DE60233420D1 - Fumagillolderivate und verfahren zu deren herstellung - Google Patents
Fumagillolderivate und verfahren zu deren herstellungInfo
- Publication number
- DE60233420D1 DE60233420D1 DE60233420T DE60233420T DE60233420D1 DE 60233420 D1 DE60233420 D1 DE 60233420D1 DE 60233420 T DE60233420 T DE 60233420T DE 60233420 T DE60233420 T DE 60233420T DE 60233420 D1 DE60233420 D1 DE 60233420D1
- Authority
- DE
- Germany
- Prior art keywords
- angiogenesis
- preparation
- fumagillol derivatives
- fumagillol
- psoriasis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2001-0060017A KR100455900B1 (ko) | 2001-09-27 | 2001-09-27 | 새로운 푸마질롤 유도체 및 그의 제조방법 |
KR10-2002-0029915A KR100483836B1 (ko) | 2002-05-29 | 2002-05-29 | 푸마질롤 유도체 및 그의 제조방법 |
PCT/KR2002/001102 WO2003027104A1 (en) | 2001-09-27 | 2002-06-11 | Fumagillol derivatives and preparing method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60233420D1 true DE60233420D1 (de) | 2009-10-01 |
Family
ID=26639368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60233420T Expired - Lifetime DE60233420D1 (de) | 2001-09-27 | 2002-06-11 | Fumagillolderivate und verfahren zu deren herstellung |
Country Status (5)
Country | Link |
---|---|
US (3) | US7087768B2 (de) |
EP (1) | EP1436286B1 (de) |
AT (1) | ATE440094T1 (de) |
DE (1) | DE60233420D1 (de) |
WO (1) | WO2003027104A1 (de) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003027104A1 (en) * | 2001-09-27 | 2003-04-03 | Idrtech Inc. | Fumagillol derivatives and preparing method thereof |
KR100552043B1 (ko) * | 2004-02-28 | 2006-02-20 | 주식회사종근당 | 푸마질롤 유도체를 포함하는 비만치료용 조성물 |
WO2006080591A1 (en) * | 2005-01-26 | 2006-08-03 | Chong Kun Dang Pharmaceutical Corp. | Fumagillol derivatives or method for preparation of fumagillol derivatives, and pharmaceutical compositions comprising the same |
WO2009003110A2 (en) | 2007-06-26 | 2008-12-31 | Children's Medical Center Corporation | Metap-2 inhibitor polymersomes for therapeutic administration |
AU2008331516B2 (en) * | 2007-11-28 | 2014-01-09 | Mersana Therapeutics, Inc. | Biocompatible biodegradable fumagillin analog conjugates |
US8865746B2 (en) | 2008-07-18 | 2014-10-21 | Zafgen, Inc. | Methods of treating an overweight or obese subject |
US8642650B2 (en) | 2008-12-04 | 2014-02-04 | Zafgen, Inc. | Methods of treating an overweight or obese subject |
WO2010065877A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Methods of treating an overweight or obese subject |
MX337575B (es) | 2009-10-09 | 2016-03-10 | Zafgen Corp | Compuestos de sulfona y métodos para lafabricación y uso de éstos. |
WO2011085198A1 (en) | 2010-01-08 | 2011-07-14 | Zafgen Corporation | Metap-2 inhibitor for use in treating benign prostatic hypertrophy (bph) |
BR112012016793A2 (pt) | 2010-01-08 | 2018-07-31 | Zafgen Corp | compostos tipo fumagilol e métodos de fazer e usar os mesmos |
WO2011127304A2 (en) | 2010-04-07 | 2011-10-13 | Zafgen Corporation | Methods of treating an overweight subject |
CN107158398B (zh) | 2010-05-25 | 2022-02-18 | 辛德弗雷克斯公司 | 聚合物缀合的MetAP2抑制剂及其应用的治疗方法 |
US9895449B2 (en) | 2010-05-25 | 2018-02-20 | Syndevrx, Inc. | Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof |
