BR9906539A - Polimorfo de ácido 2-(3-ciano-4-isobutil-óxi-fenil)-4-metil-5-tiazol-carboxì lico, composto amorfo, processos para produção de um composto amorfo, para produção de cristal, a, b, c, d, g de ácido. 2-(3-ciano-4-isobutil-óxi-fenil)-4-metil-5-tiazol-carboxì lico, e, polimorfo - Google Patents

Polimorfo de ácido 2-(3-ciano-4-isobutil-óxi-fenil)-4-metil-5-tiazol-carboxì lico, composto amorfo, processos para produção de um composto amorfo, para produção de cristal, a, b, c, d, g de ácido. 2-(3-ciano-4-isobutil-óxi-fenil)-4-metil-5-tiazol-carboxì lico, e, polimorfo

Info

Publication number
BR9906539A
BR9906539A BR9906539-8A BR9906539A BR9906539A BR 9906539 A BR9906539 A BR 9906539A BR 9906539 A BR9906539 A BR 9906539A BR 9906539 A BR9906539 A BR 9906539A
Authority
BR
Brazil
Prior art keywords
oxy
isobutyl
phenyl
methyl
thiazol
Prior art date
Application number
BR9906539-8A
Other languages
English (en)
Inventor
Koichi Matsumoto
Kenzo Watanabe
Toshiyuki Hiramatsu
Mitsutaka Kitamura
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=15953825&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9906539(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teijin Ltd filed Critical Teijin Ltd
Publication of BR9906539A publication Critical patent/BR9906539A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"POLIMORFO DE áCIDO 2-(3-CIANO-4-ISOBUTIL-óXI-FENIL)-4-METIL-5-TIAZOL-CARBOXì LICO, COMPOSTO AMORFO, PROCESSOS PARA PRODUçãO DE UM COMPOSTO AMORFO, PARA PRODUçãO DE CRISTAL A, B, C, D, G DE áCIDO 2-(3-CIANO-4-ISOBUTIL-óXI-FENIL)-4-METIL-5-TIAZOL-CARBOXì LICO, E, POLIMORFO". Um processo para preparar várias modificações polimórficas de ácido 2-(3-ciano-4-isobutil-óxi-fenil)-4-metil-5-tiazol-carboxílico, cada uma seletivamente por cristalização sob as condições específicas determinadas pela temperatura e pela relação de metanol/água do solvente misto a ser usada; e modificações polimórficas de ácido 2-(3-ciano-4-isobutil-óxi-fenil)-4-metil-5-tiazol-carboxílico como obtida por este processo. Um processo de sujeitar uma modificação polimórfica específica do ácido acima para aquecer e secar à vácuo para, desse modo, obter outra modificação polimórfica do ácido ou uma modificação amorfa do mesmo; e modificações polimórficas e amorfas do ácido obtidas por este processo.
BR9906539-8A 1998-06-19 1999-06-18 Polimorfo de ácido 2-(3-ciano-4-isobutil-óxi-fenil)-4-metil-5-tiazol-carboxì lico, composto amorfo, processos para produção de um composto amorfo, para produção de cristal, a, b, c, d, g de ácido. 2-(3-ciano-4-isobutil-óxi-fenil)-4-metil-5-tiazol-carboxì lico, e, polimorfo BR9906539A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP17307998 1998-06-19
PCT/JP1999/003258 WO1999065885A1 (en) 1998-06-19 1999-06-18 Polymorphic modifications of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazole-carboxylic acid and processes for the preparation thereof

Publications (1)

Publication Number Publication Date
BR9906539A true BR9906539A (pt) 2000-08-15

Family

ID=15953825

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9906539-8A BR9906539A (pt) 1998-06-19 1999-06-18 Polimorfo de ácido 2-(3-ciano-4-isobutil-óxi-fenil)-4-metil-5-tiazol-carboxì lico, composto amorfo, processos para produção de um composto amorfo, para produção de cristal, a, b, c, d, g de ácido. 2-(3-ciano-4-isobutil-óxi-fenil)-4-metil-5-tiazol-carboxì lico, e, polimorfo

Country Status (39)

Country Link
US (1) US6225474B1 (pt)
EP (4) EP2404910A3 (pt)
JP (1) JP3547707B2 (pt)
KR (1) KR100511183B1 (pt)
CN (3) CN1275126A (pt)
AT (2) ATE449765T1 (pt)
AU (1) AU748026B2 (pt)
BE (1) BE2010C024I2 (pt)
BG (1) BG64734B1 (pt)
BR (1) BR9906539A (pt)
CA (2) CA2566652C (pt)
CY (3) CY1109720T1 (pt)
CZ (1) CZ298170B6 (pt)
DE (2) DE69941672D1 (pt)
DK (3) DK1956015T4 (pt)
ES (3) ES2371786T5 (pt)
FR (1) FR10C0022I2 (pt)
GT (1) GT199900216A (pt)
HK (2) HK1029788A1 (pt)
HR (2) HRP20000092C1 (pt)
HU (2) HU229405B1 (pt)
ID (1) ID25775A (pt)
IL (1) IL134594A (pt)
IN (1) IN191537B (pt)
IS (4) IS9020A (pt)
LT (1) LT1956014T (pt)
LU (1) LU91682I2 (pt)
NO (1) NO321308B1 (pt)
NZ (1) NZ503326A (pt)
PL (1) PL200710B1 (pt)
PT (3) PT1956014T (pt)
RU (1) RU2198169C3 (pt)
SI (3) SI1020454T2 (pt)
SK (2) SK287946B6 (pt)
TR (1) TR200000458T1 (pt)
TW (1) TWI248439B (pt)
UA (1) UA57611C2 (pt)
WO (1) WO1999065885A1 (pt)
ZA (1) ZA200000737B (pt)

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JP7389044B2 (ja) 2018-09-28 2023-11-29 株式会社カネカ 安定性に優れた還元型補酵素ｑ１０結晶の製造方法
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