ECSP993280A - ACID POLYMORPHES 2- (3- CIANO -4 -BOBITILOXY PHENYL) -4 -METIL -5-CARBOXYL TIAZOL AND PRODUCTION METHOD OF THE SAME - Google Patents

ACID POLYMORPHES 2- (3- CIANO -4 -BOBITILOXY PHENYL) -4 -METIL -5-CARBOXYL TIAZOL AND PRODUCTION METHOD OF THE SAME

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Publication number
ECSP993280A
ECSP993280A ECSP993280A ECSP993280A EC SP993280 A ECSP993280 A EC SP993280A EC SP993280 A ECSP993280 A EC SP993280A EC SP993280 A ECSP993280 A EC SP993280A
Authority
EC
Ecuador
Prior art keywords
phenyl
bobitiloxy
polymorphes
tiazol
ciano
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Koichi Matsumoto
Kenzo Watanabe
Toshiyuki Hiramatsu
Mitsutaka Kitamura
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP993280 priority Critical patent/ECSP993280A/en
Publication of ECSP993280A publication Critical patent/ECSP993280A/en

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  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención provee una técnica para producir selectivamente un polimorfo deseado de ácido 2-(3-ciano-4-isobutiloxi fenil)-4-metil-5-tiazol carboxílico. La presente invención provee también un método para producir varios polimorfos de ácido 2-(3-ciano-4-isobutiloxi fenil)-4-metil-5-tiazol carboxílico que comprende cristalizar bajo condiciones definidas por una temperatura específica y una composición de un solvente mixto de metanol y agua, y los polimorfos obtenidos por el método. La presente invención provee además un método para producir los otros compuestos polimorfos o amorfos mediante secado de un polimorfo específico bajo presión reducida con calentamiento, y los otros compuestos polimorfos o amorfos obtenidos mediante el método.The present invention provides a technique for selectively producing a desired polymorph of 2- (3-cyano-4-isobutyl-phenyl) -4-methyl-5-thiazole carboxylic acid. The present invention also provides a method for producing various polymorphs of 2- (3-cyano-4-isobutyl-phenyl) -4-methyl-5-thiazole carboxylic acid comprising crystallizing under conditions defined by a specific temperature and a solvent composition. mixed methanol and water, and polymorphs obtained by the method. The present invention further provides a method for producing the other polymorphic or amorphous compounds by drying a specific polymorph under reduced pressure with heating, and the other polymorphic or amorphous compounds obtained by the method.

ECSP993280 1999-12-17 1999-12-17 ACID POLYMORPHES 2- (3- CIANO -4 -BOBITILOXY PHENYL) -4 -METIL -5-CARBOXYL TIAZOL AND PRODUCTION METHOD OF THE SAME ECSP993280A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP993280 ECSP993280A (en) 1999-12-17 1999-12-17 ACID POLYMORPHES 2- (3- CIANO -4 -BOBITILOXY PHENYL) -4 -METIL -5-CARBOXYL TIAZOL AND PRODUCTION METHOD OF THE SAME

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP993280 ECSP993280A (en) 1999-12-17 1999-12-17 ACID POLYMORPHES 2- (3- CIANO -4 -BOBITILOXY PHENYL) -4 -METIL -5-CARBOXYL TIAZOL AND PRODUCTION METHOD OF THE SAME

Publications (1)

Publication Number Publication Date
ECSP993280A true ECSP993280A (en) 2001-07-27

Family

ID=42044269

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP993280 ECSP993280A (en) 1999-12-17 1999-12-17 ACID POLYMORPHES 2- (3- CIANO -4 -BOBITILOXY PHENYL) -4 -METIL -5-CARBOXYL TIAZOL AND PRODUCTION METHOD OF THE SAME

Country Status (1)

Country Link
EC (1) ECSP993280A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9107912B2 (en) 2010-09-10 2015-08-18 Takeda Pharmaceuticals U.S.A., Inc. Methods for concomitant treatment of theophylline and febuxostat
US9248119B2 (en) 2010-06-16 2016-02-02 Takeda Pharmaceuticals U.S.A., Inc. Modified release dosage forms of xanthine oxidoreductase inhibitor or xanthine oxidase inhibitors

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9248119B2 (en) 2010-06-16 2016-02-02 Takeda Pharmaceuticals U.S.A., Inc. Modified release dosage forms of xanthine oxidoreductase inhibitor or xanthine oxidase inhibitors
US9937157B2 (en) 2010-06-16 2018-04-10 Takeda Pharmaceuticals U.S.A., Inc. Modified release dosage forms of xanthine oxidoreductase inhibitor or xanthine oxidase inhibitors
US9107912B2 (en) 2010-09-10 2015-08-18 Takeda Pharmaceuticals U.S.A., Inc. Methods for concomitant treatment of theophylline and febuxostat

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