BR112013001613A2 (pt) | 2010-07-22 | 2016-05-24 | Zafgen Inc | compostos tricíclicos e métodos para fazer e usar os mesmos. |
EP2638023B1 (de) | 2010-11-09 | 2016-09-07 | Zafgen, Inc. | Crystalline feststoffe von einem metap-2-hemmer, verfahren zu deren herstellung und verwendung |
CN103379905A (zh) | 2010-11-29 | 2013-10-30 | 扎夫根股份有限公司 | 使用非每天施用的6-0-(4-二甲基氨基乙氧基)肉桂酰烟曲霉醇治疗肥胖症 |
US9321740B2 (en) | 2011-01-26 | 2016-04-26 | Zafgen, Inc. | Tetrazole compounds and methods of making and using same |
KR101875988B1 (ko) | 2011-03-08 | 2018-07-06 | 자프겐 인크. | 옥사스피로[2.5]옥탄 유도체 및 유사체 |
FR2973376B1 (fr) * | 2011-03-28 | 2013-05-10 | Atlanthera | Derives utiles dans le traitement ou la prevention de tumeurs osseuses |
EA025526B1 (ru) | 2011-05-06 | 2017-01-30 | Зафджен Инк. | Частично насыщенные трициклические соединения и способы их получения и применения |
CA2835195A1 (en) | 2011-05-06 | 2012-11-15 | Zafgen, Inc. | Tricyclic sulfonamide compounds and methods of making and using same |
JP6035327B2 (ja) | 2011-05-06 | 2016-11-30 | ザフゲン,インコーポレイテッド | 三環式ピラゾールスルホンアミド化合物ならびにその製造および使用方法 |
EP2763671A2 (de) | 2011-10-03 | 2014-08-13 | Zafgen, Inc. | Verfahren zur behandlung von altersbedingten erkrankungen |
JP2015509102A (ja) | 2012-01-18 | 2015-03-26 | ザフゲン,インコーポレイテッド | 三環式スルホン化合物並びにその作製および使用方法 |
KR20140112565A (ko) | 2012-01-18 | 2014-09-23 | 자프겐 인크. | 삼환식 설폰아마이드 화합물 그리고 그의 제조방법 및 그를 이용하는 방법 |
BR112014027808A2 (pt) | 2012-05-07 | 2017-06-27 | Zafgen Inc | sal polimórfico do sal de oxalato de 6-o-(4-dimetilaminoetoxi) cinaroil fumagilol e métodos de produção e utilização do mesmo |
MX2014013599A (es) | 2012-05-08 | 2015-05-11 | Zafgen Inc | Tratamiento de la obesidad hipotalamica con inhibidores de metap2. |
CN104364251B (zh) | 2012-05-09 | 2017-02-22 | 扎夫根股份有限公司 | 烟曲霉醇型化合物及其制备和使用方法 |
EP2916833A1 (de) | 2012-11-05 | 2015-09-16 | Zafgen, Inc. | Verfahren zur behandlung von lebererkrankungen |
BR112015010223A2 (pt) | 2012-11-05 | 2017-07-11 | Zafgen Inc | compostos tricíclicos para o uso no tratamento e/ou controle de obesidade |
KR20150079952A (ko) | 2012-11-05 | 2015-07-08 | 자프겐 인크. | 트리시클릭 화합물 및 그의 제조 및 사용 방법 |
WO2014152861A2 (en) | 2013-03-14 | 2014-09-25 | Zafgen, Inc. | Methods of treating renal disease and other disorders |
MX371095B (es) | 2013-04-10 | 2020-01-16 | Syndevrx Inc | Inhibidores de metionina aminopeptidasa-2 y metodos de tratamiento de la obesidad. |
TW201636342A (zh) | 2014-12-19 | 2016-10-16 | 武田藥品工業有限公司 | 煙黴醇衍生物 |
AR105671A1 (es) | 2015-08-11 | 2017-10-25 | Zafgen Inc | Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso |
CN106432255A (zh) | 2015-08-11 | 2017-02-22 | 扎夫根公司 | 烟曲霉素醇螺环化合物和制备和使用其的方法 |
ES2893749T3 (es) | 2015-12-10 | 2022-02-10 | Syndevrx Inc | Derivados de fumagilol y polimorfos de los mismos |
CA3008960A1 (en) | 2016-01-11 | 2017-07-20 | Syndevrx, Inc. | Treatment for tumors driven by metabolic dysfunction |
US11612577B2 (en) | 2018-10-26 | 2023-03-28 | Syndevrx, Inc. | Biomarkers of METAP2 inhibitors and applications thereof |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5164410A (en) * | 1988-01-09 | 1992-11-17 | Takeda Chemical Industries, Ltd. | Fumagillol derivatives and pharmaceutical compositions thereof |
