LU91682I2 - Adenuric - febuxostat - Google Patents
Adenuric - febuxostatInfo
- Publication number
- LU91682I2 LU91682I2 LU91682C LU91682C LU91682I2 LU 91682 I2 LU91682 I2 LU 91682I2 LU 91682 C LU91682 C LU 91682C LU 91682 C LU91682 C LU 91682C LU 91682 I2 LU91682 I2 LU 91682I2
- Authority
- LU
- Luxembourg
- Prior art keywords
- polymorphs
- present
- producing
- provides
- isobutyloxyphenyl
- Prior art date
Links
- BQSJTQLCZDPROO-UHFFFAOYSA-N febuxostat Chemical compound C1=C(C#N)C(OCC(C)C)=CC=C1C1=NC(C)=C(C(O)=O)S1 BQSJTQLCZDPROO-UHFFFAOYSA-N 0.000 title abstract 3
- 229960005101 febuxostat Drugs 0.000 title 2
- 238000000034 method Methods 0.000 abstract 5
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000001035 drying Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000012046 mixed solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Physical Education & Sports Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17307998 | 1998-06-19 | ||
| PCT/JP1999/003258 WO1999065885A1 (fr) | 1998-06-19 | 1999-06-18 | Modifications polymorphes de 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazole-acide carboxylique et procedes de preparation associes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LU91682I2 true LU91682I2 (fr) | 2010-06-22 |
| LU91682I9 LU91682I9 (fr) | 2019-01-09 |
Family
ID=15953825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU91682C LU91682I2 (fr) | 1998-06-19 | 2010-04-22 | Adenuric - febuxostat |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US6225474B1 (fr) |
| EP (4) | EP1020454B2 (fr) |
| JP (1) | JP3547707B2 (fr) |
| KR (1) | KR100511183B1 (fr) |
| CN (3) | CN102020617B (fr) |
| AT (2) | ATE522512T2 (fr) |
| AU (1) | AU748026B2 (fr) |
| BE (1) | BE2010C024I2 (fr) |
| BG (1) | BG64734B1 (fr) |
| BR (1) | BR9906539A (fr) |
| CA (2) | CA2301863C (fr) |
| CY (3) | CY1109720T1 (fr) |
| CZ (1) | CZ298170B6 (fr) |
| DE (2) | DE69941672D1 (fr) |
| DK (3) | DK1956014T3 (fr) |
| ES (3) | ES2336287T5 (fr) |
| FR (1) | FR10C0022I2 (fr) |
| GT (1) | GT199900216A (fr) |
| HR (2) | HRP20120217B1 (fr) |
| HU (2) | HU229405B1 (fr) |
| ID (1) | ID25775A (fr) |
| IL (1) | IL134594A (fr) |
| IN (1) | IN191537B (fr) |
| IS (4) | IS9020A (fr) |
| LT (1) | LT1956014T (fr) |
| LU (1) | LU91682I2 (fr) |
| NO (1) | NO321308B1 (fr) |
| NZ (1) | NZ503326A (fr) |
| PL (1) | PL200710B1 (fr) |
| PT (3) | PT1956014T (fr) |
| RU (1) | RU2198169C3 (fr) |
| SI (3) | SI1956015T2 (fr) |
| SK (2) | SK287928B6 (fr) |
| TR (1) | TR200000458T1 (fr) |
| TW (1) | TWI248439B (fr) |
| UA (1) | UA57611C2 (fr) |
| WO (1) | WO1999065885A1 (fr) |
| ZA (1) | ZA200000737B (fr) |
