AR045235A1 - Metodo para producir derivados del almidon de hidroxialquilo y composiciones farmaceuticas que los contienen. - Google Patents
Metodo para producir derivados del almidon de hidroxialquilo y composiciones farmaceuticas que los contienen.Info
- Publication number
- AR045235A1 AR045235A1 ARP040102851A ARP040102851A AR045235A1 AR 045235 A1 AR045235 A1 AR 045235A1 AR P040102851 A ARP040102851 A AR P040102851A AR P040102851 A ARP040102851 A AR P040102851A AR 045235 A1 AR045235 A1 AR 045235A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- hydroxyalkyl starch
- reacting
- functional group
- compound
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/08—Ethers
- C08B31/10—Alkyl or cycloalkyl ethers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/08—Ethers
- C08B31/12—Ethers having alkyl or cycloalkyl radicals substituted by heteroatoms, e.g. hydroxyalkyl or carboxyalkyl starch
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/10—Peptides being immobilised on, or in, an organic carrier the carrier being a carbohydrate
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/003—Crosslinking of starch
- C08B31/006—Crosslinking of derivatives of starch
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/08—Ethers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/18—Oxidised starch
- C08B31/185—Derivatives of oxidised starch, e.g. crosslinked oxidised starch
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
- C08H1/00—Macromolecular products derived from proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
La presente se refiere a un método para producir un derivado de almidón de hidroxialquilo, dicho derivado de almidón de hidroxialquilo que tiene una estructura de acuerdo con la fórmula (1), que comprende hacer reaccionar: el almidón de hidroxialquilo de la fórmula (1) en su extremo reductor opcionalmente oxidado; o un derivado del almidón de hidroxialquilo que se puede obtener haciendo reaccionar el almidón de hidroxialquilo de la fórmula (1) en su extremo reductor opcionalmente oxidado con un compuesto (D), dicho compuesto (D) que comprende: por lo menos un grupo funcional Z1 capaz de hacerse reaccionar con el extremo reductor opcionalmente oxidado del almidón de hidroxialquilo; y por lo menos, un grupo funcional W, con un compuesto (L) que comprende: por lo menos un grupo funcional Z1 capaz de reaccionar con dicho almidón de hidroxialquilo, o por lo menos un grupo funcional Z2 capaz de hacerse reaccionar con el grupo funcional W comprendido en dicho derivado; y por lo menos un grupo funcional X capaz de hacerse reaccionar con un grupo funcional Y de un compuesto adicional (M), en el cual dicho grupo funcional Y es seleccionado a partir del grupo que consiste en un grupo aldehído, un grupo ceto, un grupo hemiacetal, un grupo acetal, y un grupo tio. La presente también se refiere a los derivados de almidón de hidroxialquilo como tal, y a una composición farmacéutica que comprende dichos derivados de almidón de hidroxialquilo.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40978102P | 2002-09-11 | 2002-09-11 | |
EP02020425A EP1400533A1 (en) | 2002-09-11 | 2002-09-11 | HASylated polypeptides, especially HASylated erythropoietin |
PCT/EP2003/008858 WO2004024761A1 (en) | 2002-09-11 | 2003-08-08 | Hasylated polypeptides, especially hasylated erythropoietin |
PCT/EP2003/008829 WO2004024776A1 (en) | 2002-09-11 | 2003-08-08 | Method of producing hydroxyalkyl starch derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
AR045235A1 true AR045235A1 (es) | 2005-10-19 |
Family
ID=31995520
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030103141A AR041097A1 (es) | 2002-09-11 | 2003-08-29 | Derivados de polipeptidos con hidroxilalquilalmidon especialmente derivados de eritropoyetina con hidroxilalquilalmidon |
ARP040102851A AR045235A1 (es) | 2002-09-11 | 2004-08-09 | Metodo para producir derivados del almidon de hidroxialquilo y composiciones farmaceuticas que los contienen. |
ARP040102850A AR045234A1 (es) | 2002-09-11 | 2004-08-09 | Metodo para producir derivados del almidon de hidroxialquilo y composiciones farmaceuticas que los contienen. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030103141A AR041097A1 (es) | 2002-09-11 | 2003-08-29 | Derivados de polipeptidos con hidroxilalquilalmidon especialmente derivados de eritropoyetina con hidroxilalquilalmidon |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040102850A AR045234A1 (es) | 2002-09-11 | 2004-08-09 | Metodo para producir derivados del almidon de hidroxialquilo y composiciones farmaceuticas que los contienen. |
Country Status (25)
Country | Link |
---|---|
US (5) | US7815893B2 (es) |
EP (8) | EP2154160A1 (es) |
JP (4) | JP2006516534A (es) |
KR (3) | KR101045422B1 (es) |
CN (2) | CN100348618C (es) |
AR (3) | AR041097A1 (es) |
AT (3) | ATE323723T1 (es) |
AU (6) | AU2003260393B2 (es) |
BR (3) | BR0314227A (es) |
CA (2) | CA2496317C (es) |
CY (1) | CY1109813T1 (es) |
DE (7) | DE60330098D1 (es) |
DK (3) | DK1398327T3 (es) |
ES (4) | ES2213505T3 (es) |
HK (4) | HK1063478A1 (es) |
IL (5) | IL166506A0 (es) |
MX (4) | MXPA05002594A (es) |
NO (2) | NO20051427L (es) |
PL (3) | PL216545B1 (es) |
PT (3) | PT1398322E (es) |
RU (3) | RU2329274C2 (es) |
SI (2) | SI1398327T1 (es) |
TW (1) | TW200418875A (es) |
WO (3) | WO2004024761A1 (es) |
ZA (1) | ZA200600651B (es) |
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