DE68927904T2 (de) * | 1988-09-01 | 1997-09-04 | Takeda Chemical Industries Ltd | Fumagillol-Derivate |
US5166172A (en) * | 1988-09-01 | 1992-11-24 | Takeda Chemical Industries, Ltd. | Fumagillol derivatives and pharmaceutical compositions thereof |
ES2053890T3 (es) * | 1988-09-01 | 1994-08-01 | Takeda Chemical Industries Ltd | Agente inhibidor de la angiogenesis. |
US5180738A (en) * | 1988-09-01 | 1993-01-19 | Takeda Chemical Industries | Fumagillol derivatives and pharmaceutical compositions thereof |
EP0387650B1 (de) | 1989-03-06 | 1993-03-31 | Takeda Chemical Industries, Ltd. | 6-Epifumagillole, ihre Herstellung und ihre Verwendung |
US5290807A (en) * | 1989-08-10 | 1994-03-01 | Children's Medical Center Corporation | Method for regressing angiogenesis using o-substituted fumagillol derivatives |
EP0415294A3 (en) * | 1989-08-31 | 1991-06-12 | Takeda Chemical Industries, Ltd. | Cyclohexanol derivatives, production and use thereof |
TW282399B (de) * | 1990-05-25 | 1996-08-01 | Takeda Pharm Industry Co Ltd | |
EP0799616A1 (de) * | 1996-04-01 | 1997-10-08 | Takeda Chemical Industries, Ltd. | Orale Zubereitung enthaltend ein Fumagillolderivat |
DE19653036A1 (de) * | 1996-12-19 | 1998-06-25 | Merck Patent Gmbh | Cyclopeptidderivate |
US6207704B1 (en) | 1997-06-09 | 2001-03-27 | Massachusetts Institute Of Technology | Type 2 methionine aminopeptidase [MetAP2] inhibitors and uses thereof |
KR100357541B1 (ko) * | 1998-05-15 | 2002-10-18 | 주식회사종근당 | 5-데메톡시 푸마질롤 유도체 및 그 제조방법 |
EP1202733B1 (de) * | 1999-08-12 | 2005-10-05 | Pharmacia Italia S.p.A. | 3(5)-amino-pyrazolderivate, deren herstellungsverfahren und verwendung als krebshemmende mittel |
US6114365A (en) * | 1999-08-12 | 2000-09-05 | Pharmacia & Upjohn S.P.A. | Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents |
US6458810B1 (en) * | 2000-11-14 | 2002-10-01 | George Muller | Pharmaceutically active isoindoline derivatives |
WO2003027104A1 (en) * | 2001-09-27 | 2003-04-03 | Idrtech Inc. | Fumagillol derivatives and preparing method thereof |
WO2003037330A1 (en) * | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | Sulfonyl-and sulfonylheteroaryl-pyrazoles with a hydrazinyl or nitrogen oxide substituent at the 5-position for use as cyclooxygenase inhibitors |
-
2002
- 2002-06-11 WO PCT/KR2002/001102 patent/WO2003027104A1/en not_active Application Discontinuation
- 2002-06-11 AT AT02738910T patent/ATE440094T1/de not_active IP Right Cessation
- 2002-06-11 DE DE60233420T patent/DE60233420D1/de not_active Expired - Lifetime
- 2002-06-11 EP EP02738910A patent/EP1436286B1/de not_active Expired - Lifetime
- 2002-06-11 US US10/490,588 patent/US7087768B2/en not_active Expired - Fee Related
-
2006
- 2006-07-26 US US11/494,026 patent/US20060276512A1/en not_active Abandoned
- 2006-11-21 US US11/603,688 patent/US20070149613A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1436286B1 (de) | 2009-08-19 |
WO2003027104A1 (en) | 2003-04-03 |
EP1436286A1 (de) | 2004-07-14 |
US7087768B2 (en) | 2006-08-08 |
US20060276512A1 (en) | 2006-12-07 |
ATE440094T1 (de) | 2009-09-15 |
US20070149613A1 (en) | 2007-06-28 |
US20040242681A1 (en) | 2004-12-02 |
EP1436286A4 (de) | 2004-12-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |