BE2010C024I2 - Polymorphs of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid and method of producing the same - Google Patents

Polymorphs of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid and method of producing the same

Info

Publication number
BE2010C024I2
BE2010C024I2 BE2010C024C BE2010C024C BE2010C024I2 BE 2010C024 I2 BE2010C024 I2 BE 2010C024I2 BE 2010C024 C BE2010C024 C BE 2010C024C BE 2010C024 C BE2010C024 C BE 2010C024C BE 2010C024 I2 BE2010C024 I2 BE 2010C024I2
Authority
BE
Belgium
Prior art keywords
isobutyloxyphenyl
cyano
methyl
producing
thiazolecarboxylic acid
Prior art date
Application number
BE2010C024C
Other languages
French (fr)
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=15953825&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE2010C024(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teijin Ltd filed Critical Teijin Ltd
Publication of BE2010C024I2 publication Critical patent/BE2010C024I2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention provides a technique of selectively producing a polymorph of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid.
The present invention also provides a method of producing the said polymorphs of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid, which comprises crystallizing under the conditions defined by a specific temperature and a composition of a mixed solvent of methanol and water.
BE2010C024C 1998-06-19 2010-05-12 Polymorphs of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid and method of producing the same BE2010C024I2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP17307998 1998-06-19
EP99957054A EP1020454B2 (en) 1998-06-19 1999-06-18 Polymorphic modifications of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazole-carboxylic acid and processes for the preparation thereof
PCT/JP1999/003258 WO1999065885A1 (en) 1998-06-19 1999-06-18 Polymorphic modifications of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazole-carboxylic acid and processes for the preparation thereof

Publications (1)

Publication Number Publication Date
BE2010C024I2 true BE2010C024I2 (en) 2018-08-24

Family

ID=15953825

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2010C024C BE2010C024I2 (en) 1998-06-19 2010-05-12 Polymorphs of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid and method of producing the same

Country Status (38)

Country Link
US (1) US6225474B1 (en)
EP (4) EP1020454B2 (en)
JP (1) JP3547707B2 (en)
KR (1) KR100511183B1 (en)
CN (3) CN1275126A (en)
AT (2) ATE449765T1 (en)
AU (1) AU748026B2 (en)
BE (1) BE2010C024I2 (en)
BG (1) BG64734B1 (en)
BR (1) BR9906539A (en)
CA (2) CA2301863C (en)
CY (3) CY1109720T1 (en)
CZ (1) CZ298170B6 (en)
DE (2) DE69941672D1 (en)
DK (3) DK1956014T3 (en)
ES (3) ES2336287T5 (en)
FR (1) FR10C0022I2 (en)
GT (1) GT199900216A (en)
HR (2) HRP20120217B1 (en)
HU (2) HU229405B1 (en)
ID (1) ID25775A (en)
IL (1) IL134594A (en)
IN (1) IN191537B (en)
IS (4) IS9020A (en)
LT (1) LT1956014T (en)
LU (1) LU91682I2 (en)
NO (1) NO321308B1 (en)
NZ (1) NZ503326A (en)
PL (1) PL200710B1 (en)
PT (3) PT1956015E (en)
RU (1) RU2198169C3 (en)
SI (3) SI1956014T1 (en)
SK (2) SK287928B6 (en)
TR (1) TR200000458T1 (en)
TW (1) TWI248439B (en)
UA (1) UA57611C2 (en)
WO (1) WO1999065885A1 (en)
ZA (1) ZA200000737B (en)

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NO321308B1 (en) 2006-04-24
IS3002B (en) 2018-09-15
DK1956014T3 (en) 2019-04-15
IL134594A (en) 2004-12-15
EP1956015B1 (en) 2011-08-31
LU91682I2 (en) 2010-06-22
KR100511183B1 (en) 2005-08-30
IS5377A (en) 2000-02-17
CY2010006I1 (en) 2012-01-25
PT1956015E (en) 2011-11-02
ATE522512T2 (en) 2011-09-15
EP2404910A3 (en) 2014-10-29
SI1020454T2 (en) 2013-03-29
EP1956014B1 (en) 2019-01-16
IS9020A (en) 2013-01-25
CA2301863A1 (en) 1999-12-23
PL200710B1 (en) 2009-01-30
LU91682I9 (en) 2019-01-09
KR20010023061A (en) 2001-03-26
ES2718467T3 (en) 2019-07-02
HRP20120217B1 (en) 2019-04-05
EP1020454B2 (en) 2013-01-23
TR200000458T1 (en) 2000-10-23
ES2336287T3 (en) 2010-04-09
AU4289299A (en) 2000-01-05
HUP0004325A3 (en) 2001-12-28
ES2336287T5 (en) 2013-04-02
BR9906539A (en) 2000-08-15
DK1020454T4 (en) 2013-11-25
IS9022A (en) 2013-01-25
DK1020454T3 (en) 2010-01-04
NO20000789D0 (en) 2000-02-17
DK1956015T4 (en) 2019-02-11
HK1118293A1 (en) 2009-02-06
CN102020617A (en) 2011-04-20
EP1956015B2 (en) 2018-11-14
SI1956015T1 (en) 2011-10-28
SK2202000A3 (en) 2000-11-07
PL338780A1 (en) 2000-11-20
TWI248439B (en) 2006-02-01
WO1999065885A1 (en) 1999-12-23
HRP20120217A2 (en) 2012-05-31
PT1956014T (en) 2019-04-24
CY1109720T1 (en) 2012-01-25
EP2404910A2 (en) 2012-01-11
HK1029788A1 (en) 2001-04-12
ZA200000737B (en) 2000-09-08
HRPK20000092B1 (en) 2001-10-31
CZ298170B6 (en) 2007-07-11
ID25775A (en) 2000-11-02
AU748026B2 (en) 2002-05-30
NZ503326A (en) 2002-02-01
RU2198169C2 (en) 2003-02-10
ES2371786T3 (en) 2012-01-10
SI1956014T1 (en) 2019-02-28
SK287928B6 (en) 2012-04-03
GT199900216A (en) 2001-06-08
ATE449765T1 (en) 2009-12-15
EP1020454A1 (en) 2000-07-19
HUP0004325A2 (en) 2001-10-28
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