CN1970547B - 非布司他的晶型及其制备方法 - Google Patents
非布司他的晶型及其制备方法 Download PDFInfo
- Publication number
- CN1970547B CN1970547B CN2006100952630A CN200610095263A CN1970547B CN 1970547 B CN1970547 B CN 1970547B CN 2006100952630 A CN2006100952630 A CN 2006100952630A CN 200610095263 A CN200610095263 A CN 200610095263A CN 1970547 B CN1970547 B CN 1970547B
- Authority
- CN
- China
- Prior art keywords
- febustat
- crystal
- crystal formation
- crystal form
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (6)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2006100952630A CN1970547B (zh) | 2006-12-07 | 2006-12-07 | 非布司他的晶型及其制备方法 |
PCT/CN2007/071194 WO2008067773A1 (fr) | 2006-12-07 | 2007-12-06 | Nouveaux types de cristaux de febuxostat et procédés de préparation de ceux-ci |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2006100952630A CN1970547B (zh) | 2006-12-07 | 2006-12-07 | 非布司他的晶型及其制备方法 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 201110027282 Division CN102093309B (zh) | 2006-12-07 | 2006-12-07 | 非布司他的晶型及其制备方法 |
CN201110027276A Division CN102093308B (zh) | 2006-12-07 | 2006-12-07 | 非布司他的晶型及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1970547A CN1970547A (zh) | 2007-05-30 |
CN1970547B true CN1970547B (zh) | 2011-04-06 |
Family
ID=38111592
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2006100952630A Active CN1970547B (zh) | 2006-12-07 | 2006-12-07 | 非布司他的晶型及其制备方法 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN1970547B (zh) |
WO (1) | WO2008067773A1 (zh) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101412700B (zh) * | 2007-10-19 | 2011-06-08 | 上海医药工业研究院 | 非布司他的晶型及其制备方法 |
CN101386605B (zh) * | 2008-10-23 | 2010-09-08 | 中国科学院上海药物研究所 | 非布司他新型晶体及其制备方法 |
CN101474175B (zh) * | 2009-01-20 | 2014-07-02 | 重庆医药工业研究院有限责任公司 | 一种高生物利用度非布司他口服固体制剂及其制备方法 |
CN101862326B (zh) * | 2009-04-20 | 2013-12-04 | 北京德众万全药物技术开发有限公司 | 一种含非布索坦的药物组合物 |
CN101891702B (zh) * | 2009-05-22 | 2012-07-04 | 重庆圣华曦药业股份有限公司 | 非布司他的晶体、制备方法及在药物中的应用 |
DE202010017868U1 (de) | 2009-06-10 | 2012-11-28 | Teva Pharmaceutical Industries Ltd. | Kristalline Formen von Febuxostat |
CN101929988B (zh) * | 2009-06-26 | 2014-05-07 | 北京德众万全药物技术开发有限公司 | 一种用高效液相色谱法测定非布索坦有关物质的方法 |
JP5519201B2 (ja) * | 2009-07-15 | 2014-06-11 | 光孝 北村 | 2−(3−シアノ−4−イソブチルオキシフェニル)−4−メチル−5−チアゾールカルボン酸の結晶多形体の製造方法 |
CN103936689B (zh) * | 2009-07-17 | 2016-08-17 | 北京利乐生制药科技有限公司 | 2-[3-氰基-4-异丁氧基苯基]-4-甲基噻唑-5-甲酸晶型及其制备方法 |
WO2011080651A2 (en) | 2009-12-31 | 2011-07-07 | Ranbaxy Laboratories Limited | Polymorphic forms of febuxostat |
CA2792036A1 (en) | 2010-03-04 | 2011-09-09 | Ranbaxy Laboratories Limited | Polymorph of 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid |
CN101824005B (zh) * | 2010-04-27 | 2012-06-27 | 上海凯米侬医药科技有限公司 | 一种非布索坦的晶型q及其制备方法 |
WO2012020272A2 (en) | 2010-08-13 | 2012-02-16 | EGIS GYÓGYSZERGYÁR Nyilvánosan Müködö Részvénytársaság | New salts, polymorphs and solvates of a pharmaceutical active ingredient |
WO2012048861A1 (en) | 2010-10-14 | 2012-04-19 | Gador S.A. | A novel febuxostat crystalline form and the process for the preparation thereof |
CN102018705A (zh) * | 2010-12-17 | 2011-04-20 | 江苏同禾药业有限公司 | 一种含有非布司他晶体的药物组合物及制备方法 |
CN102127033A (zh) * | 2011-01-21 | 2011-07-20 | 北京虹湾医药技术有限公司 | 非布索坦晶型及其工业化制备方法 |
CN102731430B (zh) * | 2011-04-14 | 2014-08-27 | 沈阳禾晶医药科技有限公司 | 非布司他的晶型和其制备方法以及应用 |
WO2013088449A1 (en) | 2011-12-16 | 2013-06-20 | Natco Pharma Limited | Stable crystal form of febuxostat and process for the preparation thereof |
EP2692342A1 (en) | 2012-07-30 | 2014-02-05 | Interquim, S.A. | Process for the preparation of pharmaceutical compositions comprising febuxostat in the form of tablets |
EP2902016A1 (en) | 2014-01-30 | 2015-08-05 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Febuxostat tablet |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5614520A (en) * | 1990-11-30 | 1997-03-25 | Teijin Limited | 2-arylthiazole derivatives and pharmaceutical composition thereof |