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| AU748026B2 (en) | 1998-06-19 | 2002-05-30 | Teijin Limited | Polymorphic modifications of 2-(3-cyano-4-isobutyloxyphenyl)- 4-methyl-5-thiazole-carboxylic acid and processes for the preparation thereof |
| WO2003006441A1 (fr) * | 2001-07-10 | 2003-01-23 | Pharmacia & Upjohn Company | Cristaux a base de thiazine oxazolidinones |
| ES2705063T3 (es) | 2001-08-15 | 2019-03-21 | Pharmacia & Upjohn Co Llc | Un cristal que comprende una sal de ácido L-málico de N-[2-(dietilamino)etil]-5-[(5-fluoro-1,2-dihidro-2-oxo-3H-indol-3-iliden)metil]-2,4-dimetil-1H-pirrol-3-carboxamida para su uso como un medicamento |
| CA2471144C (fr) * | 2002-01-09 | 2011-06-07 | Emisphere Technologies, Inc. | Polymorphes de 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate de sodium |
| JP2003261548A (ja) * | 2002-03-07 | 2003-09-19 | Teijin Ltd | 2−(3−シアノ−4−イソブチルオキシフェニル)−4−メチル−5−チアゾールカルボン酸の結晶多形体の製造方法 |
| DK1488790T3 (da) * | 2002-03-28 | 2014-10-13 | Teijin Pharma Ltd | Fast præparat indeholdende en enkeltkrystalform A af etthiazolcarboxylsyrederivat |
| JP2008545627A (ja) * | 2005-05-09 | 2008-12-18 | タツプ・フアーマシユーテイカル・プロダクツ・インコーポレイテツド | 腎結石症を治療する方法 |
| CN100430055C (zh) * | 2005-11-11 | 2008-11-05 | 天津泰普药品科技发展有限公司 | 2-(3-氰基-4-异丁氧基苯基)-4-甲基-5-噻唑甲酸和聚乙烯吡咯烷酮玻璃态固溶体及其制备方法 |
| JP5193863B2 (ja) * | 2006-06-23 | 2013-05-08 | 帝人ファーマ株式会社 | 2−(3−シアノ−4−イソブチルオキシフェニル)−4−メチル−5−チアゾールカルボン酸の結晶多形体の製造方法 |
| CN101812035B (zh) * | 2006-09-07 | 2012-03-21 | 上海医药工业研究院 | 2-(3-氰基-4-异丁氧基苯基)-4-甲基-5-噻唑甲酸晶型及其制备方法 |
| CN101139325B (zh) * | 2006-09-07 | 2010-05-12 | 上海医药工业研究院 | 2-(3-氰基-4-异丁氧基苯基)-4-甲基-5-噻唑甲酸晶型及其制备方法 |
| US20090124623A1 (en) * | 2006-11-13 | 2009-05-14 | Christopher Lademacher | Methods for preserving and/or increasing renal function using xanthine oxidoreductase inhibitors |
| JP2010509372A (ja) * | 2006-11-13 | 2010-03-25 | タケダ・フアーマシユーテイカルズ・ノース・アメリカ・インコーポレイテツド | キサンチン酸化還元酵素阻害剤を使用する腎機能保持方法 |
| CN102093308B (zh) * | 2006-12-07 | 2012-08-29 | 重庆医药工业研究院有限责任公司 | 非布司他的晶型及其制备方法 |
| CN1970547B (zh) * | 2006-12-07 | 2011-04-06 | 重庆医药工业研究院有限责任公司 | 非布司他的晶型及其制备方法 |
| CN102093309B (zh) * | 2006-12-07 | 2012-07-04 | 重庆医药工业研究院有限责任公司 | 非布司他的晶型及其制备方法 |
| BRPI0806608A2 (pt) * | 2007-01-19 | 2011-09-06 | Takeda Pharmaceuticals North America Inc | métodos para prevenir ou reduzir o número de surtos agudos de gota utilizando inibidores xantina oxidoredutase e agentes anti-inflamatórios |
| CN101412700B (zh) * | 2007-10-19 | 2011-06-08 | 上海医药工业研究院 | 非布司他的晶型及其制备方法 |
| CN101386605B (zh) * | 2008-10-23 | 2010-09-08 | 中国科学院上海药物研究所 | 非布司他新型晶体及其制备方法 |
| CN101759656B (zh) * | 2008-12-12 | 2013-04-03 | 重庆医药工业研究院有限责任公司 | 非布司他新晶型及其制备方法 |
| CN101768150B (zh) * | 2009-01-05 | 2014-08-06 | 常州市第四制药厂有限公司 | 2-[3-氰基-4-异丁氧基苯基]-4-甲基噻唑-5-甲酸晶型及其制备方法 |
| US20100311756A1 (en) * | 2009-01-22 | 2010-12-09 | Takeda Pharmaceuticals North America, Inc. | Methods for delaying the progression of at least one of cardiac hypertrophy, cardiac remodeling or left ventricular function or the onset of heart failure in subjects in need of treatment thereof |
| CN101891702B (zh) * | 2009-05-22 | 2012-07-04 | 重庆圣华曦药业股份有限公司 | 非布司他的晶体、制备方法及在药物中的应用 |
| KR20120140267A (ko) | 2009-06-10 | 2012-12-28 | 테바 파마슈티컬 인더스트리즈 리미티드 | 페북소스타트의 결정형 |
| EP2455372B1 (fr) | 2009-07-15 | 2017-10-11 | Teijin Pharma Limited | Procédé de fabrication de cristaux d'acide 2-(3-cyano-4-isobutyloxyphényl)-4-méthyl-5-thiazolecarboxylique polymorphique par une méthode d'addition d'un solvant médiocre |
| JP5519201B2 (ja) * | 2009-07-15 | 2014-06-11 | 光孝 北村 | 2−(3−シアノ−4−イソブチルオキシフェニル)−4−メチル−5−チアゾールカルボン酸の結晶多形体の製造方法 |
| CN103936689B (zh) * | 2009-07-17 | 2016-08-17 | 北京利乐生制药科技有限公司 | 2-[3-氰基-4-异丁氧基苯基]-4-甲基噻唑-5-甲酸晶型及其制备方法 |
| WO2011080651A2 (fr) | 2009-12-31 | 2011-07-07 | Ranbaxy Laboratories Limited | Formes polymorphes de fébuxostat |
| EP2536699A2 (fr) | 2010-02-19 | 2012-12-26 | Cadila Healthcare Limited | Sels essentiellement purs de fébuxostat et leurs procédés de préparation |
| CA2792036A1 (fr) | 2010-03-04 | 2011-09-09 | Ranbaxy Laboratories Limited | Polymorphe d'acide 2-[3-cyano-4-(2-methylpropoxy) phenyl]-4-methylthiazole-5-carboxylique |
| WO2011134101A1 (fr) * | 2010-04-27 | 2011-11-03 | 上海凯米侬医药科技有限公司 | Nouvelle forme cristalline n du fébuxostat et sa méthode de préparation |
| CN101824005B (zh) * | 2010-04-27 | 2012-06-27 | 上海凯米侬医药科技有限公司 | 一种非布索坦的晶型q及其制备方法 |
| EP2563768A4 (fr) * | 2010-04-29 | 2013-07-31 | Reddys Lab Ltd Dr | Préparation of fébuxostat |
| IT1400310B1 (it) | 2010-05-10 | 2013-05-24 | Menarini Int Operations Lu Sa | Associazione di inibitori della xantina ossidasi e statine e loro uso. |
| IT1400309B1 (it) | 2010-05-10 | 2013-05-24 | Menarini Int Operations Lu Sa | Associazione di inibitori della xantina ossidasi e calcio antagonisti e loro uso. |
| IT1400311B1 (it) | 2010-05-10 | 2013-05-24 | Menarini Int Operations Lu Sa | Associazione di inibitori della xantina ossidasi e antagonisti del recettore dell'angiotensina ii e loro uso. |
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| ES2553584T3 (es) | 2010-06-25 | 2015-12-10 | Sandoz Ag | Polimorfos de Febuxostat |
| TW201217347A (en) * | 2010-07-13 | 2012-05-01 | Interquim Sa | Process for preparing the crystalline form a of febuxostat |
| WO2012020272A2 (fr) | 2010-08-13 | 2012-02-16 | EGIS GYÓGYSZERGYÁR Nyilvánosan Müködö Részvénytársaság | Nouveaux sels, polymorphes et solvates d'un ingrédient pharmaceutiquement actif |
