BRPI0514263A - catálise de sìntese de dicetopiperazina - Google Patents

catálise de sìntese de dicetopiperazina

Info

Publication number
BRPI0514263A
BRPI0514263A BRPI0514263-6A BRPI0514263A BRPI0514263A BR PI0514263 A BRPI0514263 A BR PI0514263A BR PI0514263 A BRPI0514263 A BR PI0514263A BR PI0514263 A BRPI0514263 A BR PI0514263A
Authority
BR
Brazil
Prior art keywords
diketopiperazine
synthesis catalysis
diketopiperazine synthesis
catalysis
protected
Prior art date
Application number
BRPI0514263-6A
Other languages
English (en)
Inventor
John J Stevenson
Destardi Moye-Sherman
Original Assignee
Mannkind Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35717513&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0514263(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mannkind Corp filed Critical Mannkind Corp
Publication of BRPI0514263A publication Critical patent/BRPI0514263A/pt
Publication of BRPI0514263B1 publication Critical patent/BRPI0514263B1/pt
Publication of BRPI0514263B8 publication Critical patent/BRPI0514263B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J27/00—Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds
    • B01J27/14—Phosphorus; Compounds thereof
    • B01J27/16—Phosphorus; Compounds thereof containing oxygen, i.e. acids, anhydrides and their derivates with N, S, B or halogens without carriers or on carriers based on C, Si, Al or Zr; also salts of Si, Al and Zr

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)

Abstract

CATáLISE DE SìNTESE DE DICETOPIPERAZINA. A presente invenção se refere a um método para a síntese de bis-3, 6- ¢4-aminobutil!-2, 5-dicetopiperazina N protegida incluindo a etapa de aquecimento de uma solução de lisina <sym>protegida na presença de um catalisador selecionado do grupo consistindo em ácido sulfúrico, ácido fosfórico, e pentóxido fosforoso.
BRPI0514263A 2004-08-20 2005-08-19 método para a síntese de bis-3,6-[4-aminobutil]-2,5-dicetopiperazina n-protegida BRPI0514263B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60334004P 2004-08-20 2004-08-20
PCT/US2005/029777 WO2006023849A2 (en) 2004-08-20 2005-08-19 Catalysis of diketopiperazine synthesis

Publications (3)

Publication Number Publication Date
BRPI0514263A true BRPI0514263A (pt) 2008-06-03
BRPI0514263B1 BRPI0514263B1 (pt) 2018-05-08
BRPI0514263B8 BRPI0514263B8 (pt) 2021-05-25

Family

ID=35717513

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514263A BRPI0514263B8 (pt) 2004-08-20 2005-08-19 método para a síntese de bis-3,6-[4-aminobutil]-2,5-dicetopiperazina n-protegida

Country Status (17)

Country Link
US (8) US7709639B2 (pt)
EP (1) EP1786784B1 (pt)
JP (1) JP5078014B2 (pt)
KR (1) KR101273120B1 (pt)
CN (1) CN101010305B (pt)
AT (1) ATE486064T1 (pt)
AU (1) AU2005277208B2 (pt)
BR (1) BRPI0514263B8 (pt)
CA (1) CA2575692C (pt)
DE (1) DE602005024413D1 (pt)
DK (1) DK1786784T3 (pt)
ES (1) ES2385934T3 (pt)
HK (1) HK1105294A1 (pt)
IL (2) IL181091A (pt)
MX (1) MX2007001903A (pt)
PL (1) PL1786784T3 (pt)
WO (1) WO2006023849A2 (pt)

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