CN1275126A (zh) * | 1998-06-19 | 2000-11-29 | 帝人株式会社 | 2-(3-氰基-4-异丁氧基苯基)-4-甲基-5-噻唑甲酸的多晶型体及其制备方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1488790T3 (da) * | 2002-03-28 | 2014-10-13 | Teijin Pharma Ltd | Fast præparat indeholdende en enkeltkrystalform A af etthiazolcarboxylsyrederivat |
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2006
- 2006-12-07 CN CN2006100952630A patent/CN1970547B/zh active Active
-
2007
- 2007-12-06 WO PCT/CN2007/071194 patent/WO2008067773A1/zh active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5614520A (en) * | 1990-11-30 | 1997-03-25 | Teijin Limited | 2-arylthiazole derivatives and pharmaceutical composition thereof |
CN1275126A (zh) * | 1998-06-19 | 2000-11-29 | 帝人株式会社 | 2-(3-氰基-4-异丁氧基苯基)-4-甲基-5-噻唑甲酸的多晶型体及其制备方法 |
Non-Patent Citations (2)
Title |
---|
JP特开平10-45733A 1998.02.17 |
JP特开平6-345724A 1994.12.20 |
Also Published As
Publication number | Publication date |
---|---|
WO2008067773A1 (fr) | 2008-06-12 |
CN1970547A (zh) | 2007-05-30 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: XUZHOU WANBANG JINQIAO PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. Effective date: 20120328 |
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C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 400061 NANAN, CHONGQING TO: 221004 XUZHOU, JIANGSU PROVINCE |
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TR01 | Transfer of patent right |
Effective date of registration: 20120328 Address after: 221004, Jiangsu, Xuzhou Jinshan Development Zone, comprehensive area, the south side of the Cave Hill Patentee after: Xuzhou Wanbang Jinqiao Pharmaceutical Co.,Ltd. Address before: 400061 No. 565, Tu Shan Road, Nan'an District, Chongqing Patentee before: CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE Co.,Ltd. |
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ASS | Succession or assignment of patent right |
Owner name: JIANGSU WANBANG BIOLOGICAL PHARMACEUTICAL CO., LTD Effective date: 20150721 |
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C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20150721 Address after: 221004, Jiangsu, Xuzhou Jinshan Development Zone, comprehensive area, the south side of the Cave Hill Patentee after: Xuzhou Wanbang Jinqiao Pharmaceutical Co.,Ltd. Patentee after: JIANGSU WANBANG BIOPHARMACEUTICALS Co.,Ltd. Address before: 221004, Jiangsu, Xuzhou Jinshan Development Zone, comprehensive area, the south side of the Cave Hill Patentee before: Xuzhou Wanbang Jinqiao Pharmaceutical Co.,Ltd. |
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DD01 | Delivery of document by public notice |
Addressee: Tian Haiying Document name: Notification of Passing Examination on Formalities |
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CP01 | Change in the name or title of a patent holder |
Address after: 221004, Jiangsu, Xuzhou Jinshan Development Zone, comprehensive area, the south side of the Cave Hill Co-patentee after: JIANGSU WANBANG BIOPHARMACEUTICAL GROUP CO.,LTD. Patentee after: Xuzhou Wanbang Jinqiao Pharmaceutical Co.,Ltd. Address before: 221004, Jiangsu, Xuzhou Jinshan Development Zone, comprehensive area, the south side of the Cave Hill Co-patentee before: Jiangsu Wan Bang Biochemical Medicine Co.,Ltd. Patentee before: Xuzhou Wanbang Jinqiao Pharmaceutical Co.,Ltd. Address after: 221004, Jiangsu, Xuzhou Jinshan Development Zone, comprehensive area, the south side of the Cave Hill Co-patentee after: Jiangsu Wan Bang Biochemical Medicine Co.,Ltd. Patentee after: Xuzhou Wanbang Jinqiao Pharmaceutical Co.,Ltd. Address before: 221004, Jiangsu, Xuzhou Jinshan Development Zone, comprehensive area, the south side of the Cave Hill Co-patentee before: JIANGSU WANBANG BIOPHARMACEUTICALS Co.,Ltd. Patentee before: Xuzhou Wanbang Jinqiao Pharmaceutical Co.,Ltd. |
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CP03 | Change of name, title or address |