| CN103298466B (zh) | 2010-09-10 | 2015-11-25 | 武田制药美国有限公司 | 茶碱和非布索坦的联合治疗方法 |
| WO2012038971A2 (fr) * | 2010-09-24 | 2012-03-29 | Hetero Research Foundation | Nouveaux polymorphes de febuxostat |
| CN102442971B (zh) * | 2010-10-13 | 2014-06-18 | 欣凯医药化工中间体(上海)有限公司 | 非布司他的晶型及其制备方法 |
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| CA2814411A1 (fr) * | 2010-10-28 | 2012-05-03 | Mapi Pharma Limited | Polymorphes de febuxostat |
| TWI590821B (zh) * | 2011-01-18 | 2017-07-11 | 輝瑞有限公司 | 固體分子分散液 |
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| EP2502920A1 (fr) | 2011-03-25 | 2012-09-26 | Sandoz Ag | Procédé de cristallisation pour Febuxostat form A |
| WO2012131590A1 (fr) | 2011-03-31 | 2012-10-04 | Sandoz Ag | Procédé de préparation amélioré du fébuxostat et de sa forme cristalline polymorphe c |
| CA2833101A1 (fr) | 2011-04-15 | 2012-10-18 | Poonam KAUSHIK | Dispersion solide de febuxostat |
| WO2012153313A1 (fr) | 2011-05-11 | 2012-11-15 | Ranbaxy Laboratories Limited | Composition pharmaceutique de fébuxostat |
| WO2012168948A2 (fr) * | 2011-06-06 | 2012-12-13 | Hetero Research Foundation | Procédé de préparation de fébuxostat |
| WO2012172461A1 (fr) | 2011-06-13 | 2012-12-20 | Ranbaxy Laboratories Limited | Compositions pharmaceutiques de febuxostat |
| AU2012342011A1 (en) | 2011-11-15 | 2014-06-05 | Mylan Laboratories Ltd | Process for the preparation of Febuxostat polymorphs |
| WO2013088449A1 (fr) | 2011-12-16 | 2013-06-20 | Natco Pharma Limited | Forme cristalline stable de febuxostat et procédé de préparation correspondant |
| EP2925306A1 (fr) | 2012-07-12 | 2015-10-07 | Alembic Pharmaceuticals Limited | Composition pharmaceutique de fébuxostat |
| EP2692342A1 (fr) | 2012-07-30 | 2014-02-05 | Interquim, S.A. | Procédé pour la préparation de compositions pharmaceutiques comprenant du Febuxostat sous la forme de comprimés |
| WO2014057461A1 (fr) | 2012-10-11 | 2014-04-17 | Ranbaxy Laboratories Limited | Procédé pour la préparation de forme cristalline g de fébuxostat |
| CN103936688A (zh) * | 2013-01-21 | 2014-07-23 | 上海华拓医药科技发展股份有限公司 | 2-(3-氰基-4-(2-甲基丙氧基)苯基)-4-甲基-5-噻唑甲酸a晶的制备方法 |
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| CN103588724B (zh) * | 2013-09-10 | 2015-05-20 | 杭州华东医药集团新药研究院有限公司 | 一种非布司他晶型a及其制备方法 |
| JP6283371B2 (ja) * | 2013-10-22 | 2018-02-21 | 日本ケミファ株式会社 | 2−[3−シアノ−4−(2−メチルプロポキシ)フェニル]−4−メチルチアゾール−5−カルボン酸の小型化結晶、その微粉化物及びこれらを含有する固形製剤 |
| EP2881116A1 (fr) | 2013-12-05 | 2015-06-10 | Ranbaxy Laboratories Limited | Composition de febuxostat |
| EP2902016A1 (fr) | 2014-01-30 | 2015-08-05 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Comprimé Febuxostat |
| CN103739568B (zh) * | 2014-02-07 | 2015-09-16 | 浙江普洛康裕制药有限公司 | 2-(3-氰基-4-异丁氧基苯基)-4-甲基噻唑-5-甲酸a晶型的制备方法 |
