伝子の発現を抑制するための方法および薬剤
JP2018174668A Pending JP2019017390A (ja) 1999-01-30 2018-09-19 特定遺伝子の発現を抑制するための方法および薬剤

Family Applications After (13)

Application Number Title Priority Date Filing Date
JP2006248528A Withdrawn JP2007031443A (ja) 1999-01-30 2006-09-13 特定遺伝子の発現を抑制するための方法および薬剤
JP2006248529A Withdrawn JP2006340732A (ja) 1999-01-30 2006-09-13 特定遺伝子の発現を抑制するための方法および薬剤
JP2007186341A Pending JP2007312784A (ja) 1999-01-30 2007-07-17 特定遺伝子の発現を抑制するための方法および薬剤
JP2007186339A Pending JP2008005844A (ja) 1999-01-30 2007-07-17 特定遺伝子の発現を抑制するための方法および薬剤
JP2007186340A Pending JP2007314555A (ja) 1999-01-30 2007-07-17 特定遺伝子の発現を抑制するための方法および薬剤
JP2009002825A Pending JP2009102380A (ja) 1999-01-30 2009-01-08 特定遺伝子の発現を抑制するための方法および薬剤
JP2009002824A Pending JP2009100757A (ja) 1999-01-30 2009-01-08 特定遺伝子の発現を抑制するための方法および薬剤
JP2009002826A Pending JP2009100758A (ja) 1999-01-30 2009-01-08 特定遺伝子の発現を抑制するための方法および薬剤
JP2009285706A Pending JP2010057515A (ja) 1999-01-30 2009-12-16 特定遺伝子の発現を抑制するための方法および薬剤
JP2009285705A Withdrawn JP2010057514A (ja) 1999-01-30 2009-12-16 特定遺伝子の発現を抑制するための方法および薬剤
JP2013006076A Expired - Lifetime JP5990468B2 (ja) 1999-01-30 2013-01-17 特定遺伝子の発現を抑制するための方法および薬剤
JP2015098123A Expired - Lifetime JP6471901B2 (ja) 1999-01-30 2015-05-13 特定遺伝子の発現を抑制するための方法および薬剤
JP2018174668A Pending JP2019017390A (ja) 1999-01-30 2018-09-19 特定遺伝子の発現を抑制するための方法および薬剤

Country Status (13)

Country Link
US (17) US8119608B2 (enExample)
EP (6) EP1214945B2 (enExample)
JP (14) JP2003502012A (enExample)
AT (3) ATE297463T1 (enExample)
AU (2) AU778474B2 (enExample)
CA (1) CA2359180C (enExample)
CY (3) CY1108896T1 (enExample)
DE (7) DE19956568A1 (enExample)
DK (4) DK1214945T4 (enExample)
ES (5) ES2597953T3 (enExample)
PT (4) PT2363479T (enExample)
WO (1) WO2000044895A1 (enExample)
ZA (1) ZA200105909B (enExample)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002542263A (ja) * 1999-04-21 2002-12-10 ワイス ポリヌクレオチド配列の機能を阻害するための方法および組成物
JP2003514533A (ja) * 1999-11-19 2003-04-22 キャンサー・リサーチ・ヴェンチャーズ・リミテッド Ｄｓｒｎａによる遺伝子発現の阻害
JP2003529374A (ja) * 2000-03-30 2003-10-07 ホワイトヘッド インスチチュート フォアー バイオメディカル リサーチ Ｒｎａ干渉のｒｎａ配列特異的メディエータ
JP2005348733A (ja) * 2004-06-10 2005-12-22 National Taiwan Univ プロスタグランジンレダクターゼ
WO2006093083A1 (ja) * 2005-03-03 2006-09-08 Wako Pure Chemical Industries, Ltd. 架橋剤、架橋法、遺伝子発現調節法及び遺伝子機能調査法
WO2006112401A1 (ja) * 2005-04-18 2006-10-26 National University Corporation Hamamatsu University School Of Medicine 癌治療用組成物
WO2008140126A1 (ja) 2007-05-09 2008-11-20 Riken １本鎖環状ｒｎａおよびその製造方法
JP2012179054A (ja) * 2003-06-25 2012-09-20 Gencia Corp 細胞小器官トランスフェクションのための改質ベクター
JP2016192977A (ja) * 2009-02-12 2016-11-17 クルナ・インコーポレーテッド グリア細胞由来神経栄養因子（ｇｄｎｆ）関連疾病の、ｇｄｎｆに対する天然アンチセンス転写物の抑制による治療

