CR20210558A - Compuestos antivirales que contienen nitrilo - Google Patents
Compuestos antivirales que contienen nitriloInfo
- Publication number
- CR20210558A CR20210558A CR20210558A CR20210558A CR20210558A CR 20210558 A CR20210558 A CR 20210558A CR 20210558 A CR20210558 A CR 20210558A CR 20210558 A CR20210558 A CR 20210558A CR 20210558 A CR20210558 A CR 20210558A
- Authority
- CR
- Costa Rica
- Prior art keywords
- compounds containing
- antiviral compounds
- containing nitrile
- zqfex
- znn2nsjlt
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000000840 anti-viral effect Effects 0.000 title 1
- 150000002825 nitriles Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Physiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nutrition Science (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
La invención se refiere a compuestos de la Fórmula I <img src="data:image/png;base64,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 (***)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063073982P | 2020-09-03 | 2020-09-03 | |
US202163143435P | 2021-01-29 | 2021-01-29 | |
US202163170158P | 2021-04-02 | 2021-04-02 | |
US202163194241P | 2021-05-28 | 2021-05-28 | |
PCT/IB2021/057281 WO2021250648A1 (en) | 2020-09-03 | 2021-08-06 | Nitrile-containing antiviral compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20210558A true CR20210558A (es) | 2022-01-24 |
Family
ID=77411985
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20210558A CR20210558A (es) | 2020-09-03 | 2021-08-06 | Compuestos antivirales que contienen nitrilo |
Country Status (33)
Country | Link |
---|---|
US (4) | US11351149B2 (es) |
EP (2) | EP3953330B1 (es) |
JP (2) | JP7126628B2 (es) |
KR (2) | KR102481876B1 (es) |
CN (3) | CN114681443B (es) |
AU (3) | AU2021266232C1 (es) |
BR (2) | BR122023004755B1 (es) |
CA (1) | CA3137824C (es) |
CL (1) | CL2021002965A1 (es) |
CO (1) | CO2021015067A2 (es) |
CR (1) | CR20210558A (es) |
DK (1) | DK3953330T3 (es) |
DO (1) | DOP2023000168A (es) |
EC (1) | ECSP21080528A (es) |
ES (1) | ES2932173T3 (es) |
GE (2) | GEP20237515B (es) |
HR (1) | HRP20221379T1 (es) |
HU (1) | HUE060811T2 (es) |
IL (2) | IL299071A (es) |
LT (1) | LT3953330T (es) |
MD (1) | MD3953330T2 (es) |
MX (1) | MX2021013679A (es) |
MY (1) | MY196455A (es) |
NZ (1) | NZ782196A (es) |
PE (1) | PE20220432A1 (es) |
PL (1) | PL3953330T3 (es) |
PT (1) | PT3953330T (es) |
RS (1) | RS63714B1 (es) |
SI (1) | SI3953330T1 (es) |
TW (1) | TWI790704B (es) |
UY (1) | UY39372A (es) |
WO (1) | WO2021250648A1 (es) |
ZA (3) | ZA202108834B (es) |
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US11124497B1 (en) | 2020-04-17 | 2021-09-21 | Pardes Biosciences, Inc. | Inhibitors of cysteine proteases and methods of use thereof |
US11174231B1 (en) | 2020-06-09 | 2021-11-16 | Pardes Biosciences, Inc. | Inhibitors of cysteine proteases and methods of use thereof |
KR20230038457A (ko) | 2020-06-10 | 2023-03-20 | 알리고스 테라퓨틱스 인코포레이티드 | 코로나바이러스, 피코르나바이러스 및 노로바이러스 감염을 치료하기 위한 항바이러스 화합물 |
EP4051265A4 (en) | 2020-07-20 | 2022-12-28 | Enanta Pharmaceuticals, Inc. | FUNCTIONALIZED PEPTIDES AS ANTIVIRAL AGENTS |
US11384090B2 (en) | 2020-11-23 | 2022-07-12 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
US11352363B1 (en) | 2020-11-23 | 2022-06-07 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
US11976084B2 (en) | 2020-11-23 | 2024-05-07 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
US20240043417A1 (en) * | 2020-12-01 | 2024-02-08 | Purdue Research Foundation | Compounds for the treatment of sars |
US20220204476A1 (en) * | 2020-12-21 | 2022-06-30 | The Governors Of The University Of Alberta | Rna virus inhibitor compounds and uses thereof |
EP4122926A4 (en) | 2021-04-14 | 2023-08-30 | Shionogi & Co., Ltd | TRIAZINE DERIVATIVE HAVING AN INHIBITOR EFFECT ON THE PROPAGATION OF VIRUSES, AND PHARMACEUTICAL COMPOSITION CONTAINING IT |
CA3201360A1 (en) * | 2021-04-16 | 2022-10-20 | Shuhui Chen | Ring-modified proline short peptide compound and use thereof |
WO2022235605A1 (en) | 2021-05-04 | 2022-11-10 | Enanta Pharmaceuticals, Inc. | Novel macrocyclic antiviral agents |
US11857617B2 (en) | 2021-05-10 | 2024-01-02 | Topelia Aust Limited (652 771 670) | Methods for treating, ameliorating or preventing infections using drug and vaccination combination treatment |
US11319325B1 (en) | 2021-05-11 | 2022-05-03 | Enanta Pharmaceuticals, Inc. | Macrocyclic spiropyrrolidine derived antiviral agents |
US11753373B2 (en) | 2021-06-02 | 2023-09-12 | ACEA Therapeutics, Inc. | Protease inhibitors as antivirals |
WO2022266363A1 (en) * | 2021-06-16 | 2022-12-22 | The Scripps Research Institute | Protease inhibitors for the treatment of coronavirus infections |
CN113444144A (zh) * | 2021-06-23 | 2021-09-28 | 周龙兴 | 一种蛋白酶抑制剂及其药物组合物和用途 |
IL309732A (en) | 2021-07-09 | 2024-02-01 | Aligos Therapeutics Inc | Antiviral compounds |
US11339170B1 (en) | 2021-07-23 | 2022-05-24 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
CN114149415A (zh) * | 2021-07-26 | 2022-03-08 | 中国药科大学 | 一种拟肽类化合物及其衍生物、制备方法、药物组合物和应用 |
US11325916B1 (en) | 2021-07-29 | 2022-05-10 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
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