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| EP3002006A1 (fr) | 2014-10-01 | 2016-04-06 | Bluepharma - Industria Farmacêutica, S.A. | Composition pharmaceutique capable de l'incorporation de febuxostat dans les modifications cristallines F10, II, G et A |
| CZ27857U1 (cs) | 2014-12-12 | 2015-02-23 | Zentiva, K.S. | Formulace obsahující tuhý roztok febuxostatu |
| JP2016150917A (ja) * | 2015-02-17 | 2016-08-22 | 株式会社トクヤマ | バルサルタンの結晶の製造方法 |
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| EP3153158A1 (fr) | 2015-10-09 | 2017-04-12 | Stada Arzneimittel Ag | Pastille orale de febuxostat |
| CN107540630A (zh) * | 2016-06-29 | 2018-01-05 | 康普药业股份有限公司 | 一种非布司他化合物及制备方法 |
| GR1009119B (el) | 2016-06-30 | 2017-09-18 | "Φαρματεν Α.Β.Ε.Ε." | Φαρμακευτικο σκευασμα περιεχον ενα μη πουρινικο επιλεκτικο αναστολεα της οξειδασης της ξανθινης και μεθοδος παρασκευης αυτου |
| KR20180013563A (ko) * | 2016-07-29 | 2018-02-07 | 한미정밀화학주식회사 | 고순도 결정형 페북소스타트의 개선된 제조 방법 |
| CN106565627B (zh) * | 2016-10-10 | 2020-01-10 | 扬子江药业集团有限公司 | 一种非布司他药用晶型的制备方法 |
| GR1009659B (el) | 2018-09-07 | 2019-11-28 | Φαρματεν Α.Β.Ε.Ε. | Φαρμακευτικο σκευασμα που περιλαμβανει ενα συμπλοκο αλατος της φεβουξοστατης με οξειδιο του μαγνησιου και μεθοδος για την παρασκευη αυτου |
| JP7389044B2 (ja) | 2018-09-28 | 2023-11-29 | 株式会社カネカ | 安定性に優れた還元型補酵素q10結晶の製造方法 |
| CN112390766B (zh) * | 2019-08-13 | 2022-09-06 | 浙江天宇药业股份有限公司 | 一种非布司他a晶型的制备方法 |
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| JP7506475B2 (ja) * | 2019-12-26 | 2024-06-26 | 東和薬品株式会社 | フェブキソスタット製剤 |
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| SU1417437A1 (ru) * | 1986-12-30 | 1994-01-30 | Институт органической и физической химии им.А.Е.Арбузова | Способ получения 4-тиазолкарбоновой кислоты |
| US5015646A (en) | 1987-08-28 | 1991-05-14 | Bristol-Myers Squibb Co. | Pharmaceutically useful polymorphic modification of buspirone |
| DE69122084T2 (de) * | 1990-11-30 | 1997-04-03 | Teijin Ltd., Osaka | 2-arylthiazolderivat sowie dieses enthaltendes arzneimittel |
| JP2706037B2 (ja) * | 1993-04-13 | 1998-01-28 | 帝人株式会社 | シアノ化合物およびその製造方法 |
| JP3202607B2 (ja) * | 1996-08-01 | 2001-08-27 | 帝人株式会社 | 2−(4−アルコキシ−3−シアノフェニル)チアゾール誘導体の製造法 |
| AU748026B2 (en) | 1998-06-19 | 2002-05-30 | Teijin Limited | Polymorphic modifications of 2-(3-cyano-4-isobutyloxyphenyl)- 4-methyl-5-thiazole-carboxylic acid and processes for the preparation thereof |
| DK1488790T3 (da) | 2002-03-28 | 2014-10-13 | Teijin Pharma Ltd | Fast præparat indeholdende en enkeltkrystalform A af etthiazolcarboxylsyrederivat |
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1999
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