Families Citing this family (659)

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US20030206887A1 (en) * 1992-05-14 2003-11-06 David Morrissey RNA interference mediated inhibition of hepatitis B virus (HBV) using short interfering nucleic acid (siNA)
US20030216335A1 (en) * 2001-11-30 2003-11-20 Jennifer Lockridge Method and reagent for the modulation of female reproductive diseases and conditions
US9096636B2 (en) 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
CA2513336A1 (en) 1998-03-20 1999-09-30 Benitec Australia Ltd. Control of gene expression in a non-human eukaryotic cell, tissue or organ
AU776150B2 (en) * 1999-01-28 2004-08-26 Medical College Of Georgia Research Institute, Inc. Composition and method for (in vivo) and (in vitro) attenuation of gene expression using double stranded RNA
DE19956568A1 (de) * 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
US7601494B2 (en) 1999-03-17 2009-10-13 The University Of North Carolina At Chapel Hill Method of screening candidate compounds for susceptibility to biliary excretion
US20070021979A1 (en) * 1999-04-16 2007-01-25 Cosentino Daniel L Multiuser wellness parameter monitoring system
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
US7531718B2 (en) 1999-08-26 2009-05-12 Monsanto Technology, L.L.C. Nucleic acid sequences and methods of use for the production of plants with modified polyunsaturated fatty acids
US7067722B2 (en) 1999-08-26 2006-06-27 Monsanto Technology Llc Nucleic acid sequences and methods of use for the production of plants with modified polyunsaturated fatty acids
ATE383433T1 (de) 1999-08-26 2008-01-15 Calgene Llc Pflanzen mit veränderten mehrfachungesättigten fettsäuren
GB9925459D0 (en) 1999-10-27 1999-12-29 Plant Bioscience Ltd Gene silencing
DE10160151A1 (de) * 2001-01-09 2003-06-26 Ribopharma Ag Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens
US7829693B2 (en) 1999-11-24 2010-11-09 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of a target gene
DE10100586C1 (de) 2001-01-09 2002-04-11 Ribopharma Ag Verfahren zur Hemmung der Expression eines Ziegens
WO2003070918A2 (en) 2002-02-20 2003-08-28 Ribozyme Pharmaceuticals, Incorporated Rna interference by modified short interfering nucleic acid
US8273866B2 (en) 2002-02-20 2012-09-25 Merck Sharp & Dohme Corp. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
US7833992B2 (en) 2001-05-18 2010-11-16 Merck Sharpe & Dohme Conjugates and compositions for cellular delivery
US8202979B2 (en) 2002-02-20 2012-06-19 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
US7491805B2 (en) 2001-05-18 2009-02-17 Sirna Therapeutics, Inc. Conjugates and compositions for cellular delivery
WO2002081628A2 (en) 2001-04-05 2002-10-17 Ribozyme Pharmaceuticals, Incorporated Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies
US8202846B2 (en) 2000-03-16 2012-06-19 Cold Spring Harbor Laboratory Methods and compositions for RNA interference
JP2003526367A (ja) 2000-03-16 2003-09-09 ジェネティカ インコーポレイテッド Ｒｎａ干渉の方法とｒｎａ干渉組成物
BRPI0117341B1 (pt) * 2000-03-30 2016-06-21 Massachusetts Inst Technology método para avaliar um agente agindo em um produto de gene, método para avaliar se um produto de gene é um alvo adequado para descoberta de drogas e método para avaliar se um produto de gene é um alvo adequado para avaliar a habilidade de um agente agir no produto de gene
US20030190635A1 (en) * 2002-02-20 2003-10-09 Mcswiggen James A. RNA interference mediated treatment of Alzheimer's disease using short interfering RNA
WO2005003350A2 (en) * 2003-06-27 2005-01-13 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED TREATMENT OF ALZHEIMER’S DISEASE USING SHORT INTERFERING NUCLEIC ACID (siNA)
US20080032942A1 (en) 2000-08-30 2008-02-07 Mcswiggen James RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA)
CA2427347C (en) * 2000-10-31 2011-01-18 Commonwealth Scientific And Industrial Research Organisation Method and means for producing barley yellow dwarf virus resistant cereal plants
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