ATE244263T1 - Verfahren zur herstellung von n-glycyltyrosin - Google Patents
Verfahren zur herstellung von n-glycyltyrosinInfo
- Publication number
- ATE244263T1 ATE244263T1 AT99107190T AT99107190T ATE244263T1 AT E244263 T1 ATE244263 T1 AT E244263T1 AT 99107190 T AT99107190 T AT 99107190T AT 99107190 T AT99107190 T AT 99107190T AT E244263 T1 ATE244263 T1 AT E244263T1
- Authority
- AT
- Austria
- Prior art keywords
- producing
- salt
- dihydrate
- tyrosine
- glycyltyrosine
- Prior art date
Links
- XBGGUPMXALFZOT-VIFPVBQESA-N Gly-Tyr Chemical compound NCC(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 XBGGUPMXALFZOT-VIFPVBQESA-N 0.000 title abstract 3
- XBGGUPMXALFZOT-UHFFFAOYSA-N glycyl-L-tyrosine hemihydrate Natural products NCC(=O)NC(C(O)=O)CC1=CC=C(O)C=C1 XBGGUPMXALFZOT-UHFFFAOYSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 150000004683 dihydrates Chemical class 0.000 abstract 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 abstract 1
- 108010087823 glycyltyrosine Proteins 0.000 abstract 1
- -1 haloacetyl halide Chemical class 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 239000012046 mixed solvent Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229960004441 tyrosine Drugs 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10310098 | 1998-04-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE244263T1 true ATE244263T1 (de) | 2003-07-15 |
Family
ID=14345218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99107190T ATE244263T1 (de) | 1998-04-14 | 1999-04-13 | Verfahren zur herstellung von n-glycyltyrosin |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6197998B1 (de) |
| EP (1) | EP0950664B1 (de) |
| AT (1) | ATE244263T1 (de) |
| CA (1) | CA2268586A1 (de) |
| DE (1) | DE69909165T2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2845389B1 (fr) * | 2002-10-04 | 2007-01-12 | Solvay | Procede pour la synthese de peptides comprenant au moins une molecule de glycine |
| CN101429230B (zh) * | 2008-12-05 | 2013-10-02 | 北京博时安泰科技发展有限公司 | 一种甘谷二肽的精制方法 |
| CN102993270B (zh) * | 2011-09-15 | 2015-04-08 | 山东齐都药业有限公司 | 甘氨酰-l-酪氨酸的制备工艺 |
| CN102718833A (zh) * | 2012-05-16 | 2012-10-10 | 江苏诚信制药有限公司 | 一种甘氨酰-酪氨酸的制备方法 |
| CN102976967A (zh) * | 2012-11-13 | 2013-03-20 | 湖北一半天制药有限公司 | 甘氨酰-l-酪氨酸一种中间体的合成及研究 |
| CN103087313B (zh) * | 2013-02-06 | 2015-12-09 | 三角轮胎股份有限公司 | 制备低聚氨基酸的方法 |
| CN104447946B (zh) * | 2014-11-05 | 2017-10-31 | 济南康和医药科技有限公司 | 一种甘酪二肽一水合物的新晶型及其制备方法 |
| CN104402755B (zh) * | 2014-12-13 | 2016-06-22 | 济南诚汇双达化工有限公司 | 一种n-氯乙酰-l-酪氨酸的制备方法 |
| CN108101958B (zh) * | 2017-12-25 | 2020-06-02 | 湖北泓肽生物科技有限公司 | 一种甘氨酰-l-酪氨酸的精制方法 |
| CN113880911B (zh) * | 2021-09-15 | 2023-11-14 | 湖北泓肽生物科技有限公司 | 一种甘氨酰-l-酪氨酸的合成方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3440129B2 (ja) | 1994-04-18 | 2003-08-25 | 協和醗酵工業株式会社 | グルタミン誘導体の製造法 |
-
1999
- 1999-04-12 CA CA002268586A patent/CA2268586A1/en not_active Abandoned
- 1999-04-12 US US09/289,737 patent/US6197998B1/en not_active Expired - Fee Related
- 1999-04-13 DE DE69909165T patent/DE69909165T2/de not_active Expired - Fee Related
- 1999-04-13 EP EP99107190A patent/EP0950664B1/de not_active Expired - Lifetime
- 1999-04-13 AT AT99107190T patent/ATE244263T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0950664A1 (de) | 1999-10-20 |
| DE69909165D1 (de) | 2003-08-07 |
| EP0950664B1 (de) | 2003-07-02 |
| US6197998B1 (en) | 2001-03-06 |
| DE69909165T2 (de) | 2004-04-15 |
| CA2268586A1 (en) | 1999-10-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0950664 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |